CELLIN TECHNOLOGIES OÜ MÄEALUSE 4, MUSTAMÄE LINNAOSA TALLINN 12618 HARJUMAA ESTONIACellin Technologies LLC is a cell therapy products contract manufacturing company. Cellin Technologies focuses on providing contract manufacturing and clinical research services for developing proprietary technologies to produce cells for experimental or clinical applications on a commercial scale. Cellin Technologies provides services to pharmaceutical and biotech companies, hospitals and clinics in Estonia and external markets. Cellin Technologies has launched a state-of-the-art GMP cleanroom facility for the production of cell therapy medicinal products of the highest quality.

MÄEALUSE 4 TALLINN, 12618 EstoniaCellin Technologies LLC is a cell therapy products contract manufacturing company. Cellin Technologies focuses on providing contract manufacturing and clinical research services for developing proprietary technologies to produce cells for experimental or clinical applications on a commercial scale. Cellin Technologies provides services to pharmaceutical and biotech companies, hospitals and clinics in Estonia and external markets. Cellin Technologies has launched a state-of-the-art GMP cleanroom facility for the production of cell therapy medicinal products of the highest quality.

Riia 185 51014 Tartu EstoniaPharmaSynth AS was established in 2004, trying to answer the growing demand of certified molecules used in PET and SPECT imaging studies. The molecular imaging has proved to have high potential to impact medicine by detecting diseases in early stages, evaluating treatment effects and finding novel approaches to overcome diseases. Among these methods PET and SPECT have become a daily routine in many areas of medical diagnostics. PharmaSynth is contributing to this field by supplying precursors and standards for PET and SPECT imaging, following GMP guidelines. Our special expertise relies in molecule synthesis for brain studies and we take fast steps into becoming an important partner in oncology and other fields. What makes us competitive is the quality we deliver through our products, our personal assistance and reliability we offer to our clients and the tailored products that serve to our customer's research goals. Our production facilities are located in Tartu Science Park, Estonia. The close proximity to Tartu University offers us several opportunities, from intellectual partnerships to specialized human resources, fact that enables us to produce high quality chemistry in our labs.

406a Kurvi tee Harju maakond, 76403 EstoniaWe are the proud to be the first company in the Baltic States who can provide you with first class irradiation services. Scandinavian Clinics Estonia OÜ's modern production facility started services in September 2007 under Steri trademark.

C/ Energia,112Panlab develops software and manufactures systems in application of psychopharmacalogy, motor/sensory, and physiology services.

Eerika Tee 1 Õssu Kambja vald, Tartumaa, 61713 EstoniaIcosagen offers custom-tailored services for recombinant protein production in mammalian cells, and antibody development. By using patented state-of-the-art technologies, we deliver high quality products to the biopharmaceutical and diagnostic companies. Company's quality control and assurance system is ISO9001:2008 certified. Icosagen Cell Factory (ICF) is a European, mammalian CRDMO, bridging the CRO and CDMO expertise, hence the CRDMO designation. We drive your protein drug candidates seamlessly from R&D phase into clinical development stages. We focus on protein/antibody work, all the way from discovery, transient expression (mg to grams, ml to 50L) up to stable cell line and process development for GMP manufacturing, incl. analytics and DSP. Our own on-site GMP facility is in preparation and scheduled to be operational in early 2024. With Icosagen’s modular and integrated services, from discovery till GMP material, your project stays entirely in the hands of one site, no tech/molecule transfer, constant project team, legal agreements in place, and, importantly, with your molecule knowledge remaining in house. This saves time, costs, and nerves. Facts: • 150 people, 135 scientists (25% PhD’s) • Founded 1999, independent, family-owned ever since • worked for >150 biotechs / pharma in 2021 • a mammalian CRDMO, working in HEK293 and CHO • notably including complicated antibodies & proteins (USP, DSP, analytics) • Integrated services from discovery to 50L scale manufacturing and stable CLD (GMP manufacturing coming very soon) • antibody discovery in chicken and rabbits (in vitro is coming) • humanization, fee-for-service, royalty-free • mAb discovery against integral membrane protein (such as GPCRs, & ion channels) by proprietary pseudotyped VLP-based display technology platform and optimized chicken immunization regimen • transient protein production in HEK & CHO o from mgs to grams (prop. QMCF protein expression technology) o from ml to 50L scale (CD, serum-free medium) • stable CHO clone pools for g/L titers of mAbs/rec. proteins, Fc fusions, etc. • in-depth analytical & DSP experience • protein for in vitro and in vivo purposes • Stable CHO cell line development (fee-for-service, royalty-free) for GMP manufacturing; competitive titers and timelines • Can be started late is discovery already, saving 2 months’ time in CLD • Process development, non-GMP manufacturing • ADCC enhancement pilots for mAbs (afucosylated mAbs, GlymaxX technology) • Own anti-COVID nasal spray on the market, with anti-spike protein mAbs • Above-average client satisfaction and repeat business, professional project PhD-level managers, problem-solving skills, detailed reports

Riia 185aSolis BioDyne has been developing and producing life science reagents since 1995, having become one of the leading reagent suppliers in Europe today. High standards for production and service have made us a trusted trademark worldwide. DNA polymerases, PCR Master Mixes, qPCR Mixes, reverse transcription, and isothermal amplification reagents are used by a quickly growing number of customers across the globe, including top research institutes and biotech companies. We have partners in both private and state sectors, with cooperation projects ranging from OEM production to scientific research.

1 J. Aamisepa Jõgeva, Jõgeva maakond, 48309 EstoniaEstonian Crop Research Institute is a state research and development institute in area of governance of Estonian Ministry of Agriculture. The Institue has been formed after reorganisation of Estonian Research Institute of Agriculture and Jõgeva Plant Breeding Institute on 1 July 2013. Research and development activities of the institute support increase of efficiency and competitiveness of agricultural production, mitigate negative impact of agricultural production on the environment and help in the maintenance of agrobiodiversity. Institute carries out applied and basic studies in following areas: development and upgrade of efficient and environmentally friendly agrotechnologies, dependence of yield and quality formation from used varieties and agrotechnologies, plant protection, plant health, agrochemistry, fertilisation, and agrometeorology. For the purpose of maintenance agrobiodiversity, the institute breeds new varieties of agricultural crops, quarantees maintenance breeding of registered varieties, preserves plant genetic resources and produces and distributes certified seeds of various agricultural crops. Active national and international cooperation with research and development institutes and universities is directed towards increase of efficiency and scientific level of research. Institute provides scientific expertise for advisory system, state officials and development of legislation. Tight collaboration with farmers and industry is prerequisite for implementation of research results into the practice.

Sõbra 54 Tartu 50106 EstoniaEGeen provides clinical trials for the advancement of drug development for biotech and pharmaceutical clients.

Tallinn, Harju County EstoniaStorkbio provides antibody and peptide modifications, synthesis, labeling and sequence analysis services.

Teaduspargi 9 Tartu, Tartu county, 50411 EstoniaSolis BioDyne has been developing and producing life science reagents since 1995, having become one of the leading reagent suppliers in Europe today. High standards for production and service have made us a trusted trademark worldwide. DNA polymerases, PCR Master Mixes, qPCR Mixes, reverse transcription, and isothermal amplification reagents are used by a quickly growing number of customers across the globe, including top research institutes and biotech companies. We have partners in both private and state sectors, with cooperation projects ranging from OEM production to scientific research.

Teaduspargi 3/1 12618 Tallinn, EstoniaCambrex offers a range of specialist drug substance technologies and capabilities including biocatalysis, continuous flow, controlled substances, solid state science, material characterization and highly potent APIs. In addition, Cambrex can support conventional dosage forms including oral solids, semi-solids and liquids and has the expertise to manufacture specialist dosage forms such as modified-release, fixed dose combination, pediatric, bi-layer tablets, stick packs, topicals, controlled substances, sterile and non-sterile ointments.

Estonian Genome Center, University of Tartu Riia 23b, 51010, Tartu, EstoniaEstonian Biobank is a population-based biobank of the Estonian Genome Center at the University of Tartu (EGCUT).

1 Nooruse Tartu, Tartu maakond, 50411 Estonia

Mäealuse, 2/1 Tallinn, 12618 EstoniaExosomics is a company located in Siena (Italy), founded in 2011 with the aim to leverage the EV potential for diagnostic purposes. In 2019, Exosomics acquired HansaBioMed Life Sciences a company entirely focused on the research in the field of exosomes, extracellular vesicles (EVs) and nanoparticles. With a team of more than 30 employees between its two Sites in Italy and Estonia, our group provide a wide range of high-quality services dedicated to the field of extracellular vesicles both for research and diagnostic purposes. Our services include scalable and automated purification of exosomes and extracellular vesicles from conditioned media, biofluids, plant and microbe cultures, characterization and phenotyping of bulk or single EVs. Additionally, we provide a range of customizable pre-analytical solutions able to enrich different EVs and exosomes subpopulations (e.g.: tumor-derived) from human biofluids and analyze their biomarker content. Our technology can be used for early detection of disease-associated biomarker in liquid biopsy assays and enables the next generation of disease screening, staging, profiling and monitoring tests. Amongst our range of services we employ a versatile and powerful platform - Flow NanoAnalyzer for the multiparameter analysis of individual EVs down to 40nm. Exosomics Laboratories have been appointed as Worldwide Reference Centre for the execution of services in the exosome space, employing this cutting-edge Flow Cytometry Technique.

Laki 25, 12915 Tallinn, EstoniaStorkbio provides antibody and peptide modifications, synthesis, labeling and sequence analysis services.

Inbio Ltd. Akadeemia str 15, 12618 Tallinn EstoniaInbio provides peptide synthesis, antibody production, and contract research.

6 Tartu maantee Tallinn, Harju maakond, 10145 EstoniaSmooth Drug Development (SDD) full-service CRO that provides support to pharmaceutical and biotechnology companies in drug development from concept to post-marketing surveillance. Countries of operation include: Europe: Baltic States Belarus Bulgaria Hungary Germany Moldova Russia Serbia Spain Slovakia Asia: India Kazakhstan Uzbekistan

Vaksali 17a, 50410 Tartu, ESTONIAAsper Biotech focuses on genetic tests and interpretation for rare disorders and syndromes, including cystic fibrosis and corneal dystrophy.

Tartu mnt 67/1-13b Kesklinna linnaosa, Tallinn , 10115 EstoniaThe SciBear team analyzes all types of microbial genome sequencing data. We provide efficient, quick and reliable analysis of your data. Our specialized SciBear analysis report is designed to be readily incorporated into scientific manuscripts.

Tallinn, Harju County EstoniaCompetence Center of Food and Fermentation Technology offers characterization, cultivatino, models, analytical services, and crystallization studies.

Vaksali 17A 50410 Tartu, EstoniaGenorama provides genotyping software, microarray, and custom spotting services.