Netherlands CROs - Contract Research Map

A4 Lifesciences Admiraal Trompstraat 8 4702VA, Roosendaal Nederland

Our vision is to “deliver affinity ligands based on either DNA, peptides or mixed mode to your targets in less than a week”. We intend to establish a great impact on development speed in therapeutics, diagnostis and separation of biomolecules creating biomarkers in a couple of days. A4 has started an internal program for making custom purfication “resins”. However the company will support anyone in the field of separations with product and business development. We believe that creating strong networks will increase our value to customers and accelerate the realization of our vision.Jacques Clemens B.Sc., owner of A4 combines practical experiences in R&D (immunology) and international sales+management of bio-separation solutions. He worked as sales director for Amersham Pharmacia Biotech (GE Healthcare) and Pall Lifesciences and as vice president for Asahi Kasei Bioprocess selling chromatography, filtration and virus removal applications plus engineering solutions for the same. Most of these projects were highly customised, differing significantly for each client. Jacques founded A4 in 2013 to explore the potential of aptamers replacing antibodies and has built a solid network to deliver affinity products for various purposes.

Aurion Binnenhaven 5 Wageningen, PD 6709 The Netherlands

Aurion offers custom labeling and supplies immunogold reagents.

ABL w.a. scholtenstraat 7 PO Box 232 Assen, 9400 AE The Netherlands

ABL (Analytisch Biochemisch Laboratorium) supports clinical trials and pre-clinical drug development studies through its bioanalytical and clinical services.

AkzoNobel Functional Chemicals Akzo Nobel Head Office Strawinskylaan 2555 1077 ZZ Amsterdam Netherlands

AkzoNobel Functional Chemicals offers chemical intermediates, performance chemicals and end-use consumer products.

Arcarios NV Arcarios BV Dr. Molewaterplein 40 3015 GD Rotterdam

Arcarios is a drug development company dedicated to the discovery and development of innovative products in the field of bone and joint diseases such as osteoporosis and osteoarthritis.Current treatment options are insufficient and indicate an urgent need for disease modifying drugs. The company’s proprietary technology platform allows for the successful development of treatments focussed on restoring cartilage and bone, thereby addressing an important unmet medical need in today’s society.Having two advanced therapeutic programs with a strong technology and IP position, Arcarios is well positioned to capitalize on the market opportunity in the field of osteoarthritis and osteoporosis.

Acatris Röntgenweg 6 3752 LJ Bunschoten The Netherlands

Acatris has an excellent reputation as a supplier to the food processing industry. Acatris ingredients, services and solutions contribute to the production of high quality food, often extending well beyond the repacking of the end product. Acatris offers its customers a wide range of single ingredients (including its Acsoli® product line) and Pectacon® stabiliser systems. Besides thousands of single ingredients and blends, we can also offer an extensive package of processing services, including blending, delumping, grinding, repacking and sieving of raw materials.

A-ware Food Group 3e Industrieweg 5c 3411 MD Lopik The Netherlands

We are a family business that specializes inthe maturation, cutting, wrapping, storage, transportation, and sale of cheese and other foodproductsin climate-controlled conditions. Our ambition is to become the most valued chain partner in the European food and agriculturesector, but we are also constantly extending our horizons beyond Europe.Core objective and core valuesA-ware Food Group is a family business with a passion for cheese. We aim to provide our customers with optimal serviceby offering custom-made solutions. In other words, the best possible – A-quality – service. Our smart and pro-active approach to business means that you can count on usfor an excellent price-quality ratio.The customer is central in everything we do. Applying our flexible approach, wejoin forces with the customer to find tailor-made solutions that deliver optimal results. At the same time, we are constantly improving our service and working on innovations to keep a step ahead of the customer’s needs and market trends. That way, we can continue to guarantee that our customers get the very best services.We invest in the well-being and development of our personnel. Enthusiastic and skilledworkers are a key contributory factor to our high-quality services.

Axon Medchem Postbus 770 Groningen, 9700 AT The Netherlands

Axon Medchem offers custom synthesis, organic analysis, and medicinal chemistry services.

Abundnz Jaap Bijzerweg 19 3446 CR WOERDEN The Netherlands

Abundnz offers advanced analytical support for biotechnology and diagnostics industries and life sciences research worldwide.A range of solutions are available to our clients. Our services include the characterization and bioanalysis of innovative medicines such as peptide and protein drugs, oligonucleotides and nanomedicines. Abundnz has developed a unique ultrasensitive assay for bioanalytical studies with large molecule drugs.Due to our experience and track record, you can rely on us as your solid partner in analytical support for your projects.

Albert Einstein College of Medicine YU In Vivo Imaging System Core Ullman 1005

The IVIS facility provides access to the the Caliper Life Sciences IVIS Spectrum in vivo imaging system that enables longitudinal three dimensional intravital imaging of animals or tissue expressing bioluminescent (e.g. Firefly luciferase) or far red fluorescent probes. Einstein investigators have used the system to follow tumor growth, tumor metastasis and progression of infectious diseases. The facility is housed within BSL2 animal space. Please note that investigators planning to use the facility for imaging of whole animals must have their experimental protocol approved by the Animal Institute prior to any experiments being conducted.ServicesIn vivo imaging of small animalsBioluminescence imaging (luciferase) of whole animalsFar red fluorescence imaging of whole animals

Aptalis Amsterdam, The Netherlands

Aptalis provides controlled drug release, dosage form, bioavailability enhancement, and drug targeting.

ACE Pharmaceuticals P.O. BOX 1262 NL-3890 BB Zeewolde The Netherlands

ACE Pharmaceuticals offers medical need products and the manufacturing, packaging and supply of clinical trial material.

AkzoNobel Polymer Chemicals Akzo Nobel Polymer Chemicals B.V. Stationsstraat 77 3811 MH Amersfoort P.O. Box 247 3800 AE Amersfoort The Netherlands

Akzo Nobel Polymer Chemicals offers custom synthesis, manufacturing, and APIs.

Asinex Laan van Vredenoord, 33, 2289 DA Rijswijk, The Netherlands

Asinex provides chemical library design and construction services, as well as compound resupply, hit expansion and lead optimization services.

AcroMetrix Jan Steenstraat 1 1816 CT Alkmaar The Netherlands

AcroMetrix offers immunoassays, bloodscreening, dilution, and matrix production.

Aegisto Holland

Alpha Packaging International Bijsterhuizen 1009 NL - 6604 LA Wijchen The Netherlands

Alpha Packaging International offers a wide variety of closures and other packaging materials.

Biocult Niels Bohrweg 11 - 13 Leiden, 2333 CA The Netherlands

Biocult specializes in in vitro upscaling of immortalized cells for animal or human(ized) monoclonal antibody production and purification.

Biorizon Green Chemistry Campus Plasticslaan 1 - Port 1 4612 PX Bergen op Zoom The Netherlands

Biorizon is a Shared Research Center with an initial focus on technology development for the production of functionalized biobased aromatics for performance materials, chemicals & coatings. Biorizon is anticipating the expected growing shortage of aromatics from the petrochemical industry and the widely shared ambition to green the chemical industry.Our goal is to be a leading European Center for functionalized biobased aromatics within 3 years and to be in the global top 3 within 5 years. This way the participating companies will get the best results possible!

Biolegio Biolegio B.V. Lagelandseweg 56 6545 CG Nijmegen The Netherlands

Biolegio offers custom Oligonucleotide synthesis services. Founded in 1996, DNA synthesis has been at the core of our business for more than 20 years. Our product offering includes standard DNA & RNA Oligos through to highly specialised Oligos incorporating any commercially available modification. We specialise in the provision of long Oligos and our unrivalled coupling efficiency during long synthesis enables us to offer high quality longmer Oligos with an appreciable yield of full length material up to 300 bases in length. With satisfied customers throughout the world our Oligos are used daily in a diverse range of applications including DNA sequencing, NGS, PCR, qPCR, target enrichment, SNP detection, synthetic biology, gene expression, gene silencing and more. Our manufacturing facility is ISO 9001:2008 and ISO 13485:2003 certified, ensuring high quality, reliable and safe products as a result of strong product quality and manufacturing procedures and an ongoing development of our quality management system. As a small business we pride ourselves on our service and customer satisfaction, for example with our dispensing & packaging service you can have your Oligos delivered in any format, quantity, concentration or combination.

Biomedical Primate Research Center (BPRC) 161 Lange Kleiweg, Rijswijk, ZH 2288 GJ, NL

Disease causes misery and large numbers of deaths in human populations worldwide. For many common deadly diseases there is still a desperate need for effective medicines. BPRC is a scientific research institute that exists to perform vital research that contributes to the identification and development of these new medicines.BPRC is committed to using non-human primates for this critical research only where there are no suitable alternatives. Research is also required to identify and develop alternatives to the use of non-human primates. BPRC has an active and expanding programme to develop alternatives following the principles of reduction, refinement and replacementCorporal social responsibility (CSR) has a high priority at BPRC. The BPRC is e.g. certified for responsible environmental policy (ISO 14001/2004) and is international recognized for animal welfare policy (AAALAC).

Biomedical Primate Research Centre Postbox 3306 Rijswijk, 2280 GH The Netherlands

Biomedical Primate Research Centre focuses on research and offers primate models for the testing of therapeutics for malaria, tuberculosis, hepatitis C, HIV/AIDS, and automimmune diseases.

Brains On-line, LLC. 9701 EA Groningen The Netherlands

Brains On-Line is a contract research organization (CRO) that operates in the life sciences and pharmaceutical fields. We specialize in preclinical testing of central nervous system targeted drugs. The company is able to provide world-wide coverage from its research facilities in Groningen (The Netherlands) and San Francisco (USA), and the business offices in Kurume (Japan).Brains On-Line provides pre-phase one testing in-vivo using a broad spectrum of research techniques. Using microdialysis, bioanalysis, pharmacokinetics, electrophysiology, behavioral studies and many other techniques, we strive to provide our customers full insight into the possibilities of their compounds. Our research organization is operated by a young and dynamic team of scientists and laboratory professionals.Our contract research is particularly relevant for:Neuropsychological disorders (depression, anxiety and schizophrenia)Neurodegenerative disorders (Alzheimer's disease, Parkinson's disease)Other CNS-related research (body weight regulation, diabetes, etc.)

BAC Huizerstraatweg 28 1411 GP Naarden The Netherlands

BAC discovers, develops and manufactures affinity ligands and affinity purification products.

Bioceros Remco M. Brandt / Yalelaan 46 / 3584 CM Utrecht / The Netherlands

Bioceros provides generation of cell lines, transfection of CHO cells, preclinical manufacturing, characterization of products, and in vivo studies.

BIRD Engineering Westfrankelandsedijk 1 3115 HG Schiedam Netherlands

BIRD Engineering offers strain development, fermentation technology and sample production.

BioVisible L.J.Zielstraweg 1 Groningen, 9713 GX The Netherlands

BioVisible offers a unique analysis service for the evaluation of the effects of probiotics and prebiotics on Gut microflora using FISH (fluorescence in situ hybridization), (T)DGGE ((Temperature)Denaturing Gradient Gel Electrophoresis) and/or Real-time PCR.

BioDetection Systems Science Park 406 1098 XH Amsterdam The Netherlands

BioXpert BV Landerd Campus Nistelrooise Baan 35374 RE SchaijkThe Netherlands

We at BioXpert are experts in laboratory animal science and services to in vivo research in the life sciences. We are specialised in listening to your demands and translating them into a tailor made solution for you. We offer a wide range of services, so that we can help you with any aspect in your in vivo research. We can do this in in our own lab and animal facilities or on site.

BaseClear Einsteinweg 5 P.O. Box 1336 Leiden, 2333 CC The Netherlands

BaseClear offers sequencing, molecular biology, microbiology, and genotyping services. Our expertise lies in the field of Microbial genomics for all areas like Industrial Biotech, Food and Water companies, Pharma, Academics and Research institutes.

Batavia Biosciences Bioscience Park Leiden Zernikedreef 9 Leiden, CK 2333 The Netherlands

Batavia Biosciences is a contract development organization for biopharmaceuticals and vaccines with end to end solutions for customers. The mission is to significantly contribute to ease human suffering from disease by improving the success rate in the translation of candidate medicines from discovery to the clinic. Hereto, the company has developed a portfolio of technologies aimed to improve product yield (STEP®, SCOPE), reduce process development time (SIDUS®, SCOUT®) and increase product stability (SATIRN). These technologies have amply demonstrated to improve speed and reduce cost in biopharmaceutical development, accelerating the journey from bench to clinic. Batavia Biosciences performs projects for big pharma, biotech, academia and non-profit organizations. The company employs a highly educated staff with many years of experience in DNA cloning, mammalian cell line generation, upstream and downstream process development (mammalian, microbial & insect cell platforms), purification development, product characterization, and clinical manufacturing. As such the company, with laboratories in USA and the Netherlands, is well positioned to take on any challenge associated with the development of complex biological medicines be it proteins, antibodies, vaccines or viral vectors.

BioClinica Schipholweg 117 2316 XC Leiden The Netherlands

BioClinica offers imaging services.

Chemonaut Delftechpark 26 2628 XH Delft The Netherlands

Chemonaut offers screening compounds, building blocks, pharmacore moodeling, virtual screening and docking services.

Chemonaut Delft, The Netherlands

Chemonaut offers screening compounds, building blocks, pharmacore moodeling, virtual screening and docking services.

Clinquest Rossinistraat 46 Oss, 5344 AK Netherlands

Clinquest provides drug development consulting, clinical trial implementation, and safety surveillance overview.

Clondalkin Group Ito Tower, 9th Floor, Gustav Mahlerplein 68, 1082 MA Amsterdam, The Netherlands

CARDIOLABORATE Moreelsepark 1, 3511 EP Utrecht Netherlands

CARDIOLABORATE is an inter-academic science broker that stimulates public-private collaborations in the field of cardiovascular biomarkers in the Netherlands.CARDIOLABORATE has the ambition to build new public-private collaborations in the field of cardiovascular biomarkers by revealing a portfolio of facilities and unique opportunities in (pre)-clinical research that will accelerate biomarker discovery and assay development and validation, and generates more revenues for the Dutch players in this arena.

CENTRE FOR HUMAN DRUG RESEARCH Centre for Human Drug Research Zernikedreef 8 2333 CL Leiden The Netherlands

Centre for Human Drug Research provides a full spectrum of early stage clinical pharmacology services.

Cambridge Major Laboratories NK Weert, The Netherlands

Cambridge Major Laboratories provides custom synthesis, GMP manufacturing, analytical method development, ICH stability studies, and route scouting.

Core Laboratories Amsterdam, The Netherlands

Cardialysis Westblaak 92, entrance B, 3012 KM Rotterdam The Netherlands

Cardialysis offers cardiovascular imaging and clinical trial services.

Crucell Archimedesweg 4-6 2333 CN Leiden

Crucell focuses on research and development of therapeutic proteins and antibodies.

Chiesi farmaceutici Lange Kleiweg 52 J - 2288 GK Rijswijk - the Netherlands

Chiesi farmaceutici offers drug development, drug discovery, and clinical trials.

CERGENTIS BV 62 Yalelaan, Utrecht, UT 3584, NL

Cergentis provides services and kits based on its proprietary TLA technology. TLA was published in Nature Biotechnology in 2014 and, uniquely, enables the targeted complete Next Generation Sequencing of genes, oncogenes, gene editing events, transgenes and integration sites. Key applications of TLA include:•complete gene sequencing & haplotyping•complete sequencing of structural variants in oncogenes•transgene & integration site sequencing in (CHO) cells, animal models and plants•quality control of gene editing/genetic engineeringCergentis’ mission is to contribute to the quality of genetic research and healthcare by providing services and kits that enable the cost-effective complete sequencing of relevant genes and genomic loci. Cergentis works with and for leading research institutes, diagnostic labs and pharmaceutical and biotech companies globally.

CURAX P.O. Box 291 Houten, 3990 GB Netherlands

CURAX is specialized in animal models for immune related disorders and inflammatory diseases. CURAX has expertise with mice, rats and guinea pigs and employs highly trained bio-technicians, enabling custom-based services.

Cella Technologies 12 Molengraaffsingel, Delft, ZH 2629 JD, NL

Cella Technologies is specialized in developing assays that can be used to (attempt to) confirm protein–protein interactions (PPIs) of interest / map protein–protein interaction domains (PPIDs). From PPID information (candidate) peptide PPI inhibitors can be derived (see also media file PPI inhibition). Small peptides with PPI inhibitory activity have many applications in research and using them can provide new insights, what can lead to the development of new medicine.Currently, we offer the following services:- Confirmation of protein–protein interactions & mapping of protein–protein interaction domains (CT-100).- Construction of peptide-encoding plasmids (and other plasmid construction activities) (CT-200).To learn more about our services, refer to the media files.

Cytocentrics Eindhoven, The Netherlands

Cytocentrics AG provides cutting-edge solutions to assist drug screening of ion channel targets, especially in early drug profiling and safety pharmacology

Chiralix Toernooiveld 100 Nijmegen, 6525 EC The Netherlands

Chiralix specializes in chiral organic synthesis, chiral drug-like building blocks, and custom synthesis services.

Cell Signaling Technology 2 Schuttersveld, Leiden, ZH 2316 ZA, NL

Founded by research scientists in 1999, Cell Signaling Technology (CST) is a family-owned company focused on applied systems biology research, and especially cancer. We believe you have the right to expect more reliable results from your antibodies and reagents so our scientists produce, validate and support all our antibodies in-house. Cell Signaling Technology is able to provide target validation services, biomarker discovery services, phospho-specific antibody design services and patient stratification services.

Corning Life Sciences 12 Fogostraat, Fogostraat 12 Amsterdam, NH 1060 LJ, NL

Corning Life Sciences offers a variety of in vitro ADME Gentest® branded products and contract research services covering drug metabolism and drug interactions. These products and services support Enzyme Induction, Enzyme Inhibition, Metabolic Stability, Reaction Phenotyping, Protein Binding, Permeability and Drug Transport and other applications.

Dishman Pharmaceuticals and Chemicals Dishman Netherlands B.V. Nieuweweg 2a, 3901 BE Veenedaal PO Box 70, 3900 AB Veenendaal The Netherlands

Dishman CRAMS offers development services, kilo supply, cGMP pilot production and full scale cGMP manufacture.

Dishman Pharmaceuticals and Chemicals Veenendaal, The Netherlands

Dishman CRAMS offers development services, kilo supply, cGMP pilot production and full scale cGMP manufacture.

Disphar Tolweg 15 3741 LM Baarn The Netherlands

Disphar offers services in product development, regulatory affairs, quality assurance and pharmacovigilance.

Disphar Winkelskamp 6 7255 PZ Hengelo (Gld) The Netherlands

Disphar offers services in product development, regulatory affairs, quality assurance and pharmacovigilance.

Dorian Regulatory Affairs Soestdijkerstraatweg 7 1213 VP Hilversum, The Netherlands

Dorian Regulatory Affairs specializes in development and registration of pharmaceutical products in Europe.

Da Vinci Laboratory Solutions Cairostraat 10 3047 BC Rotterdam The Netherlands

Da Vinci Laboratory Solutions (DVLS) was established as a laboratory support provider in 2000. Today Da Vinci has become the versatile partner to laboratories by offering chromatographic solutions that address all analytical challenges starting from sample preparation, analysis,reporting, data management up to providing technical support and supplies.Our mission is to boost laboratory efficiency through:Chromatographic solutions of Da Vinci Expertise in GC, LC, MS, TOC, XRF and software developmentKnowledge of laboratory processesDistributorship of leading suppliers such as Agilent, GERSTEL, LECO, VUV Analytics and XOSDevelopment and manufacturing of innovative solutionsAs a result of our wide range of solutions and high level of expertise Da Vinci is able to meet all analytical needs. Contact us on your analytical challenges.

Derphartox BV Erasmus University Rotterdam NB-1116 Afd. Immunologie 3015 AA ROTTERDAM The Netherlands

DSM Pharmaceuticals Urmonderbaan 22 6167 RD Geleen The Netherlands

DSM provides custom manufacturing, cell culture fermentation, purification, formulation, and clinical trials.

DSM Pharmaceuticals Heerlen, NL

DSM provides custom manufacturing, cell culture fermentation, purification, formulation, and clinical trials.

DDL Diagnostic Laboratory Visseringlaan 25, 2288ER, Rijswijk, the Netherlands

DDL Diagnostic Laboratory (DDL) is a state-of-the-art laboratory specialized in (molecular) diagnostic testing and assay development.DDL performs advanced molecular diagnostic testing on behalf of pharmaceutical companies and clinical laboratories,supporting Phase II-IV clinical trials. DDL also designs, develops, and validates novel diagnostic assays, which can be tailor-made for specific diagnostic purposes.DDL is based in Rijswijk, the Netherlands, and has a core team of ~75 quality-minded employees with proven scientific and clinical laboratory experience. Therefore, DDL can offer state-of-the-art diagnostic services to its customers, and can provide flexible, creative, and cost-effective diagnostic solutions.

DDL Diagnostic Laboratory Visseringlaan 25, 2288ER, Rijswijk, the Netherlands

DDL Diagnostic Laboratory (DDL) is a state-of-the-art laboratory specialized in (molecular) diagnostic testing and assay development.DDL performs advanced molecular diagnostic testing on behalf of pharmaceutical companies and clinical laboratories,supporting Phase II-IV clinical trials. DDL also designs, develops, and validates novel diagnostic assays, which can be tailor-made for specific diagnostic purposes.DDL is based in Rijswijk, the Netherlands, and has a core team of ~75 quality-minded employees with proven scientific and clinical laboratory experience. Therefore, DDL can offer state-of-the-art diagnostic services to its customers, and can provide flexible, creative, and cost-effective diagnostic solutions.

DuSart Pharma Nijverheidstraat 15 2222 AV Katwijk Netherlands

DuSart Pharma offers research, development, production and distribution of food supplements, nutraceuticals, sports foods, cosmetic products, natural medicines and Medical Devices.

ERASMUS MC - Proteomics Core Proteomics Center Erasmus MC Office Ee-679A | Lab Ee-626 Wytemaweg 80 3015 CN Rotterdam

Erasmus MC is committed to a healthy population and excellence in healthcare through research and education.

ERASMUS MC - Proteomics Core Proteomics Center Erasmus MC Office Ee-679A | Lab Ee-626 Wytemaweg 80 3015 CN Rotterdam

Erasmus MC is committed to a healthy population and excellence in healthcare through research and education.

Exploras Agro Development BV Willem Elsschotstraat 4 5103 PM Dongen The Netherlands

Exploras Agro Development has started in 2010 and has transformed to a BV in 2012. The core activities of Exploras Agro Development are the processing of field trials and the offering of services for amongst others the agro chemical industry, fertilizer- and seed companies. Further more agro supply companies, advisory agencies, grower organizations and individual growers can apply to Exploras Agro Development for trials. Exploras Agro Development is specialised in field vegetables, such as cabbage, leek, carrot, lettuce, celery, broad beans, chicory roots, endive, spinach. More over also strawberries belong to the crop parcel. As a result of expension also research in arable crops, flower bulbs and fruitcan be offered. Exploras Agro Development has a GEP and TNG acknowledgement and is competent in processing field trials with agro chemicals. USP’s of Exploras Agro Development are:High quality of field trials: The trials are conducted mostly according to EPPO guidelines and therefore meet the GEP requirements. Furthermore, there is a lot of attention spent on artificial infection to improve the probability of success.Short communication lines with assignment provider:Exploras Agro Development is a cooperative thinker in finding solutions and gives you direct feedback at unsuspected developments before, during and after the process of the trials. Shortly, Exploras Agro Development is working as an extension of the assignment provider.Prompt reporting:Exploras Agro Development guarantees a complete report within two months after finishing your project.The cooperation in field trials is found in reliable field vegetable growers with feeling for research. As many trials as possible will be concentrated at Rinus van de Riet, a grower in Etten-Leur. Rinus takes care of the growing and will assist in the trial activities.

Enzyscreen Wassenaarseweg 72 2333 AL Leiden The Netherlands

Enzyscreen provides custom screening and development of miniaturized growth systems.

Environ Willem Arnszlaan 115 3734 EE Den Dolder The Netherlands

A premier global consultancy, Ramboll Environ is trusted by clients to manage their most challenging environmental, health and social issues. We have earned a reputation for technical and scientific excellence, innovation and client service. Our independent science-first approach ensures that our strategic advice is objective and defensible. We apply integrated multidisciplinary services and tailor each solution to our client’s specific needs and challenges.

Enestia Klöcknerstraat 1 3930 Hamont-Achel België / Belgique

Enestia provides both contract manufacturing and contract packaging for healthcare companies.

European Infrastructure for Translational Medicine (EATRIS) Giovanni Migliaccio, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands

EuroCept Trap Gans May 1244 RL Ankeveen Netherlands

EuroCept offers medicines, hospital care, medical technology and distribution.

Eurosequence Meditech Center L.J. Zielstraweg 1 9713 GX Groningen The Netherlands

Eurosequence offers protein sequence analysis, amino acid analysis, protein sequencing, protein identification with mass spectrometry, and peptide synthesis services.

European Packaging Centre P.O.Box 713 8440 AS Heerenveen The Netherlands

European Packaging Centre provides pharmaceutical contract-manufacturer and packaging.

ForTe Lindenlaan 31c 6584 AC MOLENHOEK (LB) The Netherlands

ForTe offers product & formulation technology development for the pharmaceutical, cosmeceutical and food industries.

FOSS NIRSystems Primulastraat 11 5595 EL Leende The Netherlands

FOSS NIRSystems supplies near-infrared (NIR) spectroscopy analyzers to support process development, raw materials testing, finished product testing, content uniformity testing, process monitoring, end-point determination, fluid bed drying, quality control and stability testing.

Future Diagnostics Nieuweweg 279 Wijchen, 6603 BN The Netherlands

Future Diagnostics offers diagnostic assays with specialties in anemia, autoimmune, bone metabolism, cardiovascular, diabetes, endocrine, fertility, hematology, infectious disease, and cancer.

FeyeCon Rijnkade 17a 1382 GS Weesp The Netherlands

FeyeCon specializes in using carbon dioxide technologies to support pharmaceutical formulations.

Farma Research Animal Health Nijmegan, The Netherlands

Farma Research Animal Health provides in-life phase and bioanalytical phase animal studies, regulatory affairs, and environmental risk assessment.

FUJUFILM VisualSonics, Inc. Joop Geesinkweg 140 1114 AB Amsterdam, The Netherlands

FujiFilm VisualSonics Inc. is a manufacturer of real-time, in vivo, high-resolution micro-imaging systems designed specifically for preclinical research and is a wholly owned subsidiary of SonoSite, Inc.VisualSonics’ imaging technologies allow researchers at pharmaceutical and biotechnology companies, hospitals and universities to conduct research in cardiovascular, cancer, neurobiology and developmental biology areas. The micro-imaging technologies support research applications that include genetic research, phenotypic studies and drug development. VisualSonics high-frequency micro-imaging and photoacoustic platforms combine high-resolution, real-time in vivo imaging with quantifiable data that have been published in over 850 scientific publications globally.

Global Pathology Support Benoordenhoutseweg 23 The Hague, 2596 BA The Netherlands

Global Pathology Support focuses on histopathology assessment including histology and immunohistochemistry services.

Gentaur 5521 Eersel, The Netherlands

Gentaur is a supplier of life science research products.

Good Biomarker Sciences Zernikedreef 8 2333 CL Leiden The Netherlands

Good Biomarker Sciences (GBS Leiden) provides fit-for-purpose analytical services. GBS Leiden scientists are specialized in haemostasis, and immunomodulation with a focus on functional assays. We offer scientific and analytical support for clinical trials, population studies and pre-clinical drug development. Our methods provide continuity through pre-clinical and clinical studies to accelerate drug development.

Griffin Discoveries Griffin Discoveries BV Department of Medicinal Chemistry Room P-246 De Boelelaan 1083 1081 HV Amsterdam The Netherlands

Griffin Discoveries provides screening services, medicinal chemistry, and molecular pharmacology.

Genome Diagnostics Utrecht, The Netherlands

Genome Diagnostics offers sequencing software and HLA typing.

GenomeScan 1d Plesmanlaan, Leiden, ZH 2333, NL

GenomeScan offers genomic services for the pharmaceutical industry based on genetic profiling using Next Generation Sequencing (NGS) techniques. These services include Patient Stratification strategies using WGS/WES, Trancriptome and and Epigenetic analysis. In addition since 2011 we are ISO 17025 accredited to ensure a guaranteed quality for our portfolio. On top of that we are able to work G(C)LP compliant. We also offer diagnostic genetic tests using NGS techniques. We provide a complete portfolio of the most modern techniques, including:•ExomeScan•(Targeted) panel sequencing : MODYScan, MuscleScan etc.•Transcriptomics •Epigenetics Our fully automated laboratory specializes in whole exome sequencing (WES) including FFPE sequencing and ‘ExomeScan Priority’ (ultra-fast TAT). We offer various inheritable disease panels, or we can create your custom design. The RNAseq services and data-analysis pipelines measure differential expression such as tumor vs. normal DNA. Or you can perform (targeted) methylation sequencing or micro-array analyses. Innovation by our R&D department keeps our services at the forefront of industry. Over 15 years we have been a highly regarded genomic service provider. Our tight collaboration with clinical specialists of the Leiden University MC (LUMC) and Erasmus MC ensures high quality data-interpretation. Both our collaborators have complementary proficiencies so we can provide you with in-depth clinical knowledge and additional products.

HemoLab Den Dolech2 5612 AZ Eindhoven The Netherlands

HemoLab offers tissue and organ acquisition as well as consulting services.

HaemoScan Stavangerweg 23-23 9723 JC Groningen The Netherlands

Complement assays are one of the specialties of Haemoscan. Haemoscan aspires efficiency and flexibility and distinguishes itself by offering more than standard testing. We think along with our clients to improve further development.

Hycult Biotech Frontstraat 2a 5405 PB Uden The Netherlands

Hycult Biotech offers monoclonal and polyclonal antibodies, recombinant proteins, peptides, and ELISA kits.

HLB B.V. Kampsweg 27 9418PD Wijster

HLB continually develops new expertise in the field of plant and soil health and applies this knowledge throughout the agri-chain. Our unique combination of research, diagnosis and advice gives us access to a wealth of data and practical knowledge. We translate this knowledge into practical products that have real added value for the client. We specialise in research and recognition of all diseases, plagues and weeds that effect arable crops, flower bulbs, field vegetable crops, tree nurseries and sports fields. An important specialisation in our portfolio is research in the field of quarantine organisms. Our professional quarantine laboratory and our quality assurance system make us unique in this field. HLB aims to contribute to furthering efficient and sustainable agriculture by performing excellent research and practical diagnoses and providing the right advice with demonstrable added value for the agri-chain. The agriculture and horticulture sector holds the key to the challenge of meeting the increasing demand for sustainable food and clean water all over the world. HLB is making its contribution by stimulating efficient and sustainable practices in this sector. We achieve this by conducting in-depth research and providing diagnoses and practical advice with a demonstrable added value for the agri-chain. This is how we make the latest knowledge on sustainability useful and effective for the farmer and horticulturist.

Human Metabolome Technologies (HMT) 21 J.H. Oortweg, Leiden, ZH 2333 CH, NL

HMT develops and offers mass spectrometry based metabolic profiling service. Our unique CE-MS platform provides quantitative measurements for primary metabolism including bioenergetics and biomass constitution. Based on statistical, multivariate and pathway analyses, our research coordinators support the study design and biological interpretation.

Hubrecht Organoid Technology (HUB) Uppsalalaan 8 3584 CT Utrecht The Netherlands

Hubrecht Organoid Technology (The HUB) is a not-for-profit organization founded by the Hubrecht Institute, KNAW and University Medical Center Utrecht, The Netherlands.The HUB is founded on the pioneering work of Prof. Dr. Hans Clevers who discovered methods to grow stem cell-derived human epithelial ‘mini-organs’ (organoids) from tissues of patients with various diseases including cancer and cystic fibrosis.In cell culture, organoids stably maintain the genotype/phenotype of the patient’s diseased tissue, thereby representing an in vitro platform for preclinical drug discovery and validation and a tool for precision medicine.The HUB has established a ‘Living Biobank’, a rapidly-growing collection of well-characterized organoids derived from patient tissues. Through a combination of the proprietary Organoid Technology and the ‘Living Biobank’, the HUB provides access to a unique and robust platform that links patient-specific genetic and phenotypic information to preclinical and clinical drug-responsiveness.

Interchemie Metaalweg 8 5804 CG Venray The Netherlands

Interchemie manufactures veterinary products, supplies, pharmaceuticals, drugs and medicines.

IATEC Petersburgweg 9 Amstedarm 1105 Netherlands

IATEC provides clinical trial services, antiviral research, and consulting.

Institute for Biodynamics and Biocomplexity Utrecht University Padualaan 8, 3584 CH, Utrecht The Netherlands

Biology Imaging Center provides access, support and training in advanced light and fluorescent microscopy techniques for research groups within the department of Biology and also to groups from other institutes within and outside Utrecht.

InSight Pathology BV Chopinlaan 6 5343EM Oss The Netherlands

InSight Pathology is a privately owned company located in the south-east of the Netherlands, offering services related to toxicologic pathology. With more than 30 years of experience in the pharmaceutical and chemical industry, a broad range of challenges in the field of toxicological pathology have been addressed and have strengthened our knowledge, experience, capability and insight. Straightforward studies and interpretations of toxicology issues rarely exist and bespoke solutions are often required. It is therefore a benefit to realize that InSight Pathology has the expertise to support you with these studies, by slide reading and peer reviews on the one hand and consultancy on the other. InSight Pathology can perform slide reading for your studies and the interpretation of findings in these studies. Slide reading for GLP as well as non-GLP studies can be performed. InSight Pathology uses the PathData System for entry and evaluation of pathology data resulting from toxicity and carcinogenicity studies. InSight Pathology has experience in a broad range of studies, varying from short term to carcinogenicity studies, and from studies in rodents (including transgenic animals) to studies in non-human primates, using different routes of administration. In addition, many different compounds and chemicals from a wide range of therapeutic areas have been assessed. Besides slide reading for your studies, InSight Pathology can also coordinate the peer-review process for your studies. InSight Pathology can provide you with advice on all issues related to toxicological pathology. To be able to give valuable advice, experience is key. As said, with more than 30 years of experience in the pharmaceutical and chemical industry a broad range of challenges in toxicological pathology have been faced. With this background, InSight Pathology is confident to be able to advise on the way forward for your project (when pathology is concerned), to advise on follow up activities when certain findings are difficult to interpret or make an overall interpretation of pathology findings over different studies. InSight Pathology could also help you in your Due Diligence preparation, when an in-depth evaluation of the toxicological pathology part is needed.

Ingress Health Hofplein 20, 3032 AC Rotterdam

Ingress-Health is a fast-growing European health-care consultancy with offices in Wismar, Germany and Rotterdam, Netherlands. We have years of experience and profound knowledge in health economics and outcomes research. Our core services focus on:•Real-World Evidence (RWE) Studies,•Strategic Market Access & Health Policy Communication,•Evidence Synthesis, and•Health-Economic Modelling.At Ingress health, we strongly believe that the future of health technology reimbursement in the EU will be based on flexible pricing systems and or provisional reimbursement with corresponding outcomes-based managed entry schemes and health economic evaluations. This belief is based on trends in digitalization of patient outcomes in clinical practice, the increasing number of drugs approved with conditional market authorization by EMA, and an increase in outcomes based managed entry schemes in the EU. This shift from reimbursement to conditional reimbursement requires a change of mindset in the industry as in the past, when developing Real-World Evidence studies, manufacturers often did not (need to) consider the health economic perspective. Ingress health team also strongly believes that a lot of products are underutilized because clinical trials did not show their value in terms of e.g. reduced side effects, improved quality of life and or compliance.Therefore, Ingress health was founded February 1st 2015. With Ingress health’s combined and integrated health economic and Real-World Evidence expertise and passion for the field, we feel that Ingress health team will be successful in optimizing your products pre and post-marketing value proposition.OUR VALUESIngress health team is sincerely curious about our clients, the context of the project and about the product. We are thorough in everything we do. Regarding the project, we at Ingress health will consider several different angles before presenting the final result and or approach. Ingress health team is confident that we can produce high quality timely results, as such we do offer project pay per performance schemes.With Ingress health combined Real-World Evidence and health economic expertise, we are confident that we can find the unexplored value of your product.

IDEXX Scorpius 60 Building F Hoofddorp, 2132 LR The Netherlands

IDEXX BioResearch is the premier reference lab partner providing central laboratory services (Haematology, Biochemistry, Immunology, Parasitology, Microbiology, etc.) and Point of Care tests to support pharma, biotech, pet food, and academia's clinical (GCP) and preclinical veterinary studies in Europe and North America. In addition, IDEXX BioResearch offers expert support in toxicology Histology (GLP).IDEXX BioResearch provides quality veterinary research analyzers, which can also be installed to GLP standards, for preclinical and clinical research.IDEXX BioResearch's team has developed nearly all the newest technologies in the field of research animal health monitoring, including all new techniques to help Replace, Reduce and Refine animal testing. IDEXX BioResearch provides a biological testing service for independent confirmation of quality, safety, and authenticity of biological materials.

INTEGREX Research Kadijk 3 9747 AT GRONINGEN The Netherlands

INTEGREX Research is a combination of long standing contract research experience and seasoned drug discovery expertise obtained in pharmaceutical industry.INTEGREX Research offers Integrated Drug Discovery Service in the range of hit finding up to pre-clinical candidate selection.

Intravacc 9 Antonie van Leeuwenhoeklaan, Bilthoven, UT 3721 MA, NL

Looking for a partner to develop or improve your vaccine technology?Intravacc, the Institute for Translational Vaccinology, is an experienced, not-for-profit R&D organization. We optimize vaccines, vaccine processes and vaccine technologies.In our state-of-the-art facilities, our experienced R&D institute takes your discovery up to Phase I/II clinical trials. Furthermore, we share and transfer our knowledge and technologies to public and private partners worldwide and work on collaborative R&D. Laboratory area 3500 m² BSL2, BSL3 & GMP facilities;Animal Research Center;Lab- & pilot-scale production capabilities (using glass, stainless steel, and disposable bioreactor technologies);Upstream Processing (USP) and Downstream Processing (DSP);Experience in bio safety (BSL2) and containment;Advanced analytical capabilities (including: MS, NMR, HPLC, FACS, Biacore, etc.);Design-of-Experiments (DoE) expertise, including scale-up and scale-down models for all unit operations;Mathematical model development & cost-of-goods calculations.

Institute for Risk Assessment Sciences Utrecht University PO Box 80.177 3508 TD Utrecht The Netherlands

Institute for Risk Assessment Sciences provides toxicology and epidemiology.

IBIS Technologies B.V. Pantheon 5 7521 PR Enschede The Netherlands

At IBIS, we want our customers to achieve the highest level of excellence when performing SPR measurements. To that end, we can provide you with detailed information on the physics of SPR, scientific papers, whitepapers to explain applications, instructional videos and more.

IQ Products Rozenburglaan 13a Groningen, 9727 DL Netherlands

IQ Products supplies reagents and kits in application of flow cytometry, ELISA, hematology, and fluorescence microscopy in addition to offering custom antibody development services.

Isogen Life Science Veldzigt 2a, De Meern, 3454 PW The Netherlands

Isogen Life Science provides a wide range of instruments, reagents and consumables in the areas of cell biology, molecular biology and biochemistry

IBL International Zutphenseweg 55 7418 AH Deventer The Netherlands

IBL International offers reagents, antibodies, and assay kit products for purchase.

Koppert Biological Systems Veilingweg 14 2651 BE Berkel en Rodenrijs The Netherlands

Koppert Biological Systems contributes to better health of people and the planet. In partnership with nature, we make agriculture healthier, safer and more productive. We provide an integrated system of specialist knowledge and natural, safe solutions that improves crop health, resilience and production.

Kreatech Diagnostics Vlierweg 20

Kreatech Diagnostics provides molecular diagnostics, protein science, array services, labeling services, hybridization, and research products.

Kinesis Pharma Lage Mosten 29

Kinesis Pharma provides non-clinical and clinical development, pharmacokinetics, and formulation development.

Kiadis Entrada 231-234

Kiadis provides natural products and clinical trial services.

Keygene Agro Business Park 90 6708 PW Wageningen The Netherlands

Keygene provides contract research for the plant breeding industry, partnerships, and molecular genetic services.

LabVantage Lichtenauerlaan 102-120

LabVantage provides software solutions for laboratory management.

Luminex Krombraak 13-15

Luminex provides expression profiling, genomic research, immunodiagnostics, and genetic disease studies.

LINGE AGROCONSULTANCY Oosterhoutsestraat 95 6678 PG Oosterhout (Gld) The Netherlands

Linge Agroconsultancy is an independent consulting company specialised in supporting the registration of both chemical and biological crop protection products.Since 2003, Linge Agroconsultancy acts as an evaluating authority, concerning efficacy, for the Dutch authorisation board.We have the expertise to guide you through the entire registration process of crop protection products. We carry out assignments for both the government and trade and industry.Linge Agroconsultancy takes care of your regulatory needs and provides you with tailor-made advice. We have short lines of communication and work customer-oriented. Confidentiality is, of course, guaranteed.

Leiden University PO Box 9500 Leiden, 2300 RA The Netherlands

Leiden University focuses on research in various areas. Through the Leiden Academic Centre for Drug Research (LACDR), the university offers expertise in metabolomics, medicinal chemistry, drug delivery, pharmacology, and toxicology.

LAP&P Consultants (Leiden Advanced Pharmacokinetics & Pharmacodynamics) 31 Archimedesweg, Leiden, ZH 2333 CM, NL

LAP&P Consultants provides pharmacokinetics (PK) and pharmacodynamics (PD) modelling and simulation services.

Lucron ELITechGroup Postbus 100, 6950 AC Dieren, The Netherlands

Lucron ELITechGroup offers premium quality diagnostic products and research supplies to laboratories in the entire Benelux area: Belgium, the Netherlands and Luxembourg.

Leiden University Medical Center Center for Proteomics and Metabolomics Zone S3 Albinusdreef 2 2333 ZA Leiden The Netherlands

The Center for Proteomics and Metabolomics (CPM) forms the main expertise center and technology focus area for (clinical) proteomics and metabolomics in the LUMC. The key technologies are liquid separations (liquid chromatography and capillary electrophoresis), gas chromatography, mass spectrometry (MS) and nuclear magnetic resonance (NMR). Our main field of expertise is the application of these technologies in clinical research.The Center houses over 30 state-of-the-art mass spectrometers ranging from triple-quadrupole and ion trap instruments to time-of-flight and Fourier transform mass spectrometers. Most of the instruments are coupled on-line (electrospray ionization, ESI) or off-line (matrix assisted laser desorption/ionization, MALDI) to liquid separations. The MALDI instruments are used for high-throughput screening and imaging mass spectrometry, whereas the ESI mass spectrometers are used in a wide range of proteomics and metabolomics research projects for identification and quantitation of proteins, peptides and small molecules.

Lambert Instruments BV 5th floor, Leonard Springerlaan 19 9727KB Groningen The Netherlands

Lambert Instruments was founded by Bert van Geest in 1992, who wanted to apply his knowledge of image intensifiers. He started to use image intensifiers in CCD cameras that had to be very sensitive to light and that are used in scientific applications.Intensified CCD cameras have been delivered to many institutes that are active in fields like biomedical research, astronomy and experimental physics. Special medical cameras have been developed for the analysis of the vocal cords. Imaging products from other manufacturers have been added to the product range or are integrated in systems for imaging at low light level and/or high-speed.Besides a range of standard products also custom-made products are offered.Our procedure:Analyse your problemPropose possible solutions and optionsDiscuss the difference in price and performance.Create the most effective solutionBased on the final specification the order is executed against the agreed price and delivery time.This way you will be assured of a well-defined product that fits budget and planning. According to this procedure many projects have been successfully completed for various customers.Mission StatementLambert Instruments' mission is to develop, produce and market high-end products for time-resolved imaging at low light levels guided by customer feedback. By continuously watching the latest technological developments and looking for opportunities to apply these in existing and new products, highly qualified people make sure your wishes get the best possible attention.Lambert Instruments is dedicated to development, production and worldwide sales of products for imaging at low light levels.Please do contact us for more information and for advice regarding your imaging needs.

Lonza Aluminiumstraat 1, Breda, 4823 AL, The Netherlands

Lonza offers custom manufacturing services based on biotechnologies including mammalian cell culture, and microbial fermentation, in addition to peptide synthesis, advanced chemical synthesis and cell therapy services.

Macrogen Corp. Meibergdreef 39

Macrogen, Inc. was founded in 1997, and in 2005 Macrogen Corp. in the US was established. In 2012, Macrogen Corp. was established to provide advanced clinical sequencing services to U.S. patients and hospitals. In that time, we’ve become a leading bioscience research firm and our reputation in the industry is proof of Macrogen's commitment to advanced human genomic sequencing.As a CLIA-licensed research facility, Macrogen offers highly specialized sequencing services, utilizing the latest the latest next-generation sequencing. Additionally, the Macrogen team employs highly trained researchers who are the experts in their fields. Our NGS services have been utilized by researchers from many prestigious institutions, including but not limited to: National Institute of Health (NIH), Food and Drug Administration (FDA), Stanford University, etc.

ModiQuest Research 58, Schoutstraat Nijmegen 6525 XV Netherlands

ModiQuest Research provides antibody generation and optimisation services including feasibility analyses, antibody discovery, selection, optimization and pilot scale production.

MolMo Services Pastorijstraat 11

MolMo Services offers targeted library design, high throughput screening, in silico screening, docking, structure based screening, and API services.

MiPlaza Materials Analysis High Tech Campus 11 room p309

Microbome Diagnostics Troubadour Borch 59 3992 BE Houten Netherlands

Microbiome is a company that specializes in the field of innovative molecular microbiological detection techniques for infectious diseases and specializes in the development and implementation of molecular analyzes for complex microbial niches.

Merge Healthcare De Zaale 11 (Twinning Center) 5612 AJ Eindhoven The Netherlands

Merge Healthcare specializes in clinical systems and offers cloud-based solutions for imaging and data analytics.

Molecular Modeling and Drug Design (MMDD) Dr. M.R. de Jonge

Molecular Modeling and Drug Design (MMDD) is a consultancy and service company with strong expertise in molecular modeling, computational chemistry, classical rational drug design, de novo drug design, and virtual screening.

Miltenyi Biotec Schipholweg 68 H

Miltenyi Biotec provides contract manufacturing services (for research and GMP compliant ex vivo applications), biologics, filling, and scale-up.

MPF Appelhof 13 8465 RX Oudehaske Netherlands

MPF is an independent pharmaceutical contract-manufacturer.

MPF MPF bv P.O. Box 570 8440 AN Heerenveen Netherlands

MPF is an independent pharmaceutical contract-manufacturer.

Mercachem Kerkenbos 1013

Mercachem provides a range of chemical services ranging from exclusive synthetic chemistry and medicinal chemistry to early process research to support drug discovery and development projects

Mercachem Mercachem Kerkenbos 1013 6546 BB Nijmegen The Netherlands

Mercachem provides a range of chemical services ranging from exclusive synthetic chemistry and medicinal chemistry to early process research to support drug discovery and development projects

Meelunie Vinoly Tower, 18th Floor Claude Debussylaan 40 1082 MD Amsterdam

Meelunie is a global supplier of agricultural ingredients.

Mouse Clinic for Cancer and Aging - MCCA Plesmanlaan 121 1066 CX Amsterdam The Netherlands

The aging population in developed countries leads to rapid increase in cancer incidence and other aging-related disorders. To accelerate cancer and aging research and to contribute to the theme of ‘healthy aging’, the Netherlands Cancer Institute (NKI) and the European Research Institute for the Biology of Aging (ERIBA) have established a Mouse Clinic for Cancer and Aging research (MCCA). The MCCA will accelerate the development of genetically engineered mouse models (GEMMs) of human cancer and aging syndromes. These mouse models will be used for developing new therapies against cancer and aging-related diseases.The MCCA houses three key expertises:A Transgenic facility for efficient derivation, genetic modification and distribution of embryonic stem cell (ESC) lines from GEMMs, and for production of ESC-derived mice.A Mouse Cancer Clinic for preclinical intervention studies and imaging of cancer growth and therapy response in advanced mouse models of human cancer.An Aging and Phenotyping Facility for controlled aging and phenotyping studies in different inbred mouse strains and GEMMs, and for creating a centralized biobank of frozen mouse tissues for aging research.The MCCA is partner of the EC funded Infrafrontier Project for the implementation of a sustainable European research infrastructure for systemic phenotyping, archiving and distribution of mouse models. The MCCA is also the National partner of the European Mouse Mutant Archive (EMMA) for distribution of GEMM-derived ESC lines via the Infrafrontier portal.

Mouse Clinic for Cancer and Aging - MCCA Antonius Deusinglaan 1 9713 AV Groningen The Netherlands

The aging population in developed countries leads to rapid increase in cancer incidence and other aging-related disorders. To accelerate cancer and aging research and to contribute to the theme of ‘healthy aging’, the Netherlands Cancer Institute (NKI) and the European Research Institute for the Biology of Aging (ERIBA) have established a Mouse Clinic for Cancer and Aging research (MCCA). The MCCA will accelerate the development of genetically engineered mouse models (GEMMs) of human cancer and aging syndromes. These mouse models will be used for developing new therapies against cancer and aging-related diseases.The MCCA houses three key expertises:A Transgenic facility for efficient derivation, genetic modification and distribution of embryonic stem cell (ESC) lines from GEMMs, and for production of ESC-derived mice.A Mouse Cancer Clinic for preclinical intervention studies and imaging of cancer growth and therapy response in advanced mouse models of human cancer.An Aging and Phenotyping Facility for controlled aging and phenotyping studies in different inbred mouse strains and GEMMs, and for creating a centralized biobank of frozen mouse tissues for aging research.The MCCA is partner of the EC funded Infrafrontier Project for the implementation of a sustainable European research infrastructure for systemic phenotyping, archiving and distribution of mouse models. The MCCA is also the National partner of the European Mouse Mutant Archive (EMMA) for distribution of GEMM-derived ESC lines via the Infrafrontier portal.

Medpace Rivium Boulevard 102b, 2909 LK Capelle Aan Den IJssel / Rotterdam Netherlands

Medpace offers clinical development services including medical writings, biometrics, regulatory affairs and quality assurance.

Medpace Rivium Boulevard 102b, 2909 LK Capelle Aan Den IJssel / Rotterdam, Netherlands

Medpace offers clinical development services including medical writings, biometrics, regulatory affairs and quality assurance.

MagnaMedics Burg. Lemmensstraat 366 6163 JT Geleen (The Netherlands)

MagnaMedics offers in vitro diagnostics, medical imaging and drug delivery products.

MYMETICS BV 21 J.H. Oortweg, Leiden, ZH 2333 CH, NL

MYMETICS: THE POWER OF A UNIQUE TECHNOLOGY TO DEVELOP NEXT-GENERATION PROPHYLACTIC VACCINES FOR INFECTIOUS DISEASESOur vaccines are designed to induce protection against early transmission and infection, focusing both on the mucosal immune response as a first-line defense and the systemic humoral (blood) immune response, which, for some pathogens, may be essential for the development of an effective prophylactic vaccine. Our unique approach has resulted in the development of a rich pipeline of 5 vaccine candidates for HIV-1/AIDS, intra nasal Influenza, Malaria, Herpes Simplex Virus (HSV) and the Respiratory Syncytial Virus (RSV) vaccine. Our delivery platform is being validated through partnership with leading pharmaceutical or research organisations, including Astellas Pharma, PATH-MVI and the Bill and Melinda Gates Foundation. Mymetics Corporation (OTCQB: MYMX) is a Swiss based biotechnology company, with a Research Lab in the Netherlands. The company is registered in the US and trades on the OTCQB.

Nutricia Research Uppsalalaan 12 Utrecht Science Park 3584 CT Utrecht The Netherlands

Pregnant and lactating women, infants, elderly and patients of all ages with special nutritional needs deserve nutritional support. Nutricia Research uses life science, food science, technology and the drive and expertise of over 600 employees to deliver nutritional products to those with special needs.Nutricia Research is the global R&D organisation behind Early Life Nutrition and Advanced Medical Nutrition, divisions of Danone, sharing its global mission to deliver health through food to as many people as possible. Our research and innovation areas have evolved, but we still begin with insights into nutrients and their role in optimal health, and build on that knowledge to tailor solutions for nutritional needs throughout the lifespan of our target populations.

NIZO Food Research BV Kernhemseweg 2 6718 ZB Ede The Netherlands

Good food needs good science.NIZO food research is a leading global center in proteins, bacteria, and processing. We are an independent company and one of the most advanced contract research centers in the world. We bring the latest food technologies to life in our own food grade processing plant. Our passion is to make better foods and to be an incubator of innovation. Our customers value their gains in sustainability, cost effectiveness and speed to market.- See more at: http://www.nizo.com/about-nizo/nizo-in-short/#sthash.Hnks5ozU.dpuf

New Brunswick Scientific Kerkenbos 1101, 6546 BC Nijmegen

New Brunswick Scientific offers optimization, cell expertise, computer-controlled strategies, and media formulation.

Netherlands Metabolomics Centre Catharijnesingel 54 3511 GC Utrecht The Netherlands

The Netherlands Metabolomics Centre (NMC) brings together the vast knowledge and extensive expertise of the Dutch genomics and life sciences community to develop the technologies that will meet these demands. Through active community building and collaboration within the field, the NMC functions as a liaison between groups developing and applying metabolomics technology, actively promoting the transfer of knowledge and technology in the field of metabolomics through a network of committed partners. Together, the NMC team confronts the challenges of metabolomics research and develop the tools and strategies needed most by the Dutch and international research community.NMC works closely together with the Dutch Techcentre for Life Sciences, combining metabolomics with other life sciences technologies and bio-informatics to provide biological insights resulting from integrated life sciences approaches.

Nutacon Tuinderij 25, Postbus 94, 2450 AB Leimuiden The Netherlands

Nutacon provides laboratory equipment and reagents.

Nordic Immunology Langendijk 25 Eindhoven, 5652 AX The Netherlands

Nordic Immunology supplies basic immunological reagents including antisera, antibodies, immunoconjugates, purified proteins, controls and calibrators.

NTRC Pivot Park, RE1210, Molenstraat 110, 5342 CC Oss, The Netherlands

Noldus Information Technology Nieuwe Kanaal 5, 6709 PA Wageningen

Noldus Information Technology develops software and technology in the application of tracking animal behavior.

Netherlands Cancer Institute (NKI) Sequencing Core Facility Plesmanlaan 121 1066 CX Amsterdam

SequencingSince 1999 the Netherlands Cancer Institute facilitates the Sequence Core where DNA sequencing and fragment analysis for research and diagnostic purposes is done.The 3730 DNA Analyzer with 48 capillaries and the 3500xL Genetic Analyzer with 24 capillaries (both Life technologies) are used for analyzing DNA samples. Both systems are based on polymer capillary electrophorese, with a maximum of 1,000 base read length. The reagent used for sequencing is BigDyeTerminator V3.1/V1.1. The BDT sequencing reaction has to be performed by users themselves. The Sequence Core Facility will purify and analyze the samples on one of the sequencers. Beside DNA sequencing it is also possible to analyze PCR-products with Fragment analysis. The length of PCR-products is determined using a fluorescent labeled primer.The Sequence Core Facility has a throughput of 110.000 samples a year. Within 24 hours, 90 percent of the samples is analyzed. The sequence data is available on a central server and will be stored after 6 months. Mass spectrometerThe Mass-Array system by Agena Bioscience is a detection platform utilizing mass spectrometry to accurately measure PCR-derived amplicons. It combines the benefits of a multiplexed primer extension reaction with MALDI-TOF mass spectrometry to characterize genotypes. The system is ideal for panels from 10 to 400 single nucleotide polymorphisms.WorkflowPrimers for PCR and single base extension for the SNP of interest are designed with the assay software. DNA is provided by the user and will be processed by the Sequence Core Facility:Amplification of the region of interest with PCRPurification and single base extensionDispensing PCR-products on SpectroCHIPMALDI-TOF Mass spectrometer Analysis.This entire workflow can be completed in two days. Options- Custom made assay design Panel for the clinical DNA-diagnostics laboratory (70 hotspot mutations in AKT, BRAF, DDR2, EGFR, KRAS, MEK1, NRAS, PIK3CA)Your own panel for SNP/mutation detection- Pre-designed panels Oncocarta: This panel includes more than 230 somatic mutations across 19 oncogenes.Melacarta: This panel is designed specifically for metastatic melanoma profiling and offers 70 somatic mutations in 20 oncogenes.Lungcarta: This panel provides a highly sensitive panel for evaluating more than 250 somatic mutations in 26 genes for targeted profiling in non-small cell lung cancer (NSCLC).GyneCarta: This panel is designed for epithelial ovarian, cervical and endometrial cancer profiling. ColoCarta: This panel is designed for metastatic colorectal cancer.

Netherlands Cancer Institute (NKI) Radionuclides Centre Plesmanlaan 121 1066 CX Amsterdam

In cancer research we use a lot of dangerous compounds. The carcinogen lab is a research facility where carcinogenic, mutagenic and reprotoxic compounds can be stored and were these compounds can be handled under special safety conditions.The carcinogen laboratory is mainly used to prepare solutions using chemicals in a powder form. The chemicals can be weighted in a fume hood, dissolved and then taken out of the carcinogen laboratory for use in experiments. The lab is under-pressured, has a higher than normal ventilation fold and is equipped with two safety hoods.Researchers can get instructions on how to work with carcinogens and about safety aspects. The instructions and the information is given by one of the supervisors of this facility. They also make sure everything is working properly and is kept clean and tidy.

Netherlands Cancer Institute (NKI) Electron Microscope Facility Plesmanlaan 121 1066 CX Amsterdam

The Electron Microscope (EM) facility enables researchers at the Netherlands Cancer Institute to look at cellular structures and protein complexes at high magnification. The dedicated EM operator performs the sample preparation and acquisition of data.The EM-lab is located at the NKI, location B6. Here all the preparation of the samples and sectioning with the ultramicrotomes is done. Since September of 2015 the facility makes use of the electron microscopes at the AMC.

Netherlands Cancer Institute (NKI) Mouse Clinic - Intervention Unit Plesmanlaan 121 1066 CX Amsterdam

In recent years the NKI has made major investments to establish and further develop a dedicated Mouse Cancer Clinic for therapeutic intervention studies using mouse models of human cancer. Various novel approaches to treat cancer have already been tested in the Mouse Cancer Clinic. The design of the experiments is guided by both novel insights from basic research and clinical demands. Over the past years the maximum tolerable dose and anti-cancer efficacy of various anti-cancer agents that are frequently used in the clinic such as taxanes, topoisomerase I or II inhibitors, platinum drugs, or DNA alkylating agents have been benchmarked for several mouse cancer models. In close collaboration with pharmaceutical companies and academic partners several novel anti-cancer agents that are eligible for clinical trials have been or are being tested in our advanced mouse models. This includes targeted inhibitors of pathways involved in tumor cell proliferation, cell death or DNA repair. Moreover, new generation compounds that represent optimized versions of already existing drugs are investigated.The main reason why patients with disseminated cancer die is resistance or tolerance to systemic treatment. Therefore, one focus of the Intervention Unit is to understand mechanisms of drug resistance and to identity therapeutic approaches that circumvent or reverse resistance. Another central handicap in clinical oncology is the lack of predictive markers, since many patients only suffer from the side effects of an unsuccessful treatment. Hence, a major goal of the Intervention Unit is to use mouse models to identify biomarkers that predict the response of tumors before treatment is started. In addition to systemic therapies, we are also investigating locoregional applications of drugs, surgery or radiation. The identification and treatment of tumors is greatly facilitated by dedicated systems for state-of-the-art imaging and image-guided radiation therapy of small animals.Preclinical imaging systems are essential for accurate measurement of tumor growth, metastasis formation and therapy response in mouse models of human cancer. For this purpose, a dedicated Imaging Unit has been realized within the Mouse Clinic. The goal of this unit is to carry out attractive research that addresses relevant questions encountered by clinical imaging of cancer patients. This Unit includes a NanoSPECT/CT system (Bioscan) for combined single-photon emission computed tomography (SPECT) and computed tomography (CT) imaging, as well as IVIS systems (Caliper Corp.) for bioluminescence and fluorescence imaging. These systems are frequently used to measure drug responses of mouse models of breast, lung or brain cancer and to monitor metastasis formation. Due to the generous support of the Netherlands Organisation for Scientific Research, we will upgrade our present equipment in the coming months, and invest also in magnetic resonance imaging (MRI) and positron-emission tomography (PET).In sum, the Mouse Cancer Clinic aims to provide a controlled environment with state-of-the-art infrastructure for testing of therapeutic approaches that may subsequently be applied to cancer patients.

Netherlands Cancer Institute (NKI) Proteomics Facility Plesmanlaan 121 1066 CX Amsterdam

The Facility provides assessment of protein composition of a variety of samples. Preferably, researchers first discuss with us the project(s) they have coming up, in order to design the optimal experimental setup allowing successful analysis by liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS). For quantitative proteomics experiments, stable isotope labeling at the peptide or protein level can be considered.After performing the experiment, researchers hand in their samples, which we process further for LC-MS/MS. Sample processing involves protein extraction, reduction, alkylation, proteolytic digestion, (optional) multiplex stable isotope labeling and desalting. Finally, peptides are separated by nanoflow reversed-phase liquid chromatography, and analyzed by tandem mass spectrometry. After mass spectrometry analysis, MS/MS spectra are processed with dedicated software to yield protein identification (and quantification, if applicable). Results are exported as Excel workbook and shared with the researcher. Limited bioinformatics analysis can be discussed for further data interpretation.What we take:cell pellets or cell lysates;protein fractions;immunoaffinity beads or eluates from immunoprecipitations;SDS-PAGE gels*.Other sample types? Come and discuss the possibilities!*We prefer to run SDS-PAGE gels ourselves and cut gel bands here at the Facility, so if you're interested in analyzing specific bands, we'd like you to provide protein samples rather than a gel.What we offer:Quantitative & Qualitative (full) proteome analysis;Phosphoproteome analysis;Ubiquitinated proteome analysisOther requests? Come and discuss the possibilities!Targeted protein quantitation (parallel reaction monitoring).Internal projects are on a collaborative basis and free of charge, fitting within the capacity and scope of the facility. However, certain expensive reagents (kits, antibodies etc.) may have to be purchased by the researcher.

Netherlands Cancer Institute (NKI) Peptide Facility Plesmanlaan 121 1066 CX Amsterdam

Since 1988 we have a facility in the Netherlands Cancer Institute to synthesize peptides for researchers in our institute outside.We use Fmoc-solid phase chemistry and in our facility we have three robots (a Prelude syntheziser and two Syro synthesizers). One of the Syro's can synthesize 48 peptides simultaneously. The other robot can synthesize in one run 3 times 96 peptides in small amounts (2 to 4 µmol) for screening purposes. The Prelude is used for larger amounts of peptides.Peptides are routinely synthesized in the range of 5-100 amino acids; in an amount of 2-200 µmol (larger amounts are possible). All peptides are analyzed by LCMS and if needed purified byRP-HPLC. For analytical purposes the peptide facility has a Waters liquid chromatography electro spray mass spectrometer at its disposal. More than 5,000 peptides are synthesized annually.Besides "straight forward" peptides we can also synthesize special peptides with unnatural amino acids, ubiquitin and its derivatives, biotinylated-, acetylated-, phosphorylated peptides, peptides with a side chain, custom dye labeled and UV cleavable peptides. All other options can be discussed. Please contact us if you want to know more.

Netherlands Cancer Institute (NKI) Protein Facility Plesmanlaan 121 1066 CX Amsterdam

The Protein facility of the Netherlands Cancer Institute started its activities in 2008 and shares lab space and equipment with the structural biology groups of Anastassis Perrakis and Titia Sixma at the Division of Biochemistry (B8). The facility offers an excellent infrastructure for biochemical, biophysical and structural biology experiments and contributes to a variety of research projects. Projects can be submitted to the facility (see contact details below) and will be discussed in terms of costs and feasibility before initiation of the project. Projects are classified as short-term (less than 3 days of work) and long-term (more than 3 days of work). For long-term projects hands-on assistance from the applicant is required. The activities of the facility can be subdivided into different categories.Construct design and cloningProtein productionProtein purificationAntibody productionBiophysical characterizationCrystallization screeningMass spectrometry

Netherlands Cancer Institute (NKI) Genomics Core Facility Plesmanlaan 121 1066 CX Amsterdam

Next generation sequencing, also sometimes called deep sequencing, is our core business. We have a team of over 10 people, both wet lab technicians and bioinformaticians, to support the research and the clinical application of this technology using multiple Illumina HiSeq2000 and MiSeq machines.The applications for this technology are widespread, still growing and are common practice in the institute. Every aspect of the deep sequencing process is supported by the GCF that, as a facility, has a large body of experience and knowledge. The facility has been using Illumina technology from the early onset of the NGS development in 2009 and therefore we are now in a position to support the users with clear advice as to how the experiment should be designed to increase the success rate of the experiment. We are open to suggestions and are flexible in the way users want to have their samples analyzed with regard to sequence depth and numbers of libraries that are pooled in multiplexed experiments.The facility is set up according to a fee-for-service model where the material and chemistry cost prize is the main factor that determines the fee, this makes our support very affordable compared to external service providers. Facility users can provide cells or tissues as starting material but we also work with purified RNA or DNA as well as ready to sequence DNA libraries. All the necessary equipment for the preparation of sequence libraries and the associated quality control steps are in house. For some applications, like RNAseq, the demand is so high that we run the sample preparation in 96-wells format using PE SciClone robotic pipetting systems.The bulk of the experiments are performed using validated Illumina protocols and kits, but extensive experience has made it possible to either adapt, or develop new protocols for creating sequencing libraries. This is often done in close collaboration with the end user. New developments are closely followed and can be implemented relatively quickly.The data generated by the sequencing machines is stored on a central server system and analyzed by the facilities bioinformaticians. All data can also be made directly available to the user in the desired format. We have pipelines for demultiplexing the data, the alignment of the reads to genomes of choice and experiment specific downstream analysis. We can provide the results in tabular or graphical formats or prepare them for visualization in genome viewers like IGV (http://www.broad.mit.edu/igv/). We also host licenses for third party software solutions for analysis like Ingenuity and Nexus.EquipmentHiSeq2000 (2x), MiSeq, cBot, Perkin Elmer NGSx Sciclone Workstation, Covaris, Agilent BioAnalyzer, Perkin Elmer-Gx system, Biomek Fx, Agilent Scanner, Illumina Beadarray Reader, Tecan Hybstations, Nimblegen Hybstation, MicroGrid Printrobot.

Netherlands Cancer Institute (NKI) Flow Cytometry Facility Plesmanlaan 121 1066 CX Amsterdam

Flow cytometry is a laser based, biophysical technology used for cell counting, sorting, and biomarker detection. Cells are suspended in a stream of fluid and passed by an electronic detection apparatus. It allows simultaneous multi-parametric analysis of the physical and/or chemical characteristics of up to thousands of cells per second. Based on the characteristics cells can also be sorted with high precision allowing subsequent experiments with well-defined cell populations.The Netherlands Cancer Institute has a Flow cytometry facility with several analyzers and two sorters. The two operators maintain the equipment, give advice and training and perform sorting experiments.Activities and servicesResearchers are offered hands-on training to learn the principles of flow cytometry and to operate the analysers themselves. The analysers are available to trained users 24/7.The ability to measure multiple parameters on individual cells is the most powerful aspect of flow cytometry. This allows flow cytometry to be used for a wide range of applications. Among the most common applications at the Netherlands Cancer Insitute are immune phenotyping with up to 18 colours, apoptosis assays using annexin V, cell cycle analysis, and analysis of cells expressing one or more fluorescent proteins. Lots of other applications are used and new applications are set up by the operators together with the researchers.Through close cooperation of fluidics, laser technology and electronics it is possible to separate specific cells out of a cell suspension using the sorters at the facility. We are capable of sorting up to 16 colours into 6 fractions or into multiwall plates. We can also sorting into microwell slides. The development of these cells was followed under a confocal microscope at the digital microscopy facility.EquipmentThere are currently six flow cytometry analysers and two high speed cell sorters in the facility.BD LSRII with 5 lasers (488 nm, 355 nm, 405 nm, 561 nm and 635 nm) and 18 fluorescence detectorsBD Fortessa with 4 lasers (488 nm, 405 nm, 561 nm and 635 nm) and 15 fluorescence detectors equipped with a HTS-loader for sampling out of a multiwell plateTwo Becton Dickinson FACSCalibur analysers, one of which is capable of sampling out of a multiwell plate, with 2 lasers (488 nm, 635nm) and 4 fluorescence detectorsBeckman Coulter Cyan, 3 lasers (488nm, 405 nm,633 nm) and 9 fluorescence detectorsBD FacsArray, 2 lasers (532 nm and 635) and 4 fluorescence detectors capable of sampling out of a 96-wells plateBD FacsAria Sorter with 3 lasers (488nm, 405 nm,633 nm) and 9 fluorescence detectors for high speed 4-way bulk sorting and single cell deposition sorting.Beckman Coulter Moflo Astrios 4 lasers (488nm, 405 nm, 561 nm

Netherlands Cancer Institute (NKI) Molecular Pathology & Biobanking Core Facility Plesmanlaan 121 1066 CX Amsterdam

In recent years, the need for controlling the 'secondary use' of human biospecimens for research purposes at the NKI became more apparent. To ensure human material is used properly and efficiently, especially in the case of scarce, valuable samples, a facility for use of NKI biobank materials was desired. Therefore, in 2011, the Core Facility Molecular Pathology & Biobanking (CFMPB) was founded.The CFMPB facilitates the use of NKI biobank materials for translational research. For all research projects, in which the use of NKI biobank materials is proposed, the Core Facility has to be contacted by the researcher. The CFMPB confirms that the Translational Research Board approves the usage of the material, does the sample handling (logistics), generates derivative biospecimen samples, and stores scientific results. Currently the facility's resources consist of a team of dedicated (lab) staff, dedicated lab space and equipment, and an in-house developed application and request tool.

Netherlands Cancer Institute (NKI) Mouse Clinic - Imaging Unit Plesmanlaan 121 1066 CX Amsterdam

Medical Imaging using different techniques.Instruments:Bruker Biospec 7T MRIAlbira PET/CTMILabs USPECT/CTBruker ICON 1T MRIPerkinElmer IVIS Spectrum

Netherlands Cancer Institute (NKI) Digital Microscopy Facility Plesmanlaan 121 1066 CX Amsterdam

The Digital microscopy facility is a broad, high level, light microscopy facility. It gives general microscopy support and provides access to advanced microscopes to all researchers in the Institute. At present the facility harbors nine microscopes, each with its own special functionality and together forming a complementary set of instruments. The facility has three operators (2.4 fte).Equipment and ApplicationsThe equipment consists of four confocals, four wide-field microscopes and a TIRF setup. All microscopes are of course suited to "manually" capture images of fixed or living samples. Except one, they are all fully motorized and well equipped for automated, un-attended image acquisition. Three confocals, two wide-field microscopes and the TIRF setup are equipped with home build 37 °C, 5% CO2 incubation chambers around the microscope, providing accurately controlled stable conditions, essential for demanding time-lapse studies. Four of these (two confocals, one wide-field system and the TIRF) are also equipped with a hardware autofocus system which can correct for focus drift in time. Unlike a software autofocus it does not require images to be taken and hence does not function at the expense of bleaching and photo-damage. All in all, the combination of the tightly controlled home build live-cell systems and the hardware autofocus greatly increases the chance of successful live-cell imaging, especially in case of long time-lapses at multiple positions.

Netherlands Cancer Institute (NKI) Bioanalytical Laboratory for the Pharmacy MC Slotervaart (2nd floor, B-wing) Louwesweg 6 1066 EC Amsterdam The Netherlands

The strategic location of the GLP-certified laboratory close to the clinical research units of the Netherlands Cancer Institute facilitates the support of clinical studies with anticancer drugs with time-critical samples to be analysed (rapid turnaround times for dose escalation studies and therapeutic drug monitoring) and of mass balance studies preventing the shipment of radioactive samples. The co-located clinical research units enables innovative working collaboration with clinicians, efficient analysis and faster progress of clinical studies leading to a reduction in the costs.Know-howOur bioanalytical group is comprised of specialists with over 25 years of experience in bioanalysis, cooperation with sponsors and clinics. Our employees are specialised in the development of bioanalytical methods for complex anticancer drugs. We offer validated methods for the quantification of anticancer drugs that are ready for use, including ultra-sensitive methods down to lower limits of quantification of pg/mL in body fluids and methods for the quantification of anticancer drugs in other matrices (PBMCs, tumour tissues and DNA).

Netherlands Cancer Institute (NKI) Biostatistics Center Plesmanlaan 121 1066 CX Amsterdam

Biostatistics is a key component of biomedical research and is essential for the interpretation of study results. Statistical techniques inform, among others, about the experimental design, treatment plan, evaluation of a new versus a standard treatment, and identify prognostic factors. The Biostatistics Center provides statistical expertise to researchers and doctors on diverse topics from all areas of observational and experimental biomedical cancer research. This involves developing and implementing statistical approaches to cover a wide range of topics including the design and analysis of epidemiologic studies and clinical trials, the identification of prognostic and predictive biomarkers, sample size calculations, risk prediction, as well as animal and in vitro experiments. In the recent past, the Biostatistics Center has been involved in, among others, prediction of hearing loss after cisplatin-based chemoradiation in patients with locally advanced head-and-neck cancer, biomarker-based treatment of breast cancer with adjuvant tamoxifen, comparison of platforms for array comparative genomic hybridization (aCGH) to identify breast cancers with a BRCA-like copy number profile, and dysphagia and trismus after concomitant chemo-Intensity-Modulated Radiation Therapy (chemo-IMRT) in advanced head and neck cancer. Moreover, the Biostatistics Center is closely involved with several international epidemiological studies on cancer incidence and exposure to chemicals and radiation, and it offers the annual Basic Medical Statistics Course.

Netherlands Cancer Institute (NKI) Carcinogen Laboratory Plesmanlaan 121 1066 CX Amsterdam

In cancer research we use a lot of dangerous compounds. The carcinogen lab is a research facility where carcinogenic, mutagenic and reprotoxic compounds can be stored and were these compounds can be handled under special safety conditions.The carcinogen laboratory is mainly used to prepare solutions using chemicals in a powder form. The chemicals can be weighted in a fume hood, dissolved and then taken out of the carcinogen laboratory for use in experiments. The lab is under-pressured, has a higher than normal ventilation fold and is equipped with two safety hoods.Researchers can get instructions on how to work with carcinogens and about safety aspects. The instructions and the information is given by one of the supervisors of this facility. They also make sure everything is working properly and is kept clean and tidy.

NNZ Aarhusweg 1 9723 JJ Groningen The Netherlands

NNZ is a multinational company owned and run by the family Boot since 1922. Its employees create packaging solutions for their clients in the fresh produce and industrial market.NNZ has the ambition to become a market driven company with the direct goal of creating packaging solutions for its partners through a worldwide network in both the agricultural-and industrial sector.

Netherlands Brain Bank De Nederlandse Hersenbank Meibergdreef 47 1105 BA Amsterdam The Netherlands

Netherlands Brain Bank (NBB) is a non-profit organization that collects human brain tissue for neurological and psychiatric research.

Ncardia 8 Galileiweg, Leiden, ZH 2333, NL

The business objective of Ncardia lies in the area of pre-clinical biotechnology, specifically in the development and production of stem cell-derived cell types (e.g. cardiac & neuronal cells) and cell-based assays that enable drug development. These innovative and proprietary cell types and assays accelerate and improve drug candidate selection, lower costs and thus increase overall drug development efficiency.

OctoPlus Zernikedreef 12 2333 CL Leiden The Netherlands

OctoPlus provides formulation of active ingredients for all common forms of administration.

OcellO J.H. Oortweg 21 2333 CH Leiden The Netherlands

OcellO is a CRO specialising in 3D culture models and high content amnalysis. OcellO excels in the development of clinically relevant in vitro human micro-tissue models that can be used for the screening and profiling of small molecules and biologics. The analysis of these models, many of which use patient-derived material, is enabled by OcellO’s unique high throughput 3D imaging and phenotypic profiling technology.3D screening models include:normal and cancer organoids - panel of 70 fully sequenced organoids licensed from the Hubrecht Institute.Cystic fibrosis assay - panel of CFTR rectal organoids for forskolin-induced awelling assay (Dekkers,,Clevers,, and Beekman. Nature Methods 2013). Automated morphological assessment, high throughput format.Polycystic kidney disease assay. 3D renal epithelial cyst swelling assay. Automated morphological assessment, high throughput format.Ex vivo/in vitro patient derived xenograft 3D culture screening. High throughput and high content assays using the Charles River/Oncotest PDX collection.Immune oncology models using cancer spheroids and HLA matched T cells. Automated morphological assessment of T cell infiltration and killing. High throughput format.

Onno Jongerius Consult Begijnenhof 26 · 6584 CW Molenhoek · The netherlands

Onno Jongerius Consult BV ( “Jongerius Consult”) is specialised in chemicals legislation; focussing on how to organise Chemical Regulatory Compliance (CRC) efficiently and effectively within a company in its supply chain.Jongerius Consult offers strategic and practical support of high quality to the various stakeholders working to an efficient and successful implementation of the chemicals management processes to deal with the European chemicals legislation within a company, industry sector or supply chain. The core is currently formed by the REACH Regulation (EC) 1907/2006 and the CLP regulation (EC) 1272/2008.In parallel, we offer Chemical Regulatory Compliance (CRC) support to frontrunner companies / industry sectors that have to deal with new chemical regulatory requirements or are confronted with conflicting regulatory requirements from different chemicals legislations in the European Union. We are appreciated for our fast understanding of the critical points and ‘out of the box’ thinking coming to practical solutions in connection to the existing chemicals management processes and information systems.

OYC Europe Groothandelsgebouw Conradstraat 18 Rotterdam, 3013 AP The Netherlands

OYC Europe, a wholly owned subsidiary of Oriental Yeast Co., Ltd. (OYC Japan), supplies biochemical products such as enzymes, coenzymes (co-factors), monoclonal/polyclonal antibodies, recombinant proteins and superior quality liquid stable chemistry reagents.

Ocimum Biosolutions Lagedijk, Noord 18

Ocimum offers gene and microRNA expression profiling, SNP genotyping, copy number analysis, DMET, gene sequencing, biomarker discovery and molecular diagnostic services and software development.

PamGene Wolvenhoek 10

PamGene offers biomarker identification and validation services.

Pivot Park Screening Centre Kloosterstraat 9 5349 AB Oss The Netherlands

Pivot Park Screening Centre offers High Throughput Screening (HTS), assay development and lab automation services to assist in the drug discovery process. Our two industrial-scale labs provide an open, innovative setting for automation and extensive cellular and biochemical in-vitro screening experiments. Also ample experience using 1536-well format.

Pharmaceutical Product Development (PPD) Bornweg 12c 6721 AH Bennekom The Netherlands

PPD offers central lab services, bioanalytical services, biomarker discovery services, assay development services, cGMP analytical services, CMC consulting, and pharmacology services.

Parexel Herman Heijermansweg 20

Parexel provides bioequivalence studies as well as clinical services across Phase I to Phase III of drug development including dose escalation, drug-drug interaction, biomarkers, first-in-man studies, ADME, imaging, and clinical research services.

PET Power Hermelijnweg 24877 AE Etten-Leur, The Netherlands

PET Power supplies bottles and jars and also provides appropriate lids and decorations.

PlantResearch BV Stelvenseweg 11A, 4921 PL Made, The Netherlands

PlantResearch BV is an independent, privately owned research company that specializes in the development and testing of growing media, fertilizers and plant bio-stimulants for both conventional and organic horticulture. The majority of our clients are companies that wish to develop or improve products or application methods for the EU and world markets. Our research is both fundamental and practical, undertaken in our purpose built greenhouse facilities and modern laboratory. The main focus of our work is the development and testing of growing media, (organic) fertilizers as well as growth enhancing products and technologies. In addition to the development of new products PlantResearch can also assists its clients in registering their products with relevant certifying agencies worldwide.

Proeftuin Zwaagdijk Tolweg 13 1681 ND Zwaagdijk-Oost

PHARMO Institute Van Deventerlaan 30-40 3528 AE Utrecht The Netherlands

Founded in 1999, PHARMO is an independent research organisation dedicated to the study of epidemiology, drug utilisation, drug safety, health outcomes, and utilisation of healthcare resources. PHARMO developed and maintains a large and high quality Database Network and works closely with (inter)national medical universities and European databases. Through its studies with longitudinal and real world patient data, the PHARMO Institute contributes to risk management and outcomes research and provides solutions for decision-makers in market access, health economics and health outcomes domains.Our mission is to achieve greater insights into the real world of healthcare, through the collection and expert analysis of patient-centric information.

Pharmerit International Marten Meesweg 107 3068 AV Rotterdam The Netherlands

Pharmerit is an international organization conducting worldwide research in the field of Health Economics and Outcomes Research. Our multidisciplinary team of professionals help define, build and communicate your product’s clinical, humanistic and economic value through a wide range of services tailored to our clients’ specific needs. Our mission is ‘To improve patients' access to medical care through evidence - worldwide". Pharmerit puts its team of leading scientists, clinicians, methodologists, strategists, pricing and reimbursement specialists and academicians to the task of understanding, shaping and communicating the value of health care interventions. We conduct Health Economic and Outcomes Research to inform local, national, and international decision makers in pharmaceutical, biotechnology, device, and diagnostic companies, government bodies and private organizations involved in the delivery and financing of health care. Whether you need to evaluate the value of a new treatment in early stage of development, assess the unmet needs for a product's new indication, determine the quality of life impact of a new therapy, design or interpret the results of a clinical trial, or define a reimbursement strategy, chances are that our team, with over 125 years of combined experience, has successfully addressed this or a very similar problem numerous times in the past. Whatever the unique and specific challenges you face, you will find in working with Pharmerit a team of researchers dedicated to find customized, authoritative and timely answers that have practical and actionable implications for you and other decision makers.

Pharmerit International High Tech Campus 10 5656 AE Eindhoven The Netherlands

Pharmerit is an international organization conducting worldwide research in the field of Health Economics and Outcomes Research. Our multidisciplinary team of professionals help define, build and communicate your product’s clinical, humanistic and economic value through a wide range of services tailored to our clients’ specific needs. Our mission is ‘To improve patients' access to medical care through evidence - worldwide". Pharmerit puts its team of leading scientists, clinicians, methodologists, strategists, pricing and reimbursement specialists and academicians to the task of understanding, shaping and communicating the value of health care interventions. We conduct Health Economic and Outcomes Research to inform local, national, and international decision makers in pharmaceutical, biotechnology, device, and diagnostic companies, government bodies and private organizations involved in the delivery and financing of health care. Whether you need to evaluate the value of a new treatment in early stage of development, assess the unmet needs for a product's new indication, determine the quality of life impact of a new therapy, design or interpret the results of a clinical trial, or define a reimbursement strategy, chances are that our team, with over 125 years of combined experience, has successfully addressed this or a very similar problem numerous times in the past. Whatever the unique and specific challenges you face, you will find in working with Pharmerit a team of researchers dedicated to find customized, authoritative and timely answers that have practical and actionable implications for you and other decision makers.

PRISNA P.O.Box 506 Oostvoorne, 3233 ZK The Netherlands

PRISNA (Product Isolation from Nature), a consortium of several independent Dutch companies and the department of Pharmacognosy at the Leiden University, offers natural product libraries, LC-MS analysis, NMR analysis, supercritical technologies, and Centrifugal Partition Chromatography.

Particle Sizing Systems Waterman 182

Particle Sizing Systems offers particle size analyzers, potential analyzers, classification and homogenization, and stability analyzers.

PRA Health Sciences Stationsweg 163

At PRA Health Sciences, providing innovative solutions for our clients is what we do. But innovation just for the sake of innovation isn’t why we do it. Side-by-side with our clients, we strive to move drug discovery forward, to help them develop life-saving and life- improving drugs. We help change people’s lives for the better every single day. It’s who we are. Innovating to help people is at the heart of our process, but it’s even more than that. It’s also our privilege.

PRA Health Sciences Berkenweg 1

At PRA Health Sciences, providing innovative solutions for our clients is what we do. But innovation just for the sake of innovation isn’t why we do it. Side-by-side with our clients, we strive to move drug discovery forward, to help them develop life-saving and life- improving drugs. We help change people’s lives for the better every single day. It’s who we are. Innovating to help people is at the heart of our process, but it’s even more than that. It’s also our privilege.

PRA Health Sciences Westerbrink 3

At PRA Health Sciences, providing innovative solutions for our clients is what we do. But innovation just for the sake of innovation isn’t why we do it. Side-by-side with our clients, we strive to move drug discovery forward, to help them develop life-saving and life- improving drugs. We help change people’s lives for the better every single day. It’s who we are. Innovating to help people is at the heart of our process, but it’s even more than that. It’s also our privilege.

Pyxis Discovery Delftechpark 26

Pyxis Discovery offers compound librariers, fragment libraries, medicinal chemistry, and protease screening.

PickCell Laboratories Kruislaan 406

PickCell Laboratories provide peptide, antibody, and hybridoma services.

Pepscan Presto Zuidersluisweg 2 8243 RC Lelystad, The Netherlands

Pepscan Presto provides services for the design, manufacture and use of custom peptides and combinatorial arrays of peptides, peptide constructs, peptidometics and peptide derivatives.Pepscan is a premier provider of peptide based products & services. We also offer our profound knowledge of peptides for drug discovery collaborations.Pepscan is specialized in constrained peptides, and is the inventor of the CLIPS constraining technology. Our bicyclic ‘2-CLIPS’ peptides represent a new generation of biotherapeutics, offering antibody-like affinity and selectivity in a small, fully synthetic molecule.Pepscan pioneered epitope characterization over 20 years ago with the invention of mapping with overlapping libraries of linear peptides. Given that most therapeutic antibodies have non-linear epitopes, Pepscan has since then also developed a unique, high resolution mapping technology to determine so-called discontinuous or conformational epitopes.Many leading companies apply our Precision Epitope Mapping to their most promising antibodies, several of which recently received FDA breakthrough status.

Pluriomics Biopartner building 3 Galileiweg 8 2333 BD Leiden The Netherlands

Building on groundbreaking induced pluripotent stem cell technology, Pluriomics develops and commercializes its Pluricyte Cardiomyocytes platform.Pluriomics is a biotech company focused on development of fully functional human assay systems for use in drug discovery and development. Based on our novel proprietary methods for differentiation of stem cells we develop highly functional cell types like our Pluricyte Cardiomyocytes. We use these cells in combination with phenotypic assays to deliver high quality results.There is an urgent unmet need for innovative and safe drugs as the western community ages. However, the development of these drugs is lacking because current (animal based) disease model systems do not adequately represent human disease and are therefore not suited for efficient novel target discovery and subsequent drug development. A major problem is the use of artificial in vitro assays and experimental animal models that display limited predictability when compared to the patient. It is therefore imperative that models will be developed which are more comparable to the human situation. Since human cardiomyocytes have lost their capacity to divide, it is not feasible to use primary cardiomyocyte cultures from human hearts or biopsies. The use of Pluricyte Cardiomyocytes allows researchers to overcome these problems when investigating effects on the human heart.Pluricyte Cardiomyocytes are functionally characterized, produced in large quantities, quality controlled and the use of maturation inducing media ensures consistent cell quality. These properties makes them exceptionally well suited for implementation in pharmaceutical drug discovery and development.Pluriomics supplies cardiomyocytes to pharmaceutical companies to be used in their preclinical discovery pipeline to improve decision making, reduce timelines and attrition rates and consequently reduce costs. Cardiomyocytes are also available for academic labs to assist in their projects to study human heart development, physiology and disease.Besides delivery of cell types for use in pharmaceutical & academic research, Pluriomics focusses on two applications of Pluricyte Cardiomyocytes:(1) development and validation of assays for predictive cardiac safety pharmacology(2) efficacy assays for cardiac drug discovery and development

QVQ 1 Yalelaan, Utrecht, UT 3584 CL, NL

QVQ aims at supplying single domain antibody services to research groups and companies providing the smallest, fastest and most effective antibody based research, therapeutic or imaging agents in the market. In collaboration with our customer, we provide services according to their specific requirements. In tailor-made projects with a high level of interaction with the customer, we develop a perfectly suited imaging agent.

QVQ 1 Yalelaan, Utrecht, UT 3584 CL, NL

QVQ aims at supplying single domain antibody services to research groups and companies providing the smallest, fastest and most effective antibody based research, therapeutic or imaging agents in the market. In collaboration with our customer, we provide services according to their specific requirements. In tailor-made projects with a high level of interaction with the customer, we develop a perfectly suited imaging agent.

Quest Pharmaceutical Services Petrus Campersingel 123

QPS provides bioanalytical LC/MS/MS services, immunoanalytical services, biomarker discovery services, and in vitro and in vivo ADME services.

QuickZyme Biosciences Zernikedreef 9

QuickZyme Biosciences, a provider of research materials and preclinical assay services, offers unique products and services with added value in the field of matrix related proteins, enzymes and assays.

QPS Petrus Campersingel 123 Groningen, The Netherlands 9713 AG

QPS provides Neuropharmacology, DMPK, Toxicology, Bioanalysis (small and large molecules), Translational Medicine, Early Stage Clinical Research, Phase II – IV Clinical Research, Program Management.

R C Hartelust BV Kapelmeesterlaan 112-B Tilburg, 5049 NL Netherlands

Rijk Zwaan Eerste kruisweg 9 4793 RS Fijnaart, The Netherlands

Rijk Zwaan develops vegetable varieties and sells the seeds produced from them, which places us right at the start of the food chain.Market positionIn the worldwide market of vegetable seeds, Rijk Zwaan is at the fifth place with a turnover of over 350 million euros. Every year, we invest 30% of our turnover in R&D.

Radboud University Nijmegen Centre for Molecular and Biomolecular Informatics 6500 HC Nijmegen

Radboud University Nijmegen Centre for Molecular and Biomolecular Informatics provides synthesis planning, visualization tools, modeling and computation chemistry services.

Radboud University Nijmegen Medical Centre 10 Geert Grooteplein Zuid, Nijmegen, GE 6525 GA, NL

The Radboud university medical center advances human knowledge by conducting biomedical, translational and clinical research in order to improve wellbeing.Our key strength is medical life sciences and clinical practice, with an impressive infrastructure comprising state-of-the-art technology platforms and (translational) research facilities. The Radboud university medical center is therefore uniquely positioned in the emerging Euregio and Dutch healthcare infrastructure to play a leading role in the new healthcare paradigm of prediction, prevention and personalised medicine.The Radboud university medical center focuses on scientific health challenges of today, with an eye on emerging diseases of the future.

Sylics 1081 HV, Amsterdam, The Netherlands

Sylics offers innovative research solutions for preclinical neuroscience.We specialize in developing and employing mouse models and behavioural tests to evaluate compound effects on, and disease mechanisms of, neurological and psychiatric diseases, with a strong focus on Alzheimer’s disease, Parkinson’s disease and Schizophrenia.Highly efficient, sensitive and reproducible screening for behavioural deficits is supported by our automated screening platform and proprietary analysis software AHCODA™ (available for licensing).Over the last 10 years, we successfully characterized dozens of novel mouse models, and determined compound efficacy and side-effects in numerous projects for academia, biotech, and food industry clients.

SMS-oncology Science Park 406 Amsterdam, 1098 XH The Netherlands

SMS-oncology offers clinical research services to support clinical development of oncology therapeutics.

Signifix Professor Bronkhorstlaan 10 building 48 Bilthoven, 3723 MB The Netherlands

Signifix offers quality assurance/control and regulatory affairs expertise.

Sanquin Plesmanlaan 125

Sanquin offers blood testing and immunodiagnostic services.

Synvolux Therapeutics L.J.Zielstraweg 1 9713 GX Groningen The Netherlands

Synvolux Therapeutics provide scientists with transfection reagents.

Sinensis Life Sciences Archimedesweg 23 Leiden, 2333 CM The Netherlands

Sinensis Life Sciences is an independent provider of laboratory testing and manufacturing services to the international life sciences market. Sinensis’ services range from (bio)chemical and microbiological quality control testing of pharmaceutical raw materials to finished dosage forms, thereby covering release, stability and validation studies. Method development departments can develop custom test methods from scratch or based on client methods.

SACHEM Van Voordenpark 15

SACHEM provides compound synthesis, reagents, catalysts, and chemical services.

Sylphium Life Sciences Duurswoldlaan 22

Sylphium Life Sciences offers DNA fragment subcloning, synthesis, PCR, modification, and cytochrome P450 expertise services.

Seed Processing Holland BV P.O. Box 32, 1600 AA Enkhuizen, The Netherlands

Mission Statement“ To supply worldwide vegetable and flower seed companies with high quality and safe seed processing equipment and installations which give an added value to seeds and the process efficiency ”Welcome to Seed Processing Holland B.V.Based in Enkhuizen, Seed Processing Holland was founded in the year 1967 and has specialised in the manufacture of machinery and equipment for the seed processing industry. Seed processing Holland Inc. Seed Processing Holland (SPH) has expand its activities by opening up its Seed Processing Holland Inc. (SPH) Sales Office in the US in 2014.SPH recognizes the importance of the North American seed market and it has always been our wish to enhance our service level to this region by having a direct presence. We believe in the high value of working side by side with customers and this new US platform will enable SPH to do so and bring the right solutions to any seed processing and packaging need. Jeffrey runs the SPH office in the US.

SynCon International Amsterdam, the Netherlands

SynCon International offers clinical research services including feasibility analysis, site identification, patient recruitment, data management, and clinical monitoring.

Spinnovation Toernooiveld 1, Mercator III Nijmegen, 6525 ED The Netherlands

Spinnovation offers high resolution NMR and MS services to support structure elucidation, impurity profiling, metabolite identification, and target-ligand interaction studies.

Synthon B.V. Microweg 22, 6545 CM Nijmegen, Netherlands

Synthon is a company committed to delivering affordable medicines through innovative science.

Swammerdam Institute for Life Sciences University of Amsterdam Centre for Advanced Microscopy building III, room 2.11 Kruislaan 316 SM Amsterdam 1098 The Netherlands

Swammerdam Institute for Life Sciences offers optical microscopy for scientific research.

SynCo Bio Partners Paasheuvelweg 30

SynCo Bio Partners offers process development, microbial production, mammalian cell based production, and API synthesis services.

ServiceXS Plesmanlaan 1d

ServiceXS is an ISO17025 accredited laboratory providing Next-Gen Sequencing, genotyping, methylation and microarray services.

Shimadzu Australielaan 14

Shimadzu offers analytical technology, laboratory instruments, testing machines, and scales.

Sanbio Frontstraat 2c 5405 PB Uden The Netherlands

Sanbio B.V., based in Uden (the Netherlands) and established in 1978, is an independent supplier of life science products for research and diagnostics in the Benelux and represents a large number of innovative international companies. Sanbio is also manufacturer and developer of antibodies and antibody-related products of its own brand Monosan, suitable for basic and applied life sciences projects. Our strong reputation is built on our aim to serve our customers with the highest level of service and support.

Sanbio Frontstraat 2c 5405 PB Uden The Netherlands

Sanbio B.V., based in Uden (the Netherlands) and established in 1978, is an independent supplier of life science products for research and diagnostics in the Benelux and represents a large number of innovative international companies. Sanbio is also manufacturer and developer of antibodies and antibody-related products of its own brand Monosan, suitable for basic and applied life sciences projects. Our strong reputation is built on our aim to serve our customers with the highest level of service and support.

Specs Kluyverweg 6 2629HT Delft, The Netherlands

Specs offers compound management services, compound libraries, contract research, custom synthesis,cheminformatics, compound sourcing, building blocks and natural products.

Sensus Borchwerf 3 Roosendaal, 4704 RG Netherlands

Sensus specializes in the production of Frutafit inulin and Frualose oligofructose.

Syncom 3 Kadijk, Groningen, GR 9747 AT, NL

Syncom provides world class process R&D & medicinal chemistry support. Syncom is focussing on complex synthesis including carbohydrate, vitamin D and steroid chemistry. Syncom has an exceptional track record in developing chiral resolution processes.

Toxys 4 Robert Boyleweg, Leiden, ZH 2333 CG, NL

Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development. Toxys exclusively offers the ToxTracker assay, our state-of-the-art stem cell-based reporter assay that provides mechanistic insights into the genotoxic properties of pharmaceutical compounds and chemicals. ToxTracker can contribute to a mechanism-based, animal-free, cancer hazard and risk assessment of chemicals. ToxTracker can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens by revealing genotoxic modes of action and a number of non-genotoxic modes of action, such as oxidative stress and protein damage.We often combine our unique ToxTracker assay with a range of extended protocols and additional assays to unravel the underlying mechanism of genotoxicity and predict the outcomes in the regulatory in vitro and in vivo genotoxicity assays. Toxys also offers ToxTracker ACE (Aneugen Clastogen Evaluation) being an extended version of ToxTracker assay and includes direct discrimination between an aneugenic and a clastogenic mode-of-action of genotoxic compounds.

TNO Utrechtseweg 48, 3704 HE, Zeist, The Netherlands

TNO is an independent research organisation whose expertise and research make an important contribution to the competitiveness of companies and organisations, to the economy and to the quality of society as a whole. The TNO mission is: TNO connects people and knowledge to create innovations that boost the sustainable competitive strength of industry and well-being of society. TNO’s unique position is attributable to its versatility and capacity to integrate this knowledge.Our strategy is a reflection of the trends we observe in society and technology. In close coordination with our stakeholders we have defined five transitions on which we will focus. These are in line with the challenges and ambitions of the Top Sector policy and social themes in the Netherlands and the rest of Europe. The transitions can be summarised as follows:•Industry: from economic stagnation to growth in high-technology industry•Healthy Living: from illness and treatment to health and behaviour•Defence, Safety & Security: from a wide range of threats to controllable risks•Urbanisation: from urbanisation bottlenecks to urban vitality•Energy: from conventional sources to sustainable energy systems.TNO offers translational preclinical in vitro, in vivo and in silico disease model services in the area's of cardiovascular and metabolic diseases, fibrosis and NASH.

TNO Zernikedreef 9, 2333 CK, Leiden, The Netherlands

TNO is an independent research organisation whose expertise and research make an important contribution to the competitiveness of companies and organisations, to the economy and to the quality of society as a whole. The TNO mission is: TNO connects people and knowledge to create innovations that boost the sustainable competitive strength of industry and well-being of society. TNO’s unique position is attributable to its versatility and capacity to integrate this knowledge.Our strategy is a reflection of the trends we observe in society and technology. In close coordination with our stakeholders we have defined five transitions on which we will focus. These are in line with the challenges and ambitions of the Top Sector policy and social themes in the Netherlands and the rest of Europe. The transitions can be summarised as follows:•Industry: from economic stagnation to growth in high-technology industry•Healthy Living: from illness and treatment to health and behaviour•Defence, Safety & Security: from a wide range of threats to controllable risks•Urbanisation: from urbanisation bottlenecks to urban vitality•Energy: from conventional sources to sustainable energy systems.TNO offers translational preclinical in vitro, in vivo and in silico disease model services in the area's of cardiovascular and metabolic diseases, fibrosis and NASH.

TNO Anna van Buerenplein 1, 2595 DA, Den Haag, the Netherlands

TNO is an independent research organisation whose expertise and research make an important contribution to the competitiveness of companies and organisations, to the economy and to the quality of society as a whole. The TNO mission is: TNO connects people and knowledge to create innovations that boost the sustainable competitive strength of industry and well-being of society. TNO’s unique position is attributable to its versatility and capacity to integrate this knowledge.Our strategy is a reflection of the trends we observe in society and technology. In close coordination with our stakeholders we have defined five transitions on which we will focus. These are in line with the challenges and ambitions of the Top Sector policy and social themes in the Netherlands and the rest of Europe. The transitions can be summarised as follows:•Industry: from economic stagnation to growth in high-technology industry•Healthy Living: from illness and treatment to health and behaviour•Defence, Safety & Security: from a wide range of threats to controllable risks•Urbanisation: from urbanisation bottlenecks to urban vitality•Energy: from conventional sources to sustainable energy systems.TNO offers translational preclinical in vitro, in vivo and in silico disease model services in the area's of cardiovascular and metabolic diseases, fibrosis and NASH.

The Hyve The Hyve (Het Nieuwe Kantoor) Arthur van Schendelstraat 650 3511 MJ Utrecht The Netherlands

The Hyve is a young, innovative and fast growing company with a mix of software engineers, bioinformaticians and data scientists. We focus on developing web applications that visualize large amounts of biological and clinical data. We work together with pharmaceutical companies, hospitals, universities and IT companies for a shared solution for data integration and visualization.We are dedicated to support scientists in life sciences and healthcare R&D with open source software, open data and open standards. We are highly motivated to find the solution for your next problem. We want companies in the life sciences sector to leverage open source software already available to improve the methods of research. Our ultimate goal is enhance the quality and impact of biology by enabling scientist to publish their bioinformatics data.

TNO Triskelion BV Utrechtseweg 48, 3704 HE Zeist

TNO Triskelion BV P.O. Box 844, 3700 AV Zeist, The Netherlands.

tebu-bio Bevelandseweg 80

tebu-bio is a leading European distributor of innovative life science research solutions, reagents and lab services.Our extensive network of local offices and sales representatives spanning 9 countries daily assists researchers from universities, pharma, cosmetic and biotech companies in choosing and optimally using the products suited to their research programs (United Kingdom, Germany, France, the Netherlands, Belgium, Scandinavia, Spain, Italy, Portugal).For more than 10 years now, tebu-bio’s own laboratories provide R&D contract services and are an active member of recognized professional networks and clusters (Medicen, Cosmetic Valley…).Products offered: research antibodies, ELISAs, Arrays, Proteins & Peptides, Cell-based & Functional assays, Primary cells & Media (incl. cytokines and growth factors), Stem cells and iPS cells, Human Biological samples & Prospective collections, Characterized cell lines (ex. melanoma, brain- and stem-cell derived, Molecular biology and cell line engineering tools (si/shRNA,CRISPR), Biochemicals & Compounds, Functional assays (Actin, tubulin, Lipid research tools...)…Lab services: Protein production & purification (E. coli,HEK293,CHO),Cell Biology (cell amplification & differentiation,cell-line engineering,Spheroids...),3D cell culture,Culture under hypoxia and normoxia conditions,Molecular biology (nucleic cloning,sub-cloning…),Bio-assays (gene reporter & nuclear receptor assays,outsourcing of assays commercialised by tebu-bio...),Biomarker / Target discovery (Protein Arrays,Multiplex quantification,ELISA,miRNA array...)

Telstar Life Science Solutions Kuipersweg 37

Telstar Life Science Solutions designs, manufactures, sell and support of high technology equipment solutions for the pharmaceutical, biotech and related industries

Telesis Pharma BV Hofstraat 22 - 9712 JC Groningen, The Netherlands

Telesis Pharma BV is a pharmaceutical company working on the processes and chemistry of drugs.We are developing improved drug synthesis to reduce costs significantly while maintaining the high quality standards.This way we help our customers offer highly competitive drug products and therefore contribute to the accessibility of medicine to all.

Taiwan Liposome Company, Ltd. (TLC) 19 J.H. Oortweg, Leiden, ZH 2333, NL

Taiwan Liposome Company (TLC) is a biopharmaceutical company focused on the research, development and commercialization of innovative pharmaceutical products based on its proprietary drug delivery technologies. Our strengths lie in lipid-based formulation and scale-up for parenteral drugs using micelles and nanoparticles to optimize the pharmacokinetics of drugs for better efficacy and lower toxicity, and thus prolong the product lifecycle of branded drugs.VisionTLC is dedicated to maximizing the benefits of medications for patients and improving their quality of life through constantly advancing our technology & know-how. MissionTLC strives to become a global leading biopharmaceutical company, to contribute more towards making a difference in the healthcare industry and make Taiwan biotechnology industry visible in the global arena.

Theorem Clinical Research Fazantlaan 23 5613 CB Eindhoven Netherlands

Theorem Clinical Research offers full service clinical research solutions including DM, biostatistics, programming including CDISC, PM, clinical operations, and regulatory affairs.

U-CyTech Yalelaan 48 Utrecht, 3584 CM The Netherlands

U-CyTech develops and manufactures a wide range of innovative cytokine ELISA, ELISPOT and Fluorospot systems for human, monkey and rodent use.

UbiQ Henriette Bosmansstraat 11

UbiQ develops and commercializes ubiquitinated polypeptides and offers advanced high throughput assay reagents for drug discovery in the ubiquitin field.

Agro Research International B.V. Koeleweg 5 8096 RL Oldebroek The Netherlands

Agro Research International B.V. is a contract research organization located in the Netherlands. The main areas of expertise and services include trials with agrochemicals, biological products, fertilizers and nutrients. Trials are performed on major field crops, in- and outdoor vegetable crops, ornamental crops and trees and shrubs.Agro Research International B.V. is GEP (Good Experimental Practice) and GLP (Good Laboratory Practice) certified. Field trial studies for registration, demonstration and research & development are conducted via strict quality standards and on a fully confidential basis.

Avantium Technologies Zekeringstraat 29 1014 BV Amsterdam Amsterdam 1014 Netherland

Avantium specializes in crystallization and solid state pharmaceutical chemistry of small molecules.

University Medical Center Groningen 1 Hanzeplein, Groningen, GR 9713 GZ, NL

The University Medical Center Groningen (UMCG) was established in 2005 as a joint activity of the University of Groningen and the Academic Hospital Groningen (AZG). At present, the UMCG is one of the largest hospitals in the Netherlands and the largest employer in the Northern Netherlands. More than 10,000 employees provide patient care, are involved in medical education and perform cutting-edge scientific research, focused on ‘healthy and active ageing’. Research and education at the UMCG are funded through the University of Groningen, and the Faculty of Medical Sciences functions as an integral part of the University. The Dean of the Faculty of Medicine is appointed by the Board of the University and is a member of the Board of Directors of the UMCG. More than 3,400 students of the University of Groningen study Medicine, Dentistry or Human Movement Sciences, while more than 340 physicians are doing their specialty training at the state of the art facilities of the UMCG.Patients attend the UMCG for basic care but also for very specialist diagnoses, examination or treatment. All patients from the Northern Netherlands with complicated or unusual disorders are eventually referred to the UMCG.Good quality care is always based on the latest information, and is provided by the best doctors and nurses. Together with the support staff, every day we work on achieving a single common goal: building the future of health.

U-Protein Express BV 62 Yalelaan, Utrecht, UT 3584, NL

U-Protein Express BV is a dedicated CRO that has many years experience in recombinant protein production. At U-Protein Express BV fully post-translational modified mammalian proteins are produced via its proprietary r-PEx transient expression platform (patent applications pending) based on Human Embryonic Kidney cells (HEK293E). r-PEx’ transient expression technology is much faster than traditional methods and provides superior amounts of bioactive recombinant proteins. In addition we have generated a novel proprietary HEK293 cell line (HEK293ES, patent pending) for the production of recombinant proteins suitable for structure determination via X-ray crystallography.

Utrecht University National Single Crystal Service Facility Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

Utrecht University National Single Crystal Service Facility provides crystal structure determination services.

University of Groningen University of Groningen PO Box 72 9700 AB Groningen, Netherlands

University of Groningen provides academic research and collaboration.

VU University Amsterdam - LaserLaB Amsterdam LaserLaB VU University Amsterdam De Boelelaan 1081 1081 HV Amsterdam, The Netherlands

The mission of LaserLaB Amsterdam is groundbreaking scientific research based on the interaction of light with matter, spanning from the research on atoms and molecules to the investigation of living cells and tissue and sustainable energy sources. Within LaserLaB, research is conducted in close collaboration between physicists, chemists, biologists and physicians. LaserLaB Amsterdam is hosted at the VU University, with participating research groups at the UvA, AMC and VUmc. LaserLaB is a founding partner of the new imaging center VU University medical imaging center. LaserLaB Amsterdam is part of LASERLAB-Europe, an Integrated Infrastructure Initiative of the European Union, forming a consortium of the 27 major laser centers in Europe.The discovery of the laser, 50 years ago, gave scientists access to beams of light of extremely high intensity and very short duration. The laser has become an unique tool for the research into the foundation of nature and life, such as photosynthesis, protein dynamics, chemical reactions and constants of nature.The research within LaserLaB is organized around the dominating societal needs, Human Health and Energy. Some 100 scientists are involved in laser-oriented scientific research of applied and fundamental nature.The increasing demand for health and longevity requires a better understanding of the basic processes of life. The LaserLaB research is focused on the development and application of novel optical methods, techniques and instruments to study the interaction between proteins, DNA, cells and tissue. This knowledge will lead to innovative diagnostic and therapeutic techniques.Energy production will play a crucial role in our future. The process of photosynthesis in plants serves as an example for renewable energy production. By studying this process, it is possible to develop more efficient solar cells or biofuels. The laser has made it possible to study the structure of living materials and matter and the chemical and physical processes that take place within them.The LaserLab will serve as a powerful multidisciplinary educational faculty, especially for national and international (Master's) students and will have a unique position in Europe.

VU University Amsterdam, Department for Physics and Astronomy Biophysics of Photosynthesis/Energy , Amsterdam, NH 1081 HV, NL

The Biophysics group uses advanced optical spectroscopy and microscopy to obtain fundamental knowledge on the relation between the structure, function and dynamics of proteins and other biological molecules, both in single proteins and in supramolecular aggregates.Photosynthesis Photosynthesis converts energy from light into biological energy and is essential for all life on Earth. For successful operation it requires an integration of (sub-)picosecond photophysical and photochemical processes with developmental and regulatory processes that take place over much longer timescales. Understanding the basic principles that nature exploits in its solar energy converters is of utmost importance to develop new technologies for the production of clean and sustainable energy. We study photosynthesis by a variety of advanced laser-spectroscopic and microscopic techniques, also within the framework of a European Initial Training Network.Photoactive proteins, signal transduction and enzymesMolecular processes at the basis of the action of proteins involve the transfer of electrons, protons, hydrogen or hydride atoms, which are coupled to the motion of (charged) molecular groups. Signal transduction proteins convert the event of absorption of a photon in a signal that can be sensed by other proteins. We study these events with ultrafast transient absorption spectroscopy in the visible and mid-infrared spectral regions.Mathematically based analysis of multidimensional data is an important tool in the process of converting experimental data into biophysical knowledge

VU University Amsterdam, Department of Physics and Astronomy Faculty of Sciences De Boelelaan 1081 NL-1081 HV Amsterdam The Netherlands

Our department consists of 25 research staff members, 4 (fte) teaching staff members, 6 technicians (exclusive the mechanical and electronic workshops), 75 postdocs and PhD students, and 350 students that follow bachelor and master degrees in Physics, Medical Natural Sciences and Science, Business and Innovation. Our research is organized in five research groups: Biophotonics & Medical Imaging Physics of Living Systems Biophysics / Physics of Energy Atoms, Molecules & Lasers Astro-Particle Physics Our department hosts a Physical Practica & Didactics group, responsible for the training of experimental skills of undergraduate students and the development of new didactical methods.

Van Iperen International Smidsweg 24 3273 LK WESTMAAS The Netherlands

Van Iperen International can rely on the best expertise there is in the fertilizer sector. Not only do we belong to a business group with a respectable background and history, we are also connected to a network of serious knowledge. That is part of the reason why we can help your business grow. We know how to produce fertilizers, how to use them, and how to distribute them. And we would like to share this with you. Erik van den Bergh, our Managing Director, explains who we are and what our strengths are.

Van Loon Chemical Innovations 408 Science Park, Amsterdam, NH 1098 XH, NL

Van Loon Chemical Innovations (VLCI) provides valuable and innovative R&D services to the formulation industry, on a project-by-project basis. By combining knowledge, experience and High Throughput, we boost development processes and improve properties of polymers, coatings, personal & beauty care, household and pharmaceutical products. VLCI has its own proven concept: Various products introduced onto the market up to 5 times faster, allowing our customers to save costs on R&D projects.

Vivomicx BV 53 H.W. Mesdagstraat, Groningen, GR 9718 HD, NL

Isolation of cells from tissue sections. We developed a well validated protocol for analysing gene expression profiles in subsets of cells in complex tissues from animal and human origin.Using laser dissection microscopy, we isolate predestined cells from tissue sections and subject their RNA to quantitative RT-PCR analysis. It provides a unique way to unmask the molecular control of cell behaviour in different compartments of healthy and diseased tissues. Also, the effects of therapeutic intervention can be analysed at the molecular level in the cells you are interested in.

Virtual Proteins High Tech Campus 9 Eindhoven 5656 AE The Netherlands

Virtual Proteins provides imaging and simulation services.

Viroclinics Room Ee-1989 3015 GE Roterdam The Netherlands

Viroclinics provides diagnostic testing, preclinical services, and research in virology and other related areas.

Wildlife International Waterstraat 5 7201 HM Zutphen The Netherlands

Wildlife International offers analytical chemistry, aquatic and avian toxicology, histopathology, and biodegradation services.

Wageningen UR Central Veterinary Institute Houtribweg 39

Central Veterinary Institute of the Wageningen University & Research centre focuses on research in infectious diseases while providing animal housing and experimental animal facilities.

Wacker Heiligeweg 166 1561 DM Krommenie Netherlands

Wacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

Xendo Drug Development Bio Science Park, Archimedesweg 17, 2333 CM Leiden, The Netherlands

Xendo Drug Development offers bioanalytical, in vitro drug metabolism, pharmacokinetic, and pharmacodynamic services.

Xendo Drug Development Bio Science Park, ABC building, Niels Bohrweg 11-13, 2333 CA Leiden, The Netherlands

Xendo Drug Development offers bioanalytical, in vitro drug metabolism, pharmacokinetic, and pharmacodynamic services.

Yale Pharmaceutical Research Institute Rotterdam, The Netherlands

Yale Pharmaceutical Research Institute offers drug discovery and design, combinatorial chemistry, organic synthesis, ADME testing, pharmacological models, and toxicity services.

ZoBio BV Postbus 9502 Leiden 2300RA The Netherlands

ZoBio provides structure-activity-relationship analysis (SAR), hit validation, and structure determination services.

251 Labs

A4 Lifesciences Admiraal Trompstraat 8 4702VA, Roosendaal Nederland

Aurion Binnenhaven 5 Wageningen, PD 6709 The Netherlands

ABL w.a. scholtenstraat 7 PO Box 232 Assen, 9400 AE The Netherlands

AkzoNobel Functional Chemicals Akzo Nobel Head Office Strawinskylaan 2555 1077 ZZ Amsterdam Netherlands

Arcarios NV Arcarios BV Dr. Molewaterplein 40 3015 GD Rotterdam

Acatris Röntgenweg 6 3752 LJ Bunschoten The Netherlands

A-ware Food Group 3e Industrieweg 5c 3411 MD Lopik The Netherlands

Axon Medchem Postbus 770 Groningen, 9700 AT The Netherlands

Abundnz Jaap Bijzerweg 19 3446 CR WOERDEN The Netherlands

Albert Einstein College of Medicine YU In Vivo Imaging System Core Ullman 1005

Aptalis Amsterdam, The Netherlands

ACE Pharmaceuticals P.O. BOX 1262 NL-3890 BB Zeewolde The Netherlands

AkzoNobel Polymer Chemicals Akzo Nobel Polymer Chemicals B.V. Stationsstraat 77 3811 MH Amersfoort P.O. Box 247 3800 AE Amersfoort The Netherlands

Asinex Laan van Vredenoord, 33, 2289 DA Rijswijk, The Netherlands

AcroMetrix Jan Steenstraat 1 1816 CT Alkmaar The Netherlands

Aegisto Holland

Alpha Packaging International Bijsterhuizen 1009 NL - 6604 LA Wijchen The Netherlands

Biocult Niels Bohrweg 11 - 13 Leiden, 2333 CA The Netherlands

Biorizon Green Chemistry Campus Plasticslaan 1 - Port 1 4612 PX Bergen op Zoom The Netherlands

Biolegio Biolegio B.V. Lagelandseweg 56 6545 CG Nijmegen The Netherlands

Biomedical Primate Research Center (BPRC) 161 Lange Kleiweg, Rijswijk, ZH 2288 GJ, NL

Biomedical Primate Research Centre Postbox 3306 Rijswijk, 2280 GH The Netherlands

Brains On-line, LLC. 9701 EA Groningen The Netherlands

BAC Huizerstraatweg 28 1411 GP Naarden The Netherlands

Bioceros Remco M. Brandt / Yalelaan 46 / 3584 CM Utrecht / The Netherlands

BIRD Engineering Westfrankelandsedijk 1 3115 HG Schiedam Netherlands

BioVisible L.J.Zielstraweg 1 Groningen, 9713 GX The Netherlands

BioDetection Systems Science Park 406 1098 XH Amsterdam The Netherlands

BioXpert BV Landerd Campus Nistelrooise Baan 35374 RE SchaijkThe Netherlands

BaseClear Einsteinweg 5 P.O. Box 1336 Leiden, 2333 CC The Netherlands

Batavia Biosciences Bioscience Park Leiden Zernikedreef 9 Leiden, CK 2333 The Netherlands

BioClinica Schipholweg 117 2316 XC Leiden The Netherlands

Chemonaut Delftechpark 26 2628 XH Delft The Netherlands

Chemonaut Delft, The Netherlands

Clinquest Rossinistraat 46 Oss, 5344 AK Netherlands

Clondalkin Group Ito Tower, 9th Floor, Gustav Mahlerplein 68, 1082 MA Amsterdam, The Netherlands

CARDIOLABORATE Moreelsepark 1, 3511 EP Utrecht Netherlands

CENTRE FOR HUMAN DRUG RESEARCH Centre for Human Drug Research Zernikedreef 8 2333 CL Leiden The Netherlands

Cambridge Major Laboratories NK Weert, The Netherlands

Core Laboratories Amsterdam, The Netherlands

Cardialysis Westblaak 92, entrance B, 3012 KM Rotterdam The Netherlands

Crucell Archimedesweg 4-6 2333 CN Leiden

Chiesi farmaceutici Lange Kleiweg 52 J - 2288 GK Rijswijk - the Netherlands

CERGENTIS BV 62 Yalelaan, Utrecht, UT 3584, NL

CURAX P.O. Box 291 Houten, 3990 GB Netherlands

Cella Technologies 12 Molengraaffsingel, Delft, ZH 2629 JD, NL

Cytocentrics Eindhoven, The Netherlands

Chiralix Toernooiveld 100 Nijmegen, 6525 EC The Netherlands

Cell Signaling Technology 2 Schuttersveld, Leiden, ZH 2316 ZA, NL

Corning Life Sciences 12 Fogostraat, Fogostraat 12 Amsterdam, NH 1060 LJ, NL

Dishman Pharmaceuticals and Chemicals Dishman Netherlands B.V. Nieuweweg 2a, 3901 BE Veenedaal PO Box 70, 3900 AB Veenendaal The Netherlands

Dishman Pharmaceuticals and Chemicals Veenendaal, The Netherlands

Disphar Tolweg 15 3741 LM Baarn The Netherlands

Disphar Winkelskamp 6 7255 PZ Hengelo (Gld) The Netherlands

Dorian Regulatory Affairs Soestdijkerstraatweg 7 1213 VP Hilversum, The Netherlands

Da Vinci Laboratory Solutions Cairostraat 10 3047 BC Rotterdam The Netherlands

Derphartox BV Erasmus University Rotterdam NB-1116 Afd. Immunologie 3015 AA ROTTERDAM The Netherlands

DSM Pharmaceuticals Urmonderbaan 22 6167 RD Geleen The Netherlands

DSM Pharmaceuticals Heerlen, NL

DDL Diagnostic Laboratory Visseringlaan 25, 2288ER, Rijswijk, the Netherlands

DDL Diagnostic Laboratory Visseringlaan 25, 2288ER, Rijswijk, the Netherlands

DuSart Pharma Nijverheidstraat 15 2222 AV Katwijk Netherlands

ERASMUS MC - Proteomics Core Proteomics Center Erasmus MC Office Ee-679A | Lab Ee-626 Wytemaweg 80 3015 CN Rotterdam

ERASMUS MC - Proteomics Core Proteomics Center Erasmus MC Office Ee-679A | Lab Ee-626 Wytemaweg 80 3015 CN Rotterdam

Exploras Agro Development BV Willem Elsschotstraat 4 5103 PM Dongen The Netherlands

Enzyscreen Wassenaarseweg 72 2333 AL Leiden The Netherlands

Environ Willem Arnszlaan 115 3734 EE Den Dolder The Netherlands

Enestia Klöcknerstraat 1 3930 Hamont-Achel België / Belgique

European Infrastructure for Translational Medicine (EATRIS) Giovanni Migliaccio, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands

EuroCept Trap Gans May 1244 RL Ankeveen Netherlands

Eurosequence Meditech Center L.J. Zielstraweg 1 9713 GX Groningen The Netherlands

European Packaging Centre P.O.Box 713 8440 AS Heerenveen The Netherlands

ForTe Lindenlaan 31c 6584 AC MOLENHOEK (LB) The Netherlands

FOSS NIRSystems Primulastraat 11 5595 EL Leende The Netherlands

Future Diagnostics Nieuweweg 279 Wijchen, 6603 BN The Netherlands

FeyeCon Rijnkade 17a 1382 GS Weesp The Netherlands

Farma Research Animal Health Nijmegan, The Netherlands

FUJUFILM VisualSonics, Inc. Joop Geesinkweg 140 1114 AB Amsterdam, The Netherlands

Global Pathology Support Benoordenhoutseweg 23 The Hague, 2596 BA The Netherlands