213 E White St Millstadt, IL 62260-1543 USAAdvanced Asymmetrics offers chiral compound, custom synthesis and chromatography services.

St. Louis, MO United StatesSince its inception in 1983, American Radiolabeled Chemicals, Inc. (ARC) has established itself as one of the leading suppliers of high quality radiolabeled and unlabeled chemicals in the world. Our 2023 catalog contains more than 4,000 radiolabeled and unlabeled chemicals for life science research. More than 85% of the products in our catalog are exclusively available through ARC. Our 2023 PDF catalog is now available for download in the "Get a Catalog" section of our website. Our new 2023-2024 catalog products will be merged into our searchable database in Spring 2024. Hopefully, with our wide selection of carbon-14 and tritium labeled products, one stop shopping will make it more convenient for you to order all your chemicals from ARC. ARC also offers a wide range of custom synthesis services using Carbon-14 and Tritium. On a limited basis, ARC offers custom synthesis using 33P, 35S, 125I, and stable isotopes. ATTENTION! ARC is now able to offer significant bulk discounts on Carbon-14 precursors and intermediates. Inquire today!

101 ARC Drive St. Louis MO 63146Since its inception in 1983, American Radiolabeled Chemicals, Inc. (ARC) has established itself as one of the leading suppliers of high quality radiolabeled and unlabeled chemicals in the world. Our 2023 catalog contains more than 4,000 radiolabeled and unlabeled chemicals for life science research. More than 85% of the products in our catalog are exclusively available through ARC. Our 2023 PDF catalog is now available for download in the "Get a Catalog" section of our website. Our new 2023-2024 catalog products will be merged into our searchable database in Spring 2024. Hopefully, with our wide selection of carbon-14 and tritium labeled products, one stop shopping will make it more convenient for you to order all your chemicals from ARC. ARC also offers a wide range of custom synthesis services using Carbon-14 and Tritium. On a limited basis, ARC offers custom synthesis using 33P, 35S, 125I, and stable isotopes. ATTENTION! ARC is now able to offer significant bulk discounts on Carbon-14 precursors and intermediates. Inquire today!

5988 Mid Rivers Mall Drive St.Charles MO 63304Antibody Research Corporation offers antibody development and services, in vitro bioreactor production, protein expression, cell banking services, and cell line rescue.

Saint Charles, MO United StatesAntibody Research Corporation offers antibody development and services, in vitro bioreactor production, protein expression, cell banking services, and cell line rescue.

St. Louis, MO United StatesApertus Pharmaceuticals offers custom synthesis, process development, and methods development services while also supplying bulk APIs and controlled substances.

331 Consort Dr. Saint Louis, MO 63011 USAApertus Pharmaceuticals offers custom synthesis, process development, and methods development services while also supplying bulk APIs and controlled substances.

4320 Forest Park Avenue Suite 303, - St Louis, MO 63108Apse, Inc. has developed technology that will allow the cost efficient production of RNA for broad acre topical RNAi uses in agriculture. Other high use rate applications for RNA (such as for RNAi in aquaculture or animal husbandry) could also benefit but Apse’s initial focus is agriculture crop protection and improvement.

4320 Forest Park Avenue, Suite 303 United States St. Louis, MISSOURI, 63108 United StatesArray Bridge supplies ELISA kits and reagents as well as custom antibody production and impurity analysis services to support biosimilar development, drug discovery and basic life science research.

4320 Forest Park Avenue, Suite 303 St. Louis, MO 63108 USAArray Bridge supplies ELISA kits and reagents as well as custom antibody production and impurity analysis services to support biosimilar development, drug discovery and basic life science research.

4320 Forest Park Avenue, Suite 303 United States St. Louis, MO, 63108 United StatesArray Bridge supplies ELISA kits and reagents as well as custom antibody production and impurity analysis services to support biosimilar development, drug discovery and basic life science research.

St. Louis, MO, United StatesASI Food Safety is your food safety auditing company to come to for experience and expertise. We are passionate about food safety and auditing. Our customized solutions include SQF and BRC Certification Audits, GFSI Global Markets Protocol Assessment Reports, SQF audits, ASI Food Safety GMP audits and a full line of third-party GMP audits for food processors, consumer goods, packagers, distributors and retail store chains.Our employees are committed to providing you with the highest level of customer support during the entire process.

30 Triad South Drive St. Charles, MO 63304 USAAssaypro offers ELISA and activity kits, proteins, and antibodies for purchase as well as custom assay development services.

600 S. Taylor Avenue Building, Suite 2400, St. Louis, MO 63110.The Siteman Biostatistics Shared Resource (SBSR) facility is a shared resource core supporting consultation on biostatistics and epidemiology. The facility supports cancer research through experimental designs, study monitoring and data analyses. The faculty and staff utilize efficient methods that reflect the "best practices" in biostatistics and epidemiology. Examples of SBSR core work include: NIH-funded peer reviewed cancer grants and pilot and small-scale studies to become part of successful applications for peer-reviewed funding.

Lobby of the Center for Advanced Medicine 4921 Parkview Place St. Louis, MO 63110The Biologic Therapy Core Facility: Maintains and operates an FDA registered modern pharmaceutical cleanroom facility dedicated to the manufacture of custom biologics and drugs under current Good Manufacturing Practices (cGMP) conditions. Supports translational medicine efforts (from bench to bedside) in the fields of cellular therapy, gene therapy and other treatments by providing the infrastructure needed to conduct early Phase I/II clinical trials. Develops and manufactures novel biologic, cellular and other state-of-the-art therapeutics for human administration under controlled conditions in accordance with the U.S. Food and Drug Administration and other regulations. Labels MAB for use in Immuno-radiotherapy treatments or as PET imaging agents in oncological settings Routine tissue processing and cryopreservation (e.g. cryopreservation of parathyroid tissue). Provides Research grade Lentiviral vectors, and Recombinant Proteins to SCC Members. Provides regulatory and administrative support in the therapeutic agent approval process. The Biologic Therapy Core Facility also provides consulting services for Siteman Cancer Center members, Washington University faculty and interested academic and nonacademic entities in compliance with Good Manufacturing Practice rules and regulations, and with issues regarding the new Good Tissue Practice Act, which became effective in May 2005.

4320 Forest Park Avenue, Suite 302 Saint Louis, MO 63110The Center for Biomedical Informatics (CBMI) was established in 2007 as a joint partnership between Washington University in St. Louis (WU) and BJC HealthCare to consolidate and organize disparate informatics groups. The CBMI is a multi departmental initiative that spans many schools such as Engineering and Medicine at WU. Furthermore, the CBMI has extensive collaborations with WU centers and institutes and partnerships with global informatics initiatives and other academic centers in the region. The CBMI has four broad goals: Develop and maintain the electronic infrastructure needed to facilitate clinical and translational research in a safe and ethical manner and in full compliance with prevailing regulations. Promote the use of electronic resources to maximize the safety and quality of patient care at WU and BJC practice sites and to ensure that advances in medical science are translated into improvements in patient care as rapidly as possible. Develop comprehensive training programs in biomedical informatics for scientists and health care professionals. Develop biomedical informatics as an academic discipline at WU. Active collaborations between faculty from multiple schools and departments including computer science, biomedical engineering, physics, biology and medicine will be essential for realizing this goal.

Room 7614 7th Floor 425 S. Euclid Avenue St. Louis, MO 63110Natural and therapeutically induced immune responses to cancer can prevent and/or facilitate cancer development/outgrowth. New cancer immunotherapies have shown remarkable capacities to induce durable responses in patients with advanced forms of cancer (such as stage IV melanoma) that are generally resistant to any other types of cancer therapy. These findings have significantly changed the thinking about cancer treatment and about using the immune system as an important and effective weapon against cancer. A centralized immune monitoring facility was launched in 2014 to facilitate translation of basic immune system research findings into the cancer immunotherapy arena, to support ongoing and new clinical cancer immunotherapy trials and to develop novel mechanistic insights into human immune system-cancer interactions. IML provides the means to monitor developing immune responses to new therapies in animal models of cancer treatment; to elucidate novel treatment strategies; or develop unique processes to evaluate treatment outcomes in translational studies. This shared resource provides the infrastructure and expertise to advance cancer immunotherapy outcomes.

4921 Parkview Place St. Louis, MO 63110The Proteomics Shared Resource provides cancer center members with preferred access to current and innovative proteomics technologies for molecular profiling of clinical samples and for basic cancer research. The Proteomics Shared Resource is a cooperative effort between the Siteman Cancer Center and the Washington University Department of Medicine. The facility is open to all Washington University investigators, with priority access given to cancer center members. The responsibilities of the Proteomics Shared Resource include: Providing global differential protein expression data on biological fluids, leukemias and solid tumors. Providing consultation on sample preparation and coordinating biostatistical-based experimental design. Archiving and retrieval of proteomics data for iterative analysis using protein informatics tools. Integration of proteomics data with other functional genomics data for cross queries through common data portals (in collaboration with Siteman’s Bioinformatics and Multiplexed Gene Analysis cores).

224 S. Euclid Ave. Corner of Euclid and Forest Park Avenue St. Louis, MO 63110The Small-Animal Cancer Imaging (SACI) Shared Resource provides state-of-the-art facilities and infrastructure for MRI, PET, CT, Beta, SPECT, and optical imaging of mice, rats and other small laboratory animals that serve as models of cancer. Located in the heart of the Washington University Medical Center, SACI combines instrumental and intellectual capabilities found at few other institutions and serves a broad community of cancer scientists who have a pressing need for quantitative image analysis of small laboratory animal model systems. SACI provides access to and maintenance of small-animal MRI, PET, CT, and optical imaging scanners and ancillary facilities and routinely assists and trains researchers in imaging procedures and data analysis methods. In addition to supporting research applications of small-animal cancer imaging, SACI also provides research and development at the frontier of imaging technology in an effort to make the most powerful new imaging strategies available to its community of users. The ancillary small-animal research services and capabilities provided by SACI are extraordinary. Support resources within SACI include consultation for experiment planning and data analysis, animal-procedure assistance for maintenance and monitoring of physiologic status during imaging, and informatics support for local and remote data access, analysis, visualization, and archival.

4921 Parkview Place St. Louis, MO 63110The Siteman Flow Cytometry Core offers services for flow cytometry-based cell analysis, cell sorting and flow cytometry instruction. The instrumentation includes five benchtop analyzers and four cell sorters.

11468 Schenk Drive St Louis, MO, 63043 United StatesBiCell Scientific Inc is a leading biomanufacturing solution company who is committed to providing high quality CRO&CMO services and products. BiCell Scientific's scientists have discovered that short-peptide antigens (13-19 amino acids) allow developing polyclonal and monoclonal antibodies with specific and bona fide binding to target proteins in their native conformation. This feature is particularly important for developing “precision” antibodies with improved binding specificity to suit high-resolution applications, such as immunohistochemistry studies that require undenatured proteins to be recognized in situ among millions of other proteins. BiCell Scientific has set a goal to create an expansive repository of pre-validated antibodies that encompasses the entire human and mouse proteome in cells and tissues. BiCell Scientific's scientists aim to conduct panoramic annotation of a vast number of antibodies with subcellular resolution in formalin-fixed paraffin-embedded (FFPE) human and mouse tissues.

11466 Schenk Drive St Louis, MO, 63043 United StatesBiCell Scientific Inc is a leading biomanufacturing solution company who is committed to providing high quality CRO&CMO services and products. BiCell Scientific's scientists have discovered that short-peptide antigens (13-19 amino acids) allow developing polyclonal and monoclonal antibodies with specific and bona fide binding to target proteins in their native conformation. This feature is particularly important for developing “precision” antibodies with improved binding specificity to suit high-resolution applications, such as immunohistochemistry studies that require undenatured proteins to be recognized in situ among millions of other proteins. BiCell Scientific has set a goal to create an expansive repository of pre-validated antibodies that encompasses the entire human and mouse proteome in cells and tissues. BiCell Scientific's scientists aim to conduct panoramic annotation of a vast number of antibodies with subcellular resolution in formalin-fixed paraffin-embedded (FFPE) human and mouse tissues.

595 Anglum Road Hazelwood, Missouri, 63042The Mérieux have a family tradition and a century-old commitment to the fight against infectious diseases. Marcel Mérieux, who studied under Louis Pasteur and founded the Mérieux Institute, Dr. Charles Mérieux, Alain Mérieux and Dr. Christophe Mérieux have devoted their lives to biology with a goal of improving health worldwide. By creating bioMérieux in 1963, Alain Mérieux has carried on this family tradition. At bioMérieux, we try to put ourselves in your shoes and see things from your perspective. We want to offer you more than just products & services. We want to give you the biggest picture possible of how we could help you solve specific issues. Check out some of our solutions to current key problem areas.

1100 Corporate Square Drive Helix Center Suite 221 St Louis, MO, 63132 United StatesBiorbyt supplies antibodies, proteins, small molecules, kits, and molecular biology products.

1100 Corporate Square Drive Helix Center Suite 221 St Louis, MO , 63132 United StatesBiorbyt supplies antibodies, proteins, small molecules, kits, and molecular biology products.

4340 Duncan Avenue STE 220 St. Louis, MO, 63110 United StatesResearch tools for gene editing, gene expression, and bioprocessing CLIA certified CRO for multi-omic services

1100 Corporate Square Drive 1100 Corporate Square Drive St. Louis, MO, 63132 United StatesCell Guidance Systems provides reagents and services to control, manipulate and monitor the cell, both in-vitro and in-vivo. Our technologies enable novel insights for research as well as fresh approaches to treating disease. We have developed a range of products and services to support your exosome research, from isolation to characterization to assay. Our range of products includes exosome purification kits for all biological fluids and applications, exosome marker antibodies, and exosome detection options, as well as a nanoparticle tracking analysis (NTA) service. Conventional growth factors limit the possibilities of cell culture, biomanufacturing, and therapeutics. PODS® technology addresses the limitations of conventional growth factors by placing them in a protective protein crystal lattice. This lattice stabilizes cargo proteins even at high temperatures. In the presence of proteases secreted by cells, pores develop in the lattice which allows the cargo growth factor to slowly escape. This gradual, sustained release maintains bioavailability at steady-state levels (near zero-order kinetics). The crystals can also be readily used for patterning by attachment to surfaces or suspension at specific positions in hydrogels. PODS® nanocrystals have a wide range of applications either in-vitro (2D or 3D culture) or in-vivo.

1100 Corporate Square Drive Helix Center St Louis, MO, 63132 United StatesCell Guidance Systems provides reagents and services to control, manipulate and monitor the cell, both in-vitro and in-vivo. Our technologies enable novel insights for research as well as fresh approaches to treating disease. We have developed a range of products and services to support your exosome research, from isolation to characterization to assay. Our range of products includes exosome purification kits for all biological fluids and applications, exosome marker antibodies, and exosome detection options, as well as a nanoparticle tracking analysis (NTA) service. Conventional growth factors limit the possibilities of cell culture, biomanufacturing, and therapeutics. PODS® technology addresses the limitations of conventional growth factors by placing them in a protective protein crystal lattice. This lattice stabilizes cargo proteins even at high temperatures. In the presence of proteases secreted by cells, pores develop in the lattice which allows the cargo growth factor to slowly escape. This gradual, sustained release maintains bioavailability at steady-state levels (near zero-order kinetics). The crystals can also be readily used for patterning by attachment to surfaces or suspension at specific positions in hydrogels. PODS® nanocrystals have a wide range of applications either in-vitro (2D or 3D culture) or in-vivo.

825 S Taylor Ave, St. Louis, MO 63110CID’s mission is to teach children who are deaf and hard of hearing to listen, talk, read and succeed. We partner with families and collaborate with universities, educators and other professionals worldwide to help children communicate to achieve their fullest potential.

1422 Elbridge Payne Road, Suite 200 Chesterfield, Missouri 63017Certus International provides core imaging, quality assurance, regulatory consulting, and clinical monitoring.

2672 Metro Blvd. Maryland Heights, MO 63043When you need chemical analysis, testing or formulation support, Chemir can help. Our independent chemical testing lab offers deformulation (reverse engineering), contaminant identification, custom synthesis, product development, litigation support and expert witness services.

2672 Metro Blvd. Maryland Heights MO USAChemir Analytical Services offers formulation services, reference standard characterization, impurity profiles, and extractables studies.

378 Fee Fee Road Maryland Heights, MO 63043 USAChromaprobe offers antibody purification, production, and development services in addition to supplying antibodies and reagents to support flow cytometry, cytochemistry, molecular biology, and cell biology.

1100 Corporate Square Drive STE 248 St Louis, MO, 63132 United StatesProvides custom PCR testing strategies and services for microbe detection and gene detection. We provide high-throughput PCR testing services and high-throughput DNA extraction services. We also develop PCR-based gene detection method and pathogen detection method. We provide both Reatlime PCR services and ddPCR services.

Cofactor Genomics 4044 Clayton Ave St Louis, MO 63130Cofactor Genomics uses RNA to diagnose disease. Our team of experts boasts decades of collective experience working in the Technology Development Group at the Genome Center at Washington University in St. Louis, Missouri. Our work with the largest life-sciences and pharmaceutical companies in the world has resulted in Cofactor developing unique technologies and software that use RNA to inform disease.

4044 Clayton Ave. United States St. Louis, MO, 63110Cofactor Genomics uses RNA to diagnose disease. Our team of experts boasts decades of collective experience working in the Technology Development Group at the Genome Center at Washington University in St. Louis, Missouri. Our work with the largest life-sciences and pharmaceutical companies in the world has resulted in Cofactor developing unique technologies and software that use RNA to inform disease.

4044 Clayton Ave. United States St. Louis, Missouri, 63110Cofactor Genomics uses RNA to diagnose disease. Our team of experts boasts decades of collective experience working in the Technology Development Group at the Genome Center at Washington University in St. Louis, Missouri. Our work with the largest life-sciences and pharmaceutical companies in the world has resulted in Cofactor developing unique technologies and software that use RNA to inform disease.

4340 Duncan Avenue Suite 400 Saint Louis, MO, 63110 United StatesConfluence is a Contract Research Organization providing Clients with 125+ Years of Drug R&D know-how and a proven track record having delivered 29 Phase I and 13 Phase II drug programs that resulted in 4 marketed drugs. Confluence is located in the CORTEX Bioscience District adjacent to the Washington University School of Medicine in St. Louis, Missouri. Our highly trained scientists operate a state-of-the-art laboratory to support biochemistry and enzymology, cell and molecular biology, custom assay development, translational research, as well as computational and medicinal chemistry to ensure your project’s success.

975 North Warson Road St. Louis, MO, 63132 United StatesTHE MISSION OF THE PROTEOMICS & MASS SPECTROMETRY FACILITY AT THE DANFORTH CENTER IS FOUR-FOLD: • Provide Danforth Center scientists with access to state-of-the-art instrumentation and technology with which to expand and attain their research endeavors • Offer high-quality services in biomolecule separation, identification and structural analysis to internal and external clients • Provide training to internal and external scientists interested in developing knowledge and skills in the areas of proteomics and mass spectrometry • Produce first-rate publication quality results for all clients The Proteomics & Mass Spectrometry Facility has processed thousands of service samples submitted from research laboratories located at the Danforth Center as well as from academic and commercial institutions worldwide. In addition, the facility has initiated research activities designed to expand analytic capabilities and has established collaborations with many principal investigators at various institutions. These activities have produced exciting results and publications, which are a testament to the facility's high standards and growing reputation. With highly-specialized capabilities and research initiatives, the facility is well-prepared and positioned to serve as a regional, national and international resource in the fast developing fields of proteomics and metabolomics. Browse our list of standard services, or contact us for consultation or method development.

975 North Warson Road St. Louis, MO 63132THE MISSION OF THE PROTEOMICS & MASS SPECTROMETRY FACILITY AT THE DANFORTH CENTER IS FOUR-FOLD: • Provide Danforth Center scientists with access to state-of-the-art instrumentation and technology with which to expand and attain their research endeavors • Offer high-quality services in biomolecule separation, identification and structural analysis to internal and external clients • Provide training to internal and external scientists interested in developing knowledge and skills in the areas of proteomics and mass spectrometry • Produce first-rate publication quality results for all clients The Proteomics & Mass Spectrometry Facility has processed thousands of service samples submitted from research laboratories located at the Danforth Center as well as from academic and commercial institutions worldwide. In addition, the facility has initiated research activities designed to expand analytic capabilities and has established collaborations with many principal investigators at various institutions. These activities have produced exciting results and publications, which are a testament to the facility's high standards and growing reputation. With highly-specialized capabilities and research initiatives, the facility is well-prepared and positioned to serve as a regional, national and international resource in the fast developing fields of proteomics and metabolomics. Browse our list of standard services, or contact us for consultation or method development.

1660 North Service Road East Units 106 & 107 Oakville, ON L6H 7G3 Canadadsa consultants provides regulatory affair services for drugs, medical devices, natural health products and cosmetics.

2327 Chouteau Avenue Saint Louis, MO 63103 USADYNALABS offers endotoxin testing, microbial identification, and raw material/drug product analysis services.

4633 World Parkway Circle Saint Louis, MO 63134 USAEKG Life Science Solutions, LLC (EKG Labs) is a contract analytical laboratory and solution provider to the regulated Life Science communities of Pharmaceutical and Medical Device Development.

Owensville, MO, 65066 United StatesElastin Products Company provides biochemicals, such as antiobides, elastin, and collagen.

923A East Terra Lane O'Fallon, MO 63366

15 Research Park Drive Saint Charles, MO, 63304 United StatesEurofins Discovery has supported Drug Discovery research for >40 years. We offer a complete, single-source solution for drug discovery products and services and are rooted in the deep expertise and best-in-class offerings of 6 premier CROs: Cerep, DiscoverX, EMP Millipore Drug Discovery Solutions, Panlabs, Selcia Drug Discovery, and Villapharma. Eurofins Discovery can optimize your process - whether you need complete, end-to-end services, help with one or more stages, or the products for discovery work. The Eurofins Discovery team was built by bringing together the market-leading discovery expertise of Panlabs (acquired in 2012 from Ricerca), Cerep (acquired in 2013), EMD Millipore's Discovery & Development Solutions business (acquired from Merck KGaA in 2014), Villapharma Research (acquired in 2017), DiscoverX (acquired 2017), and Selcia Drug Discovery (acquired 2018). With over 600 people in seven operational sites worldwide: St. Charles, MO (USA), Fremont, CA (USA), San Diego, CA (USA), Essex (UK), Celle Lévescault (France), Taipei (Taiwan), and Murcia (Spain) our global team offers the high quality, reliable solutions and support our clients depend on to advance their drug discovery programs Combining our broad, high quality, industry-leading drug discovery products & services portfolios together enables us to support our global clients with one of the industry’s largest and broadest portfolios.

6 Research Park Drive St. Charles, MO, 63304 United StatesEurofins Discovery has supported Drug Discovery research for >40 years. We offer a complete, single-source solution for drug discovery products and services and are rooted in the deep expertise and best-in-class offerings of 6 premier CROs: Cerep, DiscoverX, EMP Millipore Drug Discovery Solutions, Panlabs, Selcia Drug Discovery, and Villapharma. Eurofins Discovery can optimize your process - whether you need complete, end-to-end services, help with one or more stages, or the products for discovery work. The Eurofins Discovery team was built by bringing together the market-leading discovery expertise of Panlabs (acquired in 2012 from Ricerca), Cerep (acquired in 2013), EMD Millipore's Discovery & Development Solutions business (acquired from Merck KGaA in 2014), Villapharma Research (acquired in 2017), DiscoverX (acquired 2017), and Selcia Drug Discovery (acquired 2018). With over 600 people in seven operational sites worldwide: St. Charles, MO (USA), Fremont, CA (USA), San Diego, CA (USA), Essex (UK), Celle Lévescault (France), Taipei (Taiwan), and Murcia (Spain) our global team offers the high quality, reliable solutions and support our clients depend on to advance their drug discovery programs Combining our broad, high quality, industry-leading drug discovery products & services portfolios together enables us to support our global clients with one of the industry’s largest and broadest portfolios.

15 Research Park Drive St. Charles, MO, 63304 United StatesEurofins Discovery has supported Drug Discovery research for >40 years. We offer a complete, single-source solution for drug discovery products and services and are rooted in the deep expertise and best-in-class offerings of 6 premier CROs: Cerep, DiscoverX, EMP Millipore Drug Discovery Solutions, Panlabs, Selcia Drug Discovery, and Villapharma. Eurofins Discovery can optimize your process - whether you need complete, end-to-end services, help with one or more stages, or the products for discovery work. The Eurofins Discovery team was built by bringing together the market-leading discovery expertise of Panlabs (acquired in 2012 from Ricerca), Cerep (acquired in 2013), EMD Millipore's Discovery & Development Solutions business (acquired from Merck KGaA in 2014), Villapharma Research (acquired in 2017), DiscoverX (acquired 2017), and Selcia Drug Discovery (acquired 2018). With over 600 people in seven operational sites worldwide: St. Charles, MO (USA), Fremont, CA (USA), San Diego, CA (USA), Essex (UK), Celle Lévescault (France), Taipei (Taiwan), and Murcia (Spain) our global team offers the high quality, reliable solutions and support our clients depend on to advance their drug discovery programs Combining our broad, high quality, industry-leading drug discovery products & services portfolios together enables us to support our global clients with one of the industry’s largest and broadest portfolios.

8 Research Park Dr. St. Charles, MO, 63304 United StatesEurofins Discovery built its industry-leading reputation on successfully delivering best-in-class drug discovery & development outsourcing services to any organization, large or small. No matter where you are in the preclinical process—or if you need full end-to-end solutions—our experts and industry’s largest catalog of phase-appropriate off-the-shelf catalog assays can support you every step of the way with purpose, precision, and innovation. As a global leader in drug discovery solution provider for over 40 years, we have strategically curated a deep and broad range of over 8,000 off-the shelf and custom assays and related services covering cell line engineering, bioassay development for biologic and biosimilar drug lot release, chemistry, safety & efficacy, mechanism-of-action, ADME-toxicology, and translational biology. Our team of industry experts for, in vitro and in vivo services, GPCRs, and custom protein, cell line, bulk cells and assay development , gene editing projects work across disciplines to collaborate with you. Eurofins Discovery’s comprehensive capabilities, knowledge base, and skill sets enable the company to provide clients the benefit of working with a single outsourcing provider (CRO) for all drug discovery programs whether you choose to conduct the project in house or outsource. Delve into all the ways we can work together by choosing the best path forward for you from our comprehensive services.

6 Research Park Drive St Charles, MO, 63304 United StatesEurofins Discovery built its industry-leading reputation on successfully delivering best-in-class drug discovery & development outsourcing services to any organization, large or small. No matter where you are in the preclinical process—or if you need full end-to-end solutions—our experts and industry’s largest catalog of phase-appropriate off-the-shelf catalog assays can support you every step of the way with purpose, precision, and innovation. As a global leader in drug discovery solution provider for over 40 years, we have strategically curated a deep and broad range of over 8,000 off-the shelf and custom assays and related services covering cell line engineering, bioassay development for biologic and biosimilar drug lot release, chemistry, safety & efficacy, mechanism-of-action, ADME-toxicology, and translational biology. Our team of industry experts for, in vitro and in vivo services, GPCRs, and custom protein, cell line, bulk cells and assay development , gene editing projects work across disciplines to collaborate with you. Eurofins Discovery’s comprehensive capabilities, knowledge base, and skill sets enable the company to provide clients the benefit of working with a single outsourcing provider (CRO) for all drug discovery programs whether you choose to conduct the project in house or outsource. Delve into all the ways we can work together by choosing the best path forward for you from our comprehensive services.

2672 METRO BLVD. Maryland Heights, MO, 63043 United StatesEurofins EAG Materials Science, LLC has a long history, dating back to the birth of the company in 1978 in California, as Charles Evans & Associates. Over the years we have expanded from a single location offering SIMS only to having over 200 employees offering over 30 different services via 14 locations in 8 different countries. The original focus of the company was supporting semiconductor manufacturing but now we also work with multiple further industries beyond semiconductors, including: solar/PV, lighting, photonics, energy storage, aerospace & defense, medical devices, raw materials, glass, polymers and plastics and consumer products. EAG's analytical expertise is what enables us to help our clients to meet their goals. Our on-demand analytical testing services can help streamline R&D, solve urgent problems during manufacturing and help resolve materials related issues in the global supply chain, both within and between organizations.

15 Research Park Drive St Charles, MO, 63304 United StatesWith over 30,000 employees across more than 375sites in 36 countries, Eurofins Scientific is a leading international group of laboratories providing an unparalleled range of testing and support services to the pharmaceutical, food, environmental and consumer products industries and to governments.

3830 Washington Blvd #119 Saint Louis, MO 63108 USAEZ BioResearch offers molecular biology tool kits, laboratory consumables, and genotyping services.

St. Louis, MO United StatesEZ BioResearch offers molecular biology tool kits, laboratory consumables, and genotyping services.

1733 Gilsinn Lane Fenton, Missouri 63026 USAFleming Pharmaceuticals offers formulation and drug delivery research and development services as well contract manufacturing.

Fenton, MO United StatesFleming Pharmaceuticals offers formulation and drug delivery research and development services as well contract manufacturing.

4766 LaGuardia Drive St. Louis, MO 63134-3117 USAGallus Biopharmaceuticals provides contract manufacturing of clinical and commercial bulk biologics.

4559 Scott Ave., Box 8044 St. Louis, MO, 63110 United StatesThe GESC’s mission is to empower its users with access to the most up-to-date technologies in the fields of gene editing and stem cells and enable the creation of research models best fit for the unique need of each lab. With over 7 years of experience, over 600 cell lines and 400 mouse models produced, the GESC is here to assist investigators with all types of functional genomic studies using genome-editing technologies. Custom Research model generation services: CRISPR/Cas9 gene-edited cell lines & stem cell lines, mouse models, next-generation sequencing, gene knockout, knock-in, conditional KO/ KI, fluorescence tagging, mutagenesis, molecular biology services, and more.

4559 Scott Ave., Box 8044 Saint Louis, 63110 United StatesThe GESC’s mission is to empower its users with access to the most up-to-date technologies in the fields of gene editing and stem cells and enable the creation of research models best fit for the unique need of each lab. With over 7 years of experience, over 600 cell lines and 400 mouse models produced, the GESC is here to assist investigators with all types of functional genomic studies using genome-editing technologies. Custom Research model generation services: CRISPR/Cas9 gene-edited cell lines & stem cell lines, mouse models, next-generation sequencing, gene knockout, knock-in, conditional KO/ KI, fluorescence tagging, mutagenesis, molecular biology services, and more.

Department of Genetics 4515 McKinley Building St. Louis, MO 63110The GESC’s mission is to empower its users with access to the most up-to-date technologies in the fields of gene editing and stem cells and enable the creation of research models best fit for the unique need of each lab. With over 7 years of experience, over 600 cell lines and 400 mouse models produced, the GESC is here to assist investigators with all types of functional genomic studies using genome-editing technologies. Custom Research model generation services: CRISPR/Cas9 gene-edited cell lines & stem cell lines, mouse models, next-generation sequencing, gene knockout, knock-in, conditional KO/ KI, fluorescence tagging, mutagenesis, molecular biology services, and more.

4515 Couch Biomedical Research Building Room 5110 St. Louis, Missouri, 63110 United StatesThe GESC’s mission is to empower its users with access to the most up-to-date technologies in the fields of gene editing and stem cells and enable the creation of research models best fit for the unique need of each lab. With over 7 years of experience, over 600 cell lines and 400 mouse models produced, the GESC is here to assist investigators with all types of functional genomic studies using genome-editing technologies. Custom Research model generation services: CRISPR/Cas9 gene-edited cell lines & stem cell lines, mouse models, next-generation sequencing, gene knockout, knock-in, conditional KO/ KI, fluorescence tagging, mutagenesis, molecular biology services, and more.

4515 Couch Biomedical Research Building Room 5110 St. Louis, MO, 63110 United StatesThe GESC’s mission is to empower its users with access to the most up-to-date technologies in the fields of gene editing and stem cells and enable the creation of research models best fit for the unique need of each lab. With over 7 years of experience, over 600 cell lines and 400 mouse models produced, the GESC is here to assist investigators with all types of functional genomic studies using genome-editing technologies. Custom Research model generation services: CRISPR/Cas9 gene-edited cell lines & stem cell lines, mouse models, next-generation sequencing, gene knockout, knock-in, conditional KO/ KI, fluorescence tagging, mutagenesis, molecular biology services, and more.

4444 Forest Park Ave Room 3331 St. Louis, MO, 63108 United StatesThe GESC’s mission is to empower its users with access to the most up-to-date technologies in the fields of gene editing and stem cells and enable the creation of research models best fit for the unique need of each lab. With over 7 years of experience, over 600 cell lines and 400 mouse models produced, the GESC is here to assist investigators with all types of functional genomic studies using genome-editing technologies. Custom Research model generation services: CRISPR/Cas9 gene-edited cell lines & stem cell lines, mouse models, next-generation sequencing, gene knockout, knock-in, conditional KO/ KI, fluorescence tagging, mutagenesis, molecular biology services, and more.

2220 Welsch Industrial Ct. Saint Louis, MO, 63146 United StatesGeneoscopy is a molecular diagnostics company committed to providing safe, effective, and innovative non-invasive tests to improve the diagnosis, monitoring, and treatment of gastrointestinal diseases. The Company has developed a proprietary method to isolate eukaryotic RNA biomarkers from stool samples. This platform has been used to build a noninvasive diagnostic that can detect both colorectal cancer and precancercous adenomas with high sensitivity. Geneoscopy’s RNA extraction platform enables access to a variety of clinically relevant biomarkers, including: GI enterocytes, lymphocytes, and can assess host-microbiome interaction. This provides for opportunities such as standalone tests, companion diagnostics, and/or clinical trial tools.

St. Louis, MO, USAGenoMed offers drug discovery and gene-based diagnostic tests.

1001 Boardwalk Springs Place, Suite 30 O'Fallon, MO 63368 USAHuntsman is a global manufacturer and marketer of differentiated chemicals. Our operating companies manufacture products for a variety of global industries, including chemicals, plastics, automotive, aviation, textiles, footwear, paints and coatings, construction, technology, agriculture, health care, detergent, personal care, furniture, appliances and packaging. Originally known for pioneering innovations in packaging and, later, for rapid and integrated growth in petrochemicals, Huntsman has approximately 15,000 employees and operates from multiple locations worldwide. The Company had 2015 revenues of over $10 billion.

2327 Chouteau Ave. St. Louis, MO, 63103 United StatesInfinity Laboratories is a powerful network of state-of-the-art testing facilities that are FDA Registered, ISO 17025 Accredited, and DEA licensed. With an enhanced focus in the areas of chemical and microbiological sciences, we support pharmaceutical and medical device manufacturers. Our goal is to go Beyond Testing and become a partner in the success of our customers.

16100 Chesterfield Pkwy W, Chesterfield, MO, 63017 United StatesAs your laboratory partner, Inotiv provides a broad array of nonclinical and analytical services, as well as a deep knowledge of the drug discovery & development continuum that will exceed your expectations. From early in vitro and in vivo pharmacology models supporting therapeutic areas such as: Arthritis (OA/RA) Hepatic Systemic Lupus Cardio-renal IBD/GI Neurosciences Cardiovascular Inflammation Pulmonary Hepatitis B Immunology Renal Integrating your DMPK, toxicology and safety pharmacology, histopathology and image analysis, biomarker, and bioanalytical needs, we can help steer your program and equip you with strategic insights that enable informed decisions sooner. Take advantage of our extensive and impeccable regulatory history, world-class team of scientists, and authentic passion for discovering life-saving therapeutics. By partnering with Inotiv, expect more attention, more insight, and a superlative experience as we deliver stage-relevant solutions essential to meeting your program’s milestones. Inotiv’s Target Sufficiency platform analyzes the protein drug targets of diverse therapeutic approaches (small molecule, biologics, RNA therapeutics, gene editing, targeted protein degradation and cell therapeutics) across a wide range of diseases, including oncology, metabolic, autoimmune and neurodegenerative diseases. We use high resolution mass spectrometry (MS) technology to precisely measure drug target proteins and the protein pathways and networks in which they function. Target Sufficiency provides highly specific biomarkers from discovery through clinical trials. Our MS analyses quantify proteins in all specimen types, including plasma/serum and other fluids, cells and other in vitro models, and tissues, including formalin-fixed, paraffin-embedded (FFPE) sections and needle biopsies. We can systematically develop an assay for any protein or any protein form, without a requirement for antibodies or other affinity reagents. Our bioinformatics platforms translate our data to practically useful biological interpretation. We partner with client teams to customize analyses for measurement of any protein form, including post-translationally modified, sequence variant, splice isoform and gene-edited proteins. We can also quantify proteins, such as editing nucleases resulting from delivery of mRNA, thereby assessing the effectiveness and quantify tissue specificity of gene delivery systems. We can analyze FFPE tissues from archival clinical trial specimens to retrospectively analyze proteins, proteome pathways and networks associated with response/safety phenotypes or other trial outcomes. We can analyze specimens from Inotiv in-life studies to add value to these offerings.

19 Worthington Access Drive Maryland Heights, MO, 63043 United StatesAs your laboratory partner, Inotiv provides a broad array of nonclinical and analytical services, as well as a deep knowledge of the drug discovery & development continuum that will exceed your expectations. From early in vitro and in vivo pharmacology models supporting therapeutic areas such as: Arthritis (OA/RA) Hepatic Systemic Lupus Cardio-renal IBD/GI Neurosciences Cardiovascular Inflammation Pulmonary Hepatitis B Immunology Renal Integrating your DMPK, toxicology and safety pharmacology, histopathology and image analysis, biomarker, and bioanalytical needs, we can help steer your program and equip you with strategic insights that enable informed decisions sooner. Take advantage of our extensive and impeccable regulatory history, world-class team of scientists, and authentic passion for discovering life-saving therapeutics. By partnering with Inotiv, expect more attention, more insight, and a superlative experience as we deliver stage-relevant solutions essential to meeting your program’s milestones. Inotiv’s Target Sufficiency platform analyzes the protein drug targets of diverse therapeutic approaches (small molecule, biologics, RNA therapeutics, gene editing, targeted protein degradation and cell therapeutics) across a wide range of diseases, including oncology, metabolic, autoimmune and neurodegenerative diseases. We use high resolution mass spectrometry (MS) technology to precisely measure drug target proteins and the protein pathways and networks in which they function. Target Sufficiency provides highly specific biomarkers from discovery through clinical trials. Our MS analyses quantify proteins in all specimen types, including plasma/serum and other fluids, cells and other in vitro models, and tissues, including formalin-fixed, paraffin-embedded (FFPE) sections and needle biopsies. We can systematically develop an assay for any protein or any protein form, without a requirement for antibodies or other affinity reagents. Our bioinformatics platforms translate our data to practically useful biological interpretation. We partner with client teams to customize analyses for measurement of any protein form, including post-translationally modified, sequence variant, splice isoform and gene-edited proteins. We can also quantify proteins, such as editing nucleases resulting from delivery of mRNA, thereby assessing the effectiveness and quantify tissue specificity of gene delivery systems. We can analyze FFPE tissues from archival clinical trial specimens to retrospectively analyze proteins, proteome pathways and networks associated with response/safety phenotypes or other trial outcomes. We can analyze specimens from Inotiv in-life studies to add value to these offerings.

16100 Chesterfield Parkway West Suite 325 Chesterfield, MO, 63017 United StatesAs your laboratory partner, Inotiv provides a broad array of nonclinical and analytical services, as well as a deep knowledge of the drug discovery & development continuum that will exceed your expectations. From early in vitro and in vivo pharmacology models supporting therapeutic areas such as: Arthritis (OA/RA) Hepatic Systemic Lupus Cardio-renal IBD/GI Neurosciences Cardiovascular Inflammation Pulmonary Hepatitis B Immunology Renal Integrating your DMPK, toxicology and safety pharmacology, histopathology and image analysis, biomarker, and bioanalytical needs, we can help steer your program and equip you with strategic insights that enable informed decisions sooner. Take advantage of our extensive and impeccable regulatory history, world-class team of scientists, and authentic passion for discovering life-saving therapeutics. By partnering with Inotiv, expect more attention, more insight, and a superlative experience as we deliver stage-relevant solutions essential to meeting your program’s milestones. Inotiv’s Target Sufficiency platform analyzes the protein drug targets of diverse therapeutic approaches (small molecule, biologics, RNA therapeutics, gene editing, targeted protein degradation and cell therapeutics) across a wide range of diseases, including oncology, metabolic, autoimmune and neurodegenerative diseases. We use high resolution mass spectrometry (MS) technology to precisely measure drug target proteins and the protein pathways and networks in which they function. Target Sufficiency provides highly specific biomarkers from discovery through clinical trials. Our MS analyses quantify proteins in all specimen types, including plasma/serum and other fluids, cells and other in vitro models, and tissues, including formalin-fixed, paraffin-embedded (FFPE) sections and needle biopsies. We can systematically develop an assay for any protein or any protein form, without a requirement for antibodies or other affinity reagents. Our bioinformatics platforms translate our data to practically useful biological interpretation. We partner with client teams to customize analyses for measurement of any protein form, including post-translationally modified, sequence variant, splice isoform and gene-edited proteins. We can also quantify proteins, such as editing nucleases resulting from delivery of mRNA, thereby assessing the effectiveness and quantify tissue specificity of gene delivery systems. We can analyze FFPE tissues from archival clinical trial specimens to retrospectively analyze proteins, proteome pathways and networks associated with response/safety phenotypes or other trial outcomes. We can analyze specimens from Inotiv in-life studies to add value to these offerings.

1100 Corporate Square Dr. Suite 257 St. Louis, MO 63132 USAIntact Genomics (ig®) is a world leader in large DNA fragment cloning and metagenomic technologies. We have dedicated scientists and state of the art equipment housed in a modern facility, located in the Helix Center Biotech Incubator, next to Monsanto Headquarters, Donald Danforth Plant Science Center, and close to Washington University in St. Louis. We provide high-quality life science products and large insert DNA cloning, custom competent cell production, and BAC library related services to help scientists explore the genome structure and function of microorganisms, plants and animal species. Our highly experienced team of scientists provide outstanding personalized services, fast turnaround times, and the most reasonable prices in the industry. We also apply BAC related technologies in metagenomic research to develop new solutions for agricultural research, natural product-enzyme discovery, and environmental protection. At Intact Genomics Inc, our experts are the world-class leaders of high molecular weight (HMW) genomic DNA preparation, large DNA fragment manipulation, bacterial artificial chromosome (BAC) cloning, and unbiased BAC library construction. We continuously focus on genomic technology innovation. Our Mission We are dedicated to science and discovering solutions to the grand challenges in human health, agriculture and environment. Our Vision We provide advanced research tools for life science and develop new technologies for drug discovery from soil and other environmental microorganisms. Our Values Innovation, Teamwork, Integrity, and Determination. Our History Intact Genomics, Inc. was founded by Dr. Chengcang Charles Wu, a world-renowned expert in large fragment DNA cloning and BAC library technologies. Dr. Wu is the inventor of Fungal Artificial Chromosomes, the main contributor of the first soybean physical map and one of the leading inventors of plant artificial chromosomes. Dr. Wu started Intact Genomics with Rosa Ye, his wife and research associate of over 20 years, in 2013 in St Louis, Missouri, USA to pursue their curiosity and passion in life science.

11840 Westline Industrial Dr, #120 ST LOUIS, MO, 63146 United StatesIntact Genomics (ig®) is a world leader in large DNA fragment cloning and metagenomic technologies. We have dedicated scientists and state of the art equipment housed in a modern facility, located in the Helix Center Biotech Incubator, next to Monsanto Headquarters, Donald Danforth Plant Science Center, and close to Washington University in St. Louis. We provide high-quality life science products and large insert DNA cloning, custom competent cell production, and BAC library related services to help scientists explore the genome structure and function of microorganisms, plants and animal species. Our highly experienced team of scientists provide outstanding personalized services, fast turnaround times, and the most reasonable prices in the industry. We also apply BAC related technologies in metagenomic research to develop new solutions for agricultural research, natural product-enzyme discovery, and environmental protection. At Intact Genomics Inc, our experts are the world-class leaders of high molecular weight (HMW) genomic DNA preparation, large DNA fragment manipulation, bacterial artificial chromosome (BAC) cloning, and unbiased BAC library construction. We continuously focus on genomic technology innovation. Our Mission We are dedicated to science and discovering solutions to the grand challenges in human health, agriculture and environment. Our Vision We provide advanced research tools for life science and develop new technologies for drug discovery from soil and other environmental microorganisms. Our Values Innovation, Teamwork, Integrity, and Determination. Our History Intact Genomics, Inc. was founded by Dr. Chengcang Charles Wu, a world-renowned expert in large fragment DNA cloning and BAC library technologies. Dr. Wu is the inventor of Fungal Artificial Chromosomes, the main contributor of the first soybean physical map and one of the leading inventors of plant artificial chromosomes. Dr. Wu started Intact Genomics with Rosa Ye, his wife and research associate of over 20 years, in 2013 in St Louis, Missouri, USA to pursue their curiosity and passion in life science.

1100 Corporate Square Dr St. Louis, MO, 63132 United StatesIntact Genomics (ig®) is a world leader in large DNA fragment cloning and metagenomic technologies. We have dedicated scientists and state of the art equipment housed in a modern facility, located in the Helix Center Biotech Incubator, next to Monsanto Headquarters, Donald Danforth Plant Science Center, and close to Washington University in St. Louis. We provide high-quality life science products and large insert DNA cloning, custom competent cell production, and BAC library related services to help scientists explore the genome structure and function of microorganisms, plants and animal species. Our highly experienced team of scientists provide outstanding personalized services, fast turnaround times, and the most reasonable prices in the industry. We also apply BAC related technologies in metagenomic research to develop new solutions for agricultural research, natural product-enzyme discovery, and environmental protection. At Intact Genomics Inc, our experts are the world-class leaders of high molecular weight (HMW) genomic DNA preparation, large DNA fragment manipulation, bacterial artificial chromosome (BAC) cloning, and unbiased BAC library construction. We continuously focus on genomic technology innovation. Our Mission We are dedicated to science and discovering solutions to the grand challenges in human health, agriculture and environment. Our Vision We provide advanced research tools for life science and develop new technologies for drug discovery from soil and other environmental microorganisms. Our Values Innovation, Teamwork, Integrity, and Determination. Our History Intact Genomics, Inc. was founded by Dr. Chengcang Charles Wu, a world-renowned expert in large fragment DNA cloning and BAC library technologies. Dr. Wu is the inventor of Fungal Artificial Chromosomes, the main contributor of the first soybean physical map and one of the leading inventors of plant artificial chromosomes. Dr. Wu started Intact Genomics with Rosa Ye, his wife and research associate of over 20 years, in 2013 in St Louis, Missouri, USA to pursue their curiosity and passion in life science.

1100 Corporate Square Dr St. Louis, MO, 63132 United States

11810 Borman Drive St. Louis MO 63146 USAIQsynthesis (now Cyanta Analytical Services) offers CMC and associated analytical research services, prefomulation services, formulation development services, CTM manufacturing and stability testing.

17269 Wild Horse Creek Road Chesterfield, MO 63005 U.S.A.Jem Biotech Inc. is an integrated discipline offering a broad range of services in the field of biotechnology and chemistry. Our primary objective is to be your research partner. Besides our own strength which includes experienced dedicated scientists, technicians and state of the art infrastructure we work with three other research groups and we are one of the major partners of Microtest Innovations, Bangalore, India. We are in the field of biotechnology and chemistry for last 12 years and some of our scientists have well over 30 years of experience. On clients request we provide a brief resume of the scientists and the technicians in charge of the project and the client can directly communicate with the project coordinator. Everything is strictly confidential. A Premiere Antibody Company For confidential biotechnology and chemistry research you can count on, Jem Biotech Inc. aims to be your first and only choice. Jem Biotech Inc. is the premiere antibody company in the Midwestern United States. With our team of experienced scientists, whose expertise covers a broad range of research, development and custom organic synthesis, we make choosing a research firm easy. Our mission is to provide the highest quality research in the fields of taq enzyme and PAP enzyme development, as well as KlentaqS and custom assay for drug discovery companies all over the world. We provide top flight research at a price even small- to mid-sized companies can afford, and we do it on time. From the moment you contact Jem Biotech Inc., your confidentiality is guaranteed. We have worked with some of the biggest clients in our industry and we are proud of our spotless record when it comes to providing the best quality service with the highest level of confidentiality. We also strive to achieve clear communication pathways between our experienced research scientists and our clients so that there is never any misunderstanding or communication issues at any point. Jem Biotech Inc. is one of the fastest growing research firms in the country, and we look forward to providing the vitally important research your company needs.

8130 Lackland St. Louis, MO 63114Jost Chemical provides excipients manufacturing, fine chemicals, raw materials, and APIs.

1132 Wilderness Bluff Court Chesterfield, MO 63005-4926Koziatek Consulting provides drug development consulting, regulatory compliancy, and value adding commercial manufacturing services.

St. Louis, MO, 63144 United StatesLabDiet specializes in ingredients, nutrients and animal feed formulations.

456A Sovereign CourtLamda Biotech offers nucleic acid purification services, gene cloning services and protein purification services. purification of Plasmid DNA to a low endotoxin-free and high quality level.

10850 Metro Ct Maryland Heights, MO, 63043 United StatesLee Biosolutions offers high purity proteins, human/animal proteins, recombinant proteins, antibodies, biological fluids, biochemicals, and coenzymes.

2924 Mary AvenueLee Biosolutions offers high purity proteins, human/animal proteins, recombinant proteins, antibodies, biological fluids, biochemicals, and coenzymes.

St. Louis, MO United StatesLegacy Packaging provides contract pharmaceutical packaging.

13480 Lakefront Drive Earth City, MO 63045 USALegacy Packaging provides contract pharmaceutical packaging.

410 Axminister Drive Fenton, MO, 63026 United StatesLeinco Technologies provides antibody production services, custom protein conjugation, IVD reagents, and many other life science products and services.

4240 Duncan Ave Saint Louis, MO 63110We Are Phenotyping! Providing an understanding of significant biotic problems by extracting and quantifying data from biological images LemnaTec’s goal is to quantify human vision on organisms. Whatever images we take for whatever purposes: The first step will always be to generate reproducible and scientifically sound images in a wide range of light wavelengths – mostly going far beyond human vision. All phenotyping results are stored and analysed automatically. Images can be analysed and re-analysed in an unlimited number of ways, generating image-derived values for a huge amount of quantitative parameters according to varying interests and needs. LemnaTec is the Global Leader in Plant Phenomics Science testing is all about effect monitoring and quantification. Depending on the aim of the test design and data analysis, evaluations vary widely and help to generate new information. Our Scanalyzer Plant Phenomics Platform is designed to link Genotype and Phenotype information in the field of High Throughput Plant Phenotyping High Content Plant Phenomics Root and shoot Phenotyping Infield Phenotyping High precision Plant Phenotyping in Growth Chambers In ecotoxicology deviations from control growth or control behaviour are interpreted as toxic effects. In similar experiements with different objectives the results of nematode, cell culture or fish embryo testing may identify new active ingredients for human or animal care products. In plant protection the screening of aphid, fungi and plant or animal growth inhibition or growth stimulation leads to the detection of new substances for the protection of future crops. Plant phenotyping helps to identify particular gene functions by the description of specific growth patterns under stress conditions, which then in turn become key elements in plant breeding. LemnaTec develops imaging units, image analysis automatisation and data handling strategies that fit all these varied needs of research and production to help our customers to design and develop products suitable to meet future challenges.

Helix Center 1100 Corporate Square Drive St. Louis, MO 63132 United States

St. Louis, MO United StatesMedros utilizes Drosophila models to study human disease.

2038 Telegraph RdMicro Analysis offers elemental analysis, ICP analysis, biodiesel analysis, and CHN analysis services.

7259 Lansdowne Avenue, Suite 200 St. Louis, MO 63119Microbe Inotech Laboratories offers microbial detection, identification, enumeration and biofeasibility assay services.

2252 Welsch Industrial Court St. Louis, MO, 63146 United StatesMOgene provides a full range of genomics services, including support for pharmacogenomics discovery under “research” or “regulated” (CLIA) environments, for researchers in academic as well as commercial institutions. Our offerings include integrated services for DNA and RNA extraction, genotyping, sample prep and a wide range of next-generation sequencing (NGS) and gene expression studies. From qPCR to Arrays to bioinformatics—we’ve got you covered, and can handle any sample types. Leveraging over 15 years of experience, our quality and turnaround times are unparalleled in the industry.

2252 Welsch Industrial Dr Suite 403 Saint Louis, MO, 63146 United StatesMOgene provides a full range of genomics services, including support for pharmacogenomics discovery under “research” or “regulated” (CLIA) environments, for researchers in academic as well as commercial institutions. Our offerings include integrated services for DNA and RNA extraction, genotyping, sample prep and a wide range of next-generation sequencing (NGS) and gene expression studies. From qPCR to Arrays to bioinformatics—we’ve got you covered, and can handle any sample types. Leveraging over 15 years of experience, our quality and turnaround times are unparalleled in the industry.

Checkerboard Square St. Louis MO, 63164Purina built one of the first quality testing laboratories in the animal feed industry in 1916 at 8th and Gratiot in St. Louis. Today, NP Analytical Laboratories continues a 90-year tradition of providing state-of-the-art testing and consulting to support Research, Product Development, and Product Quality. Our scientific staff is focused on meeting the unique challenges of the food and feed industries. Together, we can advance knowledge of food science and animal nutrition and provide tools for developing and maintaining quality products in the marketplace. Our chemists and microbiologists are recognized industry leaders in food and feed testing and have pioneered techniques for analysis of vitamins, amino acids, carbohydrates, and preservatives. The laboratory offers comprehensive testing services for nutrients, contaminants, microbial pathogens, and quality indicators. NPAL also maintains a broad network of contacts with other leading laboratories, to quickly identify cost-effective options for specialized testing not available in our laboratory. We work closely with research and quality teams to develop proprietary test methods that keep NPAL at the forefront of testing laboratories.

Located in the Center for Emerging Technology 4041 Forest Park Ave Saint Louis, MO 63108 USAOrion Genomics offers development of research tools and molecular diagnostic products.

20 Midwest Drive Pacific, MO, 63069 United StatesPacific Valley Dairy offers contract packaging options for both dairy and non-dairy specialty food and beverage items. Our state-of-the-art production facility can provide consistent processing to your specifications. We have the capabilities and expertise to assist you from concept to finished product. BATCHING/BLENDING Our state-of-the-art blending system can combine liquids and powder ingredients for excellent quality product 450 gallon batch size minimums PROCESSING UHT (ultra-high temperature - Falling Stream Heater) HTST (high temperature short time) PACKAGING/FILLING Poly bag in box for UHT and HTST processing 1 gallon, 2.5 gallon and 5 gallon bag sizes Plastic gallons and half gallons for HTST only Specialty plastic bottles 32 ounce up to 156 ounce PRODUCT TYPES Dairy Non-dairy Cultured liquids Specialty products KOSHER CERTIFIED

4340 Duncan Ave St. Louis, MO, 63110 United StatesPanome Bio is a full-service CRO that focuses on Metabolomics and Proteomics services. We offer Next-Generation Metabolomics in the form of whole-metabolome screens as well as targeted metabolomics. Data is delivered as both raw data and in a data analysis report. Complementary targeted and untargeted proteomics assay offerings with Seer Proteograph and MRM technology.

624 Trade Center Boulevard St. Louis, MO 63005 USAPartek Incorporated offers software solutions to support microarray and next generation sequencing data analysis.

2916 South Brentwood Blvd.Pathology Services offers cytology and anatomic pathology services.

1005 N. Warson Rd. Suite 404 St. Louis MO 63132 USPharmaCon provides animal pharmacology and wet lab assays in a fully AAALAC-accredited facility in St. Louis, MO. PharmaCon has a deep network of industry experts who work with our clients to facilitate appropriate study design, data review, and follow-up work. Our core scientific staff executes the key animal models in all major therapeutic categories, and has the added capability of developing custom animal models for clients working on less common diseases. Bioanalytical and histological support are also provided as needed.

1699 South Hanley Road St. Louis, MO, 63144, USAPharsight offers non-compartmental and compartmental PK/PD analysis, simulations, and modeling as well as bioanalysis, bioequivalence, bioavailability, and in vitro metabolite profiling services.

St. Louis, MO USAAt PMI Nutrition®, we know how pet owners love their pets. That is why we have set such high standards for our line of PMI Nutrition® Pet Foods including Infinia, Exclusive and Red Flannel Brands. Our pet foods have been developed and proven through extensive research to exceed the recommended nutritional levels established for your pet. They have the quality ingredients and nutritional value you demand in a premium pet food at an affordable price. PMI Nutrition® products are offered strictly through select Professional Animal Feed Dealers who specialize in the care and feeding of dogs and cats. We invest our research and marketing funds into improved quality instead of national advertising. This allows us to offer you superior nutritional diets at a lower cost.

2305 Millpark Drive, Maryland Heights, MO 63043

675 Old Ballas RoadRadiant Research offers phase I-IV clinical research services including project management, quality assurance, biostatistics, and clinical monitoring with expertise in dermatology, endocrinology, infectious disease, and metabolism.

Washington, MO United StatesRD Laboratories offers wet chemical, stability testing, chromatography, spectrophotometry, and optical rotation services.

4011 Discovery Drive Columbia MO 65201 USAResearch Animal Diagnostic Laboratory provides histopathology, necrospy, parasitology, genotyping, cryopreservation, and microbiology.

3050 SPRUCE STREET ST. LOUIS, MO, 63103 United StatesScientist.com is the world’s largest marketplace for medical research. We help pharmaceutical scientists discover life-saving medicines in less time and at lower cost. Our mission is to make it possible to cure all human disease by 2050. By connecting scientists and enabling them to exchange ideas and transact seamlessly online, Scientist.com is speeding up and reducing the cost of medical research. We were founded in 2007, launched our first research outsourcing marketplace in 2008 and built our first enterprise marketplace for Pfizer in 2009. Today, we operate enterprise marketplaces for 24 of the world’s top 30 pharmaceutical companies, 100+ biotechnology companies and the US National Institutes of Health (NIH).

1100 Corporate Square Drive St. Louis, MO, 63132 United StatesScientist.com is the world’s largest marketplace for medical research. We help pharmaceutical scientists discover life-saving medicines in less time and at lower cost. Our mission is to make it possible to cure all human disease by 2050. By connecting scientists and enabling them to exchange ideas and transact seamlessly online, Scientist.com is speeding up and reducing the cost of medical research. We were founded in 2007, launched our first research outsourcing marketplace in 2008 and built our first enterprise marketplace for Pfizer in 2009. Today, we operate enterprise marketplaces for 24 of the world’s top 30 pharmaceutical companies, 100+ biotechnology companies and the US National Institutes of Health (NIH).

1301 Stylemaster Ln Union MO 63084Romer Labs is a leading global supplier of diagnostic solutions for mycotoxins, food pathogens, food allergens, gluten, GMO, veterinary drug residues, melamine and enzymatic food analysis. Additionally, we operate four fully accredited service labs in Austria, Singapore, UK and the USA.

3506 S. Broadway St. Louis, MO, 63118 United StatesSAFC Pharma provides custom synthesis, sourcing, solid state chemistry, and industrial cGMP services.

1 N Grand Blvd, St. Louis, , MO , 63103 United StatesFounded in 1818, Saint Louis University is one of the nation’s oldest and most prestigious Catholic universities. SLU, which also has a campus in Madrid, Spain, is recognized for world-class academics, life-changing research, compassionate health care, and a strong commitment to faith and service. Guided by our enduring Jesuit mission, we offer our nearly 13,000 students a highly rigorous and deeply transformative education that helps them develop into bold, confident leaders. Rated among the nation’s top 100 research universities, SLU boasts more than 20 graduate and undergraduate programs ranked among the top 100 in the country by U.S. News & World Report. Academically, ethics, spirituality and compassion take center stage, while outside the classroom, members of the SLU community provide more than 1.6 million service hours each year — just one reason we’re consistently known as a character-building college. In fact, more than 80 of SLU's courses integrate service into academics. Inspired by our pioneering history while firmly focused on a promising future, Saint Louis University continues to move forward with an unwavering commitment to serve a higher purpose while always seeking the greater good.

1 N Grand Blvd, St. Louis, , MO, 63103 United StatesFounded in 1818, Saint Louis University is one of the nation’s oldest and most prestigious Catholic universities. SLU, which also has a campus in Madrid, Spain, is recognized for world-class academics, life-changing research, compassionate health care, and a strong commitment to faith and service. Guided by our enduring Jesuit mission, we offer our nearly 13,000 students a highly rigorous and deeply transformative education that helps them develop into bold, confident leaders. Rated among the nation’s top 100 research universities, SLU boasts more than 20 graduate and undergraduate programs ranked among the top 100 in the country by U.S. News & World Report. Academically, ethics, spirituality and compassion take center stage, while outside the classroom, members of the SLU community provide more than 1.6 million service hours each year — just one reason we’re consistently known as a character-building college. In fact, more than 80 of SLU's courses integrate service into academics. Inspired by our pioneering history while firmly focused on a promising future, Saint Louis University continues to move forward with an unwavering commitment to serve a higher purpose while always seeking the greater good.

1 N Grand Blvd, St. Louis, MO 63103Founded in 1818, Saint Louis University is one of the nation’s oldest and most prestigious Catholic universities. SLU, which also has a campus in Madrid, Spain, is recognized for world-class academics, life-changing research, compassionate health care, and a strong commitment to faith and service. Guided by our enduring Jesuit mission, we offer our nearly 13,000 students a highly rigorous and deeply transformative education that helps them develop into bold, confident leaders. Rated among the nation’s top 100 research universities, SLU boasts more than 20 graduate and undergraduate programs ranked among the top 100 in the country by U.S. News & World Report. Academically, ethics, spirituality and compassion take center stage, while outside the classroom, members of the SLU community provide more than 1.6 million service hours each year — just one reason we’re consistently known as a character-building college. In fact, more than 80 of SLU's courses integrate service into academics. Inspired by our pioneering history while firmly focused on a promising future, Saint Louis University continues to move forward with an unwavering commitment to serve a higher purpose while always seeking the greater good.

4320 Forest Park Avenue, Ste 303SARmont is a drug design and project management services firm. Our chief drug designer is Dr. John Talley, the co-inventor of Celebrex and 8 other drugs that have entered the market.

1912 Innerbelt Business Center DriveSequoia Sciences has an unparalleled collection of structurally diverse natural product compounds isolated from plants.

109 S Second St Dupo, IL 62239 USASterling Pharmaceutical Services provides formulation and technical assistance to pharmaceutical industry.

5445 Horseshoe Lake Rd. Collinsville, IL 62234 USATeklab offers environmental testing services including air, metals, microbiology, and general chemistry analysis.

Washington, MO United StatesTrilogy Analytical Laboratory offers a wide range of specialty assays. Our analytical services include interpretation of results to aid in practical solutions for safe food and feed.

870 Vossbrink Dr. Washington, MO 63090 USATrilogy Analytical Laboratory offers a wide range of specialty assays. Our analytical services include interpretation of results to aid in practical solutions for safe food and feed.

1699 South Hanley RoadTripos provides natural product and informatics technology services.

Box 8100 660 S. Euclid Ave. St. Louis, MO 63110Total number of biospecimen collections, research participants and individual biospecimens represented in the WBN catalog. Biospecimens have been collected for both specific research projects and for general biobanking initiatives. These biospecimens may be available for secondary research use, subject to scientific and regulatory review of requests by the custodian of each biospecimen collection.

15 Research Park Drive St Charles , MO, 63304 United StatesViracor Eurofins is a wholly-owned subsidiary of Eurofins Scientific, the global leader in bio-analytical testing, and one of the world leaders in genomic services. We help biopharma clients advance clinical trials through trusted partnership, excellence in science and exceptional service. We customize assays to meet your study’s needs through our specialized testing and expertise in complex assay design/transfer, optimization and validation. Your study deserves a lab that has over 30 years of specialized experience in molecular infectious disease testing, immune response monitoring, vaccine safety/efficacy assessment and allergy/hypersensitivity testing. Viracor is an integrated arm of Eurofins, offering complex/esoteric testing for drug development. For more than 30 years, Viracor has been dedicated to helping clients by providing high quality, accurate results across multiple phases of drug development. We provide specialty testing to evaluate the effects of drug candidates in all major therapeutic categories, with an emphasis on infectious disease, immunology, allergy/ hypersensitivity, and biomarkers. We leverage a comprehensive range of analytical technologies, to support our clients' specialize testing needs, and stringent quality and safety requirements. Our validated test list includes more than 2800 assays, with new custom assays developed on a continual basis in response to our clients’ needs.

Washington StreetVirginia Bioinformatics Institute provides molecular biology, gene expression analysis, proteomics, bioinformatics, and sequencing services.

St. Louis, MO United StatesWashington University in St. Louis Biology Imaging Facility provides microscopes, data processing, and imaging experiment design.

Genome Technology Access Center 660 S. Euclid Campus Box 8232 St. Louis, MO 63110Washington University in St. Louis Genome Technology Access Center (GTAC) provides NextGen (HiSeq), microarray (all formats) and PCR (Fluidigm multiplex and standard) services.

Cortex 1 4320 Forest Park Avenue St. Louis, MO 63108Washington University in St. Louis Genome Technology Access Center (GTAC) provides NextGen (HiSeq), microarray (all formats) and PCR (Fluidigm multiplex and standard) services.

St. Louis, MO United StatesWashington University in St. Louis Histology & Microscopy Core provides tissue processing, sectioning, and microscope usage.

St. Louis, MO United StatesWashington University in St. Louis Hybridoma Center provides monoclonal antibody technology.

St. Louis, MO United StatesWashington University in St. Louis Mouse Cardiovascular Phenotyping Core provides echocardiography, hemodynamic services, and telemetry.

Nano Research Facility, 3029 Brauer Hall One Brookings Drive, Campus Box 1180, St. Louis, MO 63130Washington University in St. Louis Nano Research Facility (NRF) provides micro- and nano- fabrication, surface characterization, and particle technology.

St. Louis, MO, 63110 United StatesThe Animal Behavior Core (ABC) offers interested investigators a time-efficient, cost-effective opportunity to examine the behavioral consequences of gene mutations as well as assess the effects of specific drugs, experimental manipulations (e.g. neuronal loss), or altered development on behavior in laboratory rodents. Services include consultation, animal handling, behavioral testing, data management, statistical analysis, and help in writing manuscripts and grant proposals. Behavioral testing and related services are conducted by ABC personnel and are available to all Washington University investigators on a fee-for-services basis. The ABC offers many behavioral tests which may be organized into six functional domains: 1) sensorimotor functions; 2) learning and memory; 3) altered emotionality; 4) social behaviors and interactions; and 5) sensory-based behaviors. Services Consultation Behavioral testing Animal handling Data management Statistical analysis Manuscript and grant writing Behavioral test modification and development

St. Louis, MO, 63110 United StatesThe Animal Model Research Core facilitates research related to nutrition and obesity. The Core provides cost-effective specialized assays relevant to the nutrition and obesity mission of the NORC, access to well-characterized mouse models used in nutrition research, services critical for evaluation of appropriate mouse phenotypes, and training required for testing hypotheses related to nutrition and obesity in animal models. Services Providing genetically engineered mice from small breeding colonies for nutrition-related research. Performing biochemical assays of serum. Performing biochemical assays of tissues. Providing facilities and reagents for assaying mRNAs of genes relevant to nutrition and obesity research. Maintaining facilities for and providing instruction in assessing atherosclerosis in mice. Assaying metabolic parameters including metabolic rate and food intake. Determining blood pressure. Glucose tolerance and insulin tolerance testing. Hyperinsulinemic/euglycemic clamp procedure. Determination of body composition. Training/consultation services dealing with establishing mouse colonies and phenotyping animals. Immunocytochemistry of mouse tissues.

St. Louis, MO, 63110 United StatesThe DCM research animal diagnostic laboratory provides services in support of animal health and research. Only animal samples may be submitted. Samples should be submitted between 7:30 and 2:30, unless prior arrangements have been made. Please call the lab (362-9095) for sample requirements and to arrange sample submission.

St. Louis, MO, 63110 United StatesThe DCM Veterinary Surgical Services provides veterinary assistance to more than 500 surgical research cases per year involving laparoscopic, orthopedic, transplant, ophthalmologic, cardiologic, neurosurgical, plastic and general surgical procedures. Services include animal preparation, anesthesia and post-operative care, sample collection, injectable and oral treatments, tissue collection and general observations and care of non-rodent species. The 2500 sq.ft. facility includes 5 operating rooms, instrument prep and storage, surgeon prep areas, animal prep room and post-operative recovery space. The facility is staffed from 7:00 am – 5:00 pm M-F and four veterinary technicians are available for assistance. Veterinary technical assistance can also be arranged for non-surgical procedures and care during these times.

St. Louis, MO, 63110 United StatesThe overall objective of the Animal Surgery Core (ASC) is to assist translation of scientific discoveries to rodent models and to facilitate development of new therapeutic strategies for nervous system disorders. The ASC provides access to core equipment and facilities, and expertise for surgery or protocol development. In addition, specific surgical and genetic models of disease will be made available to the Washington University community to accelerate investigation in disorder-related neuroscience. Additionally, equipment in the facility is open to Hope Center investigators who complete appropriate training. Animal Studies Committee approval is required.

St. Louis, MO, 63110 United StatesMouse transgenesis, the stable integration of foreign DNA into the mouse genome, is a key approach used in biomedical research to explore gene function and regulation and to model human disease. Innovations in mouse transgenesis technologies include conditional gene modifications that inactivate gene function in tissue-specific manners, thereby overcoming embryonic lethality; and BAC transgenes to circumvent the position effects commonly found in standard transgenic mice. More recently, TALENs (TAL effector nucleases) and CRISPR/Cas9 systems have emerged as powerful new tools for genome modification in a variety of organisms and cell types, including mouse, rat, zebrafish, drosophila, C. elegans, and human stem cells and iPSCs (induced pluripotent stem cells). The Transgenic Vectors Core specializes in novel genome engineering technologies and vector construction using recombineering and isothermal assembly to generate complex gene modifications not possible with restriction enzymes. Large segments of genomic DNA such as those found on BACs (Bacterial Artificial Chromosomes) are now routinely modified, facilitating production of vectors that were previously impossible to generate The Transgenic Vectors Core designs and constructs TALENs, CRISPR/Cas9 and gene targeting vectors on a fee-for-service basis. Services are available for use by all Washington University investigators as well as investigators outside of the Washington University community.

660 South Euclid Ave. St. Louis, MO, 63110 United StatesThe Washington University School of Medicine In Vivo Imaging Core (IVIC) is made possible through the generous support of the Departments of Internal Medicine, Surgery, Pathology and Immunology, as well as others. The core’s purpose is to make in vivo two-photon imaging and multidimensional data analysis widely available to WUSM researchers. The IVIC is operated as a recharge center to recover the cost of staff salaries, equipment and materials. The growing popularity of two-photon microscopy in the fields of cell biology, immunology and microbiology is in large part due to its unrivaled ability to image single-cell dynamics in native 3D tissue environments. Studying the behavior of individual cells is vital for understanding complex cellular systems, since many physiological processes are rare, asynchronous and tissue context dependent. With the appropriate fluorescence reporters, two-photon imaging can also serve as an in vivo assay for many aspects of cell activation and function, including motility, chemotaxis, antigen recognition, calcium influx, gene expression, proliferation, phagocytosis, cell-mediated cytotoxicity and apoptosis.

660 S. Euclid Avenue St. Louis, MO, 63110 United StatesThe Washington University Mouse Cardiovascular Phenotyping Core (MCPC) is a leading research core that was established in 1998 and currently provides approximately 3,000 surgical, imaging and functional cardiovascular physiology services annually to its academic and industry partners throughout the world. With an experienced staff of three dedicated investigators, each with over 20 years of animal physiology experience, the MCPC provides a focused, systematic approach to studying basal physiology of the mouse cardiovascular system. We are engaged in the latest state-of-the-art cardiovascular research and development of new experimental protocols, techniques and services. The MCPC is part of the Center for Cardiovascular Research in the Cardiovascular Division at Washington University School of Medicine.

Louis Street Washington, MO, 63090 United StatesThis core assists investigators in the Cancer Center with the generation of manipulated murine ES cells used to make sophisticated mouse models of human diseases, including cancer. These altered ES cells help us to understand how both individual genes and mutations work to cause cancer. The Murine Embryonic Stem Cell Core has been created to help you make mutations in mouse embryonic stem cells. The core has several missions including: development of state-of-the art reagents for the production of targeted mutations in embryonic stem cells, the creation of quality-controlled embryonic stem cell lines, and the teaching of methods for embryonic stem cell culture and manipulation. The core provides seven different embryonic stem cell lines for the WUMS research community. In addition, this core provides a teaching service, so that 'hands-on' production of targeted ES clones can be learned. Finally, the core will arrange additional services for your ES clones such as karyotyping, MAP testing, and blastocyst injections. By providing a comprehensive service, we hope to facilitate the production of gain-of-function and loss-of-function mouse models for our faculty.​

St. Luois, WA United StatesThis core assists investigators in the Cancer Center with the generation of manipulated murine ES cells used to make sophisticated mouse models of human diseases, including cancer. These altered ES cells help us to understand how both individual genes and mutations work to cause cancer. The Murine Embryonic Stem Cell Core has been created to help you make mutations in mouse embryonic stem cells. The core has several missions including: development of state-of-the art reagents for the production of targeted mutations in embryonic stem cells, the creation of quality-controlled embryonic stem cell lines, and the teaching of methods for embryonic stem cell culture and manipulation. The core provides seven different embryonic stem cell lines for the WUMS research community. In addition, this core provides a teaching service, so that 'hands-on' production of targeted ES clones can be learned. Finally, the core will arrange additional services for your ES clones such as karyotyping, MAP testing, and blastocyst injections. By providing a comprehensive service, we hope to facilitate the production of gain-of-function and loss-of-function mouse models for our faculty.​

St. Louis, MO United StatesThe Mouse Genetics Core (MGC) is a service sponsored by the Departments of Anatomy and Neurobiology, Neurology, Medicine, Developmental Biology Department and Pediatrics. The Mission of the MGC is to provide a cost-effective method for generating and maintaining genetically altered mice for the Washington University research community. Services: Production of Transgenic Mice Production of TALENs & CRISPR Mice Production of Chimeric Mice Animal Husbandry PCR Genotyping Speed Congenics Rederivation by IVF Cryopreservation Ovarian Transplants Vasectomies

660 S. Euclid Ave St. Louis, MO, 63110 United StatesMouse genetic models have been extensively utilized by MRC investigators and are central to research in musculoskeletal biology and medicine. The Animal Models Core aims to facilitate the implementation of new technology, and the production, acquisition, and sharing of pertinent mouse genetic models among MRC investigators, as well as provide training and education for non-expert users. To foster a state-of-the-art research environment for MRC researchers, the Animal Models Core will work to support the optimization and implementation of new technologies, the generation of mouse genetic tools that will have wide use among MRC researchers, the production, preservation, and sharing of genetically altered mice in a timely and reliable manner, and the exploration of the zebrafish as a model for musculoskeletal research. Specifically, the Animal Models Core provides the following services: 1. Consultation and education on mouse genetic models. 2. Production of novel genetic tools and models to support research on musculoskeletal diseases. 3. Develop the use of zebrafish models in musculoskeletal research. 4. Establish and maintain a campus-wide database for mouse and zebrafish strains.

St. Loius, MO United StatesThe small animal/plant microPET and CT facility consists of a fully-equipped procedure room housing the necessary equipment to carry out various micro-techniques in a routine fashion. A dedicated departmental cell laboratory is also offered, enabling over 80 cell lines to be stored and cell suspensions prepared for immediate implantation. MicroPET and CT Scanners: Two Siemens microPET scanners (microPET-F220 and microPET-Inveon, Siemens Preclincial Solutions, Knoxville, TN) have been installed in the small animal imaging facilities and are fully operational. The microPET-Inveon MultiModality scanner is a combined PET and CT camera designed for the imaging of small laboratory animals and plants.

4523 Clayton Ave, CB 8052 St. Louis, MO, 63110 United StatesThe Core consists of four units including Respiratory Viral Production, Animal Physiology, Drug Delivery/Allergen-Challenge, and Cigarette Smoke Exposure Units. 1) Viral Production Unit. The Respiratory Viral Production Unit will provide standardized, fully-characterized respiratory viruses (HRV, HEV-D68, RSV, SeV and IAV) for use in human cells and the mouse model of acute infectious illness and post-viral asthma. 2). Animal Physiology Unit. The Mouse Physiology Unit houses instruments and personnel for invasive and non-invasive measurements of mouse lung function post-viral infection. Two BUXCO systems are currently on line within our laboratory space and will be utilized for lung physiology assessments. One system involves whole body plethysmography to assess airway reactivity through derivation of values for enhanced pause (Penh) following methacholine challenge (noninvasive), while the other involves invasive measurements of lung resistance (RL) and dynamic compliance (Cdyn) following methacholine challenge using the Buxco FinePoint system. 3) Drug Delivery/ Allergen-Challenge Unit. This Unit is experienced in conventional methods of drug delivery to animals, including oral, parenteral, and inhaled routes. Allergen-challenge with house dust mite to test for viral exacerbation is described below. 4) Cigarette-Smoke Exposure Unit. The Cigarette Smoking Unit has provided their facility and expertise services over 16 years.

Louis Street Washington, MO, 63090 United StatesThis facility enables large-scale, collaborative projects that would not be possible for individual investigators, helping scientists understand human development and disease, from birth defects and cancer to muscle and nerve disorders. Zebrafish embryos are transparent and develop outside the body, making them useful for observing growth and development. Washington University in St. Louis is home to one of the largest zebrafish facilities in the world. The facility is equipped with robotic feeding and cleaning systems; it is the world’s most modern. This facility allows large-scale, collaborative projects that would not be possible for individual investigators, helping scientists understand human development and disease, from birth defects and cancer to muscle and nerve disorders. The facility enables both large-scale forward genetic screens and generation of mutations in genes of interest, as well as transgenic strains. A common type of minnow, the zebrafish is popular in both scientific research and home aquariums. Zebrafish embryos are transparent and develop outside the body, making them useful for observing growth and development. The facility includes nearly 7,000 tanks, including a 2,000-tank nursery, and allows scientists to perform experiments requiring tens of thousands of fish. The robotic nature of the feeding process allows large numbers of fish to grow quickly facilitating genetic experiments. Beyond shear numbers of fish, the facility has other resources available to investigators. The facility also has the capabilities for obtaining, viewing, and manipulating fish embryos, including microinjections.

St. Louis, WA United StatesThis facility enables large-scale, collaborative projects that would not be possible for individual investigators, helping scientists understand human development and disease, from birth defects and cancer to muscle and nerve disorders. Zebrafish embryos are transparent and develop outside the body, making them useful for observing growth and development. Washington University in St. Louis is home to one of the largest zebrafish facilities in the world. The facility is equipped with robotic feeding and cleaning systems; it is the world’s most modern. This facility allows large-scale, collaborative projects that would not be possible for individual investigators, helping scientists understand human development and disease, from birth defects and cancer to muscle and nerve disorders. The facility enables both large-scale forward genetic screens and generation of mutations in genes of interest, as well as transgenic strains. A common type of minnow, the zebrafish is popular in both scientific research and home aquariums. Zebrafish embryos are transparent and develop outside the body, making them useful for observing growth and development. The facility includes nearly 7,000 tanks, including a 2,000-tank nursery, and allows scientists to perform experiments requiring tens of thousands of fish. The robotic nature of the feeding process allows large numbers of fish to grow quickly facilitating genetic experiments. Beyond shear numbers of fish, the facility has other resources available to investigators. The facility also has the capabilities for obtaining, viewing, and manipulating fish embryos, including microinjections.

Siteman Cancer Center Tissue Procurement Core Barnes-Jewish Hospital North Kingshighway Building Room 2454 216 S. Kingshighway St. Louis, MO. 63110The Tissue Procurement Core is operated under the auspices of the Divisions of Laboratory Medicine and Surgical Pathology. The facility provides Washington University researchers and their collaborators with a centralized resource to collect, store, and utilize human tissue samples for cancer research. Dedicated staff and facilities are used to generate quality controlled nucleic acids and histological sections from collected patient specimens. Using appropriate standards to ensure informed patient consent and protection of confidentiality, the Core may also provide researchers with coded medical information about each patient who has donated tissue. Novel technologies to facilitate research in molecular oncology (e.g. laser-capture tissue microdissection) are also offered.

St. Louis, MO United StatesWashington University School of Medicine SNP Research Facility provides sequencing, informatics, and genotyping services.

Cortex, Suite 209 4444 Forest Park St. Louis, MO 63108The GTAC was established in 2010 by Jeff Milbrandt, Chairman of Genetics at Washington University, to provide access to genomics technologies and services to researchers at Washington University and beyond. Since then the vision has broadened to provide access to include the clincal as well as the scientific community. We offer next-gen sequencing, microarray analyses, and cutting edge PCR services on a fee-for-service, CRO-style basis. Clinical sequencing, microarrays and PCR are done in CAP/CLIA certified laboratories. Assistance is available at all stages of a project, including experimental design, sample preparation, quality control, pcr/microarray/sequencing procedures, data clean-up, and analysis.