104 Boulevard "Akademik Ivan Evstratiev Geshov " Apt 2 Sofia, Sofia City Province, 1612 BulgariaGlobal Clinical Trials (GCT) is a premium contract-research organization (CRO) that offers support for the preclinical and clinical Phase I-IV studies as well as post-marketing activities to Big Pharma, small and medium-sized biotech enterprises, groups and funds, as well as large universities and institutions. Headquartered in Princeton, USA, GCT offers both local and global support through 8 operational offices in Bulgaria, Czech Republic, Hungary, India, Poland, Romania, Russia, Slovakia, Ukraine, USA and is a founding partner of a network of reliable partners in Scandinavia and Western Europe. GCT team, that now consists of over 60 full-time clinical research professionals, gives individualized attention to each project and provides full range of services following the latest GCP, EMA and FDA guidelines at every stage of product development path. Our monitors and project managers are all certified clinicians experienced in GCP clinical research. Our experience, competent staff, close contact with the KOLs and the immense enrollment potential of the covered region ensure fast study start-up and compliance with the set timelines. GCT owns 400 sq.m. (4300 ft2) Drug Storage and Distribution facility in St. Petersburg, Russia. It is fully equipped, disaster protected and has multiple modes of storage (ambient, climate controlled, refrigerated, frozen). High standards of work and client satisfaction are proved by the fact that more than 80% of the business come from repeat clients. Meanwhile, in the recent years the number of our clients worldwide increased dramatically. We actively participate in specialized industry events worldwide. Since 2006 GCT is also an Exclusive Partner of “The White Nights” International ophthalmology congress in Russia.

53-55 Bulevard General Eduard I. Totleben 53-55 Totleben Blvd. Sofia, Sofia City Province, 1606 BulgariaWorldwide Clinical Trials employs more than 1,600 professionals around the world, with offices in North and South America, Eastern and Western Europe, Russia and Asia. Founded by physicians committed to advancing medical science, Worldwide is out to change how the world experiences CROs – in the best possible way. From Early Phase and Bioanalytical Sciences through Late Phase and post approval, we provide world-class, full-service drug development services. With infrastructure and talent spanning 60 countries, we execute predictable, successful studies with operational excellence. We never compromise on science or safety. We’re never satisfied with the status quo. We’re the Cure for the Common CRO.

Sofia, BulgariaAssociated Medical offers clinical research services including phase I-IV studies and medical writing.

Sofia, Sofia City Province BulgariaAssociated Medical offers clinical research services including phase I-IV studies and medical writing.

Sopharma Business Towers Building B, Fl. 18, 5 Lachezar Stanchev Str. Sofia, 1756 BulgariaAsk us about our cell and gene therapy products, including both research and clinical use Discovery Leukopaks. Discovery Life Sciences are the Biospecimen & Biomarker Specialists™. We have the world’s largest biospecimen inventory and procurement network with preeminent multi-omic service laboratories to accelerate precision medicine programs in oncology, immuno-oncology, immunology, inflammation, infectious diseases, and beyond. We are pleased to announce ReachBio is now a part of Discovery Life Sciences. Our biobanks include more than 10 million biospecimens and we have hundreds of clinical sites (Discovery Partners®) that allow researchers to build bespoke study cohorts and seamlessly interrogate them using our CLIA certified, GLP-compliant service laboratories, including our world-renowned Genomic Sequencing and bioinformatics laboratory, HudsonAlpha Discovery, our expert IHC services laboratory that developed the pembrolizumab PD-L1 IHC companion diagnostic prototype, our Proteomic Services labs that offer Olink, Luminex, Seer Proteograph and Mass Spec protein profiling, and our Cell Biology laboratory provides extensive Flow cytometry and single cell RNASeq services with GMP-compliant leukapheresis products for cell therapy development and manufacturing. We also offer clinical flow cytometry services for analysis of trial samples. We are committed to quality and integrity with ISO 13485, GMP- and GCLP-compliant and CLIA-certified labs, stringent IRB and Ethics Committee compliance, and all required approvals and certifications. Navigating US and international personal data protection, drug development and diagnostic development regulations is one of our core competencies. AllCells is the CGT brand of Discovery Life Sciences

23-A Dragan Tsankov Blvd Floor 2 Sofia, 1113 BulgariaAsk us about our cell and gene therapy products, including both research and clinical use Discovery Leukopaks. Discovery Life Sciences are the Biospecimen & Biomarker Specialists™. We have the world’s largest biospecimen inventory and procurement network with preeminent multi-omic service laboratories to accelerate precision medicine programs in oncology, immuno-oncology, immunology, inflammation, infectious diseases, and beyond. We are pleased to announce ReachBio is now a part of Discovery Life Sciences. Our biobanks include more than 10 million biospecimens and we have hundreds of clinical sites (Discovery Partners®) that allow researchers to build bespoke study cohorts and seamlessly interrogate them using our CLIA certified, GLP-compliant service laboratories, including our world-renowned Genomic Sequencing and bioinformatics laboratory, HudsonAlpha Discovery, our expert IHC services laboratory that developed the pembrolizumab PD-L1 IHC companion diagnostic prototype, our Proteomic Services labs that offer Olink, Luminex, Seer Proteograph and Mass Spec protein profiling, and our Cell Biology laboratory provides extensive Flow cytometry and single cell RNASeq services with GMP-compliant leukapheresis products for cell therapy development and manufacturing. We also offer clinical flow cytometry services for analysis of trial samples. We are committed to quality and integrity with ISO 13485, GMP- and GCLP-compliant and CLIA-certified labs, stringent IRB and Ethics Committee compliance, and all required approvals and certifications. Navigating US and international personal data protection, drug development and diagnostic development regulations is one of our core competencies. AllCells is the CGT brand of Discovery Life Sciences

11 ulitsa "Kozyak" Sofia, Sofia City Province, 1407 BulgariaPharmaLex is a leading provider of specialized services for the pharma, biotech and medical device industries. We guide you from early strategic planning activities and non-clinical requirements through clinical development, regulatory submission processes and post-approval / maintenance post-launch activities. Our experts use technology-enabled solutions to support you through the entire product lifecycle. We deliver exceptional results — going above and beyond the standard to deliver tailor-made solutions worldwide.

South Side Business Centre 38, Maystor Aleksi Rilets Str., 5th fl. Res. Distr. Manastirski Livadi – West 1618 Sofia, BulgariaComac Medical provides clinical trial support, site management, biostatistics, and regulatory consultancy.

83, “Gyueshevo” str. “Serdika” Business Centre, Office 411 1330 Sofia- BulgariaChiesi farmaceutici offers drug development, drug discovery, and clinical trials.

6 Tri Ushi Str., Office 2 Sofia, 1000 BulgariaConvex Ltd. established in 1991 as an independent research company is a full service Clinical Research Organization with an incorporated Clinical Research Centre and a Phase I Pharmacological Unit for single- and multi-centre clinical trials on patient and healthy volunteer populations. Convex conducts clinical phases I–IV, BE/BA, observation, registry-based, medical devices and nutritional supplements studies. Convex manages its own network of Investigator’s sites for conducting multi-centre trials including medical centres, clinics and university hospitals.

C-5 Building 9F-BNEXUS Biosystems provides sample management, storage, combinatorial chemistry, and protein crystallography.

Crossover EOOD, 12 Vishneva Street, Lozenetz, Sofia 1164, BulgariaCrossover provides clinical research units, regulatory affairs, GCP training, and quality assurance.

James Bourchier blvd 1, Faculty of Chemistry and Pharmacy Sofia University, room 112 sofia, BULGARIA, 1164 BulgariaFrankenstein Bio Reagents (FB Reagents) was founded in 2009 in Cambridge, MA with the goal of providing more affordable stable isotope labeled lipids, detergents, and amino acids. We currently offer the largest selection of high purity, deuterated phospholipids and detergents, at the best prices. To expand our catalog, we also offer reasonable prices for custom synthesis of new compounds.

James Bourchier blvd 1 sofia, BULGARIA, 1164 BulgariaFrankenstein Bio Reagents (FB Reagents) was founded in 2009 in Cambridge, MA with the goal of providing more affordable stable isotope labeled lipids, detergents, and amino acids. We currently offer the largest selection of high purity, deuterated phospholipids and detergents, at the best prices. To expand our catalog, we also offer reasonable prices for custom synthesis of new compounds.

44A Sv. Kipriyan Str Floor 4 Sofia, Sofia, 1799 BulgariaFidelis Research, a BioIVT Company, is specialised in human biospecimens collection and processing, as well as customised R&D support services. We are a trusted partner of global pharma, biotech and research organisations. Fidelis works with a wide network of over 80 collection sites in Europe and we able to conduct projects tailored to your specific needs for fresh or frozen tissue, bone marrow aspirate, PBMCs, BMMCs, plasma, serum or whole blood samples, FFPEs, matched sets and other custom collections. Our inventory comprises banked solid tumor and hematological malignancies samples. Accelerate your translational research with our bespoke collections and research support solutions.

103 Arsenalski Blvd. Sofia, 1421 BulgariaGSA Pharma support researchers globally by collecting and processing a broad range of disease-state and control samples accompanied by comprehensive annotated data. Our extensive network of sites allows us to enroll a large number of diseased and healthy patients under custom inclusion criteria with both commonly used and difficult to find human tissue and biofluid specimens for research. GSA Pharma works with standard or customer-specified collection and processing protocols, using dedicated facilities and central laboratories in the country of collection to guarantee consistency in procedures and quality across samples. We have built a reputation of a professional partner ensuring research specimens of high quality with consistent information and de-identified patient disease information. GSA pharma LTD is an approved Scientist.com supplier.

Sveta Troiza Qtrs., bl. 378, entr. A, office 4, 1309 Sofia, BulgariaBiovantix provides clinical trials in phase II-IV, medical device trials, and post-marketing studies.

Sofia, Sofia City Province BulgariaBiovantix provides clinical trials in phase II-IV, medical device trials, and post-marketing studies.

53 Tsarigradsko Shosse bul., bl. 2, floor 1, Apt. 4, Sofia, BulgariaOCT Clinical Trials offers phase I-IV clinical research services such as clinical monitoring, clinical trials, preclinical studies, quality assurance, data management, and regulatory affairs. http://www.oct-clinicaltrials.com/

Sofia, 1729 BulgariaBCRS is full service SRO, specialized in Drug Development and Human Biospecimen procurement for research purposes. Our FFPE Tissue Cassettes, Frozen or Fresh Tissues and Blood and Blood Products as Serum, Plasma or other bio-fluids contains detailed clinical, pathological and demographic data. We are a privately held Bulgarian company, incorporated as BCRS in 2012 in Sofia, Bulgaria. 5 years later we have offices in Belgrade, and Skopje. Our partnering companies in Budapest, Prague, Ljubljana, Podgorica and Moscow are supporting our efforts to reach as big as possible diversity of indications and specimens for the shortest possible amount of time. The core team of the company has 19 employees and consultants including Pathologists, Cell Biologists, Biochemists, CRAs, and Medical Doctors. During the last 3 years we have collected considerable number of bio-specimens in our bank. The prevailing numbers of samples are FFPE tissue cassette blocks. With all other projects that requires different bio specimens or we do not have in our repository, we work prospectively. Understandably all samples are collected from our continuously growing network established during the last 5 years in more than 8 EU and non-EU countries. The specimens are collected from 65 academic and clinical institutions according to the local regulatory requirements in the countries of operation. Quality Control (QC) BCRS has developed a strict Quality Control Program to ensure that the human specimens it provides are continually checked for quality throughout their collection, processing, storage, and shipment.

8 Prof. Djovani Gorini street Bulgaria Sofia, Sofia, 1505 BulgariaBCRS is full service SRO, specialized in Drug Development and Human Biospecimen procurement for research purposes. Our FFPE Tissue Cassettes, Frozen or Fresh Tissues and Blood and Blood Products as Serum, Plasma or other bio-fluids contains detailed clinical, pathological and demographic data. We are a privately held Bulgarian company, incorporated as BCRS in 2012 in Sofia, Bulgaria. 5 years later we have offices in Belgrade, and Skopje. Our partnering companies in Budapest, Prague, Ljubljana, Podgorica and Moscow are supporting our efforts to reach as big as possible diversity of indications and specimens for the shortest possible amount of time. The core team of the company has 19 employees and consultants including Pathologists, Cell Biologists, Biochemists, CRAs, and Medical Doctors. During the last 3 years we have collected considerable number of bio-specimens in our bank. The prevailing numbers of samples are FFPE tissue cassette blocks. With all other projects that requires different bio specimens or we do not have in our repository, we work prospectively. Understandably all samples are collected from our continuously growing network established during the last 5 years in more than 8 EU and non-EU countries. The specimens are collected from 65 academic and clinical institutions according to the local regulatory requirements in the countries of operation. Quality Control (QC) BCRS has developed a strict Quality Control Program to ensure that the human specimens it provides are continually checked for quality throughout their collection, processing, storage, and shipment.

Sofia, Sofia City Province BulgariaKokiche focuses on conducting clinical drug trials for phases I to IV in the Eastern European region.