Aurigen Discovery provides integrated services from early discovery to preclinical studies, specializing in services for x-ray crystallography, small molecule synthesis, peptide synthesis, ADME assessment and invivo studies for oncology, inflammation, metabolic disorders and antiinfectives .
Our capabilities span across the integrated drug discovery spectrum starting from limited target validation studies all the way to IND enabling studies.
Chemistry - Over 50 labs equipped for Route scouting, Asymmetric/Chiral synthesis, Scaffold design-pharmacophore modeling, Niche chemistry, Solid phase, Carbohydrate, Process chem., Heterocycles, Lipids
Peptide chemistry expertise - Over 60 peptide chemists with wide technology expertise covering various types of peptide modifications. Delivered over 2500 peptides in the recent years. Multi year collaborations with large and mid pharma Tox/IND enabling pharmaceutical developability of compounds and generating data required for IND submissions
Formulation development lab - Equipped to with infra (5000 sq ft facility, Log P Analyzer, Single crystal X ray crystallography, Calorimeter, Tablet compressing machine) and expertise for polymorph screening, GLP Formulation dev. & support, Salt screening, Oral BA issues
Protein production and structural biology labs - Where we have expertise to tailor constructs (end point being Biochemistry, crystallization, NMR), express proteins in different expression systems – Bacterial Insect cells, Mammalian, Purification is carried out by conventional methods, we have expressed over 150 proteins, solved over 300 crystal structures with multiple ligands
DMPK Labs - To assess 1) Solubility & Stability; 2) PAMPA, CaCO2 & MDCK permeability ; 3) Protein binding - Tissue distribution; 4) Metabolism and drug drug interactions ( Metabolic stability on rat/mouse/dog/ human liver microsomes (S9); Cyp profiling (inhibition & induction), fluorescent probe substrate, microsomes, S9, Hepatocytes); 5) Oral bioavailability- PK Studies in rats, dogs; 6) Dose proportionality and multiple doses; 7) Tissue distribution in rodents; 8) Log D studies - Solubility and Log D data; 9) Bioanalytical (An OECD-GLP accredited lab)
Cell biology labs - Several unconditional, mechanistic and PD models across oncology and infllammation
Invivo labs - Currently running inhouse are over 20 Efficacy models set up inhouse (xenograft and syngeneic) for oncology and22 in vivo models with validation standards set up to support various indications (Acute, Arthritis, Psoriasis, Asthma, Inflammation); Several diabetes models inhouse for artherosclerosis/CV and MD (Diabetes and Obesity)
Microbiology labs for invitro and invivo effiacy studies - BSL-2 facility
Invitro tax studies - 1. Cytotoxicity in primary cells (Hepatocytes); 2. Herg functional assay (automated patch clamp); 3. Mutagenicity tests done here
Toxicology labs - GLP labs for rodent tox studies - To support Complete (90% support for FIM) Tox