12 Chemin des Aulx Plan-les-Ouates, GE, 1228 SwitzerlandAddex Therapeutics is pioneering discovery and development of an emerging class of oral small molecule drugs, called allosteric modulators, which can be exquisitely selective for their intended target and confer significant therapeutic advantages over conventional “orthosteric” small molecule or biological drugs.

3 rue Joseph et Marie Hackin 75016 PARISARVALIS - Vegetable Institute For technological agriculture, efficient and sustainable resolutely Improve farm competitiveness, create opportunities, improve the profitability of production and chains and satisfy consumers and citizens are the objectives ARVALIS Institute plant. The expertise to farmers and industries A network of engineers and experts present on the national territory ARVALIS Institute plant, applied research organization, product technical and economic references and directly applicable in the agricultural production systems. Research stations, experimental sites, farms application, laboratories, the Institute has 35 sites located throughout the national territory. The teams are piloting studies at different levels of scale: - the plant: varietal characterization, development of biotechnologies - the plot: technical route; protection; nutrition; implantation techniques, crop protection products or applications. - exploitation and watershed: risk management point and diffuse pollution, organic status and soil fertility, biodiversity management, greenhouse gases greenhouse effects and conducted rotations, operating economics and competitiveness. The Institute's jurisdiction covers production techniques, harvesting, storage and preservation as well as the qualitative aspects of productions for all opportunities. The institute offers training and disseminates information through a strong presence in the press or on its own information channels: Agricultural Outlook, ARVALIS CETIOM information, ARVALIS.fr, information meetings and symposia, pamphlets. It also offers farmers and technicians operational tools, often computerized, for the conduct of crops.

18, rue Troyon 75017 PARIS FranceAJC Pharma manufactures pharmaceutical forms of dry powder, granules, uncoated tablets, film-coated tablets and capsules.

18 chemin des Aulx Plan-les-Ouates, Genève, 1228 SwitzerlandEpithelix provides in vitro human tissues, high throughput screening, and chemical testing. Epithelix Sàrl provides alternative in vitro solutions to animal experimentation for evaluating the effects of drugs in development and assess the toxicity of chemical compounds on the human respiratory tract. The company is the European leading provider of in vitro reconstituted human respiratory tissues and related services to leading academic research laboratories. Epithelix also supplies and supports Personal Care, Medical Device, as well as Chemical and Pharmaceutical. Epithelix developed a unique technology allowing reconstituted tissues to be maintained at a homeostatic state for a long period of time; in other words, the tissues resemble the native tissue both morphologically and functionally (see our products page). The company focused initially on the respiratory system and marketed MucilAir™, the only human respiratory epithelium model able to remain fully differentiated and functional for more than one year. This model is commercialized and available in US, Europe and Asia.

18 chemin des Aulx Plan-les-Ouate Plan les Ouates, Geneva, 1228 SwitzerlandEpithelix provides in vitro human tissues, high throughput screening, and chemical testing. Epithelix Sàrl provides alternative in vitro solutions to animal experimentation for evaluating the effects of drugs in development and assess the toxicity of chemical compounds on the human respiratory tract. The company is the European leading provider of in vitro reconstituted human respiratory tissues and related services to leading academic research laboratories. Epithelix also supplies and supports Personal Care, Medical Device, as well as Chemical and Pharmaceutical. Epithelix developed a unique technology allowing reconstituted tissues to be maintained at a homeostatic state for a long period of time; in other words, the tissues resemble the native tissue both morphologically and functionally (see our products page). The company focused initially on the respiratory system and marketed MucilAir™, the only human respiratory epithelium model able to remain fully differentiated and functional for more than one year. This model is commercialized and available in US, Europe and Asia.

60, Avenue Rockefeller BioParc, Bioserra 1 Lyon, 69008 FranceHit Generation: Edelris offers premium services in Hit Generation: - Keymical Fragments: non-exclusive 3D fragments for Fragment-based lead discovery (FBLD/FBDD). These innovative compounds are tractable, Natural-by-Design (purely synthetic compounds accessible in a few reliable steps from commercially accessible starting material), and have proven successful in many FBS campaigns at clients'. See for example: https://doi.org/10.1016/j.bmcl.2019.126717 and http://practicalfragments.blogspot.com/2020/01/three-dimensional-fragments-revisited.html - Keymical Collections: non-exclusive 3D lead-like series of compounds for HTS. These innovative compounds are tractable, Natural-by-Design (purely synthetic compounds accessible in a few reliable steps from commercially accessible starting material), and have proven sucessful in many screening campaigns at clients'. See for example: H.Waldmann et al. Angew. Chem. Int. Ed. 2019, 58, 17016 – 17025 - EDEN (Edelris Discovery ENgine): based upon an in-house designed and produced screening collection of 2 million compounds from its Keymical Space, Edelris offers efficient ligand identification services using AS-MS (Affinity Selection - Mass Spectrometry), against biological targets from clients. Edelris has successfully screened dozen of targets ranging from enzymes, native GPCR, RNA, PPI... Clients screening decks can also be used, blinded if needed. - DEL by EDELRIS: DNA-encoded libraries for exclusive clients applications Hit-to-Lead, Lead Optimization: Edelris offers cost-efficient and track-proven medicinal chemistry services (Hit exploration, fast follow-up library synthesis, iterative optimization loops) towards an overall biological profile defined by the clients. See for example: https://doi.org/10.1021/acschembio.7b00708

56 Rue de Landres 75008 ParisASCOPHARM and the NOVASCO Group represent one of the most proactive Contract Research Organization in the field of Clinical Research in Europe. Founded in 1995 the original company, ASCOPHARM has now been raised to a full clinical and medical service group. Information on activities and structures can be found in History section and Global Group. The company has now specificities and expertise in a number of aspects of clinical research and post marketing support. Apart from standard services that other company may also offer, ASCOPHARM and the NOVASCO Group have raised up expertise in certain therapeutic fields (Oncology, Transplant, Immune modulators, Rheumatology, Cardiovascular disease…). The Group has also developed original services for site management and support (Site CRA services). Together will all services offered, ASCOPHARM has strongly developed its expertise in Information Technologies and Computer Software. Original tools have been developed (eCRF, Project Management tools, etc…) and an IT company has been integrated to the group. General structure is developed in Global Group while services are described in other sections.

1950 Chemin de la Guiramande Aix-en-Provence, Provence-Alpes-Côte d'Azur, 13080 FranceAix-en-Lama is an association designed to make known the Lama, emblematic animal of South America and also to make you aware of animal mediation thanks to our educational farm.

2, rue du Professeur GARGOUÏL BP 30001 Celle-L'Evescault, F- 86600 FranceEurofins Discovery built its industry-leading reputation on successfully delivering best-in-class drug discovery & development outsourcing services to any organization, large or small. No matter where you are in the preclinical process—or if you need full end-to-end solutions—our experts and industry’s largest catalog of phase-appropriate off-the-shelf catalog assays can support you every step of the way with purpose, precision, and innovation. As a global leader in drug discovery solution provider for over 40 years, we have strategically curated a deep and broad range of over 8,000 off-the shelf and custom assays and related services covering cell line engineering, bioassay development for biologic and biosimilar drug lot release, chemistry, safety & efficacy, mechanism-of-action, ADME-toxicology, and translational biology. Our team of industry experts for, in vitro and in vivo services, GPCRs, and custom protein, cell line, bulk cells and assay development , gene editing projects work across disciplines to collaborate with you. Eurofins Discovery’s comprehensive capabilities, knowledge base, and skill sets enable the company to provide clients the benefit of working with a single outsourcing provider (CRO) for all drug discovery programs whether you choose to conduct the project in house or outsource. Delve into all the ways we can work together by choosing the best path forward for you from our comprehensive services.

2, rue du Professeur GARGOUÏL BP 30001 Celle L'Evescault, 86600 FranceEurofins Discovery built its industry-leading reputation on successfully delivering best-in-class drug discovery & development outsourcing services to any organization, large or small. No matter where you are in the preclinical process—or if you need full end-to-end solutions—our experts and industry’s largest catalog of phase-appropriate off-the-shelf catalog assays can support you every step of the way with purpose, precision, and innovation. As a global leader in drug discovery solution provider for over 40 years, we have strategically curated a deep and broad range of over 8,000 off-the shelf and custom assays and related services covering cell line engineering, bioassay development for biologic and biosimilar drug lot release, chemistry, safety & efficacy, mechanism-of-action, ADME-toxicology, and translational biology. Our team of industry experts for, in vitro and in vivo services, GPCRs, and custom protein, cell line, bulk cells and assay development , gene editing projects work across disciplines to collaborate with you. Eurofins Discovery’s comprehensive capabilities, knowledge base, and skill sets enable the company to provide clients the benefit of working with a single outsourcing provider (CRO) for all drug discovery programs whether you choose to conduct the project in house or outsource. Delve into all the ways we can work together by choosing the best path forward for you from our comprehensive services.

Le Bois L'évêque Celle L'Evescault, 86600 FranceEurofins Discovery built its industry-leading reputation on successfully delivering best-in-class drug discovery & development outsourcing services to any organization, large or small. No matter where you are in the preclinical process—or if you need full end-to-end solutions—our experts and industry’s largest catalog of phase-appropriate off-the-shelf catalog assays can support you every step of the way with purpose, precision, and innovation. As a global leader in drug discovery solution provider for over 40 years, we have strategically curated a deep and broad range of over 8,000 off-the shelf and custom assays and related services covering cell line engineering, bioassay development for biologic and biosimilar drug lot release, chemistry, safety & efficacy, mechanism-of-action, ADME-toxicology, and translational biology. Our team of industry experts for, in vitro and in vivo services, GPCRs, and custom protein, cell line, bulk cells and assay development , gene editing projects work across disciplines to collaborate with you. Eurofins Discovery’s comprehensive capabilities, knowledge base, and skill sets enable the company to provide clients the benefit of working with a single outsourcing provider (CRO) for all drug discovery programs whether you choose to conduct the project in house or outsource. Delve into all the ways we can work together by choosing the best path forward for you from our comprehensive services.

Le Bois L'Evêque Celle L'Evescault, 86600 FranceEurofins Discovery built its industry-leading reputation on successfully delivering best-in-class drug discovery & development outsourcing services to any organization, large or small. No matter where you are in the preclinical process—or if you need full end-to-end solutions—our experts and industry’s largest catalog of phase-appropriate off-the-shelf catalog assays can support you every step of the way with purpose, precision, and innovation. As a global leader in drug discovery solution provider for over 40 years, we have strategically curated a deep and broad range of over 8,000 off-the shelf and custom assays and related services covering cell line engineering, bioassay development for biologic and biosimilar drug lot release, chemistry, safety & efficacy, mechanism-of-action, ADME-toxicology, and translational biology. Our team of industry experts for, in vitro and in vivo services, GPCRs, and custom protein, cell line, bulk cells and assay development , gene editing projects work across disciplines to collaborate with you. Eurofins Discovery’s comprehensive capabilities, knowledge base, and skill sets enable the company to provide clients the benefit of working with a single outsourcing provider (CRO) for all drug discovery programs whether you choose to conduct the project in house or outsource. Delve into all the ways we can work together by choosing the best path forward for you from our comprehensive services.

Parc de Génibrat 31470 Fontenilles FranceAvogadro offers a unique profile where our clients benefits from both from our Analytical Chemistry Expertise and our skilled team for in Life Work on all laboratory and veterinary species.

Amatsigroup SAS Parc de Génibrat Fontenilles, 31470 FranceAvogadro offers a unique profile where our clients benefits from both from our Analytical Chemistry Expertise and our skilled team for in Life Work on all laboratory and veterinary species.

6 allée du Levant CS 60001 La tour de Salvagny, 69890 FranceAntagene offers molecular biology, antibody production, chromatography, spectrometry, and assays.

Parc de Génibrat Fontenilles, 31470 FranceAmatsigroup is a CDMO (Contract Development and Manufacturing Organization) offering services in preclinical and clinical phases of drug development for human and veterinary use.

317 Avenue Jean Jaurès Lyon, Auvergne-Rhône-Alpes, 69007 FranceAdvanced BioScience Laboratories, Inc (ABL) is an Institut Mérieux company ABL is a contract development and manufacturing organization (CDMO) specialized in developing and manufacturing viruses for vaccine candidates, gene, and cancer therapies. ABL's mission is to provide GMP viral vectors from early-stage clinical studies to commercialization, contributing to the success of its clients' immunotherapeutic innovations. ABL's CDMO services include bulk drug substance, fill/finish of drug product, process and assay development, and bioanalytical testing. ABL is a subsidiary of the Institut Mérieux and operates from various locations in Europe and the US. www.abl-biomanufacturing.com. ABL is also a contract research organization and leading global provider of immunology and biomarker analyses, offering expert laboratory & sample management services to advance promising candidates from discovery to the clinic. www.ablinc.com

45 rue de Pommard, F-75012 Paris, FranceAxyntis offers subcontracting services for markets such as life sciences, fine specialty chemicals (electronics, etc.) and coloring agents.

2196 Boulevard de la Lironde Montferrier-sur-Lez, Occitanie, 34980 FranceAmylgen is a preclinical CRO offering a unique combination of validated in vivo models and a full range testing. Fast and predictive screening of the effects of drugs and nutraceuticals on brain health.

2196 Boulevard de la Lironde Parc Scientifique Agropolis 2 Montferrier sur Lez, 34980 FranceAmylgen is a preclinical CRO offering a unique combination of validated in vivo models and a full range testing. Fast and predictive screening of the effects of drugs and nutraceuticals on brain health.

21 quai du Clos des Roses, 60200 Compiègne, FRANCEAbliance owns key technologies and constantly innovates to develop next generation antibodies. Our team of experts closely works with research laboratories, diagnostic industry, clinical research and biopharmaceutical industry actors to understand the needs of each purpose, its regulatory environment and economic constraints. Abliance provides antibodies that perform in their application by designing unique solutions.

Compiègne, Hauts-de-France, 60200 FranceAbliance owns key technologies and constantly innovates to develop next generation antibodies. Our team of experts closely works with research laboratories, diagnostic industry, clinical research and biopharmaceutical industry actors to understand the needs of each purpose, its regulatory environment and economic constraints. Abliance provides antibodies that perform in their application by designing unique solutions.

3 Rue des Satellites Toulouse, Occitanie, 31400 FranceAmbiotis is a pre-clinical CRO focused on inflammation and with a worldwide recognized expertise on the resolution phase of inflammation. Ambiotis provides state-of-the-art bioassay and analytical services to detect and quantify specific biomarkers of the different phases of inflammatory/resolution process, to bring proof of concept of ingredients/molecules efficacy and to establish the mechanism of action in an innovative way. Ambiotis also provides lipidomics service, especially for the quantification of the main cutaneous lipids (ceramides, wax esters, squalene, cholesterol, cholesteryl ester, free fatty acids, total fatty acids...)

174 Quai de Jemmapes Paris 75010 FranceAureus Pharma offers custom databases, training, and database management products.

106 Bureaux de la Colline Bat F2, 92213 Saint Cloud, FranceAthena provides development services, dossier licensing, and scientific support.

Saint-Cloud, Île-de-France, 92210 FranceAthena provides development services, dossier licensing, and scientific support.

69004 Lyon, FRANCEAmerican Elements' catalog of more than 15,000 products makes it the world’s largest metals and chemicals manufacturer devoted exclusively to advanced materials in industrial bulk and laboratory/research quantities. Our development programs have been a key source for academic and corporate research and new product development for over two decades. Fundamental expertise in the properties, applications, and cost-effective manufacturing of advanced and engineered materials, including ultra high purity refining (99.999%) and nanoscale materials, allows us to meet the needs of thousands of global manufacturers (including over 30% of the Fortune 50), all U.S. national laboratories and military branches, universities throughout the world, and customers in a wide range of industry fields, such as energy, electronics, aerospace, defense, automotive, optics, green technology, and pharmaceuticals. American Elements also produces customer proprietary formulations from our network of production facilities worldwide. Our dedication to the highest possible quality control and lot-to-lot consistency is equally matched by our goal to be at the forefront of creating a sustainable planet that continually moves towards improving the human experience for all mankind. Invention is the means of achieving this goal, and American Elements employees are driven to engineer and deliver the basic raw materials of innovation in a socially responsible manner. All we ask of our customers and partners is reflected in two simple words... Now Invent™

Impasse Palayré Toulouse, 31100 FranceAntellis is an independent analytical laboratory specialising in elemental analysis by mass spectrometry (ICP-MS) providing services for Pharmaceuticals, Cosmetics, Chemicals, Agro Food Industry, and Environment, for routine analyses or contract research studies.

1 rue Alfred Kastler Wittelsheim, Alsace, 68310 FranceAdscientis is a company specialized in Inverse Chromatography especially in Gas Chromatography, surface property studies, characterization, and material quality services. This technique offers a precise characterization of the interaction of materials and their surfaces. It determines surface energy and measures different surfaces and bulk proprieties of solid materials (powders, fibres etc). Adscientis fabricates and sells a sets of robotised solution allowing the independent process of Inverse Chromatography directly in the entreprises.

174 Quai de Jemmapes 75010 Paris – FranceAureus Sciences provides a range of scientific knowledge solutions enabling biopharmaceutical companies to better understand the relationships of biological targets to compounds under evaluation.

Saint-Beauzire, Auvergne-Rhône-Alpes, 63360 FranceAptys Pharmaceuticals offers contract service for formulation development, analytical development, consulting and support.

C/ Pau Claris, 167 Pral. 2 Barcelona, B08037 SpainABC Farma Internacional specializes in cosmetic, transdermic and hydrogel patches.

Route des Gorges Quartier Costes Chaudes 07700 SAINT REMEZELe lama comme une oeuvre d’art! plus de vingt ans de passion ont conduit « Ardèche Lamas » à rassembler l’une des plus prestigieuses « collection » de lamas. En 2008 et 2009, deux importations viennent enrichir notre pléiade de champions. Parmi ces nouveaux venus, des lamas de types « suris ». Déjà vénérés par les incas pour leur laine considérée comme un fabuleux trésor de la nature, ces lamas sont d’une extrême rareté. Aspects historiques, scientifiques, écologie, vie sociale, tendresse et caresses, respect et douceur…voici ce que nous souhaitons vous faire partager.

69-71 rue de Miromesnil Paris, 75008 FranceSemantiweb is specialized in Consumer Insights and helps leading brands better understand their targeted audiences, understand their performances and identify new trends. We analyze spontaneous online conversations posted on blogs, forums, social networks as well as online reviews. Our methodology leverages proprietary databases, algorithms, IA as well as human analysis. We help healthcare companies: - understand specific targeted audiences (for example: patients suffering from diabetes) - identify the different steps of the patient decision journey (for example: journey of patients going through menopause) - identify and track specific key opinion leaders (for example: derms, dentists, nurses) - analyze the perception of specific OTC products (for example, what drives positive reviews of health supplements).

Paris, FranceLa recherche et l’enseignement font partie de nos missions. Nous faisons de la recherche pour améliorer en permanence les soins et mettre en place de nouveaux traitements. En France, la moitié de la recherche clinique s’effectue dans les hôpitaux de l’AP-HP. La recherche vous permet de bénéficier des traitements les plus récents et de participer, aux côtés de nos médecins et soignants, aux progrès de la médecine. Dans un hôpital universitaire, vous avez la possibilité de participer à un « essai clinique » ou à un « essai thérapeutique », mais seulement avec votre accord explicite. L’essai auquel vous participez est placé sous le contrôle d’un comité d’éthique et vous signez un « consentement.

Paris, Île-de-France FranceLa recherche et l’enseignement font partie de nos missions. Nous faisons de la recherche pour améliorer en permanence les soins et mettre en place de nouveaux traitements. En France, la moitié de la recherche clinique s’effectue dans les hôpitaux de l’AP-HP. La recherche vous permet de bénéficier des traitements les plus récents et de participer, aux côtés de nos médecins et soignants, aux progrès de la médecine. Dans un hôpital universitaire, vous avez la possibilité de participer à un « essai clinique » ou à un « essai thérapeutique », mais seulement avec votre accord explicite. L’essai auquel vous participez est placé sous le contrôle d’un comité d’éthique et vous signez un « consentement.

ZA La Papillonnière Rue Charles Amand 14500 Vire FranceFounded in 1980 by Irish biochemist and entrepreneur Dr. Pearse Lyons, Alltech is a leading global biotechnology company whose mission is to improve the health and performance of people, animals and plants through natural nutrition and scientific innovation. We pursue this mission guided by what we call the ACE principle, our promise that in doing business we have a positive impact on the Animal, the Consumer and the Environment. Animal Health Our core business improves animal health and performance by adding nutritional value to feed, naturally, through Alltech’s innovative use of yeast fermentation, enzyme technology, algae and nutrigenomics, which studies the impact of nutrition at the genetic level. Our technologies and support programs enable farmers to realize greater efficiency, profitability and sustainability on their farms. Alltech Crop Science Our Alltech Crop Science division complements our animal nutrition business by focusing on improving the health of crops. Our technologies enable us to improve the productivity of the field, in terms of yield quality and quantity, and to enhance nutrition beginning with the soil and the seed. Human Health We believe scientific innovation in animal and crop sciences is part of a much more important story, that of human health. Healthier animals and crops, nurtured naturally through Alltech’s nutritional solutions, affect human well-being. For example, fruits, vegetables and animal proteins have become less nutrient-rich in the past half-century. From fish to oranges, you need to eat more today to get the same nutritional value. Our work within animal and crop sciences is restoring value and also exploring ways to naturally enrich foods through improving the animal diet or crop produced. For example, laying hens fed a diet rich in Alltech’s algae produce eggs enriched with DHA omega-3, an essential nutrient for human cognitive development and health at all ages.

Plot No. A-713,Jamson PharmaChem offers API, intermediates, fine chemicals, and custom synthesis services.

St. Vincent de Mercuze, Grenoble, FranceAnimaScope offers preclinical in vivo imaging, including MRI, ultrasound, tomography, and optical imaging.

Grenoble, Auvergne-Rhône-Alpes FranceAnimaScope offers preclinical in vivo imaging, including MRI, ultrasound, tomography, and optical imaging.

16 Rue Ampere F-67500 Haguenau FranceANADIAG Group is a French Contract Research Organization (CRO) created in 1989 and located in Alsace, the heart of Europe. Specialized in plant protection products registration, the Group offers a wide range of expertise and services to support Global partners in their European registration projects. During these last 25 years, the Group has grown to a workforce of 150 across 12 countries engaged in various areas, such as field trials, chemical analysis, regulatory dossiers, project management, etc. With subsidiaries covering almost 80% of the European plant protection products market by value, ANADIAG Group is one of the leading agrochemical CRO with an extended field trial network across Europe. Having reached a turnover of 17 Million Euros in 2013, ANADIAG Group CEO, Eric Puy expects the future to remain both exciting and challenging! He continues to believe and invest in the Group slogan “Breadth of coverage, Depth of knowledge”. To satisfy our customers we offer an excellent quality service to develop customized and long-term partnerships whilst maintaining an ethical and confidential approach.

3 Impasse du Grand Jardin 35400 Saint-Malo FranceAmarok Biotech is a Contract Research Organization that provides services in biological reagents, automated biological analysis, flow cytometry, and biomarkers validation. Our private laboratories are designed for R&D outsourcing

31 rue du Mail Lyon, 69004 FranceAXO Science offers microarray spotting services.

34 Quai Charles De Gaulle 69006 - LyonFounded in 1992, Ad'hoc Research is a full-service research firm that uses tailored methods to conduct research and fieldwork in France and internationally. Its sector-specific teams are experts in qualitative and quantitative methodologies, whether we are collecting information face-to-face, by telephone or online. Our way of working is to provide innovative survey methods, high-tech analysis and create a relationship based on trust to achieve our goal: supply truly meaningful information to our clients.

10 rue Alfred Kastler 68310 WITTELSHEIM FranceAdscientis offers inverse gas chromatography (IGC) services.

Wittelsheim, Alsace-Champagne-Ardenne-Lorraine, 68310 FranceAdscientis offers inverse gas chromatography (IGC) services.

1, rue Alexander Fleming LYON 69007 FRANCEAguettant offers device development, aseptic processing, manufacturing, and filling services.

4 rue Yvette Cauchois Gif-sur-Yvette, 91190 FranceKimialys offers ready-to-use gold biochips (SPR) and nanoparticles (LFA) coated with an innovative and patented surface chemistry, improving the sensitivity of sensors in any type of biological matrix.

28, rue du Docteur Roux Paris, 75015 FranceAXENIS is a service company using humanized mice as preclinical models in immunology, for the pharmaceutical industry, biotechnology companies and academic research.

41, Rue MartreL'Oreal EpiSkin develops and manufactures in vitro skin models for the application of efficacy and safety testing.

1 Avenue de l’Atlantique Les Conquérants, Bat. Kilimandjaro Les Ulis, 91940 FranceWe’re here to be the solutions partner to biomedical researchers. Providing reliable and repeatable insights that transform scientific discoveries into better outcomes. Improving operating systems through more focused, methodical and consistent processes and an emphasis on quality. Delivering important value to our customers and their research.

Les Chevrières 71570 CHAINTRÉ FRANCEA.S.C. Crop Protection and A.S.C. Biocides are consulting companies expert in regulatory chemistry. Our mission is to inform you about the regulation that applies to your activity, and to help you providing the Authorities with the necessary dossiers in order to be authorised to produce, import or sell your substance or product, either new or existing. Our teams currently pool 23 scientists, whose backgrounds cover all areas related to chemical risk assessment: physico-chemistry, analysis, toxicology, ecotoxicology, biological efficacy, etc.

Chanin 523 Overview Zebrafish is a powerful system for studies of embryogenesis and to investigate mechanisms underlying human diseases. The zebrafish is particularly well suited to study complex and acquired diseases and to identify new disease genes owing to its genetic tractability, transparency of the organism, and the ease of conducting chemical screens to identify diagnostic and potential therapeutic targets. Moreover, the high degree of genetic conservation renders translation between fish and mammals a possibility. For example, this model system can be used to validate and characterize genome-wide association study (GWAS) candidates through gain of function and loss of function approaches. For loss of function analysis the candidate, the gene of interest can be transiently knocked down or stable mutant alleles can be generated through reverse genetic mutagenesis approaches. The phenotypes produced by the normal and mutant versions can provide an indication of the gene’s function in development and disease. The Einstein Zebrafish Core was established to facilitate this type of analysis.

1 Rue Eugène Boeckel Strasbourg, Bas-Rhin, 67000 FranceSPARTHA Medical is the result of 20 years of research in microbiology and biomaterials. SPARTHA Medical offers testing and coating services, ranging from proof of concept (PoC) to licensing agreements. Some non-exhaustive examples: • Accelerated aging tests • Antimicrobial efficacy tests after our antimicrobial coating • Artificial Intelligence services • Automatic robot services • Biocompatibility tests • Coating test application on the surface with our antimicrobial product • Consulting with our experts in microbiology, biofilm, biomaterials, regulatory • Contamination tests by pathogens (bacteria, viruses, yeasts, etc.) on various materials • Culture cells tests • Cytotoxicity tests • Microbiology tests • Sterilization tests (antimicrobial resistance) • Writing of scientific reports

90 Avenue des Hauts de la Chaume Saint-Benoit, 86281 FranceSGS helps pharmaceutical, biopharmaceutical, and medical device companies by providing services along the entire drug development pathway. As a global contract research organization, our global Health Science team provides integrated solutions from preclinical activities to Phase I-IV clinical trials, bioanalytical, pharmaceutical development, biologics characterization, biosafety, and quality control testing of small and large molecules, raw materials, containers and finished products. In an ever-changing world, with technological change reaching breakneck speed, SGS helps navigate the sometimes complex process to successfully deliver high quality, safe and medical devices to market. SGS boasts a wealth of global health science expertise. We will support you every step of the way as you deliver first-class, fully compliant biopharmaceutical, pharmaceutical and medical device products. Our expert staff is trained to the highest standards and has an in-depth knowledge of their fields and your business needs.

60 Avenue Rockefeller LYON, Auvergne-Rhône-Alpes, 69008 FranceBioMeca: Leading Experts in Skin Biology and Biomechanics BioMeca is a biotech service provider specializing in skin biology and biomechanics, utilizing advanced Atomic Force Microscopy (AFM) and high-resolution imaging. We offer comprehensive services in cellular biology, skin biology, and 3D modeling, including: - Development of innovative imaging techniques and biophysical characterization - Expertise in cellular, molecular biology, immunology, and optical imaging (confocal, SPIM, SHG, etc.) - Statistical analysis and 3D reconstruction Additionally, our Engineering Department focuses on transforming ideas into functional prototypes. This separate activity emphasizes the precise measurement of skin properties, supporting innovation in the medical, cosmetic, and medical device fields. We analyze skin texture, elasticity, and adhesion, driving advancements in product research and development. BioMeca is your trusted partner for excellence and progress in skin characterization and beyond.

60 F ave Rockefeller BIOPARC, BIOSERRA 2 (5th floor) LYON, 69008 FranceBioMeca: Leading Experts in Skin Biology and Biomechanics BioMeca is a biotech service provider specializing in skin biology and biomechanics, utilizing advanced Atomic Force Microscopy (AFM) and high-resolution imaging. We offer comprehensive services in cellular biology, skin biology, and 3D modeling, including: - Development of innovative imaging techniques and biophysical characterization - Expertise in cellular, molecular biology, immunology, and optical imaging (confocal, SPIM, SHG, etc.) - Statistical analysis and 3D reconstruction Additionally, our Engineering Department focuses on transforming ideas into functional prototypes. This separate activity emphasizes the precise measurement of skin properties, supporting innovation in the medical, cosmetic, and medical device fields. We analyze skin texture, elasticity, and adhesion, driving advancements in product research and development. BioMeca is your trusted partner for excellence and progress in skin characterization and beyond.

Route de Saint-André des Eaux Z.I de Brais - B.P 40309 Saint Nazaire, 44605 FranceAtlanbio offers chromatography and immunochemistry services.

Rue de la Ferollerie Orléans, Centre-Val de Loire, 45100 FranceThe AARI is a CNRS laboratory at the service of the scientific community for biomedical and pharmaceutical basic research. It offers to the latter a set of services targeted on the availability of murine models. TAAM has 3 specialized components each in a specific field of competence: CDTA (Department of Cryopreservation, Distribution, Typing and Animal Archiving) is a center for the breeding and distribution of transgenic and mutant mice under different health status. Its recognized technical expertise (axenization, in vitro fertilization, re-derivation, ...) combined with the richness of its line catalog makes it a leading player in the distribution of models. The CIPA (Small Animal Imaging Center) provides researchers with innovative 2D and 3D imaging equipment, enabling the development of non-invasive means of exploration. Its close collaborations with leading companies enable the CIPA to implement the latest technologies. SEAT (Transgenic Animal Services) proposes the creation of customized transgenic mouse models (conventional and targeted transgenesis) and the production of modified ES cells. This laboratory also offers the possibility of establishing transgenic lines from founders created on site.

3 B, Rue de la Férolerie ORLEANS CEDEX 2 , 45071 FranceThe AARI is a CNRS laboratory at the service of the scientific community for biomedical and pharmaceutical basic research. It offers to the latter a set of services targeted on the availability of murine models. TAAM has 3 specialized components each in a specific field of competence: CDTA (Department of Cryopreservation, Distribution, Typing and Animal Archiving) is a center for the breeding and distribution of transgenic and mutant mice under different health status. Its recognized technical expertise (axenization, in vitro fertilization, re-derivation, ...) combined with the richness of its line catalog makes it a leading player in the distribution of models. The CIPA (Small Animal Imaging Center) provides researchers with innovative 2D and 3D imaging equipment, enabling the development of non-invasive means of exploration. Its close collaborations with leading companies enable the CIPA to implement the latest technologies. SEAT (Transgenic Animal Services) proposes the creation of customized transgenic mouse models (conventional and targeted transgenesis) and the production of modified ES cells. This laboratory also offers the possibility of establishing transgenic lines from founders created on site.

Illkirch, Alsace-Champagne-Ardenne-Lorraine FranceAlsace Biovalley provides support for R&D and technology transfer.

Chemin des Aulx, 14 1228 Plan-les-Ouates, Geneva (Switzerland)ArisGen is a research-based team dedicated to innovation in the field of drug delivery as a way to improve health.

20, avenue Didier Daurat 31400 Toulouse - FranceAlpha MOS provides chemical analysis, odor monitoring solutions, and electronic noses, tongue, and eyes.

Toulouse, Languedoc-Roussillon-Midi-Pyrénées FranceAlpha MOS provides chemical analysis, odor monitoring solutions, and electronic noses, tongue, and eyes.

33, place des Héros Marseille, 13013 FranceLa société AZURAD, créée à l’initiative de deux enseignants chercheurs d’Aix-Marseille Université (Pr. Michelle Sergent et Dr. Magalie Claeys-Bruno), il y a 5 ans à Marseille, s’est spécialisée dans la recherche et le développement en plans d'expériences. Cette création est l’aboutissement d’une politique active de la part des tutelles pour inciter la création de start-up afin de valoriser un savoir-faire et de participer à l’économie régionale avec la création d’emplois qualifiés et un soutien actif à la recherche. Elle a depuis 2020 le statut de Jeune Entreprise Innovante, elle se révèle leader dans son domaine et est en pleine expansion. Reconnue nationalement et internationalement, AZURAD met à disposition son expertise pour accompagner les chercheurs dans la construction et l'interprétation de plans d'expériences par le biais de formations, de collaborations et le développement d'un logiciel dédié afin de répondre aux besoins. Plus spécifiquement, la société AZURAD propose un logiciel de planification expérimentale dédié à tout expérimentateur qui souhaite optimiser ses travaux dans les secteurs R&D, Production et/ou Qualité. Néanmoins, les défis majeurs de cette décennie imposent le développement de nouveaux algorithmes qui devront répondre à la demande du marché et ainsi satisfaire les exigences règlementaires pharmaceutiques, environnementales et autres.

FranceArtImmune offers analysis in animal models of lung inflammation, IBD, skin inflammation, autoimmunity, neurological disease, and infectious disease models.

13 Avenue Buffon Orléans, 45000 FranceArtImmune offers analysis in animal models of lung inflammation, IBD, skin inflammation, autoimmunity, neurological disease, and infectious disease models.

196 avenue de Thiers - CS 20342 LYON cedex 06, 69455 FranceLe groupe Heverett est composé de plusieurs sociétés d'ingénierie spécialisées dans divers domaines d'expertise, avec pour objectif d'accompagner leurs clients vers l'excellence industrielle. Axeal a développé trois domaines d'expertise centrés sur le numérique. Le premier propose des conseils en matière de maturité numérique et d'interopérabilité des systèmes d'informations. Le deuxième se concentre sur la numérisation des processus métiers historiques de l'entreprise (industrialisation, chaîne d'approvisionnement, qualité, etc.), tandis que le dernier offre le développement de solutions applicatives personnalisées pour nos clients. Acepp est en mesure d'assister nos clients dans des domaines tels que la construction, la supervision de travaux tous corps d'état, les essais et la mise en service d'installations industrielles complexes, ainsi que le maintien en conditions opérationnelles de ces infrastructures. Une offre commune aux deux sociétés opérationnelles du groupe est l'expertise en gestion de projet, englobant la planification, le contrôle des coûts, la gestion contractuelle, et bien plus encore. Heverett Group comprises a collection of engineering companies specializing in various precise technical expertises, with the aim of guiding their clients towards industrial excellence. Axeal has developed expertise in three digital-focused areas. The first involves consultancy in digital maturity and the interoperability of information systems. The second centers on the digitization of the company's historical business processes (industrialization, supply chain, quality, etc.), while the third offers the development of custom application solutions for our clients. Acepp has the capability to support our clients in areas related to construction, supervision of all trades, testing and commissioning of complex industrial installations, and the ongoing operational maintenance of these infrastructures. A shared offering across both operational companies in the group is expertise in project management, encompassing planning, cost control, contract management, and more.

1 Rue Georges Bonnet Bt B37, aile B, 1er étage, POITIERS, 86000 France@rtMolecule specializes in custom synthesis of organic molecules and provides the following design and synthesis services. - Stable isotope labeled materials (Deuterium, 13C, 15N, 18O or mixed) - Drug metabolites - Impurities for identification and quantification - Pharmacomodulation with a timely delivery of your orders. - Scaffolds (e.g. fluorinated) and Original functionalization in superacidic media.

478 RUE DE LA DECOUVERTE MINIPARC BAT 1 LABEGE, OCCITANIE, 31670 France

9 rue Dumagodoux Bègles, 33130 France

60 LYON, 69008 FranceBioMeca: Leading Experts in Skin Biology and Biomechanics BioMeca is a biotech service provider specializing in skin biology and biomechanics, utilizing advanced Atomic Force Microscopy (AFM) and high-resolution imaging. We offer comprehensive services in cellular biology, skin biology, and 3D modeling, including: - Development of innovative imaging techniques and biophysical characterization - Expertise in cellular, molecular biology, immunology, and optical imaging (confocal, SPIM, SHG, etc.) - Statistical analysis and 3D reconstruction Additionally, our Engineering Department focuses on transforming ideas into functional prototypes. This separate activity emphasizes the precise measurement of skin properties, supporting innovation in the medical, cosmetic, and medical device fields. We analyze skin texture, elasticity, and adhesion, driving advancements in product research and development. BioMeca is your trusted partner for excellence and progress in skin characterization and beyond.

60 F ave Rockefeller BIOPARC - BIOSERRA 2 LYON, 69004 FranceBioMeca: Leading Experts in Skin Biology and Biomechanics BioMeca is a biotech service provider specializing in skin biology and biomechanics, utilizing advanced Atomic Force Microscopy (AFM) and high-resolution imaging. We offer comprehensive services in cellular biology, skin biology, and 3D modeling, including: - Development of innovative imaging techniques and biophysical characterization - Expertise in cellular, molecular biology, immunology, and optical imaging (confocal, SPIM, SHG, etc.) - Statistical analysis and 3D reconstruction Additionally, our Engineering Department focuses on transforming ideas into functional prototypes. This separate activity emphasizes the precise measurement of skin properties, supporting innovation in the medical, cosmetic, and medical device fields. We analyze skin texture, elasticity, and adhesion, driving advancements in product research and development. BioMeca is your trusted partner for excellence and progress in skin characterization and beyond.

30 rue Pré Gaudry Lyon, 69007 FranceAt AltraBio, we specialize in the research and development of advanced solutions for analyzing and interpreting biomedical data across preclinical and clinical stages. Our mission is to create cutting-edge analytical and predictive tools for complex datasets, including omics data (genomics, transcriptomics, proteomics) and cytometry data (conventional, mass, spectral). Our Key Activities: - Omics: We harness the potential of genomics, transcriptomics, and proteomics to uncover valuable insights from these complex datasets. - Cytometry: Auto-gating, biomarker discovery, QC, and data visualization, allowing for comprehensive and in-depth data interpretation. Proprietary Tools: One of our most significant achievements is the development of a proprietary tool that automates cytometry file processing. Utilizing machine learning, our tool replicates predefined gating strategies across large sample sets, streamlining study processes and significantly reducing time and costs. This innovation enhances the robustness and reliability of results and has been widely validated through numerous clinical studies, successfully processing thousands of files. Why Choose AltraBio? - Cutting-Edge Technology: We stay at the forefront of technology to deliver the most advanced analytical solutions. - Proven Success: Our methods and tools have been rigorously tested and proven effective in clinical settings. - Efficiency and Cost-Effective: We aim to optimize study processes, making them more efficient and reliable. Contact us to discover how AltraBio can enhance your research and development efforts.

1 ALLEE DU LEVANT SOUCIEU-EN-JARREST, 69510 FranceAxfen Bio is a french CRO offering recombinant protein production services (from gene synthesis to purification/QC). * Expression systems : E.coli, CHO, HEK, S.cerevisiae, P.pastoris, WGE * Type of protein : Enzymes, transmembrane proteins, antigens, VHH, fusion proteins, cytokines, recombinant antibodies, Fab, scFv... * With or without Tag, endofree or not : it's your call!

1 ALLEE DU LEVANT SOUCIEU-EN-JARREST, SOUCIEU-EN-JARREST, 69510 FranceAxfen Bio is a french CRO offering recombinant protein production services (from gene synthesis to purification/QC). * Expression systems : E.coli, CHO, HEK, S.cerevisiae, P.pastoris, WGE * Type of protein : Enzymes, transmembrane proteins, antigens, VHH, fusion proteins, cytokines, recombinant antibodies, Fab, scFv... * With or without Tag, endofree or not : it's your call!

20-22 rue Henri Goudier Riom, Auvergne - Rhône-Alpes, 63200 FranceANS Biotech is an independent preclinical CRO exclusively dedicated to the in vivo pharmacology of pain. The company offers its clients a unique combination of expertise in the fundamentals of pain pharmacology and a proven record of R&D program management for new and innovative analgesics. Our mission is to collaboratively support the drug discovery and development efforts of human and animal health for Pharma as well as Food companies by offering: - Unique early screening services to profile your drug candidates for Pharma Industry and your natural extracts for Food Industry - Tailored solutions for the management of your research projects, - A growing list of clinically relevant and predictive disease and efficacy in vivo models of pain and well-being, - Comprehensive consulting services based on an extensive industrial experience. As a close Pharma, Food and Biotech partner, ANS Biotech commits itself to providing cost-effective preclinical pharmacology services performed to the highest ethical and quality standards. Our validated and customized behavioral studies can help to quantify the efficacy of your compounds before they move into clinic by: - Establishing proof of concept & mechanism of action for drug/natural extract candidates, - Achieving the critically important positioning of these agents within precise therapeutic categories (cancer pain, neuropathic pain, gastroenterology, rheumatology, ...), - Benchmarking drug candidates / natural extracts with clinical gold standards. We aim to act as an extension of your scientific team wherever you are located around the world, helping you to optimize and accelerate the development of your drug candidates.

20 Rue Henri Goudier Riom, Auvergne-Rhône-Alpes, 63200 FranceANS Biotech is an independent preclinical CRO exclusively dedicated to the in vivo pharmacology of pain. The company offers its clients a unique combination of expertise in the fundamentals of pain pharmacology and a proven record of R&D program management for new and innovative analgesics. Our mission is to collaboratively support the drug discovery and development efforts of human and animal health for Pharma as well as Food companies by offering: - Unique early screening services to profile your drug candidates for Pharma Industry and your natural extracts for Food Industry - Tailored solutions for the management of your research projects, - A growing list of clinically relevant and predictive disease and efficacy in vivo models of pain and well-being, - Comprehensive consulting services based on an extensive industrial experience. As a close Pharma, Food and Biotech partner, ANS Biotech commits itself to providing cost-effective preclinical pharmacology services performed to the highest ethical and quality standards. Our validated and customized behavioral studies can help to quantify the efficacy of your compounds before they move into clinic by: - Establishing proof of concept & mechanism of action for drug/natural extract candidates, - Achieving the critically important positioning of these agents within precise therapeutic categories (cancer pain, neuropathic pain, gastroenterology, rheumatology, ...), - Benchmarking drug candidates / natural extracts with clinical gold standards. We aim to act as an extension of your scientific team wherever you are located around the world, helping you to optimize and accelerate the development of your drug candidates.

23 rue Pierre Gilles de Gennes Lyon, 69007 FranceANAQUANT is a CRO dedicated to customized method development for proteins and peptides analysis. Our goal is to support our partners through their full R&D worflow. We are expert in method development for proteins and peptides analysis by LC-MS. We performed method development on any endogenous proteins, biomarkers, biologics but also vaccines or any compounds based on amino acids. We also developed a complete service offer HCP Profiler dedicated to HCP identification and quantification, allowing batch and bioprocess characterisation and comparison.

5 Rue de la Doua Villeurbanne, Auvergne-Rhône-Alpes, 69100 FranceANAQUANT is a CRO dedicated to customized method development for proteins and peptides analysis. Our goal is to support our partners through their full R&D worflow. We are expert in method development for proteins and peptides analysis by LC-MS. We performed method development on any endogenous proteins, biomarkers, biologics but also vaccines or any compounds based on amino acids. We also developed a complete service offer HCP Profiler dedicated to HCP identification and quantification, allowing batch and bioprocess characterisation and comparison.

5 rue de la doua Villeurbanne, Rhone, 69100 FranceANAQUANT is a CRO dedicated to customized method development for proteins and peptides analysis. Our goal is to support our partners through their full R&D worflow. We are expert in method development for proteins and peptides analysis by LC-MS. We performed method development on any endogenous proteins, biomarkers, biologics but also vaccines or any compounds based on amino acids. We also developed a complete service offer HCP Profiler dedicated to HCP identification and quantification, allowing batch and bioprocess characterisation and comparison.

4 Rue Barthelemy Danjou Boulogne-Billancourt, Île-de-France, 92100 FranceAIXIAL is the CRO of Alten Group, a global leader in Engineering and High Added-Value services with 30 000 employees worldwide and revenues of 2 Billion Euros in 2017 (www.alten.com). With more than 500 people and a strong and steady growth of 20%, AIXIAL is among the Top 5 European full-services CROs with a planned extension in the USA. Our main Departments are Clinical Operations, Clinical Data Science, Vigilance & Medical Information, Regulatory Affairs & Quality Management, Real-World Data. Our philosophy is to be a flexible and agile Digital Solution Provider for our clients, by proposing taylor-made solutions to address each specific situation of a client rather than always applying the same processes and solutions. - Flexibility in our engagement models: Workpackages, Functional Services Platforms, Consultancy - Optimization of your timelines and budget, Mitigation of risks: Study methodology, feasibility studies (countries, sites), Risk-Based Monitoring, Patient recruitment and retention - Digitalization: CTMS, eTMF, eISF (Veeva), eICF, eCRF, ePRO

71 avenue des Martyrs Grenoble, 38000 FranceALPX is the newest EMBL Spin-off providing structural biology services to accelerate the drug discovery process. Our fully automated Protein-to-Structure pipelines are based on unique Technologies developed at EMBL HTX lab: CrystalDirect™ and CRIMS.

5 rue Henri Auguste Desbruères Evry, Ile-de-France, 91030 FranceWHO ? Abcell-bio is a French biotechnology company which provides a reliable source of human primary cells isolated from perinatal tissues and adequate culture media. WHAT ? Abcell-bio is specialized in production of: • Hematopoietic Cells isolated from cord blood or peripheral blood: CD34+ Hematopoietic Progenitors, MonoNuclear Cells from cord blood (MNC), Peripheral Blood Mononuclear Cells (PBMC) • Endothelial cells isolated from umbilical cord or cord blood: Endothelial Progenitor Cells (EPC), Human Umbilical Vein Endothelial Cells (HUVEC), Human Umbilical Artery Endothelial Cells (HUAEC) • Cell Culture Media: production of cell culture media dedicated to human primary cells HOW ? Abcell-bio has a unique expertise: the company controls the entire process from blood collection in maternity wards to the production of high-quality cells in dedicated laboratory facilities Thanks to its expertise, Abcell-bio makes your research faster thanks to: • A close partnership with maternity wards • Regulatory compliance (legal authorization, ethical compliance) • High-quality cells (purity, serological testing, viability, characterisation) adaptable to customers’ needs (quantity, HLA genotyping) • Reliable source of cells • Personalised after-sales services carried out by scientists Please contact us for more information at contact@abcell-bio.com

5 Rue Henri Auguste Desbruères Évry, Île-de-France, 91030 FranceWHO ? Abcell-bio is a French biotechnology company which provides a reliable source of human primary cells isolated from perinatal tissues and adequate culture media. WHAT ? Abcell-bio is specialized in production of: • Hematopoietic Cells isolated from cord blood or peripheral blood: CD34+ Hematopoietic Progenitors, MonoNuclear Cells from cord blood (MNC), Peripheral Blood Mononuclear Cells (PBMC) • Endothelial cells isolated from umbilical cord or cord blood: Endothelial Progenitor Cells (EPC), Human Umbilical Vein Endothelial Cells (HUVEC), Human Umbilical Artery Endothelial Cells (HUAEC) • Cell Culture Media: production of cell culture media dedicated to human primary cells HOW ? Abcell-bio has a unique expertise: the company controls the entire process from blood collection in maternity wards to the production of high-quality cells in dedicated laboratory facilities Thanks to its expertise, Abcell-bio makes your research faster thanks to: • A close partnership with maternity wards • Regulatory compliance (legal authorization, ethical compliance) • High-quality cells (purity, serological testing, viability, characterisation) adaptable to customers’ needs (quantity, HLA genotyping) • Reliable source of cells • Personalised after-sales services carried out by scientists Please contact us for more information at contact@abcell-bio.com

Faculté de Médecine 8 avenue Rockefeller Lyon, 69008 FranceAntineo performs preclinical services in oncology. We offer in vitro and in vivo preclinical services. Our most sought-out service are our original CDX and syngeneic tumour models displaying acquired resistances to immunotherapies and other Standard-of-care therapies. Antineo is providing services for the evaluation of new anti-cancer compounds (small molecules, antibodies, peptides, etc.). The company provides scientific consultancy and supports its customers in optimizing the development of their anti-cancer compounds through a range of services from in vitro (cell toxicity, sample characterization...) to in vivo (anti-tumor efficacy, toxicity, pharmacokinetic studies), and also ex vivo services (determination of mechanism of action or target by flow cytometry...). The company has a library of over 150 human and murine tumor cell lines, representative of different types of cancer (colon cancer, breast cancer, cancer mutated for a particular gene, etc.). These cell lines are derived from patient tumors, which have been surgically removed and then cultured to stabilize them as cell lines. The advantage of these tumor cell lines is that they are highly stable and give highly reproducible results, both for in vitro experiments and for xenograft experiments in mice. The evaluation of immunotherapeutic agents may also require complex preclinical models with intact immune systems. In syngeneic models, the team uses immortalized allografts from murine cancer cell lines and re-implants them into the same strain of immunocompetent mice. Models implanted in this way offer several advantages, such as a functional immune system, making them suitable for evaluating the efficacy of new immunotherapeutic approaches to cancer. Antineo also has an R&D activity through which the company develops original models of resistance to reference therapies, notably immune checkpoint inhibitors currently available on the market to assess the efficacy of new anti-cancer therapies, as well as in vitro models of 3D-printed tumors.

3 rue aronnax NANTES, 44821 FranceATLANTIC BONE SCREEN is a French CRO focusing on bone and joint diseases and on bone diseases from tumor origin. ATLANTIC BONE SCREEN puts at its customers’ disposal a unique preclinical platform with a wide range of competitive in vitro and in vivo assays as well as histology and imaging services in order to screen and qualify your drug candidates, nutraceuticals and biomaterials. osteoporosis - osteoarthritis - bone cancer - bone metastases - histology - microCT biomaterials

Grenoble, FranceEuropean Synchrotron Radiation Facility (ESRF) provides synchrotron radiation source for scientific research.

3 RUE ARONNAX 44800 SAINT HERBLAIN FRANCEATLANCHIM PHARMA is a CRO which offers multi-step organic synthesis of complex molecules from few milligrams to several gram scale. The scientific team of ATLANCHIM PHARMA offers you all its experience and professionalism to move your projects forward. We can work on: Custom-made fine chemicals Isolation, Structural identification and synthesis of impurities formed during synthesis of an API Stable isotope labeling (D, 13C, 15N, 34S) Our expertise: Heterocycle chemistry Carbohydrate chemistry/Glucuronides Nucleoside chemistry Steroid chemistry Phosphorus and Sulfur chemistry Organometallic chemistry

3 Rue Aronnax Saint-Herblain, 44800 FranceATLANCHIM PHARMA is a CRO which offers multi-step organic synthesis of complex molecules from few milligrams to several gram scale. The scientific team of ATLANCHIM PHARMA offers you all its experience and professionalism to move your projects forward. We can work on: Custom-made fine chemicals Isolation, Structural identification and synthesis of impurities formed during synthesis of an API Stable isotope labeling (D, 13C, 15N, 34S) Our expertise: Heterocycle chemistry Carbohydrate chemistry/Glucuronides Nucleoside chemistry Steroid chemistry Phosphorus and Sulfur chemistry Organometallic chemistry

152 rue Dr Yersin Loos, 59320 FranceAliri (formerly ImaBiotech and Pyxant Labs) is committed to solving industry challenges by bringing innovative bioanalytical and spatial solutions to biotech and pharma, as the complexity of the drug development landscape continues to rise. Our mission is to support our customers with bringing life-saving therapies to market with speed and agility. We are focused on providing pharma and biotech companies with bioanalytical lab, spatial bioanalysis, and spatial biology solutions that will bring unique, comprehensive data to enable strategic decision making for lead optimization and strengthen regulatory submissions. The company combines expertise in biologics, oligonucleotides and small molecules bioanalysis with a large set of Mass Spectrometers and very unique imaging capabilities to measure distribution and concentrations of every type of drugs and biomarkers (proteins, oligos and small molecules) at cellular level in tissue. The combination of the different capabilities allows to measure efficacy and toxicity with high degree of precision, from drug discovery to help to select the right candidate and from clinical stages to better design and advance your molecules to the marker.

152 Rue Dr Yersin Loos, 59320 FranceAliri (formerly ImaBiotech and Pyxant Labs) is committed to solving industry challenges by bringing innovative bioanalytical and spatial solutions to biotech and pharma, as the complexity of the drug development landscape continues to rise. Our mission is to support our customers with bringing life-saving therapies to market with speed and agility. We are focused on providing pharma and biotech companies with bioanalytical lab, spatial bioanalysis, and spatial biology solutions that will bring unique, comprehensive data to enable strategic decision making for lead optimization and strengthen regulatory submissions. The company combines expertise in biologics, oligonucleotides and small molecules bioanalysis with a large set of Mass Spectrometers and very unique imaging capabilities to measure distribution and concentrations of every type of drugs and biomarkers (proteins, oligos and small molecules) at cellular level in tissue. The combination of the different capabilities allows to measure efficacy and toxicity with high degree of precision, from drug discovery to help to select the right candidate and from clinical stages to better design and advance your molecules to the marker.

19, Rue Louis Delourmel CS 49228 Noyal-Châtillon-sur-Seiche, 35230 FranceA Bio-techne brand based in Silicon Valley, ACD’s products and Pharma Assay Services are based on its proprietary RNAscope® technology, the first multiplex fluorescent and chromogenic in situ hybridization platform, capable of detecting and quantifying single molecules of RNA in situ. ACD has two product lines, namely RNAscope® and BaseScope™ consisting of assay reagent kits and 15,000+ off-the-shelf probes in addition to a Pharma Assay Services business which allow customers to run assays for their unique targets rapidly. Since its first launch in 2011, the technology boasts 1500+ citations, a new publication each day now, for single, duplex and multiplex RNA analysis. The company’s technology overcomes critical hurdles in the identification and validation of biomarkers for companion diagnostics. ACD’s RNAscope® platform provides a new way of localizing and measuring RNA in situ with exceptional levels of sensitivity, specificity, and the ability to multiplex. Turnaround time for a new assay is reduced to 2-3 weeks. These advantages make the technology a powerful tool to address the issue of patient and disease heterogeneity, thus shortening the path to personalized medicine. Through ACD's Pharma Assay Services, tissue sectioning, ISH staining, high resolution full slide scanning, scoring, and image analysis are performed by a dedicated team of highly trained specialists, scientists, and board-certified pathologists. With direct access to the developers of the technology, PAS provides unparalleled expertise in ACD’s ISH platforms and delivers fast, high quality data designed to meet your study objectives and timelines.

60 F Avenue Rockefeller BIOSERRA 2 Building - 3rd floor Lyon, 69008 FranceActive Biomarkers is an integrated bioanalytical laboratory offering multiple in-vitro immunology services: Pharmacokinetics, Immunogenicity, Receptor Occupancy assays, and soluble/cellular biomarkers monitoring. Operating in BSL2 facilities, and GCLP/ISO 9001:2015 environment, the company currently employs 30 people bringing a wealth of experience in the development, validation, and implementation of analytical methods. Its know-how is recognized in 4 major therapeutic areas: oncology, infectious diseases, inflammatory pathologies, and neurodegenerative diseases. Beyond its state-of-the-art flow cytometry and ELISpot capabilities, Active Biomarkers offers the broadest panel of immunoassay technologies in Europe, ranging from standard ELISA to multiplexed methods such as Luminex, SP-X, Gyros or ELLA systems, and ultra-sensitive technologies such as MSD or Simoa HD-1.

321 Avenue Jean Jaurès Lyon, 69007 FranceActive Biomarkers is an integrated bioanalytical laboratory offering multiple in-vitro immunology services: Pharmacokinetics, Immunogenicity, Receptor Occupancy assays, and soluble/cellular biomarkers monitoring. Operating in BSL2 facilities, and GCLP/ISO 9001:2015 environment, the company currently employs 30 people bringing a wealth of experience in the development, validation, and implementation of analytical methods. Its know-how is recognized in 4 major therapeutic areas: oncology, infectious diseases, inflammatory pathologies, and neurodegenerative diseases. Beyond its state-of-the-art flow cytometry and ELISpot capabilities, Active Biomarkers offers the broadest panel of immunoassay technologies in Europe, ranging from standard ELISA to multiplexed methods such as Luminex, SP-X, Gyros or ELLA systems, and ultra-sensitive technologies such as MSD or Simoa HD-1.

22 Rue Adam-Ledoux Courbevoie, 92400 FranceBioexpert is an independent provider of research services in the life sciences. The company takes in charge the practical steps of execution of the projects. This company works in the Paris region. Life sciences specialist: in vitro and in vivo experiments. Non-exhaustive list of services: Management and training of teams for the realisation of projects Animal experimentation (mouse, rat): Chemo-induced cancer model, Xenogenic cancer model, Inoculations: Intraperitoneal, Intramuscular, Subcutaneous, Intravenous, Intra ocular injections; -Gavage Samples : Blood, gametes, bone marrow, aorta, aqueous humour, retina, pigment epithelium, choroid, iris and ciliary body, etc. Genotyping and management of genetically modified mice and breeding management, Fertility studies, Behavioural testing Cell biology : Cell culture: cell lines, primary cultures: endothelial stem cell, mesenchymal stem cell Cytotoxicity tests In vitro angiogenesis tests - on endothelial cells: clonogenicity test, secondary/tertiary colony formation test, functional tests: Migration, Tube formation, Wound healing Marker studies Immunofluorescence (Flow Cytometry, microscopy) Immunohistochemistry and Biochemistry (Immunoprecipitation, Western Blot), ELISA, Production of monoclonal antibodies against surface molecules: Production of monoclonal antibodies against surface molecules: Production by transfection of a high producing line of the antigen of interest, purification by tag, immunisation of mice/rats, fusion, selection, obtaining monoclonal hybridomas and production/purification of the desired antibodies Coupling of antibodies with fluorochromes Study of platelet functions: Aggregation, degranulation - secretion, activation, adhesion and spreading, bleeding time, hemodynamic thrombosis formation, FeCl3 model thrombosis,

37, boulevard Aristide BRIAND AIX EN PROVENCE, Bouches du Rhone, 13100 FranceBamboo Research is a full market research company offering both qualitative and quantitative methodologies. Our small team of senior consultants is dedicated to providing the most qualitative insights to allow the most efficient decision-making.

17, Rue Olof Palme 94000 CRETEIL FranceWe offer our customers a unique panel of assays aimed at measuring different cell metabolism markers. These markers (enzymes, substrates,…) will allow either a global exploration or a specific analysis of a narrower part of cell metabolism. Using our performant technology, it becomes possible to evaluate the respective impact of each metabolism in cell behavior and to compare precisely cell function in a longitudinal manner. Biochemikon services cover the full spectrum from standard methods through to cutting-edge custom approaches developed using latest biological insights and specially developed new assays.

CHU AMIENS - Avenue René Laënnec 80480 SALOUEL - FranceBiobanque de Picardie is located at the heat of the Amiens University situated one hour from Paris. It is a bank of biological samples and data dedicated for scientific research. Certified ISO 9001 and NFS 96-900, Biobanque de Picardie is an accredited Biological Resources Center providing quality and traceability services for establishment, conservation and use of biological samples collections. Biobanque de Picardie is a secure repository where biological samples are stored for medical and research purposes. These biological samples are linked to consenting patient relative data.

Domain de Vivert Batiment 220 78350 Jouy-en-Josas, FranceBioProtein Technologies offers protein purification, pharmacology, and human therapeutic proteins and vaccines in transgenic rabbit milk.

Lyon, Auvergne-Rhône-Alpes FranceBioProtein Technologies offers protein purification, pharmacology, and human therapeutic proteins and vaccines in transgenic rabbit milk.

Moulin St Genies Belfort du Quercy, 46230 FranceBiosiris offers protein sequence analysis, protein interaction site prediction, B epitope prediction, and 3D structure determination from peptide sequences.

Route de Viélaines 10120 Saint Pouange, FRANCEn collaboration with companies specialising in plant protection and seed development, BIOTEK Agriculture conducts many studies required to check the qualities of plant protection products and seeds before they are marketed. In all phases of your projects and at all levels of your business, BIOTEK Agriculture can be of service to you.

Actiparc 1 Bâtiment 6 Traverse de la Penne La Penne sur Huveaune, 13821 FranceBIOMEOSTASIS is a leading Preclinical CRO that offers in vivo research services in the fields of Metabolic, GI and Age-related Diseases. For over 11 years, we have been assessing the efficacy and mechanisms of action of products aiming at preventing and/or treating conditions such as Obesity, Diabetes, NAFLD/NASH, Cancer Cachexia, Inflammatory Bowel Diseases, Sarcopenia...

Parc Val Saint Quentin - Bâtiment H 2 Rue René Caudron 78960 Voisins-le-Bretonneux FranceThe Boston Scientific Corporation (abbreviated BSC) is a worldwide developer, manufacturer and marketer of medical devices whose products are used in a range of interventional medical specialties, including interventional radiology, interventional cardiology, peripheral interventions, neuromodulation, neurovascular intervention, electrophysiology, cardiac surgery, vascular surgery, endoscopy, oncology, urology and gynecology. Boston Scientific is primarily known for the development of the Taxus Stent, a drug-eluting stent which is used to open clogged arteries.[3] With the full acquisition of Cameron Health in June 2012, the company also became notable for offering a minimally invasive implantable cardioverter-defibrillator (ICD) which they call the EMBLEM Subcutaneous Implantable Defibrillator (S-ICD).

46 allée d'Italie LYON, 69007 FranceBioMeca: Leading Experts in Skin Biology and Biomechanics BioMeca is a biotech service provider specializing in skin biology and biomechanics, utilizing advanced Atomic Force Microscopy (AFM) and high-resolution imaging. We offer comprehensive services in cellular biology, skin biology, and 3D modeling, including: - Development of innovative imaging techniques and biophysical characterization - Expertise in cellular, molecular biology, immunology, and optical imaging (confocal, SPIM, SHG, etc.) - Statistical analysis and 3D reconstruction Additionally, our Engineering Department focuses on transforming ideas into functional prototypes. This separate activity emphasizes the precise measurement of skin properties, supporting innovation in the medical, cosmetic, and medical device fields. We analyze skin texture, elasticity, and adhesion, driving advancements in product research and development. BioMeca is your trusted partner for excellence and progress in skin characterization and beyond.

14, rue de la Beaune Bâtiment C, 2ème étage Montreuil, Ile-de-France, 93100 FranceBforcure provides services (PCR, qPCR, RT-PCR, RT-qPCR, multiplex PCR) using existing assays and custom designed assays. Services are performed on standard qPCR machines or assays can be optimized to work on our ultra fast machines.

10 Rue Grignan Marseille, Provence-Alpes-Côte d'Azur, 13001 FranceBiocellvia has developed expertise in compound validation assay based on digital imaging analysis. Our technology allows us to measure the level of compound efficacy in a fully quantitative manner. Our automated analysis uses Artificial Intelligence to provide a more accurate, sensitive, reliable (100% reproducibility), and fully observer-independent technology than any other market technology. As Proof of Concept, Biocellvia had the opportunity to collaborate with Boehringer Ingelheim to correlate and validate our IPF assay directly with conventional methods such as « Ashcroft scoring » and published this data in PLOS ONE. "Quantification of pulmonary fibrosis in a bleomycin mouse model using automated histological image analysis" http://www.biocellvia.com/2017/02/14/biocellvia-publication-quantification-pulmonary-fibrosis/ Biocellvia's assay supports solid, evidence-based decision-making on your drug compound based on robust data and accelerates your preclinical development; a conventional study (250 slides) only takes a few hours. Our current validation assays portfolio : • IPF, idiopathic pulmonary fibrosis: the new validated reference in pulmonary fibrosis evaluation • COPD, chronic obstructive pulmonary disease: Emphysema: an innovative multi-parametric analysis • COPD, chronic obstructive pulmonary disease: Small airway remodeling: a unique, comprehensive automated quantitative tool, peribronchial collagen included. • NASH/NAFLD: Fibrosis, steatosis, ballooning inflammation quantification • PAH, pulmonary arterial Hypertension. • Kidney Fibrosis

115, avenue Lacassagne 69003 Lyon, FranceBased on unique knowledge of nucleotide metabolism, NovoCIB provides analytic services for nucleotides profiling in cell extracts and innovative enzyme activity assay kits for Life Scientists and for Food R&D and Quality Control.

Novocib sas 115 avenue Lacassagne Lyon, Auvergne-Rhône-Alpes, 69003 FranceBased on unique knowledge of nucleotide metabolism, NovoCIB provides analytic services for nucleotides profiling in cell extracts and innovative enzyme activity assay kits for Life Scientists and for Food R&D and Quality Control.

FranceBV Transgenic Services offers embryology, genotyping, histology, and phenotyping services.

Parc de Lantarése Baziege, 31450 France

25 Rue Lotissement la Chute des Eaux Prouilly Grand Est, 51140 FranceNatExplore is specialized in the chemical profiling of natural extracts

1 rue Georges Bonnet Poitiers, 86000 FranceEarly phase Drug Development Services Drug chemistry Drug Delivery System

70 av. Marx Dormoy 92120 Montrouge FranceOur core business is the study of pharmacokinetics (PK) in the human brain. The molecules that we study can have CNS targets as well as peripheral targets.

2 rue George SAND OBERHAUSBERGEN, 67205 France

Parc d'Activités de Magellan 14 rue Claude Chappe FR - 33600 PessacBIO-HC is a privately-owned independant laboratory, created 1996 by 4 scientists. Specialised in the assessment and validation of your cosmetic and toiletry products. TOLERANCE and EFFICACY of your products assessed in accordance with current regulations. From ACTIVE INGREDIENT to FINISHED PRODUCT, made-to-measure support through every stage of your product development.

227, Route de la Chapelle 74540 SAINT FELIX - FranceWith 15 years' experience in the field of structural biology, our team confidently tackles the new challenges brought by our customers. Our scientists' dedication and creativity are our trademark. This allows Bioxtal to deliver more than the expected results whatever the challenges may be. Our determination allows us to offer a "no result- no fee" delivery i.e. we only charge if work is 100% completed.

410 Chemin Departemental 60 Gardanne, 13120 FranceNeuro-Sys is a specialized CRO dedicated to advancing neuro-discovery research. Leveraging extensive expertise and state-of-the-art laboratory facilities, Neuro-Sys specializes in the development and utilization of preclinical models for CNS and PNS diseases (in vitro/in vivo) to achieve high-quality efficacy pharmacology and mode of action studies. Recognizing the diverse needs of our clients, Neuro-Sys provides customized solutions with flexible study designs to address specific research objectives. Partner with us to unlock the full potential of your preclinical drug development program!

Parc d’activités du Pas du Lac 10 bis avenue Ampère Montigny le Bretonneux, 78180 FranceBertin Pharma, a subsidiary of Bertin Technologies, offers preclinical/clinical, pharmaceutical development, biosafety, and biomarker assay tools and services.

Parc d'Activité du Pas du Lac 10 bis avenue Ampère Les Yvelines, 78180 Montigny-le-Bretonneux FranceBertin Pharma, a subsidiary of Bertin Technologies, offers preclinical/clinical, pharmaceutical development, biosafety, and biomarker assay tools and services.

5, rue de labbé de lEpée Paris 75005 FranceBioQuanta offers molecular modeling, data generation, structure-activity prediction, target identification, optimization services, and toxicity prediction.

5, Rue des Aqueducs BP10 Marcy-L´Etoile, 69280 FranceSafety of cosmetics and personal care products has been a focus of bioMérieux for over 50 years. We are a leading provider of rapid and traditional microbiological solutions that help ensure consumers receive products free of microbial contamination. Our cosmetics testing portfolio includes CHEMUNEX® rapid microbiology solutions for microbial detection and enumeration. The fully-automated D-Count and BactiFlow ALS are powerful enough to detect a single bacterium, yeast or mold and allow you to shorten your production cycle by releasing your products in as little as 24 hours.

1 rue de l'Europe Claix FR-38640 FranceBio-Logic offers design and manufacturing for rapid kinetics, spectroscopy, physiology, neuroscience, electrochemistry, and fuel cells.

Claix, Auvergne-Rhône-Alpes FranceBio-Logic offers design and manufacturing for rapid kinetics, spectroscopy, physiology, neuroscience, electrochemistry, and fuel cells.

Parc 2000 244, rue Claude François - Les Fauvettes 34080 MontpellierSince 1993, Biophyderm has been developing a high level of know-how in the domain of dermocosmetic assessments. Run by a dermatologist specialized in industrial dermocosmetologic developments, Biophyderm's strength lies in its staff. Biophyderm is a multidisciplinary and well-skilled team which has been working for years in a strong collaboration with its partners. In 2005, the firm incorporated Biophymed, a company specialized in developing innovative devices. Biophyderm now has a double proficiency in dermocosmetic assessments and development of scientific devices. Our speciality: biometrology, dermocosmetic assessment and biotechnological innovation.

244 Rue Claude François Montpellier, Occitanie, 34080 FranceSince 1993, Biophyderm has been developing a high level of know-how in the domain of dermocosmetic assessments. Run by a dermatologist specialized in industrial dermocosmetologic developments, Biophyderm's strength lies in its staff. Biophyderm is a multidisciplinary and well-skilled team which has been working for years in a strong collaboration with its partners. In 2005, the firm incorporated Biophymed, a company specialized in developing innovative devices. Biophyderm now has a double proficiency in dermocosmetic assessments and development of scientific devices. Our speciality: biometrology, dermocosmetic assessment and biotechnological innovation.

9 Rue de Pacy Miserey, 27930 FranceBiogalenys offers permeability studies in rat and rabbit as well as in vitro skin, intestine, cornea, mucous membrane and nail models.

ZI Jalday 64500 Saint-Jean-de-Luz FranceBioluz manufactures aseptic fill/finish capacity for IV drugs in flexible bags.

World Trade Center 5 Place Robert Schuman - BP 1516 38025 Grenoble, FranceB-Lands Consulting provides consultancy services for compliance to EU, US, and China regulations.

8 Rue Alfred de Vigny Besançon, Bourgogne Franche-Comté, 25000 FranceBIOEXIGENCE, Private Research laboratory, created in 2004 thanks to the French law on research and innovation, offers services of high technological level and works for pharmaceutical and cosmetic laboratories. Studies are performed from specific cell lines, obtained after biopsies from leg ulcer, keloids, striae distensia or wrinkles. We are able to obtain cell lines with specific age thanks to collaborations with hospital or private clinics, A leg ulcer that does not heal, the appearance of wrinkles or stretch marks ... Thanks to SKINBioTest, which offers services including in vitro tests on cell cultures and ex vivo tests on operative wastes, BIOEXIGENCE is able to provide proofs of efficacy of a medicine or cosmetic actives.

Marseille, FranceBiovays offers biomarkers, molecular biology, cellular services, fluorescence services, imaging, and genetics.

60 Avenue Rockefeller F-69008 Lyon, FranceBioClinica offers imaging services.

87 Quai des Queyries 87, quai de Queyries Bordeaux, Nouvelle-Aquitaine, 33100 FranceThanks to its network of qualified experts from the industry, Bio4ward proposes custom solutions based on complementary skills addressing the needs of your project. Pharma, Biotech, Medical devices… Bio4ward supports start-ups and companies looking for high added value expertise on a temporary or long term basis. Bio4ward is a single point of contact for the support of start-ups and SMEs so that bio-entrepreneurs can focus on their core business, avoid the development pitfalls, and optimise value creation. Bio4ward is a unique combination of: The experience and professionalism from major companies. The start-up culture and pragmatism. To the service of innovative life sciences companies

140 Chemin de l'Armée d'Afrique Marseille, 13010 FranceBioCytex provides services to pharma and biotech companies worldwide. BioCytex develop, validate, manufacture fit-for-purpose cell-based assays. BioCytex is using cell culture and immunological tools including : Flow cytometry, ELISA, Luminescence, Cytotoxicity assays, Consulting. BioCytex perform PoC, feasibility and validation studies, and offers PK/PD services.

227 Route de la Chapelle 227 Route de la Chapelle Saint-Félix, Auvergne-Rhône-Alpes, 74540 FranceBioxtal is a biotech company providing services to Pharmaceutical and biotechnology companies as well as academic research labs. Bioxtal offers molecular biology and purification services (E. coli, baculovirus/insect cells, mammalian). We produce batches of recombinant proteins (with or without fusion tags, labelled protein for NMR, crystallography or imaging) for HTS or other applications. Biochemistry and biophysical services include: domain boundaries and solubility screening (Split GFP systems), activity assays development, protein interactions characterization (Protein/protein, Protein/ligand, Lead compounds screening) by TR-FRET, Isothermal Titration Calorimetry, Microscale thermophoresis, Biolayer Interferometry or Thermal shift assay. We also offer protein structure determination by X-ray crystallography (protein, protein complexes, protein/antibody complexes; protein ligand complexes; structure based drug design).

Parc d’activités du Pas du Lac 10 bis, avenue Ampère 78 180 Montigny-le-Bretonneux FranceBertin Instruments is a brand of CNIM Group, dedicated to innovative measurement and sampling solutions for key worldwide markets such as: Lab Equipment (sample preparation, air sampler) Nuclear Instrumentation (radon professional monitoring, environmental radiation monitoring systems, radiation portal monitors, health physics) Defense, Security and Safety / Oil & Gas (CBRN, gas detection, optronics) Our instruments allows our customers to measure, sample and detect invisible elements (DNA, gases, ionizing radiation, night concealed targets…). Our customized sales and R&D approach is based on: a product-specific and customer-centered organization a global presence with a wide network of local partners targeted markets where our engineers can stand out with technological excellency a high technical & scientific digital support

12/14 Rond Point des Champs Elysées, 75008 Paris, FranceNumoda offers support and consultation for companies moving from clinical development to marketing partners.

60, route de SartrouvilleNew Brunswick Scientific offers optimization, cell expertise, computer-controlled strategies, and media formulation.

56 Rue du Port Lille, Hauts-de-France, 59800 FranceThe research teams of the Faculty of Medicine have access to state-of-the-art methodological platforms and common services that optimize technical resources and strengthen synergy between the teams: Methodological Platforms - Molecular and cellular imaging - Genomics, proteomics and bioinformatics platform - Cytometry and cell sorting platform - Platform for therapeutic innovation - Biotherapy platform - Experimental resources platform - Platform Imaging - Clinical evaluation platform

Espace Porte du Gresivaudan 3 9 rue Marcel-Chabloz Saint Martin d'Hères, 38400 FranceNatX-ray offers crystallization screening, structure resolution, and in silico docking services.

9 rue Marcel Chabloz Saint Martin d'Hères, 38400 FranceNatX-ray offers crystallization screening, structure resolution, and in silico docking services.

ZA des Grandes Terres 1305, Route de Lozanne DOMMARTIN, 69380 FranceVOXCAN is a private CRO type company, created in 2007, which offers innovative preclinical services through medical imaging, making it possible to improve and accelerate the development of new therapies, in an ethical and economic manner (reduction up to to 80% of the number of animals used), and reduce time to market. Infectiology, oncology and osteoarticular pathologies are the main areas of expertise in which Voxcan has strong experience. We carry out all our studies in our new preclinical platform (animal facility and imagery) of 500m2, located near Lyon (France), with bio-containment areas (BSL2 & BSL3). In infectious diseases, we can offer in-vivo efficacy studies of your drug candidates in many models of bacterial infection (osteoarticular infection, biofilm on intravenous, pulmonary, subcutaneous catheter on medical tissue, etc.), but also viral or fungal, requiring bio-containment type 2 (BSL-2). We can also use bioluminescent infectious strains (bacterial or viral) allowing, via optical imaging, real-time monitoring of the infection. Voxcan also has its own type 3 bio-containment zone (BSL-3) for infectious challenges requiring a high level of containment. In oncology, we provide you with preclinical services ranging from the in-vitro determination of the action mechanism of the treatment (chemotherapies, antibodies, ADC, immunotherapies…) to in-vivo studies using subcutaneous (ectopic) or orthotopic murine tumor models (Colorectal, Glioblastoma, Pulmonary, Pancreatic, Gastric, Ovarian, Leukemia, Lymphoma, Myeloma… Cancer models).

Aile 1 niveau 3 1, avenue Bourgelat Marcy l'Etoile, 69280 FranceBioVetim is an immunoassay laboratory specialized in hormone and biomarker analysis. BioVetim is a testing laboratory involved in preclinical studies for the pharmaceutical industry, chemical industry and CRO.

38043 Grenoble CEDEX 9 Grenoble FranceThe University hospital Grenoble Alpes (CHU of Grenoble ) is a French university hospital center.

15 Rue Georges Clemenceau Orsay, Île-de-France, 91400 FranceLe Laboratoire de Chimie Physique (LCP) est une unité mixte de recherche (UMR 8000) de l’Université Paris-Sud et du CNRS, localisée sur le campus de la faculté des Sciences d’Orsay.

44 Rue Boson Vienne, 38200 FranceAn Integrated Contract Chemistry Service Organisation Since 2010, Bellen Chemistry has been providing chemistry CRO/CDMO services as an integrated Contract Chemistry Service Organization. With years of accumulated technical advantages and experience in chemical synthesis of small molecule compounds, Bellen has built a one-stop-shop chemistry service platform, supporting big pharmas, biotech innovators and new drug development institutions for their research programs from discovery to commercial stage through comprehensive chemistry solutions. Our R&D, production, sales and operation team are based globally and at present, Bellen has nearly 1,000 employees worldwide, of which our technical team accounts for around 50%. Bellen is committed to continuing investing in innovation and state-of-the-art facilities to enable a one-stop-shop chemistry service platform, adding value to your project from library synthesis to API GMP manufactory. Our Key Services & Capabilities: - Key intermediates & RSMs (non-GMP & GMP) - cGMP APIs - Flow chemistry & Biocatalysis - Process development & optimisation - Process safety assessment - Early phase scale up - Late phase API & intermediates manufacturing - Solid Phase & Recrystallisation platforms (New for 2023) Watch our introductory video here: https://www.youtube.com/watch?v=6EoahD-c6WI

Parc d’activités Bièvre Dauphine 885 rue Alphonse Gourju 38140 Apprieu – FranceExpert in immunotechnologies since 1980, BIOTEM is a hybrid Contract Research Organization (CRO) and Contract Manufacturing Organization (CMO) which provides high added value services for the development / production of custom monoclonal antibodies and immunoassays (ELISA & LFIA). Complying with ISO 9001:2008 Quality Standards, the company has been the privileged partner of more than 500 prestigious industrial and academic laboratories for their projects in fundamental research, development of improved diagnostics or generation of promising therapeutic tools. Based on a high level of expertise and exclusive technologies, BIOTEM implements the most relevant strategies for each project according to the client’s specifications. As a benefit, BIOTEM is keen to propose contracts with guaranteed results. From the generation of original monoclonal antibodies ̶ by hybridoma and Phage Display technologies ̶ through their production, characterisation (affinity & specificity determination, sequencing, stability studies,…) and immunoassay developments, BIOTEM offers a wide range of customised services.

Parc d’activités Bièvre Dauphine 885 rue Alphonse Gourju Apprieu, 38140 FranceExpert in immunotechnologies since 1980, BIOTEM is a hybrid Contract Research Organization (CRO) and Contract Manufacturing Organization (CMO) which provides high added value services for the development / production of custom monoclonal antibodies and immunoassays (ELISA & LFIA). Complying with ISO 9001:2008 Quality Standards, the company has been the privileged partner of more than 500 prestigious industrial and academic laboratories for their projects in fundamental research, development of improved diagnostics or generation of promising therapeutic tools. Based on a high level of expertise and exclusive technologies, BIOTEM implements the most relevant strategies for each project according to the client’s specifications. As a benefit, BIOTEM is keen to propose contracts with guaranteed results. From the generation of original monoclonal antibodies ̶ by hybridoma and Phage Display technologies ̶ through their production, characterisation (affinity & specificity determination, sequencing, stability studies,…) and immunoassay developments, BIOTEM offers a wide range of customised services.

7-9 rue Jean-Louis Bertrand RENNES, 35000 FranceBiotrial offers in vivo studies and GLP safety pharmacology services.

Baugy, FranceCERB (Centre de Recherches Biologiques) offers in vivo and in vitro toxicology studies, pharmacological disease models, and bioanalytical services.

22 Rue Bizard Distré, Pays de la Loire, 49400 FranceCreated in 1988, the Mushroom Technical Centre is the "arm" of the inter ANICC technique (National Interprofessional Association of Mushroom Layer). The industry players, producers and processors involved, animate and fund the CTC The CLC receives approval GEP (Good Experimental Practice) obtained in 1998 and regularly renewed since. Created in 1988, the Mushroom Technical Centre is the "arm" of the inter ANICC technique (National Interprofessional Association of Mushroom Layer). The industry players, producers and processors involved, animate and fund the CTC The CLC receives approval GEP (Good Experimental Practice) obtained in 1998 and regularly renewed since.

21 Rue de Chemnitz Mulhouse, Grand Est, 68200 France1) Multi-material expertise on Metals, Polymers, composites, Glass - Failures and investigations in laboratory and on-site. - Ruptures, cracks, corrosion, various degradations,… - Surface treatments and coatings - Defect searching - Chemical and physicochemical analysis - VOC analysis, pollution, foreign parts,… - Mechanical characterisation (parts and systems) 2) Engineering of materials (Polymers, Ceramics, Recycled composites) - Formulation - Compounding - Pilot production 3) Multiphysics engineering and sustainability - Multiphysic engineering … - Cycled pressure tests - Pressure-Vibration-Temperature tests - Testing under electrical environment - Testing under combined solicitations - Vibration tests - Climatic tests and thermal shocks - Salt spray, UV and fluid resistance tests - Standard and custom testing

1, rue de la Bodinière Fondettes, 37230 FranceCebiphar, French CRO member of TERANGA Group (150 employees), offers its expertise to the veterinary pharmaceutical, chemical and cosmetics industry. This expertise encompasses 4 strategic activities: Development and control Stability studies Veterinary preclinical and clinical studies Technical and regulatory affairs Member of TERANGA Group, Cebiphar offers relevant synergies with its sister companies : ACM Pharma with regards to microbiological services UPS Consultants with regards to training sessions. Cebiphar is a team of 70 employees with 40years experience, 1800 products being studied, 800 veterinary preclinical & clinical studies. More than 150 clients work with us on a regular basis, in France and internationally: start-up, big pharma, generic companies, CMOs (API & DP)s, Cebiphar’s sustained commitment to quality enables the performance of studies according to GMP, GLP and GCP quality standards. Cebiphar benefits from the Research Credit Tax certification.

3 Rue des Satellites 3 Rue des Satellites Toulouse, Occitanie, 31400 FranceCebiphar, French CRO member of TERANGA Group (150 employees), offers its expertise to the veterinary pharmaceutical, chemical and cosmetics industry. This expertise encompasses 4 strategic activities: Development and control Stability studies Veterinary preclinical and clinical studies Technical and regulatory affairs Member of TERANGA Group, Cebiphar offers relevant synergies with its sister companies : ACM Pharma with regards to microbiological services UPS Consultants with regards to training sessions. Cebiphar is a team of 70 employees with 40years experience, 1800 products being studied, 800 veterinary preclinical & clinical studies. More than 150 clients work with us on a regular basis, in France and internationally: start-up, big pharma, generic companies, CMOs (API & DP)s, Cebiphar’s sustained commitment to quality enables the performance of studies according to GMP, GLP and GCP quality standards. Cebiphar benefits from the Research Credit Tax certification.

11 avenue Albert Einstein 69100 Villeurbanne FranceCovalAb offers antibodies, peptide design, antibody services, synthesis, and ELISAs.

11 Avenue Albert Einstein Villeurbanne, 69100 FranceCovalAb offers antibodies, peptide design, antibody services, synthesis, and ELISAs.

110 Avenue Pierre Brossolette Malakoff, 92240 FranceClinSearch is a European Health Research Organizationwhich provides Consultancy and Operational services for Medical Device and Drug Development. We offer more than quality at each step of your project, more than a highly qualified team, more than customer satisfaction… ClinSearch is committed to offer cost-effective solutions for designing and managing clinical evaluations, real-life studies or any other healthcare assessment. This is why ClinSearch is known as a company committed to results and has earned a reputation for delivering practical, measurable and high added-value data.

Fontenay-sous-bois, FranceCenexi offers contract manufacturing for tablets,hard gelatine capsules,ampoules,syrups,packaging and suppositories.

77 Boulevard de la République La Garenne-Colombes, Île-de-France, 92257 FranceCogent expedites the secure transfer of large data files between domestic and global locations including the U.S., U.K., Europe, Japan, China, Korea, Singapore, Australia, and Brazil. [NASDAQ: CCOI] Cogent is a Tier 1 Global Internet Service Provider with the most interconnected network in the world – connecting to 6700 networks and 1200 Data Centers in over 200 markets spanning 45 countries. Approximately 21% of the world’s Internet traffic travels our network daily. Our core product offerings include Dedicated Internet Access, Ethernet Point-to-Point, Ethernet VPLS, SDWAN, and Colocation services offered over our award-winning fiber optic, IP data-only network.

7 rue Labie 75017 Paris FranceCDM Lavoisier specializes in the production of pharmaceutical drugs and medical devices.

Paris, Île-de-France FranceCDM Lavoisier specializes in the production of pharmaceutical drugs and medical devices.

Mas du Sonnailler n°80 VC 108 de Gimeaux 13200 ARLESThe French Rice Center's mission is to provide rice farmers how to produce quality rice at competitive prices, as part of a harmonious relationship with the environment. Taking the usual missions a technical center, the Rice French Centre is experimenting with cultivation techniques, implements a variety selection program also provides ongoing technical support to rice farmers. This site aims to present our technical center, research topics, publications and to report the results of our experiments. You will also find an image bank, illustrating the land of Camargue rice and a directory of the sector. Enjoy!

Illkirch, Alsace-Champagne-Ardenne-Lorraine FranceNMRTEC provides solution and solid state NMR techniques, 33-D structure resolution, polymorphism assessment, API interactions, and structure/activity relationship.

Parc Scientifique & Technologique de Luminy, Case 906, 13288 Marseille cedex 09, FRANCEThe Imaging Immunity – ImagImm - facility offers resources in light and fluorescence microscopy to decipher the operating mechanisms of the immune system, from molecules to whole organisms. Two engineers, Mathieu Fallet and Sébastien Mailfert manage this scientific facility under the scientific supervision of Didier Marguet. Founded in 2012 by merging the former core microscopy platform and IM2V (research and development platform). The aims of the service are to: Develop light and fluorescence microscopy methods at the state-of the-art Provide scientific and technical assistance to acquire and analyze data Train users with on-demand theoretical and practical courses Maintain instruments and ensure quality control processes Perform R&D activity for operating new biophotonic methods appropriate to the CIML scientific community ImagImm is member of the PICsL microscopy core facility (Plateforme d’Imagerie Commune du Site de Luminy) created in 2002 through a partnership between the CIML and the IBDML (Institut de Biologie du Développement de Marseille-Luminy). ImagImm is identified at the national level as “Infrastructure en Biologie Santé et Agronomie“ (IBISA) and as part of the France BioImaging network.

4 Rue Sadi Carnot ZA le point du jour Montaigu Vendée, Vendée, 85600 FranceClean Cells is a French GMP-licensed committed to deliver high-level quality services, and specialized in: (1) QC testing of biopharmaceuticals (from raw/in-process material to commercial release in biosafety, identity, purity, potency) - including specific assays for ATMPs such as karyotyping, RCL/rcAAV, human and veterinary. On cell and gene therapy products, vaccine, cell banks, antibody- and protein-based products (2) Biomanufacturing activities: > GMP cell & viral manufacturing > Biostorage (3) Bioassay development and validation of molecular biology and cell-based assay – (e.g. development and validation of innovative non-radioactive cytotoxicity read-out methods applicable to CAR products).

Boufféré, FranceClean Cells is a French GMP-licensed committed to deliver high-level quality services, and specialized in: (1) QC testing of biopharmaceuticals (from raw/in-process material to commercial release in biosafety, identity, purity, potency) - including specific assays for ATMPs such as karyotyping, RCL/rcAAV, human and veterinary. On cell and gene therapy products, vaccine, cell banks, antibody- and protein-based products (2) Biomanufacturing activities: > GMP cell & viral manufacturing > Biostorage (3) Bioassay development and validation of molecular biology and cell-based assay – (e.g. development and validation of innovative non-radioactive cytotoxicity read-out methods applicable to CAR products).

Boufféré, Pays de la Loire, 85600 FranceClean Cells is a French GMP-licensed committed to deliver high-level quality services, and specialized in: (1) QC testing of biopharmaceuticals (from raw/in-process material to commercial release in biosafety, identity, purity, potency) - including specific assays for ATMPs such as karyotyping, RCL/rcAAV, human and veterinary. On cell and gene therapy products, vaccine, cell banks, antibody- and protein-based products (2) Biomanufacturing activities: > GMP cell & viral manufacturing > Biostorage (3) Bioassay development and validation of molecular biology and cell-based assay – (e.g. development and validation of innovative non-radioactive cytotoxicity read-out methods applicable to CAR products).

Rue Marie Curie Parc d’Activités Vendée Sud Loire 1 Montaigu-Vendée, 85600 FranceClean Cells is a French GMP-licensed committed to deliver high-level quality services, and specialized in: (1) QC testing of biopharmaceuticals (from raw/in-process material to commercial release in biosafety, identity, purity, potency) - including specific assays for ATMPs such as karyotyping, RCL/rcAAV, human and veterinary. On cell and gene therapy products, vaccine, cell banks, antibody- and protein-based products (2) Biomanufacturing activities: > GMP cell & viral manufacturing > Biostorage (3) Bioassay development and validation of molecular biology and cell-based assay – (e.g. development and validation of innovative non-radioactive cytotoxicity read-out methods applicable to CAR products).

75 Route de Lyons la Forêt Rouen, 76000 FranceCELENYS, a biotechnology company committed to the creation, development, production and commercialisation of a new generation of 3D cell culture scaffolds to bring an innovative dimension to your research! AN INNOVATIVE BIOTECHNOLOGY CELENYS is based in Rouen, France. Cofounded by Chairman and CSO, Elise Demange and Nicolas Dubois, CELENYS now comprises a competent and dynamic team of 8 individuals. CELENYS’ mission is to develop innovative scaffolds for 3D cell culture to better mimic the cell microenvironment and provide more predictive tools for drug development. In 2014 CELENYS raised 1M€ and 500 000€ in 2016 of investment from NCI Gestion and Go Capital. This funding has enabled CELENYS to develop a multidisciplinary team.

Vonnas, Auvergne-Rhône-Alpes, 01540 FranceCentre Lago specializes in production of polyclonal antibodies in rabbits.

Fontenay-sous-Bois, Île-de-France, 94120 FranceCenexi offers contract manufacturing for tablets,hard gelatine capsules,ampoules,syrups,packaging and suppositories.

10 Rue des Boules 63200 Riom, FranceCreapharm-MP5 offers cytotoxics, high potency products, protein, antibody, and manufacturing services.

7 avenue Marcel Langer 31400 TOULOUSE, FRANCEClinReal Online is a company specialized in the field of Observational Consumer Tests in real conditions of use in Beauty Care. ClinReal Online, a limited liability company with the authorized capital of 40.000 euros, was created in 2005 and constitutes the result of over twenty years of research devoted to the methods and techniques in clinical research and provision of services. ClinReal Online collaborates with the industrialist and his teams of research and marketing throughout the process of development of the produced dermo-cosmetic and other products of care: methodological and organisational advice, monitoring, data management, biostatistics, exploitation and development of the results, administrative management of the relations between investigators and promoters, scientific papers, …

ZAC de Champ Lamet Rue de Chambussière Pont du Château, 63430 FranceCell&Co Biorepository offers a flexible, high-quality, secure, traceable and complete solution for any organization confronted with a problem related to the management or storage of biological or clinical samples.

218, avenue Marie Curie Archamps Technopole Archamps, 74160 FranceCapEval Pharma provides pharmaceutical consultancy services from early pre-clinical to clinical development, specifically in the sectors of Safety, Toxicology, Pharmacology, Ophthalmology, ADME/PK, analytical development, QA, CMC-Regulatory Affairs and Compliance. In addition, CapEval provides expert assessment for due diligence, veterinary drugs, cosmetics, agrochemicals and chemicals as well as staff training.

Calle Komentutxiki Kalea 28 , Hondarribia, , Gipuzkoa, 20280 SpainWho are we? ONDAX Scientific is an independent Contract Research Organisation (CRO) specialised in providing high quality Clinical Trial and Development services to the Pharmaceutical industry. Why choose ONDAX Scientific for your Clinical Trials? There are many reasons for choosing ONDAX Scientific, some of which include: A multidisciplinary, multilingual scientific team highly experienced in Clinical Trials and the Pharmaceutical Industry. A company structure that allows us to be totally flexible and highly responsive to individual client requirements. A working philosophy based on client focus, high quality standards and operating within agreed timelines. Our commitment We are totally committed to our projects: what's good for our clients is good for us. We only embark on a project if we have the human and technical resources to conduct and complete the project with guaranteed success. We commit to providing a professional, dedicated and high quality service to all our clients. Our references Since our creation in the year 2000, our portfolio of business clients has rapidly increased and today we collaborate with numerous companies in the pharmaceutical sector. Our clients range from large multinationals to small biotechnology companies with most of our clients choosing us as their Clinical Trial partners time and time again. This consistent high level of client satisfaction has made us one of the leading European specialists in Clinical Trials.

25-27 Avenue du Quebec BP 27627 Villebon-sur-Yvette , 91140 FranceOncodesign Services is a Contract research organization (CRO) specializing in drug discovery and preclinical services. Founded in 1995, Oncodesign Services mission’ is to contribute to the discovery of innovative therapies with unmet medical needs, in particular in oncology, inflammation and infectious diseases. From target identification, hit-to-lead and lead optimization to IND filing, Oncodesign Services support the R&D programs of customers globally (whether pharmaceutical companies, biotechs, public research institutions, etc.). Oncodesign Services offers a full spectrum of services in medicinal chemistry, DMPK, pharmaco-imaging, bioanalysis, in vivo/In vitro pharmacology (including humanized models). This continuum enables, either as stand-alone (SOLO) or as integrated (DRIVE) programs, the drug discovery of small molecule, molecular radiotherapy and biologicals entities. As a pioneer in translational medicine to evaluate the efficacy of treatments, the company challenge relies on increasing throughput, minimizing timelines from bench to bedside while having a differential proposition of treatment for patients and therefore innovative science. For that, Oncodesign Services has been creating new technological pathways to find and select the best drug candidates. Oncodesign Services has BSL1, BSL2 and BSL3 laboratories and all sites maintain the full AAALAC international accreditation for our animal care and use program. Based in Dijon, France, in the heart of the university and hospital cluster, within the Paris-Saclay cluster and in Montreal, Canada, Oncodesign Services benefits from 15,000m² of fully equipped chemistry and biologic laboratories. Oncodesign Services has 230 employees in France, United Kingdom, Germany, Canada and the United States, with highly competent in discovery research and translational pharmacology).

18, route du Panorama BP 6 Fontenay-aux-Roses cedex, 92265 FranceOncodesign Services is a Contract research organization (CRO) specializing in drug discovery and preclinical services. Founded in 1995, Oncodesign Services mission’ is to contribute to the discovery of innovative therapies with unmet medical needs, in particular in oncology, inflammation and infectious diseases. From target identification, hit-to-lead and lead optimization to IND filing, Oncodesign Services support the R&D programs of customers globally (whether pharmaceutical companies, biotechs, public research institutions, etc.). Oncodesign Services offers a full spectrum of services in medicinal chemistry, DMPK, pharmaco-imaging, bioanalysis, in vivo/In vitro pharmacology (including humanized models). This continuum enables, either as stand-alone (SOLO) or as integrated (DRIVE) programs, the drug discovery of small molecule, molecular radiotherapy and biologicals entities. As a pioneer in translational medicine to evaluate the efficacy of treatments, the company challenge relies on increasing throughput, minimizing timelines from bench to bedside while having a differential proposition of treatment for patients and therefore innovative science. For that, Oncodesign Services has been creating new technological pathways to find and select the best drug candidates. Oncodesign Services has BSL1, BSL2 and BSL3 laboratories and all sites maintain the full AAALAC international accreditation for our animal care and use program. Based in Dijon, France, in the heart of the university and hospital cluster, within the Paris-Saclay cluster and in Montreal, Canada, Oncodesign Services benefits from 15,000m² of fully equipped chemistry and biologic laboratories. Oncodesign Services has 230 employees in France, United Kingdom, Germany, Canada and the United States, with highly competent in discovery research and translational pharmacology).

25-27 Avenue du Québec Villebon-sur-Yvette , 91140 FranceOncodesign Services is a Contract research organization (CRO) specializing in drug discovery and preclinical services. Founded in 1995, Oncodesign Services mission’ is to contribute to the discovery of innovative therapies with unmet medical needs, in particular in oncology, inflammation and infectious diseases. From target identification, hit-to-lead and lead optimization to IND filing, Oncodesign Services support the R&D programs of customers globally (whether pharmaceutical companies, biotechs, public research institutions, etc.). Oncodesign Services offers a full spectrum of services in medicinal chemistry, DMPK, pharmaco-imaging, bioanalysis, in vivo/In vitro pharmacology (including humanized models). This continuum enables, either as stand-alone (SOLO) or as integrated (DRIVE) programs, the drug discovery of small molecule, molecular radiotherapy and biologicals entities. As a pioneer in translational medicine to evaluate the efficacy of treatments, the company challenge relies on increasing throughput, minimizing timelines from bench to bedside while having a differential proposition of treatment for patients and therefore innovative science. For that, Oncodesign Services has been creating new technological pathways to find and select the best drug candidates. Oncodesign Services has BSL1, BSL2 and BSL3 laboratories and all sites maintain the full AAALAC international accreditation for our animal care and use program. Based in Dijon, France, in the heart of the university and hospital cluster, within the Paris-Saclay cluster and in Montreal, Canada, Oncodesign Services benefits from 15,000m² of fully equipped chemistry and biologic laboratories. Oncodesign Services has 230 employees in France, United Kingdom, Germany, Canada and the United States, with highly competent in discovery research and translational pharmacology).

20 rue Jean Mazen Dijon, 21076 Cedex FranceOncodesign Services is a Contract research organization (CRO) specializing in drug discovery and preclinical services. Founded in 1995, Oncodesign Services mission’ is to contribute to the discovery of innovative therapies with unmet medical needs, in particular in oncology, inflammation and infectious diseases. From target identification, hit-to-lead and lead optimization to IND filing, Oncodesign Services support the R&D programs of customers globally (whether pharmaceutical companies, biotechs, public research institutions, etc.). Oncodesign Services offers a full spectrum of services in medicinal chemistry, DMPK, pharmaco-imaging, bioanalysis, in vivo/In vitro pharmacology (including humanized models). This continuum enables, either as stand-alone (SOLO) or as integrated (DRIVE) programs, the drug discovery of small molecule, molecular radiotherapy and biologicals entities. As a pioneer in translational medicine to evaluate the efficacy of treatments, the company challenge relies on increasing throughput, minimizing timelines from bench to bedside while having a differential proposition of treatment for patients and therefore innovative science. For that, Oncodesign Services has been creating new technological pathways to find and select the best drug candidates. Oncodesign Services has BSL1, BSL2 and BSL3 laboratories and all sites maintain the full AAALAC international accreditation for our animal care and use program. Based in Dijon, France, in the heart of the university and hospital cluster, within the Paris-Saclay cluster and in Montreal, Canada, Oncodesign Services benefits from 15,000m² of fully equipped chemistry and biologic laboratories. Oncodesign Services has 230 employees in France, United Kingdom, Germany, Canada and the United States, with highly competent in discovery research and translational pharmacology).

21, quai du Clos des RosesP.A.R.I.S provides antibody solutions that perform to life science clients worldwide. Solutions for biopharmaceutical industry are development of mouse monoclonal antibodies, production of pre-clinical batches of antibodies, cross-reactivity studies of antibodies.

Biopôle Clermont-Limagne Saint Beauzire, 63360 FranceProteodynamics specializes in protein and peptide characterization services including mass spectrometry, glycosylation analysis, sequencing, chromatography, and purification.

218-228, Avenue de Haut LévêquePhysica Pharma offers drug formulation development and delivery services.

62 Rte Nationale 113 Bernis, 30620 FrancePhylogene SA is an R&D and servicing lab in genomics, transcriptomics, (PCR, rtPCR, NGS) proteomics, metabolomics (LC-MS/MS and immunotechniques) dedicated bioinformatics. These applications are mainly services to food, cosmetics and health industries including in vitro diagnostics, and environment industry.

avenue de Sécheron 15 Switzerland Geneva, 1202 SwitzerlandQuartz Bio is a service company specialized in the computational analysis of biomarker data from clinical trials.

Avenue de Sécheron 15, Geneva, CH-1202 SwitzerlandQuartz Bio is a service company specialized in the computational analysis of biomarker data from clinical trials.

Paris, Île-de-France FranceCEPiA specializes in the manufacturing of opiates/opioids, coricosteroids, hormones, biotech, fermentation, prostaglandins and synthesis products.

7 Boulevard Jeanne d’Arc DIJON CEDEX 21079 BP 87900 FranceCOHIRO offers fee-for-services research and development activities to companies involved in the production of pharmaceutical products and dietary complements and to the chemical industry. COHIRO is a spin-off of the LPPCM (Laboratory of Cardio-Metabolic Pharmacology and Physiopathology) located in Faculty of Medicine and Pharmacy of the University of Burgundy in Dijon (France).

Marcy l'Étoile, FranceCynbiose est une société de services unique en Europe qui a pour but le développement et la commercialisation de modèles innovants dans les espèces primates afin d’accélérer les phases précliniques du développement des candidats médicaments. Nous mettons en œuvre des études exploratoires et nous développons également des modèles de pharmacologie dans les principales aires thérapeutiques afin d’établir un lien solide entre le développement préclinique et les phases cliniques. Nous souhaitons donner un sens aux services apportés à nos clients, convaincus que la qualité de la relation ainsi que la mise en commun de nos expertises sont des leviers essentiels pour assurer la réussite d’un projet.

Marcy l'Étoile FranceCynbiose est une société de services unique en Europe qui a pour but le développement et la commercialisation de modèles innovants dans les espèces primates afin d’accélérer les phases précliniques du développement des candidats médicaments. Nous mettons en œuvre des études exploratoires et nous développons également des modèles de pharmacologie dans les principales aires thérapeutiques afin d’établir un lien solide entre le développement préclinique et les phases cliniques. Nous souhaitons donner un sens aux services apportés à nos clients, convaincus que la qualité de la relation ainsi que la mise en commun de nos expertises sont des leviers essentiels pour assurer la réussite d’un projet.

Incubateur de l’Institut de la Vision (Voir et Entendre), 74 rue du Faubourg Saint Antoine, 75012 Paris – FranceCILcare is an R&D services company dedicated to hearing deficiencies. CILcare supports biotechs, medtechs and pharmas from all over the world in their preclinical and clinical development in hearing loss and tinnitus. CILcare has developed a unique lab platform gathering acoustic, electrophysiology, behavioral, histology and imaging technologies to perform preclinical efficacy studies on different models of hearing loss and tinnitus in rodents as well as pharmacokinetics studies to assess the exposure of the candidates in the inner ear and other targeted organs. The three founders began working on issues related to the aging population at pharma giant Sanofi – in complementary disciplines. They realized there was a niche but growing market servicing research into hearing deficiencies and founded CILcare in 2014. Today, the 9-person team is considered the worldwide leader of services in hearing research and development.

2196 Boulevard de la Lironde Parc Scientific Agropolis II Batiment 2 34980 Montferrier sur Lez FranceCILcare is an R&D services company dedicated to hearing deficiencies. CILcare supports biotechs, medtechs and pharmas from all over the world in their preclinical and clinical development in hearing loss and tinnitus. CILcare has developed a unique lab platform gathering acoustic, electrophysiology, behavioral, histology and imaging technologies to perform preclinical efficacy studies on different models of hearing loss and tinnitus in rodents as well as pharmacokinetics studies to assess the exposure of the candidates in the inner ear and other targeted organs. The three founders began working on issues related to the aging population at pharma giant Sanofi – in complementary disciplines. They realized there was a niche but growing market servicing research into hearing deficiencies and founded CILcare in 2014. Today, the 9-person team is considered the worldwide leader of services in hearing research and development.

Rond-Point B. Franklin - Cap Omega, CS39521 France Montpellier, Choisir, 34960 FranceCILcare is an R&D services company dedicated to hearing deficiencies. CILcare supports biotechs, medtechs and pharmas from all over the world in their preclinical and clinical development in hearing loss and tinnitus. CILcare has developed a unique lab platform gathering acoustic, electrophysiology, behavioral, histology and imaging technologies to perform preclinical efficacy studies on different models of hearing loss and tinnitus in rodents as well as pharmacokinetics studies to assess the exposure of the candidates in the inner ear and other targeted organs. The three founders began working on issues related to the aging population at pharma giant Sanofi – in complementary disciplines. They realized there was a niche but growing market servicing research into hearing deficiencies and founded CILcare in 2014. Today, the 9-person team is considered the worldwide leader of services in hearing research and development.

378 rue du Professeur Blayac Montpellier, Occitanie, 34080 FranceCILcare is an R&D services company dedicated to hearing deficiencies. CILcare supports biotechs, medtechs and pharmas from all over the world in their preclinical and clinical development in hearing loss and tinnitus. CILcare has developed a unique lab platform gathering acoustic, electrophysiology, behavioral, histology and imaging technologies to perform preclinical efficacy studies on different models of hearing loss and tinnitus in rodents as well as pharmacokinetics studies to assess the exposure of the candidates in the inner ear and other targeted organs. The three founders began working on issues related to the aging population at pharma giant Sanofi – in complementary disciplines. They realized there was a niche but growing market servicing research into hearing deficiencies and founded CILcare in 2014. Today, the 9-person team is considered the worldwide leader of services in hearing research and development.

378 rue du Professeur Blayac Montpellier, county (optional), 34080 FranceCILcare is an R&D services company dedicated to hearing deficiencies. CILcare supports biotechs, medtechs and pharmas from all over the world in their preclinical and clinical development in hearing loss and tinnitus. CILcare has developed a unique lab platform gathering acoustic, electrophysiology, behavioral, histology and imaging technologies to perform preclinical efficacy studies on different models of hearing loss and tinnitus in rodents as well as pharmacokinetics studies to assess the exposure of the candidates in the inner ear and other targeted organs. The three founders began working on issues related to the aging population at pharma giant Sanofi – in complementary disciplines. They realized there was a niche but growing market servicing research into hearing deficiencies and founded CILcare in 2014. Today, the 9-person team is considered the worldwide leader of services in hearing research and development.

ZA Air Space Avenue Magudas Le Haillan, 33185 FranceCreapharm offers clinical supply production, packaging, distribution, and logistic services.

Le Haillan, Aquitaine-Limousin-Poitou-Charentes, 33185 FranceCreapharm offers clinical supply production, packaging, distribution, and logistic services.

La Tronche, Auvergne-Rhône-Alpes, 38700 FranceCreaCell provides recombinant cell lines, cytotoxicity testing, efficacy testing, lipolysis, primary cultures, and genome integrity.

Technopole Montesquieu 2, Allée Ulysse Gayon MARTILLAC, 33650 FranceCovalX offers a complete solution for the full characterization of biotherapeutics. Our company is a leader in protein interaction analysis by mass spectrometry taking benefits of its unit technology platform (Epitope mapping HDX-MS and XL-MS; aggregation analysis, protein complex stoechiometry, cmpds/target interactions, SPR affinity analysis) . CovalX is offering all the analytical services for the characterization of your biotherapeutics: Denovo sequencing, LC-MS, MALDI-MS, Glycans characterization and the complementary analysis for the preparation of IND subimission following ICH-Q6B guidlines.

53 avenue Montaigne Paris, 75008 FranceWe are a consulting firm specialised in the fields of Global HEOR, Access and Pricing, informing Access and HTA strategy from early to late stage product development. For launch preparation, we provide integrated team of experts who develop all necessary core deliverables and strategic guidance for successful HTA submissions.

14 Rue de la Beaune Montreuil, 93100 FranceCherry Biotech is a world-class PharmaTech, French leader in early preclinical 3D cell culture and Organ on Chips/Microphysiological systems. Our expertise and technology allow maintaining vascularized and immunocompetent organoids of any organ in a standard multiwell plate. Already used by pharma and biotech companies in their early drug development phases (immuno- oncology, tox-efficacy, Pharmacokinetics), we are also providing services for proof of feasibility.

7 avenue du Hoggar Les Ulis, 91940 FranceCortecNet is a Stable Isotopes-driven company, devoted to identifying, developing and marketing innovative products in the fields of NMR, MS, MRI, and PET. These techniques play a key role in the characterization of the structure and dynamics of proteins, bio-molecules and materials, and in metabolic imaging applications. However, their success strongly relies on labeling techniques. The driving force of our company is therefore to providing to the MR and MS communities, both in academia and in industry, isotopically-enriched compounds the best adapted for their research purposes

144 rue de la GibauderieSynexel offers analytical chemistry, biomarkers, clinical studies, kinetic studies, formulation, and bioanalytical methods in diverse species and matrices.

28 Quai Pierre Scize Lyon, 69009 FranceCARPACCIO.cloud operates in the Digital Pathology space offering a custom, high throughput quantitative and qualitative histological image-analysis service with unsurpassed quality and speed. Currently focusing on muscle cross-sections and biopsies, we measure key parameters, presented in an easy to read report to assist the pathologist in formulating a diagnostic or the researcher in appreciating the physiological state of the tissue. Our solution is distributed as a full-service and will soon be available via internet anywhere in the world!

28 Quai Pierre Scize Lyon / Auvergne Rhône-Alpes, Rhône, 69009 FranceCARPACCIO.cloud operates in the Digital Pathology space offering a custom, high throughput quantitative and qualitative histological image-analysis service with unsurpassed quality and speed. Currently focusing on muscle cross-sections and biopsies, we measure key parameters, presented in an easy to read report to assist the pathologist in formulating a diagnostic or the researcher in appreciating the physiological state of the tissue. Our solution is distributed as a full-service and will soon be available via internet anywhere in the world!

Zone Industrielle de Camagnon Ploërmel, Bretagne, 56800 FranceCapsugel provides, dosage form development, powder formulation, capsule gels, and filling equipment.

Bâtiment Laennec 60 avenue ROCKEFELLER LYON , 69008 FranceCalixar develops new approaches to isolate in solution - with the highest purity levels - full-length membrane antigens and proteins (GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins), while keeping their structural and functional integrity. Calixar’s approach represents an opportunity for pharmaceutical companies to start and work with high quality targets or antigens before formulating vaccines, developing antibodies, and/or discovering a primary lead through Structure Based Drug Design or High Throughput Screening assays. CALIXAR's team is trained to perform ligand binding assays using the MicroScale Thermophoresis (MST) combined with Isothermal Spectral Shift detection. This cutting-edge technology offers to scientists and researchers the possibility to obtain accurate ligand binding parameters and compare several ligands in terms of binding properties. Thanks to the Monolith X (Nanotemper) device, CALIXAR enhances its analytical capabilities for characterizing protein-ligand interactions adapted to a wide range of membrane targets (GPCRs, ion channels, transporters, enzymes, …).

384 chemin des fontaines St Maximin la Ste Baume, 83470 FranceCytobodX is a french biotech company based in Marseille. At CytobodX, we produce, purify and characterize soluble and membrane proteins using state-of-the-art technologies to meet the specific needs of your research. The originality of CytobodX is to be able to rapidly produce native membrane proteins by using an innovative technology. Membrane proteins are directly expressed and embedded on the surface of purified Extracellular Vesicles (EVs) and ready for downstream applications : Interaction or functional studies, structural characterization or antibody/nanobody generation. This technology allows CytobodX to guarantee optimal quality and stability of the proteins produced and marketed.

170 traverse dy Rayol Saint Maximin la Sainte Baume, 83470 FranceCytobodX is a french biotech company based in Marseille. At CytobodX, we produce, purify and characterize soluble and membrane proteins using state-of-the-art technologies to meet the specific needs of your research. The originality of CytobodX is to be able to rapidly produce native membrane proteins by using an innovative technology. Membrane proteins are directly expressed and embedded on the surface of purified Extracellular Vesicles (EVs) and ready for downstream applications : Interaction or functional studies, structural characterization or antibody/nanobody generation. This technology allows CytobodX to guarantee optimal quality and stability of the proteins produced and marketed.

74 Rue Des Suisses Nanterre, 92000 FranceCliniSciences is a French company headquartered in Paris. CliniSciences is a distributor products & services from suppliers based all around the world. CliniSciences owns 10 other companies (Anawa, Biotrend, Generon, Hexabiogen, Kyvobio, Quimigen) based throughout Europe including the United Kingdom, Germany, Spain, Italy, The Netherlands & Switzerland. Through these companies we offer life science reagents, services and instruments. We sell products & services for research and diagnostic use. Products include reagents, cells, human samples and more. Services include antibody development, peptide synthesis, bulk manufacture, humanization and more.

74 rue des Suisses Nanterre, France, 92000 FranceCliniSciences is a French company headquartered in Paris. CliniSciences is a distributor products & services from suppliers based all around the world. CliniSciences owns 10 other companies (Anawa, Biotrend, Generon, Hexabiogen, Kyvobio, Quimigen) based throughout Europe including the United Kingdom, Germany, Spain, Italy, The Netherlands & Switzerland. Through these companies we offer life science reagents, services and instruments. We sell products & services for research and diagnostic use. Products include reagents, cells, human samples and more. Services include antibody development, peptide synthesis, bulk manufacture, humanization and more.

Batiment A16, 5 avenue Lionel TERRAY MEYZIEU, Rhone, 69330 FranceCTIBiotech develops and produces predictive models of human cells and tissues for biomedical, pharmaceutical and dermato-cosmetic research and development. CTIBiotech is home to a team of world-renowned experts who have innovated in the fields of bioengineering and regenerative medicine over the past 30 years. CTIBiotech works in partnership with public and private organizations to develop innovative solutions for efficacy and safety testing of active ingredients, dermatocosmetic products, therapeutic candidates, cell therapies and medical devices. CTIBiotech is organized around three divisions. CTIBiosourcing®: a large human cells and tissue biobank with dedicated human biological samples procurement team, manufacturing of biological models, cells and human tissues. More than 50,000 tissue samples in stock or on demand for biological supply from a network of 200 healthcare partners around the world. Please check our catalogue of cells and tissue products and current biobank inventory: http://ctibiotech.com/news/Official_CTIBiotech_PriceList_NOPRICE_2022.pdf http://ctibiotech.com/news/CTIBioBank_Inventory_TL20210301v1.xlsx Further to this, CTIPharma™ open innovation (model development) and services (contract testing) activities to support drug development, biologics, medical device in oncology, immuno-oncology & regenerative medicine. CTISkin™ open innovation (model development) and services (contract testing) activities to support your skin biology safety & efficacy evaluation projects. Our human tissue models are of three types; Ex Vivo: skin biopsy, scalp biopsy, baby skin model, sebaceous gland model etc Blood samples, bone marrow samples, tumour and cancer biopsies (lung, prostate, pancreas, liver, breast, ovary, head & neck, colorectal, haematological malignancies, etc). In Vitro: with a qualified and accredited Biobank of several thousand cell samples from donors of different ages, genders, phototypes Keratinocytes, Fibroblasts, Sebocytes, Melanocytes, Dermopapilla, Immune cells etc A range of cancer cell types and cancer associated fibroblasts. 3D Bioprinted human Skin: Our 3D bioprinted skins have a defined structure with a functional basement membrane separating a dermis (containing fibroblasts) from the epidermis (containing keratinocytes at different levels of maturation/cornification). These models are derived from single human donors and can be supplemented with other cell types depending on the model required for the efficacy claim being made. For example, the immune system (involved in inflammation or allergies), melanocytes (involved in pigmentation) or sebocytes (involved in acne, oily skin, dry skin). Research into the involvement of the M1 and M2 immune pathways in the different stages of inflammation has led us to produce models suitable for screening the safety and efficacy of ingredients, formulated or finished products, cosmetic or medical devices. CTIBioTumor cancer research bioassays accurately reproduce, in vitro, the interactions between human cancer cells and all other types of cells that form the tumor microenvironment. Delivery of standardised skin models to your laboratories: => CTISkin™Ex vivo kit. This new product is a standardised and ready-to-use solution for your efficacy and safety tests. Collected immediately after surgery, we provide you with the freshest possible skin biopsies that can be used for up to 11 days. Suitable for all ex vivo skin bioassays including: ✔ Anti-pollution test ✔ Hydration test ✔ Revitalisation test ✔ Healing test ✔ Sun protection test ✔ Anti-inflammatory test ✔ etc Also => CTISkin™ dermatomed frozen skin Dermatomed skin samples frozen after surgery and delivered to your laboratory And also => CTISkin™ Single Donor Kit Provides access to primary human cells from a single donor to support your ethical and regulatory compliant in vitro bioassays. Included in the kit are: ✔ From 2 to 6 primary cell types (keratinocytes, fibroblasts, adipocytes, sebocytes, melanocytes, blood cells) from the same donor. ✔ Cell culture media defined for each cell type: CTISKIN reagent. ✔ Certificate of analysis ✔ Recommended protocol ✔ Data sheet

60 Avenue Rockefeller Bâtiment BioSerra 2 Lyon, 69008 FranceCellenion is a company offering solutions and technologies for controlled cell dispensing with applications in the field of single-cell isolation and spheroid and oirganoïd sorting. Cellenion has developed cellenONE®, a revolutionary platform for automated single cell isolation and dispensing. Gentle piezo-acoustic technology, combined with an optical setup for automated image based selection, cellenONE allows high throughput manipulation of single cell while providing outstanding precision unlike any other dispensing and microfluidic platforms. These features make it an ideal platform for both cloning applications and sample preparation prior to single cell analyses. By precisely dispensing single cells and reagents in picoliter droplets, cellenONE® is compatible with a range of substrates from microplates (384, 1536wp) to microwells substrates. The later allow drastic reduction in reaction volumes and subsequently costs per single-cell analysis. Additionally, ability to work with minute volume and cell numbers makes cellenONE a unique platform for single cell isolation from small biopsies or other rare cell samples. Indeed, recent collaborative work with leading researchers has demonstrated unseen cell recovery (> 95%) from minute patient samples (< 5µL) containing fewer than 100 cells. This platform is now allowing researchers and clinicians alike new insights in samples that were previously not analysable using other single cell analytical techniques. Recently, Fluorescent Image Based Single Cell Isolation technology (FIBSCITM ) was launched. It now allows the use of fluorescent markers to select only single cell of interest. Initial investigations have demonstrated its benefit for excluding dead cells and also enrichment of cancer cells of interest from mixed cell population for both cloning and single cell sequencing applications.

60 Avenue Rockefeller Lyon, Auvergne-Rhône-Alpes, 69008 FranceCellenion is a company offering solutions and technologies for controlled cell dispensing with applications in the field of single-cell isolation and spheroid and oirganoïd sorting. Cellenion has developed cellenONE®, a revolutionary platform for automated single cell isolation and dispensing. Gentle piezo-acoustic technology, combined with an optical setup for automated image based selection, cellenONE allows high throughput manipulation of single cell while providing outstanding precision unlike any other dispensing and microfluidic platforms. These features make it an ideal platform for both cloning applications and sample preparation prior to single cell analyses. By precisely dispensing single cells and reagents in picoliter droplets, cellenONE® is compatible with a range of substrates from microplates (384, 1536wp) to microwells substrates. The later allow drastic reduction in reaction volumes and subsequently costs per single-cell analysis. Additionally, ability to work with minute volume and cell numbers makes cellenONE a unique platform for single cell isolation from small biopsies or other rare cell samples. Indeed, recent collaborative work with leading researchers has demonstrated unseen cell recovery (> 95%) from minute patient samples (< 5µL) containing fewer than 100 cells. This platform is now allowing researchers and clinicians alike new insights in samples that were previously not analysable using other single cell analytical techniques. Recently, Fluorescent Image Based Single Cell Isolation technology (FIBSCITM ) was launched. It now allows the use of fluorescent markers to select only single cell of interest. Initial investigations have demonstrated its benefit for excluding dead cells and also enrichment of cancer cells of interest from mixed cell population for both cloning and single cell sequencing applications.

102, avenue Gaston Roussel Romainville, Ile de France, 93230 FranceCyprio develops and commercializes physiologically-relevant 3D models: 1/- 3D organoids of primary human and rat hepatocytes,(HepatoPearls) and of HepaRG cell lines (HCLPearls), encapsulated within alginate solution, allowing self assembly of cells in organoids in less than 7 days, protection of these organoids, easy manipulation, and high throughput measures of DMPK, toxicity, DDI ... 2/- A customized encapsulation service for any cell line provided by our clients (cancer line, kidney, intestine, etc...) to grow organoids (e.g. for disease modeling, or subcloning of cancer lines). Cyprio's cutting edge patented technology (originated from ESPCI) is based on the high throughput encapsulation of a precise number of cells within a liquid-core alginate capsule. In this porous microenvironment, the cells can self-assemble to form a 3D structure, which more accurately reproduces functionalities of the tissue under study than monolayer 2D cell cultures. These easy to handle organoids are adaptable to any bioassay (number of organoids capsules per well from 1 to 200) or bioimaging , and can predict liver in vivo response with improved precision and can represent an interesting alternative to animal models For more information, see our web site : https://www.cyprio.fr/

6 Rue Jean Calvin IPGG - 2nd floor Paris, 75005 FranceCyprio develops and commercializes physiologically-relevant 3D models: 1/- 3D organoids of primary human and rat hepatocytes,(HepatoPearls) and of HepaRG cell lines (HCLPearls), encapsulated within alginate solution, allowing self assembly of cells in organoids in less than 7 days, protection of these organoids, easy manipulation, and high throughput measures of DMPK, toxicity, DDI ... 2/- A customized encapsulation service for any cell line provided by our clients (cancer line, kidney, intestine, etc...) to grow organoids (e.g. for disease modeling, or subcloning of cancer lines). Cyprio's cutting edge patented technology (originated from ESPCI) is based on the high throughput encapsulation of a precise number of cells within a liquid-core alginate capsule. In this porous microenvironment, the cells can self-assemble to form a 3D structure, which more accurately reproduces functionalities of the tissue under study than monolayer 2D cell cultures. These easy to handle organoids are adaptable to any bioassay (number of organoids capsules per well from 1 to 200) or bioimaging , and can predict liver in vivo response with improved precision and can represent an interesting alternative to animal models For more information, see our web site : https://www.cyprio.fr/

10 Rue Vauquelin Paris, 75005 FranceCyprio develops and commercializes physiologically-relevant 3D models: 1/- 3D organoids of primary human and rat hepatocytes,(HepatoPearls) and of HepaRG cell lines (HCLPearls), encapsulated within alginate solution, allowing self assembly of cells in organoids in less than 7 days, protection of these organoids, easy manipulation, and high throughput measures of DMPK, toxicity, DDI ... 2/- A customized encapsulation service for any cell line provided by our clients (cancer line, kidney, intestine, etc...) to grow organoids (e.g. for disease modeling, or subcloning of cancer lines). Cyprio's cutting edge patented technology (originated from ESPCI) is based on the high throughput encapsulation of a precise number of cells within a liquid-core alginate capsule. In this porous microenvironment, the cells can self-assemble to form a 3D structure, which more accurately reproduces functionalities of the tissue under study than monolayer 2D cell cultures. These easy to handle organoids are adaptable to any bioassay (number of organoids capsules per well from 1 to 200) or bioimaging , and can predict liver in vivo response with improved precision and can represent an interesting alternative to animal models For more information, see our web site : https://www.cyprio.fr/

201 Route de Genas VILLEURBANNE, 69100 FranceCYPATH-RB is a company dedicated to research and development in pathology. Part of the CYPATH Group, which analyzes more than 700,000 samples per year, CYPATH-RB provides researchers, pharmaceutical groups or CROs with human biological samples analyzed as part of the treatment. CYPATH-RB thus provides digitized slides (HE and / or HES) as well as biological samples (FFPE, +/- fresh tissue) annotated on the histopathological, molecular +/- clinical level. CYPATH-RB also offers technical and medical services in tumor pathology. Finally, CYPATH-RB has specialized in the co-development and clinical validation of artificial intelligence tools in pathology, wishing to become a major player in digital pathology and clinical research in France. The 100% digital turn for all routine diagnostics of the CYPATH group is part of this desire. Contact: cypath-rb@cypath.fr

280 rue de l'Hers Escalquens, 31750 FranceCardiomedex is specialized in cardiovascular diseases and complications (heart failure with reduced or preserved ejection fraction (HFpEF), myocardial infarction, cardiac arrhythmia, cardiac hypertophy, heart failure, hypertension).

1 place Pierre Potier Toulouse, Toulouse, 31100 FranceBeCytes Biotechnologies is a biotechnological company that offers products and services (CRO) based on tissue procurement, cell isolation, and cell solutions for in vitro models addressed to the research community worldwide. The company’s main focus is the isolation and full characterization of primary human and animal hepatic and skin cells, as well as providing different tissue explants (pathological and healthy donors), together with CRO services related to our cells and tissues. BeCytes Biotechnologies offers an extensive portfolio of *fresh and cryopreserved human and animal cells*. Among others, plateable and suspension *hepatocytes, stellates, Kupffers, hepatic endothelial, liver sinusoidal endothelial cells, liver subcellular fractions, skin fibroblasts, and keratinocytes*. Some of BeCytes competitive advantages are: • Access to unlimited healthy and pathological human tissue • High expertise in cell isolation and cryopreservation with proprietary protocols • End-to-end control of the whole isolation process, from organ procurement to cell distribution • Production of Human hepatocytes and NPCs from the same donor • Extensive donor medical information • Adapted Liver Cells Conditions and CRO services • Logistic expertise to distribute fresh and cryopreserved cells • Laboratory with GMP conditions under requirement

10-12 rue Roland Moreno Frépillon, 95740 FranceFor over 35 years, Cerba Research has been setting the industry standard for exemplary Laboratory conduct. Today, across five continents, with a focus on precision medicine, we are changing the paradigm of the central lab’s role in complex clinical research. From protocol inception through development and to market, our passionate experts deliver the highest quality specialized and personalized laboratory and diagnostic solutions. Cerba Research provides testing in therapeutic areas such as Cardiovascular diseases, Infectious diseases (microbiology, vaccine studies on virology and other IDs), Inflammatory disorders, Autoimmune diseases, Oncology, Metabolic diseases and Rare/Orphan diseases. Performing testing from Phase I to Phase IV studies. Cerba Research’s central lab services include routine testing, custom assay development, biobanking & storage, global project management & logistical support, operational support (including logistics, sample handling, kit building & data management) and artificial intelligence.

RN 13, ROUTE de PACY Miserey, 27930 FranceFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

329 Impasse Du Domaine Rozier Saint Germain-Nuelles, Lyon, 69210 FranceFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

9, allée du Moulin Berger Ecully, 69130 FranceFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

1 Rue Graham Bell Zi De Brais CS 40309, Saint-Nazaire, 44605 FranceFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

RN 13 Route de Pacy, Miserey, 27930 FranceFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

2109 Route De Châtillon Domaine des Oncins Nuelles, Romans, 01400 FranceFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

2109 Route De Chatillon Chatillon-sur-Chalaronne, Oncins Nuelles, 1400 FranceFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

Les Oncins Saint Germain , Nuellles, 69210 FranceFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

329 Impasse Du Domaine Rozier Saint-Germain-Nuelles, 69210 FranceFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

1 RUE GRAHAM BELL Zi De Brais CS, Saint-Nazaire, 44605 FranceFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

Lyon, FranceDendritics provides dendritic cell antibodies and dendritic cell related services.

BP61 - 27 chemin des peupliers- 69572 Dardilly FranceDendritics provides dendritic cell antibodies and dendritic cell related services.

Lyon, Auvergne-Rhône-Alpes FranceDendritics provides dendritic cell antibodies and dendritic cell related services.

6 rue du Noyer Roissy-en-France, Roissy CDG, 95 734 FranceFounded in 2000, DIVERCHIM is the leading French company for organic synthesis of original molecules bringing its customers a top level expertise. DIVERCHIM is a Contract Research Organisation (CRO) in organic chemistry. Our teams combine experience in drug discovery and process development, medicinal chemistry, parallel synthesis, biochemical tools and fine chemicals to deliver you with unique chemistry solutions to achieve your requirements. Diverchim specifies in complex multi-steps synthesis, low temperature chemistry, asymmetric, organometallic, cyclopropane, pyrrolidine, oxetane chemistry... Besides Diverchim can scale-up existing processes or develop a new process for existing products. Our Custom Synthesis capabilities range from mg to cGMP kilogram scale. DIVERCHIM offers reference products for screening and building blocks for discovery (catalog).

15, rue du Helder Paris, 75 439 FranceDanone focuses on research in nutrition, microbiology, immunology, and neuroscience.

5 rue Jean-Baptiste Clément Châtenay-Malabry, 92290 FranceDrugabilis offer includes solubility screenings, polymorphism, salt selection, crystallization test, formulation for animal dosing, or phase I formulation strategy set-up…

1 Place Pierre Potier Toulouse, Occitanie, 31100 FranceDIVA Expertise is a French preclinical CRO specialized in applied research on Human adipose tissue. We assess the efficiency of test items on our in vitro and ex vivo models we developed from Human adipose tissue. The aim is to bring either the first proof-of-concepts OR the preclinical proof of efficiency of your items. To achieve these goals, DIVA Expertise has set-up state-of-the-art technologies in cell and molecular biology, imaging and biochemistry; as well as an established and functional network with renowned facilities and clinical partners. DIVA Expertise assists you in the optimization of your R&D projects, the identification of novel targets and shorten the time to market of your final products.

Chemin de Mazerolles IDRON, 64320 France, EuropeDBI offers high potency products and manufacturing services for APIs, cytotoxics, peptides, proteins, monoclonal antibodies, and vaccines.

169 rue des Cordineaux Dommartin, 69380 FranceDriving impactful solutions on the use and protection of research animals and alternatives Life science services including: - Institutional and corporate life science strategy - Assessment and performance of animal care and use program, - Establishment and promotion of 3Rs program and ethics - Externalisation of animal studies and supply - Management of risks, image and reputation - Setting a culture of care and staff engagement And more...

42 rue de glatigny vernon, 27200 FranceDeepLife is a pioneering biotech company that leverages the power of artificial intelligence to revolutionize the drug development pipeline. By providing an ever-expanding catalog of harmonized single-cell omics datasets and comprehensive atlases for specific diseases and organs, DeepLife empowers researchers, pharmaceutical companies, and biotechnology firms with the insights they need to drive innovation and achieve breakthroughs in understanding complex biological systems. With a mission to create digital twins of cells, DeepLife aims to streamline drug discovery by identifying molecular triggers that can revert cells to a healthy state. Our innovative approach combines multi-omics data, machine learning, and systems engineering, working collaboratively to transition laboratory discoveries directly to patient care. Through its commitment to data quality, constant updates, and customer-centric approach, DeepLife stands at the forefront of the single-cell revolution.

8 Rue Jean Antoine de Baïf Paris, 75013 FranceDeepLife is a pioneering biotech company that leverages the power of artificial intelligence to revolutionize the drug development pipeline. By providing an ever-expanding catalog of harmonized single-cell omics datasets and comprehensive atlases for specific diseases and organs, DeepLife empowers researchers, pharmaceutical companies, and biotechnology firms with the insights they need to drive innovation and achieve breakthroughs in understanding complex biological systems. With a mission to create digital twins of cells, DeepLife aims to streamline drug discovery by identifying molecular triggers that can revert cells to a healthy state. Our innovative approach combines multi-omics data, machine learning, and systems engineering, working collaboratively to transition laboratory discoveries directly to patient care. Through its commitment to data quality, constant updates, and customer-centric approach, DeepLife stands at the forefront of the single-cell revolution.

Chemin des Aulx, 16 Plan-les-Ouates, Geneva, 1228 Switzerland

213 rue de Gerland Bâtiment C LYON, 69007 FranceDésirade is a small application programming company for the trades.

116 route d'Espagne BAL 511 – Bât. Hélios 5 – 3ème étage TOULOUSE, 31100 FranceDésirade is a small application programming company for the trades.

L'Orme des Merisiers Départementale 128 Saint Aubin, 91190 FranceShareholding of the French public centers CNRS and CEA, SOLEIL serves the international scientific community and industry. It is also a place for dissemination of scientific culture. Accelerator for innovation, growth and business competitiveness, SOLEIL makes available advanced skills and high performance equipment to manufacturers and industry service providers, and involves scientific instrumentation companies in its technological research: upstream within the framework of collaborative projects and downstream in the industrial and commercial exploitation of innovative devices designed by its teams.

Rue des Adèles Bâtiment 440 Orsay, 91400 FranceAccelerate and de-risk the development of Biotech/Pharma therapeutic antibodies with an integrated optimization solution to achieve expected characteristics in less than 3 months.

DRF – Institut Joliot /SIMoS Bât. 152 Pièce 35A Gif-sur-Yvette Cedex , F-91191 FranceAccelerate and de-risk the development of Biotech/Pharma therapeutic antibodies with an integrated optimization solution to achieve expected characteristics in less than 3 months.

DRF – Institut Joliot /SIMoS/Bât. 152 Pièce 35A Gif-sur-Yvette Cedex , F-91191 FranceAccelerate and de-risk the development of Biotech/Pharma therapeutic antibodies with an integrated optimization solution to achieve expected characteristics in less than 3 months.

Marseille, Provence-Alpes-Côte d'Azur FranceSyncrosome - your partner in preclinical in vitro and in vivo drug evaluation. Our pharmacological expertise is centred in three areas: 1) In vitro Proof of Efficacy in the fields of CNS ( Parkinson, Stroke, Alzheimer and Neuroinflammation) 2) In vivo Proof of Efficacy - in the fields of respiratory system, cardiovascular system, gastroenterology and central nervous system. 3) Early Pharmacokinetics - on different species 4) Early Safety - using innovative and appropriate methods of functional exploration

BIOPARC 850 Boulevard Sébastien Brant 67400 ILLKIRCH-STRASBOURG FranceDomain Therapeutics NA (DTNA) Inc. specializes in G Protein-Coupled Receptor (GPCR) and Receptor Tyrosine Kinase (RTK) signaling and function. Our BRET-based bioSensAllTM biosensor technology allows for detailed and broad-spectrum signaling profiling of GPCRs, RTKs and their ligands, while leaving these receptors untagged. This technology revolves primarily around the real-time monitoring of receptor proximal events immediately linked to the transmembrane receptor activity, namely heterotrimeric G protein activation and β-arrestin coupling for the GPCRs, and SH2-domain proteins for the RTKs. The GPCR assay brings the unique capacity to quantify the engagement of 14 distinct heterotrimeric G protein subtypes as well as both non-visual β-arrestin isoforms. The RTK assay gives the possibility to follow the recruitment of various SH2-domain proteins and study the complete trafficking of these receptors. Both assays provide a complete and detailed fingerprint of any GPCR / RTK ligand and allow to study the impact of receptor mutations on their signaling. This data is particularly valuable in a screen / early drug development program to select and optimally design your lead compound. Domain Therapeutics applies a multi-string corporate strategy to grow its business through: validation of its technologies through collaborative partnerships with Pharma/Biotechs, generation of an internal pipeline of 1st in class drug candidates for high unmet needs in CNS and oncology, valuation of its preclinical assets through spin-out vehicles, financed by leading investment funds or supported by development-only companies.

54 Rue Dunois Paris, 75013 FranceIntelligent and Automated Flow Cytometry Panel Design Platform.

51, avenue de Paris 94300 VINCENNES FranceIn 1969, Pr Philippe Masson creates Evic Ceba, laboratory located in Bordeaux, France, designated to pharmacological and toxicological experiments. The success of this first company and the expertise of its scientists naturally lead to the extension of the know-how to the global exploration of ingredients and products from the pharmaceutical, cosmetic, chemical and food fields: in 1987, creation of Evic Idec, clinical research organization on healthy subjects; in 1991, foundation of in vitro / ex vivo department (Evic Bio). In 2000 Evic Ceba becomes Evic France and expands its capacities abroad. In a world of internationalisation of the needs of the industry and globalisation of the markets, Evic France enlarges its service offer and creates with local partners research and evaluation centres in Brazil, Romania, Italy, Spain, China, thus introducing the renown “Evic” label. To optimize this new network of laboratories, EVIC International is created in 2005, meant to manage independently the group organisation and functioning. The purpose of EVIC International is to coordinate and harmonize the activity of the companies and induce them on a common level of excellence.

Avenue de JouquesSartorius Stedim BioOutsource Ltd. is a leading provider of contract testing services to the global biopharmaceutical and biotechnology industries. BioOutsource has operations in both Europe and the USA, with testing laboratories in Glasgow, UK, and Cambridge, MA, USA. BioOutsource was founded in 2007 and was acquired by Sartorius Stedim Biotech in 2015. We are accredited for cGMP, GLP and GCP and provide contract testing services to assess the quality and safety of biologic drugs and vaccines including: A range of off-the-shelf assays for biosimilar characterization and comparability Biosafety testing of cell banks and bulk harvest as well as cell line stability and lot release At Sartorius, we don’t just perform contract testing services; we are committed to delivering service excellence, with an in-house R&D department, we are constantly adding to our existing portfolio of services to address market demands. Our innovative approach and client management model ensure’s projects are managed efficiently, cost-effectively and delivered on-time.

83 Avenue Philippe Auguste 75011 Paris FRANCEElveflow® focuses on the development of high performance and Plug and Play flow control systems fitted to microfluidic research. We provide the only microfluidic flow control systems using Piezo technology and that enable blazing fast flow changes in your microdevice. Our team develops microfluidic instruments with unrivaled performances in accordance to researchers’ needs. Our product line is built around the best seller OB1 flow controller and includes all that is needed to control your microfluidic chip. All our instruments can be controlled at once on the same computer, through our software or Standard Development Kits.

172 Rue de charonne Paris 11, 75011 FranceElveflow® focuses on the development of high performance and Plug and Play flow control systems fitted to microfluidic research. We provide the only microfluidic flow control systems using Piezo technology and that enable blazing fast flow changes in your microdevice. Our team develops microfluidic instruments with unrivaled performances in accordance to researchers’ needs. Our product line is built around the best seller OB1 flow controller and includes all that is needed to control your microfluidic chip. All our instruments can be controlled at once on the same computer, through our software or Standard Development Kits.

IRMB - Hopital Saint Eloi 80 avenue Augustin Fliche Montpellier Cedex 5, Hérault, 34295 FranceStem Genomics is a biotech company, located in France and in the USA, specialized in the design of innovative testing technologies for stem cells. A spin-out of the Institute for Regenerative Medicine & Biotherapy (IRMB) and co-founded by Prof. John de Vos and Dr. Said Assou, experts in stem cell genomic integrity, Stem Genomics has emerged from a prestigious scientific environment. Located at the heart of the University Hospital Centre of Montpellier, the IRMB houses research groups working on basic stem cell research and innovative applications for regenerative therapy with the aim of facilitating the transfer from research to clinical applications. Founded in 2018, we work with +150 clients worldwide, from academic institutions to biotech companies and core facilities. We service our North American clients from our laboratory based in the Research Triangle in Durham, North Carolina, and our European and other international clients from our headquarters in Montpellier, France. Stem Genomics is a team of passionate and committed individuals whose aim is to support research scientists in achieving qualitative and reliable cell lines for their work. We have developed in-house expertise in stem cells and in innovative genetic stability assay technologies which enable us to perform most of our tests on our own platform. In parallel, our R&D team is continuously developing latest generation quality controls assays. We pride ourselves on our reactivity and availability in our relationship with our clients throughout the process. Technologies we have selected for stem cell characterization: - Digital PCR (dPCR) is the most accurate PCR method for assessing the genetic integrity of stem cells through the detection of Copy Number Variants (CNVs). It is ideal for regular in-process controls and fast clone screening. - G-banding karyotyping is helpful in providing an exhaustive structural and numerical variant analysis. - Next-Generation Sequencing (NGS) offers a hypothesis-free approach that does not require prior knowledge of sequence information. NGS enables the simultaneous analysis of numerous genes, making it both feasible and cost effective. It is particularly well-suited to key stages in the workflow such as cell line acquisition, banking and/or end of workflow.

59, bd. Général Martial Valin 75015 Paris - FranceEmka TECHNOLOGIES develops, manufactures and sells hardware and software for studies in physiology, pharmacology and toxicology.

59, bd. Général Martial Valin Paris, 75015 FranceEmka TECHNOLOGIES develops, manufactures and sells hardware and software for studies in physiology, pharmacology and toxicology.

ZA du Borrey -F-01100 MARTIGNAT FranceErcé plasturgie specializes in liquid dosing systems and primary packaging.

20 Boulevard du Roi René Aix-en-Provence, 13100 FranceMisson & Goals The mission of ESBB is to advance the field of biobanking in support of research relating to healthcare, agriculture and the environment. The goals of ESBB are as follows: Identify problems in the biobanking field and provide solutions. Encourage high professional standards in biobanking. Provide high value membership services for key actors in the biobanking field. Encourage participation from a wide range of repositories across the EMEA region. Provide a strong united voice for biobankers in the region, to influence development in their field.

10 rue Vauquelin Paris, 75231 FranceESPCI ParisTech offers laboratories focused in various areas including organic chemistry, neurobiology, and genetics.

450 rue Antoine Lavoisier Kergaradec III, Brest-Guipavas 29490 FranceEpsilon Chimie supplies chemical intermediates and offers custom synthesis and structural analysis services.

1 Place du 8 mai 1945 Hénin-sur-Cojeul, Hauts-de-France, 62128 FranceEssais+, a dynamic and growing company. Essais+, a private family and independent company, became a major actor in the development of agriculture projects with international companies. During all these years, we constantly innovated in order to adapt the demands of our customers for the agricultural market. 10% of the annual capital is devoted to investments, protection of operators and respect of the environment.

12-12 bis rue Jean Jaurès 92800 Puteaux • FranceELITech offers manufacturing and distribution of in vitro diagnostic equipment and reagents.

Puteaux, Île-de-France, 92800 FranceELITech offers manufacturing and distribution of in vitro diagnostic equipment and reagents.

94, chemin de la Peyrette 31170 Tournefeuille, FranceEurofins EAG Materials Science, LLC has a long history, dating back to the birth of the company in 1978 in California, as Charles Evans & Associates. Over the years we have expanded from a single location offering SIMS only to having over 200 employees offering over 30 different services via 14 locations in 8 different countries. The original focus of the company was supporting semiconductor manufacturing but now we also work with multiple further industries beyond semiconductors, including: solar/PV, lighting, photonics, energy storage, aerospace & defense, medical devices, raw materials, glass, polymers and plastics and consumer products. EAG's analytical expertise is what enables us to help our clients to meet their goals. Our on-demand analytical testing services can help streamline R&D, solve urgent problems during manufacturing and help resolve materials related issues in the global supply chain, both within and between organizations.

Annonay, Auvergne-Rhône-Alpes, 07100 FranceExcelvision offers full service manufacturing of pharmaceutics and cosmetics.

Parc d'Activité Bièvre Dauphine 100, rue Eugène Perrin Colombe, 38690 FranceExpert in immunotechnologies since 1980, BIOTEM is a hybrid Contract Research Organization (CRO) and Contract Manufacturing Organization (CMO) which provides high added value services for the development / production of custom monoclonal antibodies and immunoassays (ELISA & LFIA). Complying with ISO 9001:2008 Quality Standards, the company has been the privileged partner of more than 500 prestigious industrial and academic laboratories for their projects in fundamental research, development of improved diagnostics or generation of promising therapeutic tools. Based on a high level of expertise and exclusive technologies, BIOTEM implements the most relevant strategies for each project according to the client’s specifications. As a benefit, BIOTEM is keen to propose contracts with guaranteed results. From the generation of original monoclonal antibodies ̶ by hybridoma and Phage Display technologies ̶ through their production, characterisation (affinity & specificity determination, sequencing, stability studies,…) and immunoassay developments, BIOTEM offers a wide range of customised services.

26 rue d’Ulm Paris , 75248 FranceThe Institute Curie/CNRS Chemical Library was created from the chemical molecules synthesized by the chemists of the Institute Curie of Paris and Orsay. This academic chemical library, one of the most important of France, contains almost 10000 substances. Such a set of chemicals is constituted not only of the final products, but also of synthetic intermediates obtained during the programs of optimization against various therapeutic targets. Since its creation, 65 years ago, the main motivation of the chemistry laboratory of the Institute Curie has been the discovery of molecules for cancer treatment. A direct consequence of this activity is the existence (often in significant quantities) of samples of several thousands of synthesized compounds. Moreover, advances in proteomics and genomics have led to the discovery of an increasing number of new protein targets with therapeutic potential. The Chemical Library consists of 15,509 unique structures including 9891 compounds available in powder and 9200 compounds available in solution.

Gières, Auvergne-Rhône-Alpes FranceEurofins Optimed offers clinical research services including clinical pharmacology, data management, and project management.

34 rue Henri Matisse - BP 23 Lempdes 63370 FranceEUROPHARTECH manufactures pharmaceuticals and food supplements.

Paris, FranceExonHit Therapeutics provides clinical validation, diagnostic tests, and RNA splicing.

Paris, Île-de-France FranceExonHit Therapeutics provides clinical validation, diagnostic tests, and RNA splicing.

France

11 Rue Jacques Latrille Site Montesquieu Martillac, 33 650 FranceCHEMSTEP carries out contract research and developement in all areas of organic, medicinal chemistry and biotechnology.

Prologue Biotech, Quai C7/C8 516, rue Pierre et Marie Curie Labège, Midi-Pyrénées, 31670 FranceEnterosys has developed a solid expertise in quantification of nitric oxide (NO) and hydrogen peroxide (H2O2) in real time by amperometry. This technology makes it possible to quantify, in an absolute manner, the release of these two biomarkers of oxidative stress in different biological models: primary cell cultures or cell lines in 2 or 3D, in organs or in vivo in anesthesied animals. We offer different applications: - evaluation of the antioxidant capacities of your assets (chemical molecules, natural extracts, formulations ...) - comparative study of the efficacy of assets compared to a standard or bioactive molecule already on the market - development of stress models with an innovative approach for the creation of new lines of cosmetics (sensitizing agents, pollution, infectious agents, atopic dermatitis, hormonal imbalance ...)

229 cours de l'Argonne Bordeaux, 33000 FranceExplicyte offers a wide range of integrated and highly customizable drug R&D services (in vitro, in vivo and translational research). Our services range from cell-based assays - for the phenotypic screening of novel immunotherapeutics and the in vitro determination of the molecular mechanism of action of new anti-cancer immune modulators - to in vivo studies, using syngeneic mouse tumor models treated with antitumor immunotherapies. Furthermore, our comprehensive translational research platform spans from stainings to image artificial intelligence-based analysis, and is strongly suited to support digital pathology programs aiming at biomarker and/or novel target evaluation & identification.

Université Rennes 1 Plateforme H2P2 2 avenue du Pr Léon Bernard RENNES CEDEX, 35043 FranceSince its creation Excilone has developed an unique expertise in sample’s analysis through the image or the molecular content. We use what we sell and we sell what we use Our dual approach of service provider as well as vendor of our solutions brings us an unequaled expertise on the performance and the use of our products that benefit our customers. Pharmaceutical and cosmetic companies, academic research labs and other CROs are all users of our services. Our R&D department allows us to regularly supplement our offer as recently with the isolation, characterization and analysis of extracellular vesicles from any type of sampling (blood, urine, milk, tissues, …). Our services are aimed at all private and academic labs that need to use operational analysis techniques without having to invest in expensive devices which also are time consuming to set protocols and to validate them. To reply to the needs of the scientific community about the analysis of samples through images or molecular content Excilone offers a wide range of services in Microgenomics, Nanogenomics, and Cellular Imaging. As the understanding of biological phenomena is now done at the scale of the cell, Excilone presents you the excellence in epsilon quantity.

INRAE Domaine de Vilvert 4, avenue Jean Jaurès Bat221 JOUY EN JOSAS, 78352 FranceSince its creation Excilone has developed an unique expertise in sample’s analysis through the image or the molecular content. We use what we sell and we sell what we use Our dual approach of service provider as well as vendor of our solutions brings us an unequaled expertise on the performance and the use of our products that benefit our customers. Pharmaceutical and cosmetic companies, academic research labs and other CROs are all users of our services. Our R&D department allows us to regularly supplement our offer as recently with the isolation, characterization and analysis of extracellular vesicles from any type of sampling (blood, urine, milk, tissues, …). Our services are aimed at all private and academic labs that need to use operational analysis techniques without having to invest in expensive devices which also are time consuming to set protocols and to validate them. To reply to the needs of the scientific community about the analysis of samples through images or molecular content Excilone offers a wide range of services in Microgenomics, Nanogenomics, and Cellular Imaging. As the understanding of biological phenomena is now done at the scale of the cell, Excilone presents you the excellence in epsilon quantity.

6 Rue Blaise Pascal Élancourt, Île-de-France, 78990 FranceSince its creation Excilone has developed an unique expertise in sample’s analysis through the image or the molecular content. We use what we sell and we sell what we use Our dual approach of service provider as well as vendor of our solutions brings us an unequaled expertise on the performance and the use of our products that benefit our customers. Pharmaceutical and cosmetic companies, academic research labs and other CROs are all users of our services. Our R&D department allows us to regularly supplement our offer as recently with the isolation, characterization and analysis of extracellular vesicles from any type of sampling (blood, urine, milk, tissues, …). Our services are aimed at all private and academic labs that need to use operational analysis techniques without having to invest in expensive devices which also are time consuming to set protocols and to validate them. To reply to the needs of the scientific community about the analysis of samples through images or molecular content Excilone offers a wide range of services in Microgenomics, Nanogenomics, and Cellular Imaging. As the understanding of biological phenomena is now done at the scale of the cell, Excilone presents you the excellence in epsilon quantity.

84 Rue Bechevelin Lyon, 69007 FranceMathematician Specialist of modeling (PKPD, RL, AI technics, mechanistic modeling, ...) http://perso.ens-lyon.fr/egrenier/ Professor at the Ecole Normale Supérieure of Lyon Former associate professor at Ecole Polytechnique phD, phD Habil

7 Allées de chartre Bordeaux, aquitaine, 33000 FranceEphyX Neuroscience is a CRO specialized in in vitro electrophysiology applied to CNS-related preclinical research and drug discovery. Our goal is to help our clients optimize their compound selection by providing detailed mechanisms of action. Our highly qualified experts perform in vitro electrophysiological recordings on both rodent and human models, which makes our data truly predictive.

15 Rue Traversière Paris, 75012 FranceEUROAPI delivers as CDMO small molecules APIs, Oligonucleotides & Peptides and Ionizable Lipids for LNPs for R&D, clinical phases and commercial batches. Our TIDES & small molecule platform in Frankfurt is responsible for small non-GMP batches in R&D projects and doing process development and analytical development from small scale to large GMP batches supporting clinical phases 1/2/3. We also do chemical conjugations like GalNac, peptides, PEG, sugars, or small molecules. For R&D developments and small scale oligos (also GMP phase1) we use our facility from BianoGMP in Gera (Germany).

75 VOIE DU TOEC BP 57611 TOULOUSE, 31076 Franceprivate life sciences and agronomical engineering university with the status of a not-for-profit organization.

4, Rue Alexandre Fleming 69366 - LYON FranceEpiskin provides our worldwide clients RELIABLE AND RELEVANT IN VITRO TOOLS FOR SAFETY AND EFFICACY PROFILING Episkin, world leader in tissue engineering, is partnering with cosmetical, pharmaceutical and chemical industries to develop relevant and reliable safety and efficacy tests for decision making during research and development phases. Some screening tests are already referenced and validated as alternatives to animal use, and others are in the process of validation. Developed in the early 90, our unique cell culture process allows to mass produce in vitro various models of reconstructed human tissues with well characterized histology, functionality and ultrastructure features. The production unit is geared to serve every week our clients with thousands of human tissues.

45 rue des Saints Pères Paris, Ile-de-France, 75006 FranceEverZom develops a new manufacturing platform of large-scale cGMP grade exosomes for research purposes and clinical studies based on a unique proprietary process. Our process, based on turbulence stimulation allows in average a 10-fold higher and a 10-fold faster increase in EV production per cell compared to starvation method for different cell lines. We also provide characterization services with an NTA, an Exoview, a Videodrop from Myriade and a flow cytometry platform.

Bioparc-Batiment Adenine 60c Avenue Rockefeller LYON, 69008 FranceERBC Group is a leading CRO committed to bridge the gap between discovery, preclinical and clinical development by evaluating the efficacy and safety of new compounds including new therapies, drugs, medical devices, chemicals, agro-chemicals and cosmetics. Offering a comprehensive range of innovative models and services, regulatory pre-IND package and consultancy services, ERBC Group allows biopharmaceutical and chemical industry professionals to de-risk innovation and enhance R&D productivity.

43 Bd du Onze Novembre VILLEURBANNE, 69100 FranceERBC Group is a leading CRO committed to bridge the gap between discovery, preclinical and clinical development by evaluating the efficacy and safety of new compounds including new therapies, drugs, medical devices, chemicals, agro-chemicals and cosmetics. Offering a comprehensive range of innovative models and services, regulatory pre-IND package and consultancy services, ERBC Group allows biopharmaceutical and chemical industry professionals to de-risk innovation and enhance R&D productivity.

Parc de Lantarèse Baziège, 31450 FranceERBC Group is a leading CRO committed to bridge the gap between discovery, preclinical and clinical development by evaluating the efficacy and safety of new compounds including new therapies, drugs, medical devices, chemicals, agro-chemicals and cosmetics. Offering a comprehensive range of innovative models and services, regulatory pre-IND package and consultancy services, ERBC Group allows biopharmaceutical and chemical industry professionals to de-risk innovation and enhance R&D productivity.

1305, route Lozanne Dommartin, 69380 FranceERBC Group is a leading CRO committed to bridge the gap between discovery, preclinical and clinical development by evaluating the efficacy and safety of new compounds including new therapies, drugs, medical devices, chemicals, agro-chemicals and cosmetics. Offering a comprehensive range of innovative models and services, regulatory pre-IND package and consultancy services, ERBC Group allows biopharmaceutical and chemical industry professionals to de-risk innovation and enhance R&D productivity.

6 Rue des Champs Godin Saint-Laurent-Nouan, 41220 FranceERBC Group is a leading CRO committed to bridge the gap between discovery, preclinical and clinical development by evaluating the efficacy and safety of new compounds including new therapies, drugs, medical devices, chemicals, agro-chemicals and cosmetics. Offering a comprehensive range of innovative models and services, regulatory pre-IND package and consultancy services, ERBC Group allows biopharmaceutical and chemical industry professionals to de-risk innovation and enhance R&D productivity.

Chemin de Montifault BAUGY, 18800 FranceERBC Group is a leading CRO committed to bridge the gap between discovery, preclinical and clinical development by evaluating the efficacy and safety of new compounds including new therapies, drugs, medical devices, chemicals, agro-chemicals and cosmetics. Offering a comprehensive range of innovative models and services, regulatory pre-IND package and consultancy services, ERBC Group allows biopharmaceutical and chemical industry professionals to de-risk innovation and enhance R&D productivity.

17/19 Avenue Tony Garnier Lyon, 69007 FranceEurofins Biomnis is a member of the Eurofins Clinical Diagnostics France network of laboratories. This network pools a wide variety of disciplines together to create comprehensive, innovative clinical diagnostics solutions, embracing everything from clinical research to hyperspecialised clinical pathology. Specialised medical pathology Eurofins Biomnis focuses mainly on specialised pathology testing, which requires highly skilled expertise, and which cannot be performed in routine private or hospital-based laboratories. Eurofins Biomnis specialises in all areas of pathology and testing is performed using the most recent and cutting-edge techniques, which necessitate complex calibrations and validations, highly qualified experts and sophisticated equipment. Clinical trials The Clinical Trials Department at Eurofins Biomnis was created in 1998, and runs clinical studies and develops assay methods for the pharmaceutical industry.

2 Rue des Rochambelles Caen, Normandie, 14000 FranceETAP-Lab provides preclinical models and pharmacology services in the fields of Dermatology and Neurology. ETAP-Lab works for about 150 clients worldwide and performed more than 800 studies. The company has strong expertise in the field of Dermatology research to evaluate both drugs, regenerative approach (e.g. skin grafting) and medical devices. We offer a large portfolio in vivo rodent models such as chronic skin inflammation, ischemic ulceration, psoriasis, hyperkeratosis, wound healing, atopic dermatitis, actinic keratosis, skin cancer… ETAP-Lab is also leader in the field of preclinical stroke research with a unique portfolio consisting of innovative and translational models proposed under the brand STROK@LLIANCE. We also provide non GLP safety studies related to stroke (Hemorrhagic transformations, drug-drug interaction with the standard of care). It is the only CRO 100% dedicated to preclinical stroke research. The Strok@lliance Scientific Advisory Board is coordinated by a renowned scientist in the field of Stroke : Pr Denis Vivien (PhIND Laboratory, INSERM/Caen university). Also, ETAP-Lab provide both in vitro and in vivo services in the fields of Neurodegenerative diseases, namely Alzheimer's and Parkinson's diseases, based on its unique know-how in production of stable and soluble toxic oligomers (Amyloid-Beta 1-42 oligomers, Tau oligomers, Alpha-synuclein oligomers). With a largel panel of tools and methodologies, ETAP-Lab is also able to address most of routine protocols in rodents (stereotaxic injection, medical imagery, microsurgery). With more than 2 decades of experience, ETAP-Lab has become a best-in-class service provider for top tier Pharma, Medical device and Agri-food companies and obtained ISO9001:v2015 certification for all its preclinical services. ETAP-Lab provided customized solution for drug testing. Thus, our team is able to develop and customize relevant animal models with high translational value that fit to specific goals, from the proof-of-concept to the early development.

13 Rue du Bois de la Champelle Vandœuvre-lès-Nancy, Grand Est, 54500 FranceETAP-Lab provides preclinical models and pharmacology services in the fields of Dermatology and Neurology. ETAP-Lab works for about 150 clients worldwide and performed more than 800 studies. The company has strong expertise in the field of Dermatology research to evaluate both drugs, regenerative approach (e.g. skin grafting) and medical devices. We offer a large portfolio in vivo rodent models such as chronic skin inflammation, ischemic ulceration, psoriasis, hyperkeratosis, wound healing, atopic dermatitis, actinic keratosis, skin cancer… ETAP-Lab is also leader in the field of preclinical stroke research with a unique portfolio consisting of innovative and translational models proposed under the brand STROK@LLIANCE. We also provide non GLP safety studies related to stroke (Hemorrhagic transformations, drug-drug interaction with the standard of care). It is the only CRO 100% dedicated to preclinical stroke research. The Strok@lliance Scientific Advisory Board is coordinated by a renowned scientist in the field of Stroke : Pr Denis Vivien (PhIND Laboratory, INSERM/Caen university). Also, ETAP-Lab provide both in vitro and in vivo services in the fields of Neurodegenerative diseases, namely Alzheimer's and Parkinson's diseases, based on its unique know-how in production of stable and soluble toxic oligomers (Amyloid-Beta 1-42 oligomers, Tau oligomers, Alpha-synuclein oligomers). With a largel panel of tools and methodologies, ETAP-Lab is also able to address most of routine protocols in rodents (stereotaxic injection, medical imagery, microsurgery). With more than 2 decades of experience, ETAP-Lab has become a best-in-class service provider for top tier Pharma, Medical device and Agri-food companies and obtained ISO9001:v2015 certification for all its preclinical services. ETAP-Lab provided customized solution for drug testing. Thus, our team is able to develop and customize relevant animal models with high translational value that fit to specific goals, from the proof-of-concept to the early development.

13 rue du Bois de la Champelle Vandoeuvre-lès-Nancy, 54500 FranceETAP-Lab provides preclinical models and pharmacology services in the fields of Dermatology and Neurology. ETAP-Lab works for about 150 clients worldwide and performed more than 800 studies. The company has strong expertise in the field of Dermatology research to evaluate both drugs, regenerative approach (e.g. skin grafting) and medical devices. We offer a large portfolio in vivo rodent models such as chronic skin inflammation, ischemic ulceration, psoriasis, hyperkeratosis, wound healing, atopic dermatitis, actinic keratosis, skin cancer… ETAP-Lab is also leader in the field of preclinical stroke research with a unique portfolio consisting of innovative and translational models proposed under the brand STROK@LLIANCE. We also provide non GLP safety studies related to stroke (Hemorrhagic transformations, drug-drug interaction with the standard of care). It is the only CRO 100% dedicated to preclinical stroke research. The Strok@lliance Scientific Advisory Board is coordinated by a renowned scientist in the field of Stroke : Pr Denis Vivien (PhIND Laboratory, INSERM/Caen university). Also, ETAP-Lab provide both in vitro and in vivo services in the fields of Neurodegenerative diseases, namely Alzheimer's and Parkinson's diseases, based on its unique know-how in production of stable and soluble toxic oligomers (Amyloid-Beta 1-42 oligomers, Tau oligomers, Alpha-synuclein oligomers). With a largel panel of tools and methodologies, ETAP-Lab is also able to address most of routine protocols in rodents (stereotaxic injection, medical imagery, microsurgery). With more than 2 decades of experience, ETAP-Lab has become a best-in-class service provider for top tier Pharma, Medical device and Agri-food companies and obtained ISO9001:v2015 certification for all its preclinical services. ETAP-Lab provided customized solution for drug testing. Thus, our team is able to develop and customize relevant animal models with high translational value that fit to specific goals, from the proof-of-concept to the early development.

18 chemin des Aulx CH-1228 Plan-Les-Ouates Genève SwitzerlandEpithelix provides in vitro human tissues, high throughput screening, and chemical testing. Epithelix Sàrl provides alternative in vitro solutions to animal experimentation for evaluating the effects of drugs in development and assess the toxicity of chemical compounds on the human respiratory tract. The company is the European leading provider of in vitro reconstituted human respiratory tissues and related services to leading academic research laboratories. Epithelix also supplies and supports Personal Care, Medical Device, as well as Chemical and Pharmaceutical. Epithelix developed a unique technology allowing reconstituted tissues to be maintained at a homeostatic state for a long period of time; in other words, the tissues resemble the native tissue both morphologically and functionally (see our products page). The company focused initially on the respiratory system and marketed MucilAir™, the only human respiratory epithelium model able to remain fully differentiated and functional for more than one year. This model is commercialized and available in US, Europe and Asia.

195, route d'Espagne Campus Curie Toulouse, 31036 FranceEvotec is a global leader in drug discovery and development, offering extensive CRO and CDMO services across all stages of the R&D continuum, from target identification to the clinic, delivering efficient, high-quality, and cost-effective solutions. We integrate deep disease understanding, a multimodality approach, advanced technologies and tailored solutions to enhance the probability of success. Our innovative and flexible approach supports collaboration through standalone CRO/CDMO services, integrated drug discovery and development programs, or strategic partnerships, regardless of your stage in the discovery-development journey. Expertise in Modalities and Therapeutic Areas Our broad capabilities cover small molecules, antibodies, antibody drug conjugates, oligonucleotides, peptides, cell therapy, RNA-targeted therapies and other advanced modalities. With particular strength in pharmacology, toxicology, and preclinical formulation, we help de-risk development and optimize the selection of therapeutic candidates. Our consultative approach ensures partners benefit from our deep expertise in complex disease areas, enabling better outcomes from early discovery to clinical development. Innovative R&D Platforms Our AI-powered proprietary R&D platforms, including PanOmics and iPSC technologies, integrate advanced analytics and automation to enhance disease understanding and ensure human relevance. By leveraging continuous manufacturing and high-throughput platforms, we provide faster, more reliable access to high-quality drug candidates, reducing time to clinic and enabling data-driven decision-making. Global Presence and Flexibility Evotec operates globally with an expansive R&D infrastructure, allowing us to offer flexibility in partnering models and scalability in operations. Our state-of-the-art facilities and diverse scientific team of over 4,000 experts are equipped to handle the most complex challenges across therapeutic areas and modalities, including biologics, small molecules, and cell therapies. Driving Impact through Science In an era of rapid innovation, Evotec’s fully integrated drug development solutions position us as a trusted partner for organizations aiming to accelerate their R&D pipelines. Our commitment to scientific excellence, operational flexibility, and deep therapeutic expertise enables us to deliver the highest quality outcomes—from concept to clinical development and beyond. Together, we are creating medicines that matter.

Pessac, FranceFluofarma (CRO Research) is a leading company in High Content Screening (HCS) providing services to improve the drug discovery potential of its clients. The Fluofarma divisions provide the most complete High Content Screening service offer on the market.

2 Rue Robert Escarpit Pessac, 33600 FranceFluofarma (CRO Research) is a leading company in High Content Screening (HCS) providing services to improve the drug discovery potential of its clients. The Fluofarma divisions provide the most complete High Content Screening service offer on the market.

Bâtiment Le Ponant D 25, rue Leblanc Paris, 75015 FranceLe Commissariat à l’énergie atomique et aux énergies alternatives (CEA) est un organisme public de recherche à caractère scientifique, technique et industriel (EPIC).​ Acteur majeur de la recherche, du développement et de l'innovation, le CEA intervient dans le cadre de quatre missions : la défense et la sécurité, l'énergie nucléaire (fission et fusion), la recherche technologique pour l'industrie et la recherche fondamentale (sciences de la matière et sciences de l​a vie). S'appuyant sur une capacité d'expertise reconnue, le CEA participe à la mise en place de projets de collaboration avec de nombreux partenaires académiques et industriels.

27 rue du 4eme RSM Rouffach 68250 FranceForenap Pharma offers screening, toxicology, metabolism analytics, submission documents, pharmaceutical development, and exploratory studies.

Rouffach, Grand Est, 68250 FranceForenap Pharma offers screening, toxicology, metabolism analytics, submission documents, pharmaceutical development, and exploratory studies.

6, Allée de Bethléem Gières, 38610 FranceFloralis, a subsidiary of the University Joseph Fourier, assists in technology transfer by offering proof of concept, intellectual property, and licensing support services.

Geneva, SwitzerlandFirmenich is in the perfume and flavor business and also provides organic synthesis and biotechnology services.

80, Avenue de la grande armée Paris, 75017 FranceFareva offers contract manufacturing services including formulation, production, and filling.

13 Rue Pauline Kergomard Dijon, Bourgogne Franche-Comté, 21000 FranceFILAB is a high-end laboratory that provides pharmaceutical industrie with : - Chemical Analysis by ICP-MS / ICP-AES, GC-MS, LC-MSMS, NMR, IC, XRD, SEM-EDX, BET, granulometry, UV, FTIR... - Analytical Development - Materials Characterization - Troubleshooting - R&D support services

13 RUE PAULINE KERGOMARD France DIJON, Veuillez sélectionner, 21000 FranceFILAB is a high-end laboratory that provides pharmaceutical industrie with : - Chemical Analysis by ICP-MS / ICP-AES, GC-MS, LC-MSMS, NMR, IC, XRD, SEM-EDX, BET, granulometry, UV, FTIR... - Analytical Development - Materials Characterization - Troubleshooting - R&D support services

Rue du Champ-Blanchod 4 Plan-les-Ouates, Geneva, 1228 SwitzerlandFasteris is the Life Science brand of Genesupport, a Swiss laboratory which serves, not only genetic diagnostic services, but also Next Generation Sequencing (NGS) and Sanger sequencing services for LifeScience reseach worldwide, such as private, academic, governmental and industrial research laboratories, as well as to biotechnology and pharma companies. Genesupport is part of Medisupport, the Swiss laboratory networks, a strategical partnership that allows us to offer a large panel of medical and diagnostic analyses. Medisupport belongs to the SONIC Healthcare network, a global healthcare company with reputation for excellence in laboratory medicine and pathology, radiology and diagnostic imaging, as well as primary care medical services.

5, Chemin de la Parfumerie Vernier, 1214 SwitzerlandAs the world’s leading flavour and fragrances company, we unveil the tastes and scents that suit you best, and that you love most.

4, rue Pierre Fontaine Evry, 91058 FranceGenoSplice Technology offers next generation sequencing and microarray data analysis, with specific expertise in alternative splicing.

172 rue de Charonne Le Dorian B2 75011 Paris, FranceGenewave is a development-stage diagnostics company that provides information to curb the spread of hospital-acquired infections and anti-microbial resistance.

Romainville, FranceGalapagos provides disease models, target discovery and screening, compound libraries, and medicinal chemistry.

Hôtel Technologique, 45 rue Frédéric Joliot-Curie – CS 10002 Technopôle de Château-Gombert MARSEILLE, 13382 FranceDuring the last 10 years, medical genetics has drastically changed with the emergence of new sequencing technologies. It is thus now possible to sequence individual genomes in few hours. The challenge is therefore not anymore to generate the data but to efficiently identify disease-causing mutations among millions of variations: the "search a needle in a haystack" challenge. Thanks to a fruitful partnership with experts from renown academic bioinformatics research teams from the Aix-Marseille University (AMU) and the French National Institute of Health and Medical Research (Inserm), the Genomnis company is providing the most efficient systems to predict the pathogenicity of mutations from any human gene. The Human Splicing Finder system allows the identification of splicing signals and the impact of mutations on these signals, while the UMD-Predictor system is dedicated to the prediction of exonic substitutions. Genomnis is also providing services to assist you to design your experiments and analyze data. Our vision is to provide you the power of bioinformatics coupled with the experience of genetics experts to simplify your genomics journey.

Immeuble le Doublon - 11 Avenue Dubonnet, 92400 Courbevoie - FranceChiesi farmaceutici offers drug development, drug discovery, and clinical trials.

Parc Eurasanté 885, Avenue Eugène Avinée 59120 Loos FranceGENFIT is focused on the development of innovative therapeutic and diagnostic solutions for prevention and treatment of diabetes and related disorders.

Lyon, FranceGattefosse specializes in the creation, development, manufacture, and marketing of specialty ingredients and innovative formulation solutions for the Health and Beauty industries.

147, Avenue Paul Doumer 92500 Rueil Malmaison FranceGenomeQuest provides large-scale genomic software applications.

1 rue Aronnax Saint-Herblain, 44800 FranceChelatec is a client oriented CRO founded in 2000. With state-of-the-art fully equipped laboratories for radiolabeling, radioanalyses, handling of cells and housing of animals, Chelatec is recognized for its reliable expertise and offers a unique combination of custom radiolabeling, in vitro assays and in vivo investigations capabilities.

Impasse des Sources Ruffieux, Auvergne-Rhône-Alpes, 73310 FranceCellMade is a biopharmaceutical company focused on the development and commercialization of early diagnostic and prognostic tests and novel therapeutics to prevent development of Metabolic Disease and related co-morbidities. The ever-increasing prevalence of Obesity affects millions of people worldwide. The Metabolic Syndrome and its hepatic manifestation, NAFLD-NASH is a key pathological condition triggered by the noxious biochemical pathways of Obesity. Despite the high unmet medical needs, there are currently no approved drugs for treating NAFLD-NASH. The current main recommendation is lifestyle modification, which is only partially effective. The scientific evidence on the looming pandemic of Obesity is now overwhelming. It is thought that the spreading of the disease is mediated via circulating inflammatory messengers. As in any degenerative disease, early diagnosis is the key to avoid harmful, and even deadly, effects. There is high demand for a non-invasive, high-accuracy diagnostic and prognostic approach. CellMade identified and validated a set of blood lipids that allow for discrimination between the various stages of NAFLD-NASH enabling to predict patient's risk profile and reactivity to treatment schedules. The successful validation of the biomarker signatures represents a cornerstone advancement to address the societal challenges related to the Obesity pandemic and the development of associated comorbidities such as T2DM, CVD and COPD. Early diagnosis will overcome the costs issues affecting the current clinical scenario, as the disease development is still reversible and could be addressed therapeutically. We at CellMade believe in Open Innovation and therefore established a dedicated range of laboratory services, derived from our own research activities, that can help scientists in further developing tools for Metabolic Disease. Our multidisciplinary team has developed an innovative systems biology approach enabling high-content and robust analysis of cell models required for a diverse range of applications such as efficacy and safety testing of new drug compounds or the discovery of biomarkers. CellMade provides a comprehensive catalog of Services: Biobanking, Cell-based assays, Cytometry and Mass Spectrometry assays and Bioinformatics for annotation of obtained data and construction of data-bases.

Les Templiers - 2400, route des Colles Sophia Antipolis, Biot 06410 FranceGalderma focuses on the drug development for the therapeutic areas of skin diseases as well as an array of genome analysis, screening, imaging, and pharmacokinetic/pharmakodynamic services.

9, rue Lagrange, 75005 Paris, FranceGentaur is a supplier of life science research products.

Evry, FranceGenoSafe offers molecular analysis, immune response characterization, quality control of gene therapy products, and cell line/stem cell characterization.

114 boulevard du 11 novembre 1918 - 69100 Villeurbanne - FRANCELaboratoire Dermscan provides in vitro toxicity studies of cell models as well as in vivo efficacy and tolerance trials. Operating for over 23 years in France, and abroad, we can draw on a panel of over 15,000 volunteers and a host of devices and methods to quantify and visualise the impact of your raw materials and finished products. Our R&D Department provides a technological monitoring service as a vital component in the establishment of innovative protocols. Working in compliance with standards and good clinical practice (GCP), we first achieved ISO 9001 certification over 10 years ago, in our bid to offer you top-quality service and bring full satisfaction in terms of responsiveness, adaptability and meeting deadlines.

1bis, rue de l’Internationale – Évry, 91002 FranceGenethon focuses their efforts in developing new vector and plasmid designs and contructing them in the application of gene therapy studies. Their expertise includes bioprocess development, bioanalytical development, and sample storage.

29, Quai du Mont-Blanc-PO Box 133 Geneva 21, CH-1211 SwitzerlandGenexion offers development of biopharmaceutical products specifically targeting chronic inflammatory and autoimmune disease.

25, av. Jean Léon Laporte Anglet, 64600 FranceGemacbio offers immunogen synthesis and antibody production services.

Campus de l'Institut Pasteur de Lille Bâtiment Guérin-4th floor 1 rue du Pr Calmette Lille, 59000 FranceGenoscreen offers sequencing, genotyping, and bioinformatics services.

1, rue du Professeur Calmette Lille, Hauts-de-France, 59000 FranceGenoscreen offers sequencing, genotyping, and bioinformatics services.

2-8 Route de Rouen Porcheville, 78440 FranceGenEvolutioN®, a specialist in in vitro toxicology and in vitro genetic toxicology, is developing an innovative technique for their clients: the telomere / centromere micronucleus test differentiating the aneugene and clastogenic effect. This technique that we develop, coupled with our know-how, allows our highly experienced employees to significantly reduce the delivery time of study results (saving up to 4 weeks), while respecting quality and giving our customers the benefit of our personalized support in their projects. Specialist for genotoxicity of plant extractc (herbal medecine, and cosmetic ingredient), in standard Ames test , and using treat and wash method.

8 Rue de Rouen 2-8 rue de Rouen Porcheville, 78440 FranceGenEvolutioN®, a specialist in in vitro toxicology and in vitro genetic toxicology, is developing an innovative technique for their clients: the telomere / centromere micronucleus test differentiating the aneugene and clastogenic effect. This technique that we develop, coupled with our know-how, allows our highly experienced employees to significantly reduce the delivery time of study results (saving up to 4 weeks), while respecting quality and giving our customers the benefit of our personalized support in their projects. Specialist for genotoxicity of plant extractc (herbal medecine, and cosmetic ingredient), in standard Ames test , and using treat and wash method.

31 Rue Saint-Jean-de-Dieu Lyon, Auvergne-Rhône-Alpes, 69007 FrancegenOway develops customized, highly physiologically relevant genetically modified rodent models including conditional and constitutive knockout, knockin and humanized transgenic mice and rats.

22, route 128 Gif sur Yvette, IDF, 91190 FranceGEG-tech R&D team is focused on innovation in gene transfer tools and constantly innovate to improve lentiviral vector features, capabilities and safety. We aim at creating new tools which take every advantage of the lentivirus biology.

ZA Pra de Serre, Rue Pra de Serre Veyre-Monton, 63960 FranceGTP Bioways CDMO is a CDMO offering expert services for process development and cGMP manufacturing of antibodies and proteins using both mammalian and microbial expression systems. Founded in 2000, the company has gathered over 20 years of experience in developing custom processes for even the most challenging proteins and monoclonal antibodies (mAbs). GTP Tech is part of GTP Bioways group that offers end-to-end CDMO services for the manufacturing of therapeutics, including: R&D services: - Developability and manufacturability assessment - Batches manufacturing for efficacy or non-GLP toxicology studies Process development: - Cell line and strain development - USP development - DSP development - Analytical methods development - Custom ELISA development for HCPs analysis - Pre-formulation, formulation and stability assessment - Manufacturing of pre-clinical non-GMP batches DS manufacturing: - MCB/WCB manufacturing - GMP batch manufacturing (10 to 1000L for mammalian and 350L for microbial) - Stability studies - Analytical methods validation DP manufacturing: - F&F of vials and pre-filled syringes (batches up to 10 000 units) - Stability studies - Analytical methods qualification Support for IMPD

18 rue Jean Perrin TOULOUSE, 31100 FranceGTP Bioways CDMO is a CDMO offering expert services for process development and cGMP manufacturing of antibodies and proteins using both mammalian and microbial expression systems. Founded in 2000, the company has gathered over 20 years of experience in developing custom processes for even the most challenging proteins and monoclonal antibodies (mAbs). GTP Tech is part of GTP Bioways group that offers end-to-end CDMO services for the manufacturing of therapeutics, including: R&D services: - Developability and manufacturability assessment - Batches manufacturing for efficacy or non-GLP toxicology studies Process development: - Cell line and strain development - USP development - DSP development - Analytical methods development - Custom ELISA development for HCPs analysis - Pre-formulation, formulation and stability assessment - Manufacturing of pre-clinical non-GMP batches DS manufacturing: - MCB/WCB manufacturing - GMP batch manufacturing (10 to 1000L for mammalian and 350L for microbial) - Stability studies - Analytical methods validation DP manufacturing: - F&F of vials and pre-filled syringes (batches up to 10 000 units) - Stability studies - Analytical methods qualification Support for IMPD

Batiment Gould 52 l'Occitane Labège, Languedoc-Roussillon-Midi-Pyrénées, 31670 FranceGTP Bioways CDMO is a CDMO offering expert services for process development and cGMP manufacturing of antibodies and proteins using both mammalian and microbial expression systems. Founded in 2000, the company has gathered over 20 years of experience in developing custom processes for even the most challenging proteins and monoclonal antibodies (mAbs). GTP Tech is part of GTP Bioways group that offers end-to-end CDMO services for the manufacturing of therapeutics, including: R&D services: - Developability and manufacturability assessment - Batches manufacturing for efficacy or non-GLP toxicology studies Process development: - Cell line and strain development - USP development - DSP development - Analytical methods development - Custom ELISA development for HCPs analysis - Pre-formulation, formulation and stability assessment - Manufacturing of pre-clinical non-GMP batches DS manufacturing: - MCB/WCB manufacturing - GMP batch manufacturing (10 to 1000L for mammalian and 350L for microbial) - Stability studies - Analytical methods validation DP manufacturing: - F&F of vials and pre-filled syringes (batches up to 10 000 units) - Stability studies - Analytical methods qualification Support for IMPD

Campus Merieux Marcy l’Etoile Metropolis of Lyon, 69280 FranceGenesisCrest is a life sciences consulting firm that help clients in medtech and lifescience businesses to improve and effectively meet the industry challenges by offering a selective suite of services including R&D due-diligence, market research, scientific writing, and medical communication services. Our other extended services include competitive intelligence, In-licensing support, KOL management, regulatory, reimbursement, and market insights to help clients develop successful R&D portfolio, product strategies and sound knowledge of industry as a whole. To streamline the business outcomes and delivery expectations, our operations are supported by ISO 9001:2015 certified management system.

326 chemin de Gatipet La Frette, 38260 FranceGeneCreek meets the complex interplay of human metabolism and microbiota up-front, generating leads from exploratory human in vivo studies, thus creating a rationalized, reduced risk development workflow for probiotic- and pharmaceutical solutions.

3 allée du Titane Orléans, 45100 FranceGreenpharma is specialized in natural products and their valorization cosmetics, food, pharmacy, phytosanitary and veterinary industries. We provide molecules and libraries for R&D and cosmetic active ingredients. Our services include analytical, computational and medicinal chemistry, cosmetic formulation and R&D project management. Furthermore, we have a multiple process pilot extraction platform including supercritical CO2 and subcritical water. Greenpharma is also the owner of the following brand: - ambinter.com, a website for molecule procurement with a searchable database of 38 million of references - Prestwick Chemical Library with off-patent drugs from FDA, EMEA,... for drug repositioning

3, allée du Titane Orléans, 45100 FranceGreenpharma is specialized in natural products and their valorization cosmetics, food, pharmacy, phytosanitary and veterinary industries. We provide molecules and libraries for R&D and cosmetic active ingredients. Our services include analytical, computational and medicinal chemistry, cosmetic formulation and R&D project management. Furthermore, we have a multiple process pilot extraction platform including supercritical CO2 and subcritical water. Greenpharma is also the owner of the following brand: - ambinter.com, a website for molecule procurement with a searchable database of 38 million of references - Prestwick Chemical Library with off-patent drugs from FDA, EMEA,... for drug repositioning

1 place Pierre Potier Centre Pierre Potier Toulouse, France, 31100 FranceGenoskin is a pioneering biotechnology company that leverages biological, non-clinical immunoprofiling testing to reduce the risks associated with human therapeutic drugs, vaccines, medical devices, and cosmetics development, by providing earlier access to higher quality human data during the drug development process. We are committed to ethical and sustainable practices by offering reliable alternatives to experimentation using animal models. Genoskin’s human skin platforms use biostabilized and immunocompetent ex vivo human skin from diverse donor populations to evaluate the efficacy and toxicity of injectable biotherapeutics. These human skin models are highly representative of in vivo conditions, allowing for more accurate and reliable biological testing of drug candidates using various cellular and molecular biology assays. We employ advanced analytical technologies such as next-generation transcriptomics and multiplexed proteomics, combined with machine-learning and artificial intelligence to generate actionable, consistent human data to accelerate the development of human therapeutics.

102, avenue Gaston Roussel Romainville, 93230 FranceHelios BioSciences builds dynamic models mimicking the behavior of cell signaling cascades to accelerate the selection of reliable therapeutic targets or biomarkers.

184 Rue du Faubourg Saint Antoine 75571 Paris FranceHopital Saint Antoine focuses on clinical research areas.

Marseille, Provence-Alpes-Côte d'Azur FranceHelioscience offers in vitro and in vivo efficacy, photostability, mutagenicity, and phototoxicity testing services.

184 Rue du Faubourg Saint Antoine Hôpital Saint Antoine Paris, 75012 FranceHuman HepCell is a preclinical Contract Research Organization specialized in liver pathologies (fibrosis, HCV). Human HepCell is specialized in the evaluation of molecules on human normal and pathological cells and tissues.

Prologue Biotech, 516 Rue Pierre et Marie Curie Labege, 31670 FranceHumana Biosciences is a preclinical Contract Research Organization specialized in Translational research in Digestive, Respiratory and Genito-Urinary therapeutic areas. The Company services include histological and immunohistochemical staining as well as RNA purification and PCR arrays on both normal controls and pathologically-confirmed human tissues (fresh, frozen or formalin-fixed, paraffin-embedded) obtained in full compliance with international Ethical Guidelines. Humana Biosciences also performs in vivo studies on small experimental animals, including transgenic mice, for the evaluation of the efficacy of drug candidates on validated experimental models for the pathologies of interest.

Rue Pierre et Marie Curie Labège, Occitanie, 31670 FranceHumana Biosciences is a preclinical Contract Research Organization specialized in Translational research in Digestive, Respiratory and Genito-Urinary therapeutic areas. The Company services include histological and immunohistochemical staining as well as RNA purification and PCR arrays on both normal controls and pathologically-confirmed human tissues (fresh, frozen or formalin-fixed, paraffin-embedded) obtained in full compliance with international Ethical Guidelines. Humana Biosciences also performs in vivo studies on small experimental animals, including transgenic mice, for the evaluation of the efficacy of drug candidates on validated experimental models for the pathologies of interest.

1 Rue Pierre Fontaine Genopole Biocluster Campus 3 Évry, Île-de-France, 91058 FranceHybrigenics Services is a complete service provider of cutting-edge technologies dedicated to the study of proteins and their interactions in 35+ organisms and any research thematic. We offer three main lines of services: • Interactions Discovery: ULTImate Y2H™ to discover novel protein-protein interactions in various tissues/cell types o Several adapted versions allow to identify interactions with transmembrane proteins, DNA and RNA o Associated services: Interaction Domain Mapping, Low binders, super binders • Drug Discovery Services (Adapted from ULTImate Y2H) o Target deconvolution: ULTImate YChemH™ to identify on- and off-targets of small bioactive molecules - mechanism of action, polypharmacology, drug repositioning, prediction of toxicity o Protein-protein interactions induced by molecular glues (protein stabilization, targeted protein degradation) • Nanobody® (or Synthetic Antibodies, VHH) to select and validate high-affinity single-domain antibodies (Hybribody™) - for IF, ELISA, high-resolution microscopy, video-microscopy, target inhibition applications but also for diagnosis and therapeutic purposes Our optimized screening platform in yeast enables the identification of the protein partners of proteins, DNA sequences, RNA and small molecules of therapeutic interest. Highly complex protein domain libraries, prepared from any cell type or tissue, are screened to saturation to identify partners and their interacting domains using a transcriptional read-out. Sophisticated bioinformatics analysis allows to attribute confidence scores to each interaction. With more than 3,200 academic and industrial customers from over 40 countries, Hybrigenics Services is internationally recognized. Among our services, our yeast two-hybrid screening technology, ULTImate Y2H, is extensively used in many research projects. The results obtained at Hybrigenics have been quoted in more than 480 scientific publications to date. Hybribody offers single-domain antibody selection and validation services. We handle the in vitro selection of antibodies against your protein from a fully synthetic humanized VHH library by an optimized Phage Display technology. VHHs have the advantages of being very small (15 kDa), affine and stable molecules. We validate the selected VHHs for in vitro and in vivo applications (ELISA, IF, Intrabody…). We can also fuse the VHH with Fc fragments from the species of your choice to deliver fully functional recombinant antibodies. In addition, Hybrigenics Services provides optimization of nanobodies coming from the Llama using yeast display technology. Nanobody® is a trademark of Ablynx.

80b rue Paul Camelle Bordeaux, 33100 FranceHORIANA is a consulting company dedicated to epidemiology and biostatistics, designing and conducting Healthcare Real-World Studies. Founded by a team of 6 specialists, all of them having more than 15 years of experience in biostatistics, epidemiology, and project management, Horiana aims to support its clients at all stages of their projects. Our clients are both private and public/academic professionals in the healthcare field.

1 Pl. Pierre Potier Entree B Toulouse, 31100 FranceHere at Human Cell Design, we are convinced that human cell models are the way forward to getting better medication to patients faster: - We are a CRO specialists in human beta cells culture (>20 years) - We have a unique terminal maturation platform to have a large quantity of mature cells - We have a unique modelization EndoC-βH5 platform to create genome edited cells - We perform custom human primary-based cell services - We have been recognized by >450 labs worldwide & >160 peer reviewed publications We propose a large number of custom services: - Production of genome edited EndoC-βH5: Model your cells with ADAPT® platform - Target discovery: Target identification and validation - Compounds screening: GLP1-R/GIP agonist screening, IC50 - Disease modelling: IC50, inflammation, T1D T-cell killing, T2D glucolipotoxicity - Specific assay development: Reporter genes, luminescence, microscopy, specific readouts, … As well as different beta cell models: - EndoC-βH1: Immortalized beta cells for proliferation assays - EndoC-βH5: Mature naive-like cells for functional assays - EndoC-βH5 HLA-A2: T1D-specific disease model for T-cell killing assays - EndoC-βH5 GLTx: T2D-specific disease model for glucotoxicity assays

1 Place Pierre Potier BP 50624 Toulouse, Occitanie, 31000 FranceHere at Human Cell Design, we are convinced that human cell models are the way forward to getting better medication to patients faster: - We are a CRO specialists in human beta cells culture (>20 years) - We have a unique terminal maturation platform to have a large quantity of mature cells - We have a unique modelization EndoC-βH5 platform to create genome edited cells - We perform custom human primary-based cell services - We have been recognized by >450 labs worldwide & >160 peer reviewed publications We propose a large number of custom services: - Production of genome edited EndoC-βH5: Model your cells with ADAPT® platform - Target discovery: Target identification and validation - Compounds screening: GLP1-R/GIP agonist screening, IC50 - Disease modelling: IC50, inflammation, T1D T-cell killing, T2D glucolipotoxicity - Specific assay development: Reporter genes, luminescence, microscopy, specific readouts, … As well as different beta cell models: - EndoC-βH1: Immortalized beta cells for proliferation assays - EndoC-βH5: Mature naive-like cells for functional assays - EndoC-βH5 HLA-A2: T1D-specific disease model for T-cell killing assays - EndoC-βH5 GLTx: T2D-specific disease model for glucotoxicity assays

c/o INRAE, UMR, ISP, Batiment 311 Route de Crotelles Nouzilly, 37380 FranceINVENesis is a swiss biotechnology company based in Neuchâtel. We provide R&D services for drug discovery to industrial partners in the Animal Health, Plant Protection (Crop) and Pharmaceutical fields as well as Academia. We are an agile structure offering electrophysiology (on Xenopus oocytes and invertebrates) and organism-based (model organisms and parasitology) platforms to look for drugs, pheromones, bio-control and biologics with applications in parasitology, agriculture and human medicine. We provide the Science and the Technologies allowing you to screen chemical compounds and generate your own Intellectual Property. We offer a flexible business model where you pay for what you need.

26 rue d’Ulm Paris Cedex 05, 75248 The treatment of cancer is continually improving due to increasing knowledge in oncogenesis and the development of new targeted compounds. Many candidate compounds for clinical trials are therefore generated each year.

26 rue d’Ulm Paris Cedex 05, 75248 FranceThe flow cytometry core facility of the Institut Curie in Orsay is available for Institut Curie research teams, external academic and to industry. Flow cytometry is generally used for a multiparametric analysis of individual cells in suspension, with the possibility of subsequently sorting subpopulations of interest. The cells in suspension may be simultaneously marked with many fluorochromes, each identifying a molecule of interest. The marked cells flow pass through a laser and, for each cell, the fluorescence intensity is quantified for each fluorochrome. Fluorescent probes can be used to detect different parameters such as: cell cycle, proliferation, apoptosis, pH changes and calcium flux. The purpose of the flow cytometry core facility is to sort cells for users, and to train facility users on the self-service cytometers and related software for data acquisition and analysis.

Toulouse, FranceInvivoGen provides life scientists with innovative research reagents. As experts in innate immunity and cell culture, we offer a large selection of products including PRR ligands, cell lines, selective antibiotics, antimicrobial agents, vaccine adjuvants, and antibodies. Our TLR-expressing cell lines allow us to offer efficient TLR ligand screening.

5 Rue Jean Rodier TOULOUSE, 31400 FranceInvivoGen provides life scientists with innovative research reagents. As experts in innate immunity and cell culture, we offer a large selection of products including PRR ligands, cell lines, selective antibiotics, antimicrobial agents, vaccine adjuvants, and antibodies. Our TLR-expressing cell lines allow us to offer efficient TLR ligand screening.

28 Rue du Docteur Roux 75015, Paris France

17 RUE ALFRED KASTLER SCHILTIGHEIM, 67300 FranceTrade of industrial machines for the food industry and hygiene products for decontamination and cleaning

3 rue des Satellites F-31400 Toulouse FranceImavita is an innovating technology company proposing preclinical services in the exploration of preclinical models of pathologies by the use of imaging techniques and analysis.

FACULTE DE MEDECINE POLE RECHERCHE BD DU PROFESSEUR JULES LECLERC 59045 Lille Cedex FranceIntestinal Biotech Development provides leading-edge research services in digestive diseases. Our expertise includes all aspects of intestinal and hepatic inflammation, visceral pain, and metabolic issues. We are collaborating and partnering with an outstanding team of clinicians and a world-class academic research center dedicated to IBD. At the forefront of the industry, Intestinal Biotech Development has teamed with leading researchers, pharmaceutical companies, and food ingredient companies to bring fertile ideas into marketed medicines and food ingredients.

5 Avenue du Grand Sablon La Tronche, Auvergne-Rhône-Alpes, 38700 FranceINOVOTION is a biotech company which offers you a unique in vivo technology dedicated to oncology efficacy studies and early toxicity evaluations. Our Fast, Sensitive, Reliable and Affordable assay will save you time and money, to give you a clear competitive advantage. This breaking-thought technology, based on chick embryo, provides early analysis of your treatments before the classical preclinical stages. By eliminating low-value molecules early, INOVOTION accelerates your drug discovery process, increases your R&D productivity and reduces its costs. It’s rapid Go/No Go decision with multi-cancer screening capacities. This next generation of in vivo efficacy and toxicity tests covers fours main aspects: - EFFICACY assays for your anti-cancer treatments - EARLY TOXICITY assays for your drug candidates - TARGET VALIDATION in oncology - MULTI-CANCER SCREENING to (re)positioning your treatment We help chemists and biologists from companies and universities to validate a target and develop treatments by getting them through in vivo evaluation, while staying within their budget. These accessible efficacy and toxicity assays open really new perspectives of screening for wide variety of project researches.

Biopolis, 5 Av du Grand Sablon France La Tronche, 38700 FranceINOVOTION is a biotech company which offers you a unique in vivo technology dedicated to oncology efficacy studies and early toxicity evaluations. Our Fast, Sensitive, Reliable and Affordable assay will save you time and money, to give you a clear competitive advantage. This breaking-thought technology, based on chick embryo, provides early analysis of your treatments before the classical preclinical stages. By eliminating low-value molecules early, INOVOTION accelerates your drug discovery process, increases your R&D productivity and reduces its costs. It’s rapid Go/No Go decision with multi-cancer screening capacities. This next generation of in vivo efficacy and toxicity tests covers fours main aspects: - EFFICACY assays for your anti-cancer treatments - EARLY TOXICITY assays for your drug candidates - TARGET VALIDATION in oncology - MULTI-CANCER SCREENING to (re)positioning your treatment We help chemists and biologists from companies and universities to validate a target and develop treatments by getting them through in vivo evaluation, while staying within their budget. These accessible efficacy and toxicity assays open really new perspectives of screening for wide variety of project researches.

50 rue de Dijon Daix, 21121 FranceInventiva has significant biology and chemistry expertise in nuclear receptor, transcription factor, epigenetics, and in therapeutic areas such as oncology, immuno-inflammation, fibrosis, cardiometabolic and neurodegenerative disorders

1, avenue Bourgelat Marcy L'etoile, 69280 FranceIODOLAB specializes in biochemistry, performs trace element, mineral and vitamin analysis in several matrices (plasma, serum, urine, milk).

Marcy-l'Étoile, Auvergne-Rhône-Alpes, 69280 FranceIODOLAB specializes in biochemistry, performs trace element, mineral and vitamin analysis in several matrices (plasma, serum, urine, milk).

Cedex, FranceImmunID Technologies provides humanized mice for immuno-monitoring, immuno-profiling, and immuno-diagnostics.

26 rue d’Ulm Cedex 05, Paris, 75248 FranceReverse Phase protein Arrays represent an innovative technology that allows studying protein expression levels and the activation status of cell signalling pathways. It combines high throughput analysis with minimal sample consumption. Using a dedicated arrayer, only 1 ng of proteins extracted from tissues or cell lines are printed onto nitrocellulose covered microscope slides (arrays). Proteins of interest are then quantified using highly specific primary antibodies. Up to one thousand samples can be analysed simultaneously on the same array. We systematically print serial dilutions and replicates for all samples, making the technology highly robust and quantitative. Our platform has validated almost 600 primary antibodies for RPPA labelling so far, among which almost 150 antibodies against phosphorylated proteins. This panel of antibodies covers the majority of cell signalling pathways. For each project, the project leader selects the antibodies of interest for his/her project among the validated antibodies. New antibodies are continuously being tested in the context of ongoing scientific projects.

26 rue d’Ulm Paris , 75248 FranceThe Institut Curie provides to researcher technological platforms for scientific imaging, genomics, proteomics and bioinformatics. Facilites improve diagnosis, treatment of cancer and follow-up of patients. Platforms include: * Chemical Library * Next Generation Sequencing * Synthetic Genetic Array (SGA) * Genomics * Mass Spectrometry and Proteomics Facility * Therapeutic Antobodies (TAB-IP) and Recombinant Antibodies * Protein Expression and Purification Core Facility * Reverse Phase Protein Array * "Cell & Tissue Imaging":/wares/make-a-request/quote_groups/new?name=Institut+Curie+-+Cell+and+Tissue+Imaging+Platform+%28PICT%29&provider=Institut+Curie+-+Cell+and+Tissue+Imaging+Platform+%28PICT%29 * Biophenics * Flow CYtometry * Cytometry: Cell Sorting & Analysis * Experimental Radiotherapy * In Vivo Experiments * Pre-clinical Investigation Laboratory (LIP) * Bioinformatics Platform

Montpellier, Cedex, FranceIdenix provides discovery and development of drugs for viral and infection diseases such as Hepatitis C and HIV.

26 rue d’Ulm Paris Cedex 05, 75248 FranceThe Biomaging Cell and Tissue Core Facility of the Institut Curie (PICT-IBiSA) gathers highly sophisticated equipments and up to date technologies in advanced microscopy. Its main aim is to provide research groups from inside and outside the Institut Curie with a workflow of state to the art imaging approaches to study at different scales and with complementary methods molecules, organelles, cells, whole organisms and tissues in normal and pathological states. Our Imaging Core Facility gathers equipment in advanced light microscopy (Optogenetics and Active Illumination setups, d-STORM, high resolution SIM, LLSM; multiple MP(NLO), Multi-Angle TIRFM…), electron microscopy (immunololabelling, cellular EM, High-pressure freezing, CryoEM, room temperature and cryo-EM tomography, STEM and EFTEM 2D/3D, chemical mapping) and NanoSIMS, and correlative light-electron microscopy.

Paris FranceInsideBiotec consulting is a French consulting firm specialized in supporting biotech companies in developing their business activities (including product and service-based offers) through marketing & communication services. Whether your company is at an early stage of its development (from project design in incubation to its first years of growth) or an already well-established structure, we can support you with marketing & communication services to answer your specific challenges.

La Grande Carrée 98, rue de Portillon F- 37540 Saint-Cyr-sur-Loire, FranceInternational Preclinical Services (IPSAR) provides toxicology and toxicopathology consulting.

Rangueil University Hospital, Toulouse, FranceINSERM Renal Fibrosis Lab offers fibrosis models in addition to proteome and metabolome analysis services.

Toulouse, Languedoc-Roussillon-Midi-Pyrénées FranceINSERM Renal Fibrosis Lab offers fibrosis models in addition to proteome and metabolome analysis services.

26 rue d’Ulm Paris Cedex 05, 75248The Institut Curie Bioinformatics platform is composed of thirty bioinformaticians, biostatisticians and software engineers who offer a multidisciplinary expertise to support the biotechnological platforms, the research units and the hospital in their daily activities. Our skills range from statistical data analysis, data management, software development and high performance computing. We have five main missions: (1) knowledge and data integration, (2) collaborative support to biologists or clinicians for bioinformatics and biostatistics data analysis, (3) delivering advices and training in biostatistics and bioinformatics, (4) support to high performance computing and (5) coordination of bioinformatics activities within Institut Curie.

Illkirch, Grand Est FranceInstitut Clinique de la Souris (ICS) Mouse Clinical Institute specializes in translational research and functional genomics while offering genetic model validation, phenotypic analysis, and mouse model generation.

88 Boulevard des Belges - 69006 Lyon - France"Setup in the 1990, IEC carries out safety and efficacy studies, in vitro tests, sensory analysis studies, and consumer tests for products of dermatological and ophtalmologic use in the cosmetic, pharmaceutical and chemical areas. The safety of your products and proof of their efficacy are the objectives we propose to undertake with you, to promote and highlight your creative capacities. Several yearly customer satisfaction survey amongst our customers, have enabled us to identify the strengths of IEC: ♦ quality and rigour ♦ fast execution ♦ respect of deadlines ♦ improvement and implementation of new technologies ♦ best value for money ♦ international opening We hope IEC will continue to answer to your expectations and reflect the image of an international service company."

60 Rue Notre Dame-des-Champs Paris, 75006 FranceIMSTAR draws on its in-house expertise in biomodelling and statistics, cell biology and bioinformatics as wells on a network of experts in the fields of biology, cell biology, pathology, oncology, neurosciences, dermatopathology, cytogenetics, molecular genetics, and molecular medicine.

Paris, Île-de-France FranceIMSTAR draws on its in-house expertise in biomodelling and statistics, cell biology and bioinformatics as wells on a network of experts in the fields of biology, cell biology, pathology, oncology, neurosciences, dermatopathology, cytogenetics, molecular genetics, and molecular medicine.

101 rue de Tolbiac Paris, 75654 FranceInstitut national de la santé et de la recherche médicale (Inserm) or National Institute of Health and Medical Research focuses on research in many areas of discipline.

22 Boulevard Benoni Goullin Nantes, Pays de la Loire, 44200 France

22, Bd Benoni Goullin Nantes, 44200 France

Marseille, Provence-Alpes-Côte d'Azur FranceIpsogen provides a diagnostic tests designed to map diseases, biomarker-based diagnostics for cancer, microarrays, and genomic profiling.

EUROSafe Parc d'affaires de la Bretèche Bldg A4 and Bât B1 Saint-Grégoire, Ille-et-Vilaine, 35760 FranceEurosafe offers in vitro -pharmacology, -ADME, including skin/intestinal permeability studies, blood brain barrier studies, genotoxicity, cytotoxicity, metabolite characterization, and protein binding studies. -Tox services, in vitro evaluation of the safety, security, sensibilisation (H-Clat, DPRA- sens-is)DPRA, H-Clat, Sens-is, for cosmetic ingredients and provides solutions allowing faster and cost-effective drug discovery by identifying at early stages the most promising drug candidates

263, avenue du Général Leclerc / Campus de Beaulieu BAT 24 Rennes, 35000 FranceInnova Proteomics provides high speed identification, biomarkers, peptide discovery, proteomics, and absolute quantification.

26 rue d’Ulm Paris Cedex 05, 75248 FranceThe Protein Production and Purification Facility is a core service and resource to overcome the major bottleneck in recombinant protein expression and purification. Mainly we provide advice and active support for researchers scientific community in the use of the procaryotic and eukaryotic expression system for recombinant protein production. The facility offers equipment and materials required for the expression of protein in bacterial, Yeast, insect (baculovirus) and mammalian cell. We can execute the complete cloning, expression, scale-up and purification process or specific tasks within the project. We have optimized different expressions vectors in combination with various bacterial strains, yeast strain, insect strain and mammalian cell for specific expression of different types of proteins.

1 rue de l'internationale, Evry, France 91000Integragen offers genomic and sequencing services.

Evry, FranceIstem provides screening, pathology models, therapeutic molecule development, genomics, stem cell services, and high throughput screening.

5, rue Jacques Monod - 33652 Martillac FranceSince 1999, IDEA is specialized in the evaluation of cosmetic products. IDEA's activities are split into 4 departments: clinical, in vitro, microbiology and regulatory advice. IDEA is based at 5 locations in Europe : 2 in Bordeaux, Brest, Annecy and Bucharest*. As an independent lab, IDEA is your guarantee that results are objectively obtained.

11, Rue du Bocage Fontaine Les Dijon, 21121 FranceICTA (International Clinical Trials Association) offers support in clinical research and development including project management, clinical monitoring, data management, and biostatistics.

Hôpital Saint Eloi - Bâtiment INM 80, rue Augustin Fliche - BP 74103 Montpellier cedex 5, 34091 FranceThe Institute for Neurosciences of Montpellier (INM) concentrates basic research for studying transduction, integration and disorders of sensory and motor systems. The INM houses several teams working on vision, hearing, somatosensory wiring, and myelination. Molecular to systems level investigations are carried-out through core technical facilities at the INM. Our outputs favor the development of new treatments for sensory and motor deficits, with the strong interest on inherited retinal and optic blindness, auditory neuropathies (deafness and tinnitus), neurodegenerative diseases (amyotrophic lateral sclerosis, giant axonal neuropathy), sensitivity disorders (touch and pain) and glial pathologies (gliomas and Charcot Marie Tooth disease).

74 Rue Jean-Jacques Rousseau Paris-1ER-Arrondissement, Île-de-France, 75001 FranceQui sommes nous? Une fédération au service des agriculteurs multiplicateurs depuis plus de 50 ans ! La FNAMS (Fédération Nationale des Agriculteurs Multiplicateurs de Semences) est une organisation professionnelle agricole spécialisée dans la multiplication des semences. Elle représente les 18 000 agriculteurs multiplicateurs de semences français. Sa mission est de promouvoir la production de semences française et défendre les intérêts des agriculteurs multiplicateurs de semences.

3 rue des satellites - Canal Biotech 2 France Toulouse, Languedoc-Roussillon-Midi-Pyrénées, 31400 FranceFlash BioSolutions is a dynamic Contract Development and Manufacturing Organization (CDMO) pioneering the frontier of innovative technologies in biopharmaceuticals. Our foundation is rooted in scientific ingenuity, driving us to discover and produce highly effective RNA and DNA GMP2transfer solutions that redefine possibilities in healthcare. At Flash BioSolutions, we are committed to revolutionising the field of gene and cell therapy by providing high quality viral vectors for research and clinical use. We work closely with biotechnology and pharmaceutical companies to accelerate the development of innovative treatments that have the potential to transform patients’ lives.

46, Rue d’Ulm 75005 Paris, France

33, avenue de la Californie Oullins Oullins FranceIndicia Biotechnology provides immuno-diagnostics, microbiology, OEM production, microbiology, and sterile reagents.

12 quai Henri IV 75194 Paris Cedex 04 FranceIsochem offers custom chemical synthesis and manufacturing services.

26 rue d’Ulm, Paris Cedex 05, 75248 FranceThe Institut Curie Research Center provides a spectrum of facility areas for housing a variety of different Vertebrate models, allowing the Institut Curie research community access to advanced technical expertise.

211 Bis avenue J.F. Kennedy - BP 1140 Montluçon, 03100 FranceInterchim manufactures and distributes consumables and instruments for research and industry.

INTERCHIM Montluçon, Auvergne-Rhône-Alpes, 03100 FranceInterchim manufactures and distributes consumables and instruments for research and industry.

26 rue d’Ulm Paris Cedex 05, 75248 FranceThe group uses its own fully synthetic phage display library of humanized llama recombinant single domain antibody that can provide high affinity binders without animal immunization. The library contains 3.109 independent nanobodies.

1, Place Alexis Ricordeau Nantes Cedex 1 44093 FranceIn Cell Art provides gene synthesis, PCR, immunohistochemistry, microplate assays, microscopy, and fluorescence.

26 rue d’Ulm Paris Cedex 05, 75248 FranceFlow cytometry measures the fluorescence or light diffraction of a large number of particles at high speed, such as cells, beads, bacteria, yeast, or organelles. At Institut Curie, flow cytometry is used mainly to quantify multiple markers on cells, with the option of simultaneously sorting multiple sub-populations of interest. The primary advantage of flow cytometry is how quickly it produces data for a very large number of cells, allowing for complex and/or rare sub-populations of cells to be analyzed and sorted so that they can then be cultured or analyzed with molecular biology tools. The cells in suspension may be simultaneously marked with 11 fluorochromes, each identifying a molecule of interest. The marked cells flow past a laser and, for each cell, the fluorescence intensity is quantified for each fluorochrome.
Fluorescent probes can be used to detect various parameters such as membrane potential, pH, or cell cycle (proliferation, apoptosis, etc). The flow cytometry platform performs cell sorting, and also trains people to independently use high-speed multiparameter cytometers and the supporting software to acquire and analyze data.

26 rue d’Ulm Paris Cedex 05, 75248 FranceBioPhenics facility specializes in chemical biology as it relates drug discovery, biological probe discovery and phenotypic characterization of small-molecule effects (siRNAs and chemical compounds) on cellular systems. The facility provides basic and applied research teams with the technical resources and expertise needed to carry out high-content screens. The facility has enabled screening projects for different research groups in Europe, most of them located in cancer centers, aiming to benefit from the platform capabilities for identifying both the genes and pathways that mediate disease states and novel compounds that modulate these pathways. BioPhenics operates with a philosophy of collaboration, rather than fee-for-service. These screens can be carried out using small molecule or siRNA libraries curated by BioPhenics or with custom libraries developed by researchers.

Theix Saint Genes Champanelle Saint Genes Champanelle, 63122 FranceInrae Gentyane is a genomic platform part of the unit Genetic Diversity and Ecophysiology of Cereals. This unit is part of units in the department Auvergne Rhône Alpes. INRAE is France's National Research Institute for Agriculture, Food and Environment, created on January 1, 2020, It was formed by the merger of INRA, the National Institute for Agricultural Research, and IRSTEA, the National Research Institute of Science and Technology for the Environment and Agriculture. Gentyane, a high-throughput genotyping and sequencing service platform, a young and dynamic team to always best meet your requests. We offer you the latest tools and develop new approaches for you to best meet your expectations. Kaspar chemistry genotyping on LightCycler 480, Fluidigm Biomark. Affymetrix Axiom ultra-high-throughput SNP genotyping on GeneTitan. AgriSeq Thermo genotyping by sequencing (GBS) NGS Long Reads sequencing on PacificBiosciences Sequel 8M and Revio. Optical map, study of structural variants on BionanoGenomics Saphyr. High-throughput DNA extraction. Quality approach: ISO9001: 2015 and NF X 50-900 certification.

Pépinière d'entreprises Biopôle 6 Rue Pierre Joseph Colin RENNES, RENNES, 35000 FranceInsight Biosolutions (IBS) is a new startup company formed by expert team of Biologist, Clinician, Information technology and Commercial people. IBS team jointly have more than 20 years of working experience in Scientific innovation, biological materials & reagents manufacturing, commercialization of in-vitro models, in-vitro and in-silico services to Pharma and cosmetic industries.

1 chemin du saulxier Bâtiment 4b Longjumeau, 91160 FranceThe IntegraCell platform carry out high quality functional metabolism exploration analyses of several central cell metabolisms, namely oxidative stress and mitochondria energy production, on your preferred biological model (cell, animal, …). It uses high throughput, muti-parametric, non-radioactive, quantitative readouts technology.

78 rue du Bourbonnais 1er Etage Lyon, 69009 FranceExtensive expertise in immunoassays design. Specialized in Multiplexing for serological biomarkers. De Novo Antigens and Antibodies for infectious diseases management

128 Rue de Beaugé Le Mans, Pays de la Loire, 72000 Francebiological and chemical analysis in the areas of environment, food quality, animal and plant health for official organisms, industrialists, individuals

251 Rue Saint-Jacques Paris, Île-de-France, 75005 FranceAs part of its service delivery business, Inovarion develops and provides tailor-made services in life sciences: 1. Research expertise project missions 2. Missions of expertise in the pooling of technical services Furthermore, Inovarion has a recognized expertise in the field of biosensors.

4 rue Pierre Fontaine Evry-Courcouronnes, Ile-De-France, 91000 FranceINNOVHEM is a french startup focused on pahtologies involving red blood cells. We have developed a unique method for single cell quantification of fetal hemoglobin and new biomarkers aiming to track hemolysis in different conditions. These biomarkers are proposed to assess the efficacy of treatments from research to clinical stage of development.

3 Place de l’Eglise Liglet, Nouvelle-Aquitaine, 86290 FranceAt i3 Consult, we offer a trilogy of business intelligence excellence in value chain, life cycle and cost reduction analyses solutions for pharma, healthcare & life science. i3 Consult is endowed with a broad range and depth of in-house skills with specialist expertise consolidated from a stringent selection of outsourced associates. Thus we are confident that our solutions remain affordable, results deliverable, practical and success critical for our clients. For more information please check out our company Website at: www.i3consult.com or our video at: https://www.youtube.com/watch?v=gsg9jUzjQOs

90 rue Nicolas Chedevile Garosud Montpellier, Occitanie, 34070 FranceSpecimens sourcing and Lab services

8 rue Jacqueline Auriol Zone d'Activités des Gravanches Clermont-Ferrand, Auvergne-Rhône-Alpes, 63100 FranceSpecimens sourcing and Lab services

ZI Les Nertières, Allée Hector Pintus F-06610 La Gaude FranceIris Pharma is a world-leading Contract Research Organization (CRO) offering preclinical and clinical ophthalmology research services. Iris Pharma works hand-in-hand with customers and has helped bring more than 70 ocular drugs and medical devices to international markets to date. The company is able to do this as efficiently as possible by maintaining a global view of the development process and by bringing personalized advice. Iris Pharma indeed addresses all ophthalmology challenges by offering programs and study designs that perfectly suit the needs of customers: therapeutic value assessment, full preclinical regulatory package, product value creation or à la carte studies. Compliance with GLP, ICH-GCP and GCLP requirements; CIR agreement.

Les Nertières Allée Hector Pintus La Gaude, 06610 FranceIris Pharma is a world-leading Contract Research Organization (CRO) offering preclinical and clinical ophthalmology research services. Iris Pharma works hand-in-hand with customers and has helped bring more than 70 ocular drugs and medical devices to international markets to date. The company is able to do this as efficiently as possible by maintaining a global view of the development process and by bringing personalized advice. Iris Pharma indeed addresses all ophthalmology challenges by offering programs and study designs that perfectly suit the needs of customers: therapeutic value assessment, full preclinical regulatory package, product value creation or à la carte studies. Compliance with GLP, ICH-GCP and GCLP requirements; CIR agreement.

Incubateur de l'Institut de la Vision, Bâtiment B1/B2 74 rue du Faubourg Saint Antoine Paris, 75012 FranceIris Pharma is a world-leading Contract Research Organization (CRO) offering preclinical and clinical ophthalmology research services. Iris Pharma works hand-in-hand with customers and has helped bring more than 70 ocular drugs and medical devices to international markets to date. The company is able to do this as efficiently as possible by maintaining a global view of the development process and by bringing personalized advice. Iris Pharma indeed addresses all ophthalmology challenges by offering programs and study designs that perfectly suit the needs of customers: therapeutic value assessment, full preclinical regulatory package, product value creation or à la carte studies. Compliance with GLP, ICH-GCP and GCLP requirements; CIR agreement.

8 Bis Rue Gabriel Voisin Reims, 51100 FranceInnov'Orga offers custom synthesis, R&D services in organic chemistry, the synthesis or the isolation / identification of impurities. Innov'Orga's team is highly qualified and has an expertise in fluorine organic chemistry.

Innov'Orga Faculte des Sciences Moulin de la Housse Bat. 18 Chemin des Rouliers 51100 Reims FranceInnov'Orga offers custom synthesis, R&D services in organic chemistry, the synthesis or the isolation / identification of impurities. Innov'Orga's team is highly qualified and has an expertise in fluorine organic chemistry.

chemin des rouliers, Faculte des sciences - Bat 18 France Reims, 51100 FranceInnov'Orga offers custom synthesis, R&D services in organic chemistry, the synthesis or the isolation / identification of impurities. Innov'Orga's team is highly qualified and has an expertise in fluorine organic chemistry.

Route des Chênes Secs LE GENEST-SAINT-ISLE, 53940 FranceAs an international player of biomedical research, JANVIER LABS supplies experimental models with the highest standards to meet the needs of researchers. With the support of our teams of experts and our unique site in Europe – purpose built and designed at the forefront of innovation - entirely dedicated to rodent breeding, we guarantee strict breeding around 4 fundamental elements: highest standards for health quality, animal welfare, genetic stability, one sole microbiota. We offer a complete product and services portfolio to support rodent research models from creation to delivery. This includes a large range of research models (mice, rats, hamsters and gerbils) and dedicated support departments for model creation, customized breeding and the preparation of the models. Composed of scientists and veterinarians, our scientific support team supplies our users with rodent breeding expertise and knowledge of model characteristics. As a key player in Europe with more than 60 years experience, JANVIER LABS provides its models and services on the international stage with the same quality wherever our research partners are in the world. Our mission: to support research in order to improve tomorrow’s health

5 Avenue Napoléon III 5 Av. Napoléon III Saint-Julien-en-Genevois, Auvergne-Rhône-Alpes, 74160 FranceJubilant Biosys Limited has over 20 years of experience in delivering Integrated Drug Discovery (IDD) and GMP development and manufacturing of intermediates and APIs. Serving the global pharma industry, Jubilant Biosys employs over 2,400 people operating from five sites in India, with a presence in the USA, Europe, and Japan. The company is recognized in the industry for its scientific innovation, problem-solving mindset, and unwavering attention to customers' needs. Jubilant Biosys Limited is a leading CRDMO (Contract Research, Development, and Manufacturing Organization) player, providing comprehensive drug discovery (CRAM), contract research, development (CDMO), and manufacturing services (intermediates and APIs). These services constitute the core activities for conceiving and realizing new medicines. Jubilant Biosys has evolved into an integrated organization capable of providing end-to-end services, ranging from early discovery (Biology, Structural Biology, Medicinal Chemistry, DMPK, and Toxicology) to chemical development and the manufacturing of GMP intermediates and APIs for clinical phases and commercial supplies.

VetAgro Sup - CRB aile 2 niveau 1 1, avenue Bourgelat Marcy l'Etoile, 69280 FranceKallistem is a biotech company specialized in spermatogenesis. The company was founded in 2012 with the objective to anticipate and treat male infertility. It promotes a technology and expertise developed by Philippe Durand and Marie-Helene Perrard, two internationally renowned scientists in the field of the reproductive biology and more specially in in vitro spermatogenesis. Kallistem has developed, in collaboration with its partners, two original and innovating technologies of germinal cell culture for male fertility preservation and the treatment of male infertility.

Ecole Normale Supérieure de Lyon 46 allée d'Italie Lyon Cedex 07, 69364 FranceKallistem is a biotech company specialized in spermatogenesis. The company was founded in 2012 with the objective to anticipate and treat male infertility. It promotes a technology and expertise developed by Philippe Durand and Marie-Helene Perrard, two internationally renowned scientists in the field of the reproductive biology and more specially in in vitro spermatogenesis. Kallistem has developed, in collaboration with its partners, two original and innovating technologies of germinal cell culture for male fertility preservation and the treatment of male infertility.

13 Avenue Buffon Orleans, 45100 FranceKey-Obs provides in vivo models and services related to the preclinical studies in central nervous system. Key-Obs proposes rodent models to examine the therapeutic efficacy of drugs for the treatment of psychiatric, neurologic and neurodevelopmental disorders such as attention deficit/hyperactivity disorder, depression, anxiety, obsessive-compulsive disorder, sleep disorders, stress, post-traumatic stress disorder (PTSD), drug abuse and dependence, alcoholism, schizophrenia, autism spectrum disorder, Parkinson disease, Huntington disease or others

8-29 2-chomeKokusan Chemical offers peptide synthesis and antibody preparation services in addition to supplying reagents.

20 Rue Clément Bayard Levallois-Perret, Île-de-France, 92300 France

20 rue Marc Donadille Technopôle de Chateau Gombert, Marseille 13013 FranceKaïronKem supplies various fine chemicals, screening libraries, and building blocks in addition to offering custom synthesis services.

4, rue Gustave Eiffel ZA Kervault-Est Questembert, 56230 FranceKorilog offers bioinformatics services.

13, Impasse Serge Reggiani BP 10222 Saint Herblain cedex, 44800 FranceKeosys is a central imaging lab, we manage and read CT, MRI, PET, SPECT scans for biotech and pharma clients worldwide.

Allee le Corbusier Lacq, France, 64170 FranceKHiMii develops innovative reactors for flow chemistry, with outstanding performances at extreme temperature or pressure and with a strong focus on the industrialization at large scale. As an example, our equipment delivers strong performances on hydrogenation, with or without heterogeneous catalyst. Our equipment is available from the kilo-lab to the thousand tone scales. This equipment is available for technical studies in our partner lab or can be leased or purchased. Our reactors are made in France by a breakthrough welding technology.

6 rue Paul Baudry Paris, France, 75008 FranceKHiMii develops innovative reactors for flow chemistry, with outstanding performances at extreme temperature or pressure and with a strong focus on the industrialization at large scale. As an example, our equipment delivers strong performances on hydrogenation, with or without heterogeneous catalyst. Our equipment is available from the kilo-lab to the thousand tone scales. This equipment is available for technical studies in our partner lab or can be leased or purchased. Our reactors are made in France by a breakthrough welding technology.

74 rue du fauboug Saint-Antoine Paris, 75012 FranceKeen Eye is an AI platform company aiming at bringing decision-support and image analysis services for accelerating drug development from translational research to clinical phases and improving cancer diagnosis and therapies. Keen Eye brings accurate, standardized and undiscovered tissue insights through its cloud-based computational pathology platform which optimize users’ process and scale up their capacity.

60 F Avenue Rockefeller Bioserra 2 Bldg., 3rd Floor Lyon, 69008 FranceKCAS Bio has offered GLP and non-regulated Bioanalytical, Biomarker, Flow Cytometry, and PCR support for the last 40 years in studies from preclinical through clinical with a strong record of regulatory approvals. We offer international services with facilities in the US and in Europe. Our services include the following clinical and preclinical support in a wide variety of species and matrices: - LC-MS/MS and HRMS - Flow Cytometry - ddPCR and qPCR - Hybrid LC-MS/MS - Ligand Binding Assays – PK and ADA - Soluble Biomarkers - Biospecimen Management - Sample Kitting Services (clinical and non-clinical) - Dose Solution Analysis for preclinical studies We pride ourselves on our ability to be flexible and consultative in our approach to solutions. Our focus on quick initiation of projects allows us to meet your timing needs. Please contact us to see how we can support your drug development programs.

8 rue Méchain Paris, 75014 FranceKimialys offers ready-to-use gold biochips (SPR) and nanoparticles (LFA) coated with an innovative and patented surface chemistry, improving the sensitivity of sensors in any type of biological matrix.

7 bis rue du sabot Ploufragan, Bretagne, 22440 FrancePublic Veterinary Diagnostic Laboratory

10 bis rue Claude Bourgelat Javené, Bretagne, 35133 FrancePublic Veterinary Diagnostic Laboratory

28 Rue Laennec 69008 Lyon, California, 04 78 78 28 28 United StatesThe Léon Bérard Center has three essential missions: care, research and teaching. The vocation of the center is to offer quality care to people suffering from cancer. This care that goes from screening to the most innovative treatments also takes into account the nutritional, psychological and rehabilitation aspects adapted to each individual.

Carros, ItalyLHS Laboratoire specialize in private label manufacturing.

67 rue de la Gare 50510 CERENCES France TVA FR 12 692 015 266Lesaffre Ingredients Services is a wholly-owned subsidiary of the Lesaffre group. We provide a range of services for processing food ingredients, including spray-drying, vacuum belt drying, granulation and microencapsulation. We act as service providers only and do not sell any of the ingredients that we handle.

20 rue Louis-Charles Vernin 77190 Dammarie-Les-Lys FranceLaboratoires Galéniques Vernin specializes in manufacturing pharmaceutical and health industry products.

29 avenue Roger Hennequin Trappes , 78197 FranceA public industrial and commercial institution (EPIC designation), LNE has been placed under the trusteeship of the French Ministry for the Economy and Finance with oversight for Industry. Relying on an excellent scientific and technical skill set, LNE's research efforts have formed the basis of multiple applications: calibration, testing, certification, etc. Renowned for its expertise both in France and abroad, LNE performs measurements that serve the economy and society.

ZA l'Etang Vignon CS30003 37210 VOUVRAY FranceLaboratoires Chemineau specialize in the manufacture of aerosols, semi-liquid and liquid pharmaceutical products.

Lorris, Centre-Val de Loire, 45260 FranceLaboratoire Cat provides blister packaging, sterilization, and secondary packaging of drugs.

Z.I Des REYS DE SAULCE Rue du Progrés 26270 SAULCE/RHÔNE FRANCELaboratoire M. Richard manufactures powders, granules, tablets, capsules, syrups, solutions for drinking and drops.

23 Quai Perrache Lyon, Rhone, 69002 FranceFounded in 2003, Laviana Pharma focus on innovative drug process research and manufacturing outsouring services. Our CDMO services are tailored to accelerate commercial success by offering comprehensive manufacturing solutions customized to meet your unique needs. From the early stages of development to the final manufacturing process, we offer comprehensive support at every step. Our agile development model ensures that your project receives the attention it deserves, pilot and clinical batches manufacture, analytical method development and validation, and ICH stability studies. With our tailor-made solutions, we can assist you in bringing your products to market efficiently and cost effectively.

Cité InternationaleL2D Services provides consulting and operational management of services ranging from preclinical development to manufacturing.

Paris, Île-de-France FranceL2D Services provides consulting and operational management of services ranging from preclinical development to manufacturing.

4, Rue de la PrayaLaboratoires Codipharm provides cosmetics, body care products, and cosmetic manufacturing.

Lège-Cap-Ferret, Aquitaine-Limousin-Poitou-Charentes FranceLaboratoires Codipharm provides cosmetics, body care products, and cosmetic manufacturing.

20, Rue Léon Blum Valence, 26000 FranceLatoxan supplies natural libraries of venoms and toxins from animal and plant origins.

Avenue du général De Gaulle BP 115 14200 Hérouville Saint-Clair FranceLaboratoires GILBERT develops health products and cosmetics.

3, avenue des TropiquesLFB Group provides therapeutic proteins, plasma-derived medicinal products, and biological drugs. LFB offers cell line development, preclinical process development, and clinical manufacturing services through its biomanufacturing division.

Le Riou 41250 TOUR-EN-SOLOGNE

3 rue des satellites Bat. Canal Biotech. 31400 Toulouse FranceLibraGen provides biocatalysis, process development, industrial transfer and research services.

Toulouse, Occitanie FranceLibraGen provides biocatalysis, process development, industrial transfer and research services.

61 rue du mont-cenis Paris, Idf, 75018 France

Rue Wilson - 38 Rixheim , Grand-Est, 68170 FranceWe are a software engineering startup focusing on the most advanced technologies to process big data and ensure reproducible data science and AI. We support biotech and pharmaceutical companies in areas like AI and data governance and strategy, enterprise and system architecture, advanced software engineering, traceable software solutions and generative AI solutions. We provide a platform for fully Transparent, Traceable, Reproducible, Replicable (T2R2) AI and complex data science cloud to edge pipelines. We are experts in cloud native, edge to cloud and fully distributed architectures as well as in Computer System Validation (CSV, ex. GxP, Part 11). Our preferred technology stack includes Scala, Spark, Akka, Quine, Kafka, Milvus, Docker and Kubernetes.

36 Avenue de Metz La Rochelle, 17000 FranceLabtoo: Your Trusted Partner in Biological Samples procurement Welcome to Labtoo, a company committed to accelerating the R&D projects of the best research teams! As a company of scientists, we are dedicated to empowering our clients in their quest for scientific discovery and breakthroughs. Our mission is to support and fortify your R&D activities across every critical stage, from preclinical testing to clinical studies and the exploration of unique human biological samples. 🔬 Pioneering Rare and Complex Sample Procurement 🧬 At Labtoo, we specialize in the realization of tailor-made and unique requests. Our unparalleled expertise lies in the discovery and procurement of rare and hard-to-find samples, elevating your research capabilities to new heights. Explore the uncharted territories of science with us as we seamlessly navigate the intricate world of genetic diseases, cystic fibrosis, and infectious samples. 🌐 Why Labtoo? ✨ Unmatched Sample Access: Gain access to a limitless supply of rare biological samples, accelerating your research timelines. ✨ R&D Optimization: We streamline your research processes, allowing you to focus on what truly matters - groundbreaking discoveries. ✨ Biotech and Pharma Expertise: Our team of PhDs possesses an in-depth understanding of human diseases and drug development requirements. ✨ Security and Compliance: Your data and samples are treated with the utmost confidentiality and adhere to the highest industry standards. ✨ Customized Solutions: We tailor our services to your specific needs, ensuring you receive the support you require.

7 AV DU SANCY PARC LOGISTIQUE CLERMONT AUVERGNE GERZAT, 63360 FranceSpécialisée dans le transport des produits de santé, la société s’articule autour de six activités principales : Transports de produits biologiques avec spécialisation ADR et IATA, Transports animaliers, Transports de produits pharmaceutiques sous température dirigée, Transports d’organes, de tissus et de prélèvements biologiques, Transports d’équipes chirurgicales, et matériel de PMO, Convoyage de greffons (cellules souches, moelle osseuse, lymphocytes).

7 avenue du Sancy Parc logistique Clermont Auvergne GERZAT, 63360 FranceSpécialisée dans le transport des produits de santé, la société s’articule autour de six activités principales : Transports de produits biologiques avec spécialisation ADR et IATA, Transports animaliers, Transports de produits pharmaceutiques sous température dirigée, Transports d’organes, de tissus et de prélèvements biologiques, Transports d’équipes chirurgicales, et matériel de PMO, Convoyage de greffons (cellules souches, moelle osseuse, lymphocytes).

CEA IDMIT 18 route du Panorama Fontenay-aux-roses, IDF, 92260 FranceLife and Soft is a bioinformatics company We offer bioinformatics and biostatistics services. We have a sequencing platform in France covering Illumina and Nanopore sequencing but also scRNA-seq. Our packaged offer in genomics covers DNA, microbiome, transcriptomics and methylation analysis. If you have sequencing data to analyze, our apps: Nanobiome, Onco Lifepipe and Nanoware Cloud hosted will give you a wide range of analysis (16S, Full 16S, Shotgun, targeted sequencing, ARTIC, COVIDseq...)

VALLEE SUD BIO PARC 28 rue de la redoute Fontenay-aux-Roses, IDF, 92260 FranceLife and Soft is a bioinformatics company We offer bioinformatics and biostatistics services. We have a sequencing platform in France covering Illumina and Nanopore sequencing but also scRNA-seq. Our packaged offer in genomics covers DNA, microbiome, transcriptomics and methylation analysis. If you have sequencing data to analyze, our apps: Nanobiome, Onco Lifepipe and Nanoware Cloud hosted will give you a wide range of analysis (16S, Full 16S, Shotgun, targeted sequencing, ARTIC, COVIDseq...)

1 Chemin de Saulxier 91160 Longjumeau FranceCustom-made studies in claims substantiation for cosmetic and pharmaceutical companies. Created in 1998, BIO-EC is a research center dedicated to cosmetic and dermatological professionals. Our goal is to answer all kind of needs in claims substantiation. Several methods to assess products efficacy : animal-free efficacy testing for (dermo)cosmetics, clinical studies on volunteers, gene expression analysis, percutaneous absorption, RAMAN spectroscopy, topography.

1 chemin de Saulxier Longjumeau, 91160 FranceCustom-made studies in claims substantiation for cosmetic and pharmaceutical companies. Created in 1998, BIO-EC is a research center dedicated to cosmetic and dermatological professionals. Our goal is to answer all kind of needs in claims substantiation. Several methods to assess products efficacy : animal-free efficacy testing for (dermo)cosmetics, clinical studies on volunteers, gene expression analysis, percutaneous absorption, RAMAN spectroscopy, topography.

6 Rue Alfred Kastler BP 83076 Molsheim, Cedex, 67123 FranceATCC is a trusted and innovative global partner for high-quality authentic biomaterials, standards, and services. They are one of the world’s largest and most diverse resource centres providing human and animal cell lines, as well as molecular genomic tools, bacteria, viruses, protists, fungi, and biological reagents. LGC's partnership with ATCC facilitates the exclusive distribution of this extensive collection to Life Science researchers throughout Europe and Africa.

Biopôle Clermont Limagne,Saint Beauzire, 63360 FranceLonza provides advanced cell biology and cell engineering solutions that support customers from discovery to the clinic. We provide primary human cells, specialized media, advanced cell culture and transfection tools, supported by best-in-class quality, regulatory and scientific support. We support customers from basic research through preclinical and process development stages of small molecules, biologics, and cell and gene therapy programs in drug discovery and immuno-oncology. This includes immunogenicity prediction and assessment, manufacturability risk assessment and protein re-engineering.

19 Rue Marc Antoine Petit Lyon, 69002 FranceMarhshall BioResources provides animal models for research.

Chemin des Aulx 14 Plan-les-Ouates Geneva, Geneva, 1228 SwitzerlandMesenFlow Technologies provides a high-throughput inflammatory human tissue engineering service for use in preclinical drug and cosmetic preclinical development. Our mission is to evaluate compound safety, efficacy & mechanism in early drug discovery, leading to reduced attrition in the clinical phase. This has been achieved by developing cutting-edge techniques in translational medicine, where the use of human tissue generates a more accurate prediction (or translation on how drugs will behave in humans. Our aim is to provide a commercial “fee-per-service” platform that can be used by Pharma and cosmetics companies to test their products on real human cells in blood and tissue models, before proceeding to animal and clinical testing. The technology is fully humanised, and will contribute substantially to reduced animal experimentation. The MesenFlow Technologies platform consists of a series of in vitro technologies that allow the construction of human blood vessel under flow, with corresponding tissue models, by using freshly isolated blood and human disease clinical samples. This has led to the development of higher-throughput human "organoid" models, suitable for commercial screening and use.

Eclosion Foundation Chemin des Aulx, 14 Geneva, Geneva, CH1228 SwitzerlandMesenFlow Technologies provides a high-throughput inflammatory human tissue engineering service for use in preclinical drug and cosmetic preclinical development. Our mission is to evaluate compound safety, efficacy & mechanism in early drug discovery, leading to reduced attrition in the clinical phase. This has been achieved by developing cutting-edge techniques in translational medicine, where the use of human tissue generates a more accurate prediction (or translation on how drugs will behave in humans. Our aim is to provide a commercial “fee-per-service” platform that can be used by Pharma and cosmetics companies to test their products on real human cells in blood and tissue models, before proceeding to animal and clinical testing. The technology is fully humanised, and will contribute substantially to reduced animal experimentation. The MesenFlow Technologies platform consists of a series of in vitro technologies that allow the construction of human blood vessel under flow, with corresponding tissue models, by using freshly isolated blood and human disease clinical samples. This has led to the development of higher-throughput human "organoid" models, suitable for commercial screening and use.

4 rue Pierre Fontaine 91058 Evry cedex FranceMETAFORA biosystems is a biotechnology company dedicated to developing the use of RBDs which are ligands of nutrient transporters.

4 rue Pierre Fontaine Evry cedex, 91058 FranceMETAFORA biosystems is a biotechnology company dedicated to developing the use of RBDs which are ligands of nutrient transporters.

15 rue Pierre BasseresMedelis provides clinical and preclinical management, medical monitoring, biostatistics, document preparation, model development, and animal models.

Rue de la Cardonille 34090 Montpellier, FranceMontpellier GenomiX provides sequencing services.

Paris, Île-de-France FranceMicroBioChips provides protein array, biomarker, and screening services.

17 rue des martyrsMellitech provides zinc imaging, beta cell biology, stable cell line generation, immuno-labeling, and insulin secretion measurement.

43, Porte du Grand Lyon F-017100 Neyron, FranceMedelpharm provides tableting equipment, software, formulation, powder analysis and characterization.

31, avenue Arsène d’Arsonval F-01000 Bourg en Bresse, FranceMedelpharm provides tableting equipment, software, formulation, powder analysis and characterization.

22 Avenue Foch 54000 Nancy, FranceMerge Healthcare specializes in clinical systems and offers cloud-based solutions for imaging and data analytics.

Faculté de Médecine secteur Nord Boulevard Pierre Dramard Marseille, 13344 FranceMyEnterix is a biotechnology company that pioneered patch clamp recording on human enteric neurons

Marseille, Provence-Alpes-Côte d'Azur FranceMyEnterix is a biotechnology company that pioneered patch clamp recording on human enteric neurons

Avenue de l’Europe Clapiers, 34830 FranceMedinCell is a clinical stage pharmaceutical company that develops a portfolio of long-acting injectable products in various therapeutic areas.

Clapiers, Occitanie FranceMedinCell is a clinical stage pharmaceutical company that develops a portfolio of long-acting injectable products in various therapeutic areas.

Avenue 36-42 Marc Sangnier 92390 VILLENEUVE LA GARENNE FranceMACORS manufactures low dose products, bags and hormonal products.

PO Box 1826 20, rte de Pré-Bois 1215 Geneva 15, SwitzerlandMMV, a not-for-profit public-private partnership, was established as a foundation in Switzerland in 1999. Our mission is to reduce the burden of malaria in disease-endemic countries by discovering, developing and delivering new, effective and affordable antimalarial drugs. Our vision is a world in which these innovative medicines will cure and protect the vulnerable and under-served populations at risk of malaria, and help to ultimately eradicate this terrible disease.

Villenave-d'Ornon, Nouvelle-Aquitaine, 33140 FranceMetaboHUB is a national infrastructure of metabolomics and fluxomics that provides tools and services to academic research teams and industrial partners in the fields of health, nutrition, agriculture, environment and biotechnology.

12, Chemin des Aulx,SGS M-Scan offers mass spectrometry and chromatography services, including protein analysis, glycosylation analysis, antibody analysis, oligonucleotide analysis and bioanalysis.

29, avenue Tony Garnier 67007 Lyon FranceMerial is a world-leading animal health company. We are on the cutting edge of product development and innovation with a proven track record in producing pharmaceutical products and vaccines for pets, production animals, horses and wildlife.

2, rue du Belvédère, 91120 Palaiseau, FranceMedit provides CRO consulting, hit discovery, protein vaccine design, and drug design.

1 impasse du Palais Waza coworking Tours, 37000 FranceMAbSilico is a TechBio company developing and providing AI-based solutions for antibody drug design and discovery. We help biotech and pharma companies to leverage antibody discovery risks by providing computational candidates in days which are designed and characterized in silico and validated with state-of-the-art biological technologies. While MAbSilico combines 3D modeling, interaction simulation and linear sequences analysis, the antibody drug candidates are defined through their epitope, affinity, off-target risk, cross-species reactivity and developability assessment to be ready for biological activity evaluation. Using NLP technologies we gather information about antibodies and their target in different databases to ensure competitive landscape analysis and the freedom to operate of the computationally designed antibodies candidates.

1 Parvis Notre-Dame Pl. Jean-Paul II Paris, 75004 FranceMAbSilico is a TechBio company developing and providing AI-based solutions for antibody drug design and discovery. We help biotech and pharma companies to leverage antibody discovery risks by providing computational candidates in days which are designed and characterized in silico and validated with state-of-the-art biological technologies. While MAbSilico combines 3D modeling, interaction simulation and linear sequences analysis, the antibody drug candidates are defined through their epitope, affinity, off-target risk, cross-species reactivity and developability assessment to be ready for biological activity evaluation. Using NLP technologies we gather information about antibodies and their target in different databases to ensure competitive landscape analysis and the freedom to operate of the computationally designed antibodies candidates.

Domaine de l'Orfrasière Nouzilly, 37380 FranceMAbSilico is a TechBio company developing and providing AI-based solutions for antibody drug design and discovery. We help biotech and pharma companies to leverage antibody discovery risks by providing computational candidates in days which are designed and characterized in silico and validated with state-of-the-art biological technologies. While MAbSilico combines 3D modeling, interaction simulation and linear sequences analysis, the antibody drug candidates are defined through their epitope, affinity, off-target risk, cross-species reactivity and developability assessment to be ready for biological activity evaluation. Using NLP technologies we gather information about antibodies and their target in different databases to ensure competitive landscape analysis and the freedom to operate of the computationally designed antibodies candidates.

145 chemin des LilasMinakem offers API, fine chemicals, custom synthesis, and manufacturing services.

67 rue Saint-Jacques Paris, 75005 FranceMETHYS Dx offers digital PCR testing services, based on a portfolio of unique, cancer-specific molecular signatures, especially pertinent for liquid biopsy approaches. These highly performing tests can be carried out quickly, and allow dynamic monitoring of patients, ensuring fast access to crucial information on cancer evolution.

102 Avenue Gaston Roussel ROMAINVILLE , 93230 FranceMitologics S.A.S. is a biotechnology company specialized in detection of mitochondrial alterations. The company has developped technological platforms dedicated to compounds screening to identify compounds toxicity (DILI, cardio-toxicity) or efficacy (Oncology, Neuro-, Cardio-protection...). Among them, respiratory chain activity is measured in cultured cells or isolated mitochondria using Seahorse XFe-96 analyzer or soluble probes. Since 2009, Mitologics has performed more than 200 R&D studies for pharmaceutical companies and biotech, as well as cosmetic and agro-chemistry companies especially in Europe, the United States and Japan.

Faculté de Médecine 8, rue du Général Sarrail Créteil, 94000 FranceMitologics S.A.S. is a biotechnology company specialized in detection of mitochondrial alterations. The company has developped technological platforms dedicated to compounds screening to identify compounds toxicity (DILI, cardio-toxicity) or efficacy (Oncology, Neuro-, Cardio-protection...). Among them, respiratory chain activity is measured in cultured cells or isolated mitochondria using Seahorse XFe-96 analyzer or soluble probes. Since 2009, Mitologics has performed more than 200 R&D studies for pharmaceutical companies and biotech, as well as cosmetic and agro-chemistry companies especially in Europe, the United States and Japan.

3 rue Henri Baigue Besançon, 21000 FrancemAbexperts, a team of 5 companies based on complementary expertise in the field of Antibody Engineering, with a large panel of custom services and products. RD-BIOTECH: High added value custom services in Immunology, Genetic and Cell Engineering: Development and biomanufacturing services: plasmid DNA, monoclonal antibodies, recombinant proteins and antibodies (Fab, bispecific, scFv…). Antiby engineering platform From DNA to recombinant antibodies development (antibody sequencing, reformatting, humanization, characterization...). Analytical platform for proteins characterization and its FastELISA kits range for Ig quantification and isotyping. DIACLONE: Centre of excellence in Monoclonal Antibody and Immunoassay development, with an extensive product portfolio of mAbs (catalog and bulk format - cytokins, cell adhesion markers, ...), ELISA and ELISpot kits (such as its murine and human IFN- ELISpot). Expertise in antibody development (hybridoma and phage display), immunoassay development, and bioassays services for antibody validation and characterisation (ELISA, cytometry, Octet...). SYNABS: A catalogue of anti-species secondary antibodies (anti-human, mouse, rat, bovine, rabbit,…) and an extensive expertise in the development of monoclonal antibodies in mice, as well as in rats (LOU rats) and guinea pigs using highly innovative technologies. QVQ: Recognized expertise in the phage display development of antibody fragments (VHH) from llamas. In addition to its services, offers a range of exclusive and high-quality VHHs. SMALTIS : offers tailor-made solutions with high added value, to fight against antibiotic resistance, to explore microbiota, and to optimize bioprocesses through bacterial strain engineering.

Val-de-Reuil, 27100 FranceOur dynamic and responsive team has more than 15 years of experience in pharmaceutical development and provides reliable and efficient solutions for the biocompatibility and stability of your products. Holopharm specializes in formulation and analytical development and develops batches from 1g to pilot size

to Innovation Pharmaparc II , Val-de-Reuil, 27100 FranceOur dynamic and responsive team has more than 15 years of experience in pharmaceutical development and provides reliable and efficient solutions for the biocompatibility and stability of your products. Holopharm specializes in formulation and analytical development and develops batches from 1g to pilot size

161 Rue de la belle Etoile Roissy, 95700 FranceMacrogen Europe is a leading sequencing provider. We provide DNA and RNA sequencing for all types of samples using technology provided by our partnerships Illumina, PacBio, and Oxford Nanopore Technologies among others. However, what is most important for us is to provide high-quality data together with committed customer service. From assisting you in sending samples to us, a personal following of your project, and data delivery.

64, Avenue de la Roseraie Geneva, Geneva, 1205 Switzerland Neurix was established in 2011 by Prof. Karl-Heinz Krause as a University of Geneva spin-off, the company maintains its focus on studying neurodegenerative diseases and other related brain disorders using its in-house MiniBrain™ technology. Since incorporation, the company has received over one million euros in European research grants that allowed it to develop several neurodegenerative disease models, namely, Alzheimer’s Disease, Parkinson’s Disease and Multiple Sclerosis. Neurix’s has been fine-tuning its know-how in 3D neural cultures for over a decade, which include the development of neurospheres (relatively high-throughput) and the MiniBrains™ (larger organoids, low-medium throughput). Our team has developed in-house differentiation protocols to obtain well-characterised 2D and 3D neural cultures from human pluripotent stem cells. The production of our human brain 3D tissues is scalable and reproducible. We provide custom services to fit different research goals (drug testing, biomarker research, or disease modelling). We can functionally analyse neurospheres through multi-electrode array electrophysiology and Ca2+ imaging. There are also a wide range of other assays available (e.g. histology, immunocytochemistry, RNA-seq, single cell RNA-seq). In addition, Neurix provides services around human 3D models of neurodegenerative diseases.

23, Boulevard de L'EuropeNewLab provides oncology and animal management software.

153 avenue d’Italie, 75013 Paris, FranceImmunodiagnostic Systems (IDS) develops immunoassays and automated immunoanalyser technologies for use in clinical and research laboratories.

Bld. Sebastien Brandt Bioparc - Bat. B 67400 Illkirch, Graffenstaden, FranceNMRTEC provides solution and solid state NMR techniques, 33-D structure resolution, polymorphism assessment, API interactions, and structure/activity relationship.

4 rue Pierre Fontaine, Evry 91000, FranceNOKAD provides functional knockout aniamls, functional characterization, mammalian adenoviral overexpression, and antibodies against low antigenic protein.

Évry, Île-de-France FranceNOKAD provides functional knockout aniamls, functional characterization, mammalian adenoviral overexpression, and antibodies against low antigenic protein.

25, rue des Généraux RicardNeuroAct Communication provides consulting for CNS drug discovery.

Paris, FranceNoldus Information Technology develops software and technology in the application of tracking animal behavior.

Nantes, FranceNoldus Information Technology develops software and technology in the application of tracking animal behavior.

BioParc, Blvd Brant, BP 30170, F-67405, Illkirch, FranceNovalyst provides organic synthesis, medicinal chemistry, drug design, and outsourcing services.

81 rue de Sevres, 92100, Boulogne-BillancourtNovasyn Organics specializes in multi-step synthesis of substituted pyridine compounds.

Sciences III - University of GenevaNCCR Frontiers in Genetics offers genomics and bioimaging services.

17, rue des Martyrs CEA Grenoble Grenoble, 38054 France​L'Institut de Biosciences et Biotechnologies de Grenoble (BIG) développe des approches multidisciplinaires dans le but de décrypter les mécanismes moléculaires qui sont mis en jeu par les grands processus biologiques. Grâce aux plateformes de très haute technologie de l'institut et de son environnement, les architectures dynamiques qui composent le Vivant sont étudiées, de l'échelle atomique jusqu'à l'organisme entier. C'est grâce à la connaissance issue de cette approche multi-échelles que sont développés, avec nos partenaires académiques et industriels, de nouveaux dispositifs qui s'inspirent du Vivant. Les ruptures technologiques permises par cette approche bio-inspirée annoncent des retombées prometteuses qui participeront à l'amélioration de la santé et à un plus grand respect de notre environnement. ​

Préchac, Nouvelle-Aquitaine, 33730 France

Bordeaux, U862 France

Pépinière d'entreprises Biopôle 6 Rue Pierre Joseph Colin RENNES, 35000 FranceInsight Biosolutions (IBS) is a new startup company formed by expert team of Biologist, Clinician, Information technology and Commercial people. IBS team jointly have more than 20 years of working experience in Scientific innovation, biological materials & reagents manufacturing, commercialization of in-vitro models, in-vitro and in-silico services to Pharma and cosmetic industries.

Ecole Normale Supérieure de Lyon 46 allée d'Italie 69364 Lyon Cedex 07 FranceKallistem is a biotech company specialized in spermatogenesis. The company was founded in 2012 with the objective to anticipate and treat male infertility. It promotes a technology and expertise developed by Philippe Durand and Marie-Helene Perrard, two internationally renowned scientists in the field of the reproductive biology and more specially in in vitro spermatogenesis. Kallistem has developed, in collaboration with its partners, two original and innovating technologies of germinal cell culture for male fertility preservation and the treatment of male infertility.

4 route de la Noue
 91190 Gif-sur-Yvette – FranceKayentis offers a various range of software, medical solutions and services electronic patient reported outcome for facilitating your job in clinical data management.

OOCAP SAS, 5 AVENUE DE L’EUROPE ZA LA PILE 13760 SAINT-CANNAT FRANCE

Avenue du Lac 64150 Mourenx FRANCENovasep provides chiral separations, custom synthesis, manufacturing, generics development, and purification scale-up.

Rue Démocrite 72000 Le Mans FRANCENovasep provides chiral separations, custom synthesis, manufacturing, generics development, and purification scale-up.

Route de Givors 38670 Chasse-sur-Rhône FRANCENovasep provides chiral separations, custom synthesis, manufacturing, generics development, and purification scale-up.

Boulevard de la Moselle BP 50 - 54340 Pompey FRANCENovasep provides chiral separations, custom synthesis, manufacturing, generics development, and purification scale-up.

5 chemin du Pilon St Maurice de Beynost 01708 Miribel FRANCENovasep provides chiral separations, custom synthesis, manufacturing, generics development, and purification scale-up.

82, Boulevard de la MoselleNovasep provides chiral separations, custom synthesis, manufacturing, generics development, and purification scale-up.

Institut de Neurosciences de la Timone, Campus Santé Timone 27 Bd Jean Moulin Marseille - Cedex 05, 13385 FranceNSrepair is a preclinical services company, highly specialized in acute neurological injuries

2 avenue Favard Entrée 5, 1er étage GRADIGNAN, 33170 FranceNovaptech, the expert company for aptamer selection, characterization, optimization and functionalization.

516 rue Pierre et Marie Curie Labege, Occitanie, 31670 FranceNEPHRIX Biosolutions proposes innovative in vitro and in vivo services for efficacy & toxicity evaluation dedicated to pharmaceutical industries, biotechnology companies and other private & public laboratories developing compounds targeting kidney diseases. Validated in vitro and in vivo models for renal fibrosis, ischemia reperfusion, ureteral obstruction, diabetic nephropathy, nephrotoxicity, and more...

Europarc du Chêne 11 rue Edison BRON, Rhône Alpes, 69500 FranceNovotec provides ECM analysis, cell cultures, image analysis, culture supernatant dosages, and cellular viability.

243, route de Sandrancourt F-78520 Saint Martin La Garenne, FranceNovotec provides ECM analysis, cell cultures, image analysis, culture supernatant dosages, and cellular viability.

Saint-Martin-la-Garenne, Île-de-France FranceNovotec provides ECM analysis, cell cultures, image analysis, culture supernatant dosages, and cellular viability.

Campus de Maigremont. BP615 Val-de-Reuil, 27106 FranceNovAliX is a fully integrated drug discovery CRO supporting therapeutic programs from target identification to the delivery of preclinical candidates. NovAliX enables successful discovery programs through an award-winning team of medicinal chemistry and pharmacology scientists, and a variety of screening and characterization technologies, including an outstanding DNA-encoded library platform and a comprehensive portfolio of biophysical techniques, including an in-house cryo-EM facility. For additional information, please visit www.novalix.com or follow us on LinkedIn and Twitter.

12 Avenue de Scandinavie Courtaboeuf Cedex, Île-de-France, 91967 FranceLFB Group provides therapeutic proteins, plasma-derived medicinal products, and biological drugs. LFB offers cell line development, preclinical process development, and clinical manufacturing services through its biomanufacturing division.

Biopole Clermont-Limagne 2 Rue Michel Renaud Saint-Beauzire, 63360 FranceNeuroservices-Alliance is a CNS-focused CRO specializing in translational data, delivering functional readouts in neuropharmacology for pharmaceutical and biotech companies. Our data is generated from complementary CNS platforms, encompassing both in vitro and in vivo CNS electrophysiology and behavioral tests. Backed by a robust team of experts, we integrate functional data from rodent and human tissues, accelerating CNS and pain research programs. Our services support rapid and reliable lead selection and optimization, mechanism of action (MOA) investigation, and target engagement validation. Our capabilities include: - Electrophysiological recordings in rodent, cyno, and NHP neuronal cultures (including DRG) - Electrophysiological recordings in human iPSC-derived neurons - Electrophysiological recordings in human brain slices - Electrophysiological recordings in rodent brain slices - Electrophysiological recordings in rodent spinal cord slices - Electrophysiological recordings in vivo in rodent brain - Electrophysiological recordings in vivo in rodent spinal cord - EEG recordings in rodents - In vivo addiction assessment in rodents - In vivo CNS behavioral analysis in rodents

Neurocentre Magendie 146 Rue Léo Saignat Bordeaux, 33000 FranceNeuroservices-Alliance is a CNS-focused CRO specializing in translational data, delivering functional readouts in neuropharmacology for pharmaceutical and biotech companies. Our data is generated from complementary CNS platforms, encompassing both in vitro and in vivo CNS electrophysiology and behavioral tests. Backed by a robust team of experts, we integrate functional data from rodent and human tissues, accelerating CNS and pain research programs. Our services support rapid and reliable lead selection and optimization, mechanism of action (MOA) investigation, and target engagement validation. Our capabilities include: - Electrophysiological recordings in rodent, cyno, and NHP neuronal cultures (including DRG) - Electrophysiological recordings in human iPSC-derived neurons - Electrophysiological recordings in human brain slices - Electrophysiological recordings in rodent brain slices - Electrophysiological recordings in rodent spinal cord slices - Electrophysiological recordings in vivo in rodent brain - Electrophysiological recordings in vivo in rodent spinal cord - EEG recordings in rodents - In vivo addiction assessment in rodents - In vivo CNS behavioral analysis in rodents

Les Jardins de l'entreprise Quartier de la Confrérie Le Puy Sainte Réparade, 13610 FranceNeuroservices-Alliance is a CNS-focused CRO specializing in translational data, delivering functional readouts in neuropharmacology for pharmaceutical and biotech companies. Our data is generated from complementary CNS platforms, encompassing both in vitro and in vivo CNS electrophysiology and behavioral tests. Backed by a robust team of experts, we integrate functional data from rodent and human tissues, accelerating CNS and pain research programs. Our services support rapid and reliable lead selection and optimization, mechanism of action (MOA) investigation, and target engagement validation. Our capabilities include: - Electrophysiological recordings in rodent, cyno, and NHP neuronal cultures (including DRG) - Electrophysiological recordings in human iPSC-derived neurons - Electrophysiological recordings in human brain slices - Electrophysiological recordings in rodent brain slices - Electrophysiological recordings in rodent spinal cord slices - Electrophysiological recordings in vivo in rodent brain - Electrophysiological recordings in vivo in rodent spinal cord - EEG recordings in rodents - In vivo addiction assessment in rodents - In vivo CNS behavioral analysis in rodents

Les Jardins de l’entreprise Quartier de la Confrérie C/O Pays D’Aix Techno Park Le Puy Ste Réparade, 13610 FranceNeuroservices-Alliance is a CNS-focused CRO specializing in translational data, delivering functional readouts in neuropharmacology for pharmaceutical and biotech companies. Our data is generated from complementary CNS platforms, encompassing both in vitro and in vivo CNS electrophysiology and behavioral tests. Backed by a robust team of experts, we integrate functional data from rodent and human tissues, accelerating CNS and pain research programs. Our services support rapid and reliable lead selection and optimization, mechanism of action (MOA) investigation, and target engagement validation. Our capabilities include: - Electrophysiological recordings in rodent, cyno, and NHP neuronal cultures (including DRG) - Electrophysiological recordings in human iPSC-derived neurons - Electrophysiological recordings in human brain slices - Electrophysiological recordings in rodent brain slices - Electrophysiological recordings in rodent spinal cord slices - Electrophysiological recordings in vivo in rodent brain - Electrophysiological recordings in vivo in rodent spinal cord - EEG recordings in rodents - In vivo addiction assessment in rodents - In vivo CNS behavioral analysis in rodents

Les Jardins de l’entreprise Quartier de la Confrérie Le Puy Ste Réparade, 13610 FranceNeuroservices-Alliance is a CNS-focused CRO specializing in translational data, delivering functional readouts in neuropharmacology for pharmaceutical and biotech companies. Our data is generated from complementary CNS platforms, encompassing both in vitro and in vivo CNS electrophysiology and behavioral tests. Backed by a robust team of experts, we integrate functional data from rodent and human tissues, accelerating CNS and pain research programs. Our services support rapid and reliable lead selection and optimization, mechanism of action (MOA) investigation, and target engagement validation. Our capabilities include: - Electrophysiological recordings in rodent, cyno, and NHP neuronal cultures (including DRG) - Electrophysiological recordings in human iPSC-derived neurons - Electrophysiological recordings in human brain slices - Electrophysiological recordings in rodent brain slices - Electrophysiological recordings in rodent spinal cord slices - Electrophysiological recordings in vivo in rodent brain - Electrophysiological recordings in vivo in rodent spinal cord - EEG recordings in rodents - In vivo addiction assessment in rodents - In vivo CNS behavioral analysis in rodents

QUARTIER DE LA CONFRERIE TECHNO PARK LE PUY STE REPARADE, BDR, 13610 FranceNeuroservices-Alliance is a CNS-focused CRO specializing in translational data, delivering functional readouts in neuropharmacology for pharmaceutical and biotech companies. Our data is generated from complementary CNS platforms, encompassing both in vitro and in vivo CNS electrophysiology and behavioral tests. Backed by a robust team of experts, we integrate functional data from rodent and human tissues, accelerating CNS and pain research programs. Our services support rapid and reliable lead selection and optimization, mechanism of action (MOA) investigation, and target engagement validation. Our capabilities include: - Electrophysiological recordings in rodent, cyno, and NHP neuronal cultures (including DRG) - Electrophysiological recordings in human iPSC-derived neurons - Electrophysiological recordings in human brain slices - Electrophysiological recordings in rodent brain slices - Electrophysiological recordings in rodent spinal cord slices - Electrophysiological recordings in vivo in rodent brain - Electrophysiological recordings in vivo in rodent spinal cord - EEG recordings in rodents - In vivo addiction assessment in rodents - In vivo CNS behavioral analysis in rodents

321 avenue Jean Jaurès LYON, AURA, 69007 FranceNETRI, an industrial start-up, offers healthcare industries the ability to generate mini human organs on a chip which, coupled with AI treatments, can predict the clinical effect of a drug candidate. NETRI offers its customers support throughout the development of their drug or product candidate, providing predictive answers on toxicity, efficacy and modes of action in the discovery, preclinical and clinical phases. Organ-on-a-chip devices enable the creation of healthy or pathological physiological models. Using its high-throughput microfluidic technologies, NETRI's models recreate human physiology in vitro by co-culturing cells, either primary or derived from human stem cells, compartmentalized and coupled with functional activity measurements. NETRI today markets its NeuroFludidics™ organ-on-a-chip models in pain, cosmetics and nutritional health applications.

213 rue de Gerland Bulding A Lyon, Auvergne Rhône-Alpes, 69007 FranceNETRI, an industrial start-up, offers healthcare industries the ability to generate mini human organs on a chip which, coupled with AI treatments, can predict the clinical effect of a drug candidate. NETRI offers its customers support throughout the development of their drug or product candidate, providing predictive answers on toxicity, efficacy and modes of action in the discovery, preclinical and clinical phases. Organ-on-a-chip devices enable the creation of healthy or pathological physiological models. Using its high-throughput microfluidic technologies, NETRI's models recreate human physiology in vitro by co-culturing cells, either primary or derived from human stem cells, compartmentalized and coupled with functional activity measurements. NETRI today markets its NeuroFludidics™ organ-on-a-chip models in pain, cosmetics and nutritional health applications.

2400 Route Des Colles Biot, 06410 FranceNUVISAN IN A NUTSHELL Introduction - NUVISAN is a fully integrated contract research organization "from the molecule to the patient" - With a track record of nearly four decades as one of the first German CROs (est. 1979) - Capabilities are distributed over five locations in Germany and France - Balanced client portfolio: pharmaceutical industry, biotech companies & academic institutions Staff - Headcount of 870 employees - 40% of the staff are academics and 38% of these with PhD level - High staff loyalty ensures business continuity during the project as also the opportunity build up reliable long-term relations Quality Metrics - >90% percent of our business is based on repeat business and reflects our clients satisfaction - High quality was multiple times confirmed by various authority inspections (e.g. BfArM, EMA, FDA, ANVISA) - 71 sponsor audits & inspections in 2022 SERVICE PORTFOLIO Drug Discovery R&D Services - Lead discovery & early development - Medicinal and computational chemistry - In vitro biology - In vivo pharmacology - DMPK & toxicology - Biomarker Discovery Analytical Labs - Nonclinical & clinical PK/TK analysis - Immunogenicity & biomarkers - Central lab services Non-Clinical Studies - DMPK in discovery & development - In vitro & in vivo PK studies - Isotope/radiolabeling Pharmaceutical Services - QP services - Clinical trial supply - Formulation support - Pharmaceutical testing Clinical Trials - In-house phase I/IIa - Multicenter trial management - Monitoring Complementary & Standalone Services - Consultancy - Data management - Data sciences - Medical writing - PK analysis

111, Bd Duhamel de MonceauNucleoSyn offers DNA and RNA monomers, amino acid building blocks and synthetic sphingolipids and phospholipids.

Rond-Point de Gomberville PA Gomberville Magny-les-Hameaux, Île-de-France, 78114 FranceORGA-LINK is an independant CRO which proposes efficient services of Research and Development in Organic Synthesis on the scale from miligrams to kilograms. ORGA-LINK services also include extraction of natural products and analysis as well as the development of new compounds. ORGA-LINK proposes services in organic chemistry based on quality, flexibility and efficiency tailored to your needs with optimized costs. As multi-skilled chemists, we can realize every type of chemistry, from pharmaceuticals to peptide chemistry to inorganic chemistry with particularly strong expertise in the field of heterocyclic chemistry. TO KEEP YOUR TEAMS FOCUSED ON SUBJECTS OF HIGHER ADDED VALUE AND SAVE YOU BOTH TIME AND MONEY REDUCING YOUR COSTS OF SYNTHESIS : OUTSOURCE A PART OF YOUR R&D WORK. ORGA-LINK can meet your needs in term of : • Organic synthesis : multi-stage synthesis from the mg to multi-kg of derivatives, impurities, products, targets / leads and analogues • Classical or original synthesis: high pressure reaction, photosensitive (inactinic light), stable isotopic labelling (D, 13C, 15N) • R&D under contract in organic chemistry • Structural analysis, extraction • Quantitative analysis, dosage • Sourcing of compounds • Database and literature searching

1 rue Amedee Gordini PA Gomberville Magny Les Hameaux, 78114 FranceORGA-LINK is an independant CRO which proposes efficient services of Research and Development in Organic Synthesis on the scale from miligrams to kilograms. ORGA-LINK services also include extraction of natural products and analysis as well as the development of new compounds. ORGA-LINK proposes services in organic chemistry based on quality, flexibility and efficiency tailored to your needs with optimized costs. As multi-skilled chemists, we can realize every type of chemistry, from pharmaceuticals to peptide chemistry to inorganic chemistry with particularly strong expertise in the field of heterocyclic chemistry. TO KEEP YOUR TEAMS FOCUSED ON SUBJECTS OF HIGHER ADDED VALUE AND SAVE YOU BOTH TIME AND MONEY REDUCING YOUR COSTS OF SYNTHESIS : OUTSOURCE A PART OF YOUR R&D WORK. ORGA-LINK can meet your needs in term of : • Organic synthesis : multi-stage synthesis from the mg to multi-kg of derivatives, impurities, products, targets / leads and analogues • Classical or original synthesis: high pressure reaction, photosensitive (inactinic light), stable isotopic labelling (D, 13C, 15N) • R&D under contract in organic chemistry • Structural analysis, extraction • Quantitative analysis, dosage • Sourcing of compounds • Database and literature searching

1682 rue de la Valsière Montpellier, 34189 FranceOxeltis is a medicinal chemistry services company founded in 2010 by former researchers at Idenix Pharmaceuticals (Ex MSD-company) in Montpellier - France. The company has a small-scale custom synthesis business, as well as hit and lead optimization services, in various areas such as of antivirals, antibiotics and anticancer compounds. The Oxeltis team comprises experienced medicinal chemists (65% with PhDs) in 800 m² research labs, with expertise in particular areas of multi-step complex organic synthesis: heterocycles, macrocycles, nucleos(t)ides/phosphoramidites, modified sugars and oligosaccharides... and services of synthesis of E3 ligase ligand-linker conjugates for PROTAC programs. The team focuses on speed, quality and confidentiality in the services and collaborative ventures that it develops. Oxeltis works with European, Japanese and North American start-up and big pharma companies as well as research institutions.

1682 Rue de la Valsière Grabels, 34790 FranceOxeltis is a medicinal chemistry services company founded in 2010 by former researchers at Idenix Pharmaceuticals (Ex MSD-company) in Montpellier - France. The company has a small-scale custom synthesis business, as well as hit and lead optimization services, in various areas such as of antivirals, antibiotics and anticancer compounds. The Oxeltis team comprises experienced medicinal chemists (65% with PhDs) in 800 m² research labs, with expertise in particular areas of multi-step complex organic synthesis: heterocycles, macrocycles, nucleos(t)ides/phosphoramidites, modified sugars and oligosaccharides... and services of synthesis of E3 ligase ligand-linker conjugates for PROTAC programs. The team focuses on speed, quality and confidentiality in the services and collaborative ventures that it develops. Oxeltis works with European, Japanese and North American start-up and big pharma companies as well as research institutions.

17, rue de Pontoise 95520 Osny - FranceOSNY Pharma offers integrated pharmaceutical services, from formulation to commercial manufacturing and packaging, focusing on highly-potent compounds.

Osny, Île-de-France, 95520 FranceOSNY Pharma offers integrated pharmaceutical services, from formulation to commercial manufacturing and packaging, focusing on highly-potent compounds.

2 rue Antoine Etex Créteil, 94000 FranceOxiProteomics is a CRO pioneering an innovative approach focused on protecting and repairing skin and hair against environmental damage and biochemical stressors. Our main goal is to maintain skin and hair health through science-based solutions, delivering science-based results. Specializing in providing innovative testing solutions, ranging from human cell cultures (such as keratinocytes, fibroblasts, melanocytes, and sebocytes) to advanced human skin models, scalp tissue, hair strands, and hair follicle assessments. Our analytical platform is versatile, enabling protein biomarker analysis across various organ tissues and body fluids. We offer accurate, actionable, and specific Predictive biomarkers for skin health & longevity research. With our comprehensive capabilities and dedication to scientific excellence, we are committed to helping you evolve with innovative scientific testing solutions in the field of skincare and haircare.

Rond Point de l'Echangeur Les Levées SOLAIZE, 69360 FranceExperts in Machine Learning and process supervision, the Ondalys team supports manufacturers in analyzing their data to better understand processes using Machine Learning methods, but also to supervise processes and detect drifts in real time (Process monitoring). With a long experience and a solid know-how on spectroscopy, analytical and process data, Ondalys offers services in data analysis for the process development and supervision. Ondalys also provides data analysis training sessions for beginners and confirmed trainees and is also reseller of chemometrics / Machine Learning and process supervision software.

4 rue Georges Besse CLAPIERS, 34830 FranceExperts in Machine Learning and process supervision, the Ondalys team supports manufacturers in analyzing their data to better understand processes using Machine Learning methods, but also to supervise processes and detect drifts in real time (Process monitoring). With a long experience and a solid know-how on spectroscopy, analytical and process data, Ondalys offers services in data analysis for the process development and supervision. Ondalys also provides data analysis training sessions for beginners and confirmed trainees and is also reseller of chemometrics / Machine Learning and process supervision software.

Alès, Occitanie FranceMAbgène offers monoclonal antibodies, recombinant proteins from animal cell lines, expression, optimization, scale up and manufacturing services.

102 avenue Gaston Roussel Romainville, 93230 FranceOroxcell is a CRO and R&D partner in the field of ADMET (Absorption Distribution Metabolism, Excretion, Toxicity), Efficacy and Bioanalysis. For many years Oroxcell has specialized in alternative methods to animal use and extensively invested in ADMET assays using promising 3D Human Organotypic models. Oroxcell is also a state-of-the-art bioanalytical testing facility; our team will deliver you quality and reliable results thanks to our LC-MS/MS instruments and our personnel’s wide range of skills. Our clients are pharmaceutical, dermato-cosmetic, nutrition health and medical device companies. Oroxcell laboratories are regularly inspected for GLP compliance.

20 rue Jean Mazen BP 27627 Dijon, 21076 Cedex FranceOncodesign Services is a Contract research organization (CRO) specializing in drug discovery and preclinical services. Founded in 1995, Oncodesign Services mission’ is to contribute to the discovery of innovative therapies with unmet medical needs, in particular in oncology, inflammation and infectious diseases. From target identification, hit-to-lead and lead optimization to IND filing, Oncodesign Services support the R&D programs of customers globally (whether pharmaceutical companies, biotechs, public research institutions, etc.). Oncodesign Services offers a full spectrum of services in medicinal chemistry, DMPK, pharmaco-imaging, bioanalysis, in vivo/In vitro pharmacology (including humanized models). This continuum enables, either as stand-alone (SOLO) or as integrated (DRIVE) programs, the drug discovery of small molecule, molecular radiotherapy and biologicals entities. As a pioneer in translational medicine to evaluate the efficacy of treatments, the company challenge relies on increasing throughput, minimizing timelines from bench to bedside while having a differential proposition of treatment for patients and therefore innovative science. For that, Oncodesign Services has been creating new technological pathways to find and select the best drug candidates. Oncodesign Services has BSL1, BSL2 and BSL3 laboratories and all sites maintain the full AAALAC international accreditation for our animal care and use program. Based in Dijon, France, in the heart of the university and hospital cluster, within the Paris-Saclay cluster and in Montreal, Canada, Oncodesign Services benefits from 15,000m² of fully equipped chemistry and biologic laboratories. Oncodesign Services has 230 employees in France, United Kingdom, Germany, Canada and the United States, with highly competent in discovery research and translational pharmacology).

20 rue Jean Mazen B.P. 27627 Dijon, 21076 Cedex FranceOncodesign Services is a Contract research organization (CRO) specializing in drug discovery and preclinical services. Founded in 1995, Oncodesign Services mission’ is to contribute to the discovery of innovative therapies with unmet medical needs, in particular in oncology, inflammation and infectious diseases. From target identification, hit-to-lead and lead optimization to IND filing, Oncodesign Services support the R&D programs of customers globally (whether pharmaceutical companies, biotechs, public research institutions, etc.). Oncodesign Services offers a full spectrum of services in medicinal chemistry, DMPK, pharmaco-imaging, bioanalysis, in vivo/In vitro pharmacology (including humanized models). This continuum enables, either as stand-alone (SOLO) or as integrated (DRIVE) programs, the drug discovery of small molecule, molecular radiotherapy and biologicals entities. As a pioneer in translational medicine to evaluate the efficacy of treatments, the company challenge relies on increasing throughput, minimizing timelines from bench to bedside while having a differential proposition of treatment for patients and therefore innovative science. For that, Oncodesign Services has been creating new technological pathways to find and select the best drug candidates. Oncodesign Services has BSL1, BSL2 and BSL3 laboratories and all sites maintain the full AAALAC international accreditation for our animal care and use program. Based in Dijon, France, in the heart of the university and hospital cluster, within the Paris-Saclay cluster and in Montreal, Canada, Oncodesign Services benefits from 15,000m² of fully equipped chemistry and biologic laboratories. Oncodesign Services has 230 employees in France, United Kingdom, Germany, Canada and the United States, with highly competent in discovery research and translational pharmacology).

Z.I du ClairayPANPHARMA offers contract manufacturing for powders for injection, liquids, and suspensions in addition to API supply/analysis services.

18 rue Alain Savary 25000 Besançon ConnexionPROVISKIN propose des solutions innovantes destinées à la recherche en cosmétologie, dermatologie et toxicologie. La société a pour mission de renforcer l'efficience des tests de nos clients, principalement des laboratoires cosmétiques, pharmaceutiques et vétérinaires, en optimisant leurs processus de recherche sur explants de peau humaine et animale, tant congelée que fraiche. Pour répondre aux attentes de nos clients, la société Proviskin a développé une solution complète : une gamme de produits brevetés : Kit de peau K-Skin, cellule de diffusion D-Skin l’un des plus vastes réseaux de collecte de tissu humain en Europe, d’origine humaine et animale. une expertise d’études et de services dans le domaine cutané.

280 RUE DE L'HERS ESCALQUENS, OCCITANIE, 31750 FrancePhysiogenex is a preclinical contract research organization (CRO) specializing in metabolic and cardiovascular diseases. We provide, first level phenotyping and screening, efficacy and proof-of-concept studies in metabolic diseases, diabetes, insulin resistance, obesity, dyslipidemia, cardiometabolic, kidney diseases, and liver diseases (NAFLD/NASH/liver fibrosis), lung and kidney fibrosis. We have a 20-year expertise in animal models of metabolic diseases and drug development. Our customer satisfaction rate is 97.5% in 2022.

3, rue Arronax Saint-Herblain, Loire Atlantique, 44800 FranceProfileHIT is a French company specialized in drug profiling. ProfileHIT provides you with an innovative solution for assessing toxicity and pharmacological activity of any compound of interest on human vascular cells through a large array of functional readouts.

Saint-Herblain, 44800 FranceProfileHIT is a French company specialized in drug profiling. ProfileHIT provides you with an innovative solution for assessing toxicity and pharmacological activity of any compound of interest on human vascular cells through a large array of functional readouts.

321 avenue Jean Jaurès Lyon, 69007 FrancePlatine Pharma Services offers immunomonitoring solutions including assays for cytotoxicity, proliferation, immunophenotyping, ligand binding, chemokines, cytokines, and anti-drug antibodies.

20 Rue Marc Donadille Marseille, Provence-Alpes-Côte d'Azur, 13013 FranceAt PROVEPHARM LIFE SOLUTIONS, we vitalize pharmaceutical and cosmetic research programs in small molecules and peptide chemistry. We add value to our clients’ preclinical and clinical projects at every step from process research through development to market. For all collaboration, our strength is to act as our clients’ labs. Small Molecules: Route scouting, custom synthesis, impurity isolation and characterization, process optimization for pilot scale, full package development prior to GMP production. > Heterocyclic chemistry, nucleosides, sugar chemistry, macrocycles Peptides: Drug product pre-formulation, supply of ready for use experimental batches, API GMP production, supply of finished product for clinical trials, one-stop shop. > Peptide-based vaccines, Multi-epitope polypeptide (one shot or ligation), MAP construction, Immuno-conjugated peptides (KLH, CRM) and folded, cyclic, stapled peptides.

22 Rue Marc Donadille Marseille, Provence-Alpes-Côte d'Azur, 13013 FranceAt PROVEPHARM LIFE SOLUTIONS, we vitalize pharmaceutical and cosmetic research programs in small molecules and peptide chemistry. We add value to our clients’ preclinical and clinical projects at every step from process research through development to market. For all collaboration, our strength is to act as our clients’ labs. Small Molecules: Route scouting, custom synthesis, impurity isolation and characterization, process optimization for pilot scale, full package development prior to GMP production. > Heterocyclic chemistry, nucleosides, sugar chemistry, macrocycles Peptides: Drug product pre-formulation, supply of ready for use experimental batches, API GMP production, supply of finished product for clinical trials, one-stop shop. > Peptide-based vaccines, Multi-epitope polypeptide (one shot or ligation), MAP construction, Immuno-conjugated peptides (KLH, CRM) and folded, cyclic, stapled peptides.

PROVECUBE, 22 rue Marc Donadille France Marseille, 13013 FranceAt PROVEPHARM LIFE SOLUTIONS, we vitalize pharmaceutical and cosmetic research programs in small molecules and peptide chemistry. We add value to our clients’ preclinical and clinical projects at every step from process research through development to market. For all collaboration, our strength is to act as our clients’ labs. Small Molecules: Route scouting, custom synthesis, impurity isolation and characterization, process optimization for pilot scale, full package development prior to GMP production. > Heterocyclic chemistry, nucleosides, sugar chemistry, macrocycles Peptides: Drug product pre-formulation, supply of ready for use experimental batches, API GMP production, supply of finished product for clinical trials, one-stop shop. > Peptide-based vaccines, Multi-epitope polypeptide (one shot or ligation), MAP construction, Immuno-conjugated peptides (KLH, CRM) and folded, cyclic, stapled peptides.

126 blvd Pereire, 75017 Paris, FrancePREDECT is an IMI-funded partnership between 9 academic, 3 SME (Small and Medium Enterprise) and 7 EU pharmaceutical partners, aiming to develop novel, advanced, complex in vitro and in vivo models for breast, prostate and lung cancers.

5 chemin du Quilourin Moulin du Pont 29170 PLEUVEN – FrancePolaris has been an expert in the field of lipochemistry and is specialised in the production, development and formulation of polyunsaturated fatty acids, and marine-derived Omega-3 in particular.

FrancePhenotype Expertise offers CNS and pain models for efficacy testing.

16 rue Jean Rostand, Gaillac, FrancePierre Fabre Med. Plantes & Industrie offers pharmaceutical ingredient development, chemistry manufacturing and controls, systems manufacturing, and process development.

Gaillac, Occitanie, 81600 FrancePierre Fabre Med. Plantes & Industrie offers pharmaceutical ingredient development, chemistry manufacturing and controls, systems manufacturing, and process development.

115 Chemin de l'Islon Chasse-sur-Rhône, Auvergne-Rhône-Alpes, 38670 FranceNAMSA is a Medical Research Organization (MRO), accelerating product development through integrated laboratory, clinical and consulting services. Driven by our regulatory expertise, NAMSA’s MRO® Approach plays an important role in translational research, applying a unique combination of disciplines—consulting, preclinical, toxicology, microbiology, chemistry, clinical and quality—to move client’s products through the development process, and continue to provide support through commercialization to post-market requirements, anywhere in the world.

31 rue d'Aguesseau 92100 Boulogne Billancourt FranceProfilomic is an innovative company offering a wide range of services in chemical, lipidomic and metabolomic analyses using liquid chromatography coupled to mass spectrometry ultra-high resolution (LC-FTMS). Through in-house and public databases, our software and our dedicated statistical analysis tools, we can meet all requests for biomarker discovery and characterization of small organic molecules in the health, environment and food areas. Profilomic has access to recent LC-MS instruments: LTQ-Orbitrap Discovery™, Q-Exactive™, Exactive™ (Thermo Scientific) and Maxis Q-TOF (Bruker).

18 avenue de l'Opéra 75001. Paris, FrancePeritesco offers occular toxicity, efficacy testing, and imaging services.

Paris, Île-de-France FrancePeritesco offers occular toxicity, efficacy testing, and imaging services.

Route d’AvignonPCAS provides custom synthesis, intermediates, custom manufacturing, microelectrics, and protection additives.

19 route de Meulan, 78520 Limay, FrancePCAS provides custom synthesis, intermediates, custom manufacturing, microelectrics, and protection additives.

Route de Lassay, 61410 Couterne, FrancePCAS provides custom synthesis, intermediates, custom manufacturing, microelectrics, and protection additives.

15 avenue des frères-Lumière, 38300 Bourgoin-Jallieu, FrancePCAS provides custom synthesis, intermediates, custom manufacturing, microelectrics, and protection additives.

BP 181 - 23 Rue Bossuet, Z.I. La Vigne aux Loups, 91160 Longjumeau, FrancePCAS provides custom synthesis, intermediates, custom manufacturing, microelectrics, and protection additives.

1 rue Grandville Nancy, 54000 FrancePROGEPI - PROCESSlab is the centre for technology transfer of the LRGP (Reactions and Chemical Engineering Laboratory), located in ENSIC-Nancy. Since 2007, PROGEPI is integrated in the *ICEEL* institute (a national label given by ANR French Research National Agency) covering the Energy and Environment areas. Since its creation in 2005, PROGEPI has carried out about 600 studies for companies. We have a full-time team, an expertise of laboratories, as well as an access to their whole infrastructure (analytical equipment, test floors, documentation centre, computational equipment, mechanical workshop…).

7, parvis Louis NéelPX'Therapeutics is a CDMO offering services for the development and production of recombinant proteins, monoclonal/polyclonal antibodies, antibody fragments and whole microorganisms. Founded in 2000, PX'Therapeutics can support your biological projects from DNA sequence optimization, screening of expression systems (microbial, yeast, mammalian), small scale production, process development up to GMP manufacturing.

7 Parvis Louis Néel - CS20050 - MINATEC BHT 52A Grenoble, 38040 FrancePX'Therapeutics is a CDMO offering services for the development and production of recombinant proteins, monoclonal/polyclonal antibodies, antibody fragments and whole microorganisms. Founded in 2000, PX'Therapeutics can support your biological projects from DNA sequence optimization, screening of expression systems (microbial, yeast, mammalian), small scale production, process development up to GMP manufacturing.

Nantes, Pays de la Loire FranceProtNeteomix offers array fabrication, molecular interaction detection, and protein production.

Zone Industrielle La Carie, Argentré 53210Expert in single or automated equipment dedicated to the food industry since 1994, our company is based in Mayenne, in Argentré next to Laval. Located at the crossroads of major food regions such as the Loire Valley, Brittany and Normandy, we operate throughout France and abroad.

20 Rue Henri Goudier Riom, 63200 FranceProteodynamics specializes in protein and peptide characterization services including mass spectrometry, glycosylation analysis, sequencing, chromatography, and purification.

Nimes, Occitanie FranceProtéus discovers, engineers, optimizes and produces new proteins and protein-based products and processes.

Rue d'Aste Beon, BP 27 F- 64121 Serres Castet FranceSince its creation in 1985, PROMO-VERT S.A.S., is present on the CRO business through a network of 5 experimentation locations in France and is a leader on its market by offering the following services: · Open field trials for testing agrochemicals products, fertilizers, seed varieties. The results of these trials allow in fine to write down the BADs (Biological Assessment Dossier) to get the sales authorizations. These trials are set up according to the Good Experiment Practices for which PROMO-VERT S.A. has an agreement on behalf of the Ministry of Agriculture according to the new requirements of COFRAC, renewed in 2013. · Residue trials are designed to measure the residues of an agrochemical product after its application on the crop or in the soil. These trials are carried out according to the Good Laboratory Practices : PROMO-VERT S.A.S is agreed by the GIPC (Interministerial Grouping of Chemical products) in France renewed in 2013. PROMO-VERT S.A.S has also developed an European offer by creating a subsidiary in Spain in 1990 : PROMOVERT CROP Services (see web site down) which carries through the same type of services on the whole Spanish territory with the corresponding GEP or GLP Spanish certificates. On the other hand, through long-time co-workers, PROMO-VERT S.A.S coordinates the realization of European experimentation programs in Italy, Germany, Greece and United Kingdom.

72 rue du Maréchal Foch Lingolsheim, 67380 FranceOctapharma develops and produces medicines based on human proteins from human cell lines and human plasma, sourced from our own plasma donation centers and other external sources.

6 rue Jean Calvin Paris, 75010 FranceOria Bioscience is an organelle provider. We purify viable lysosomes, mitochondria and endoplasmic reticulum at high throughput thanks to a microfluidic technology. The organelles are stockable and compatible with high throughput screening platform.

2 Avenue de la source de la bièvre UFR Sciences de la Santé MONTIGNY-LE-BRETONNEUX, Île-de-France, 78180 FrancePELVIPHARM is a contract research organization (CRO) delivering preclinical services in urology and genitourinary disorders, male and female sexual dysfunctions, cardiovascular / metabolism medicine, urology and women's health disorders using a unique platform of both in vivo experimental models and in vitro animal and human tissue-based specific research outsourcing services.

Le Campus 6 rue Jean Pierre Timbaud 78180 Montigny le Bretonneux Paris FrancePopsi Cube has a unique profile for an international Clinical Research Organisation providing distinctive and innovative dual expertise by combining clinical research implementation with the development of customized IT applications specific to the pharmaceutical industry, using agile method and digital iot for data capture optimization. Our expertise stems from many years of experience spent inside the largest CRO or pharmaceutical companies. We always considered IT as a valuable tool and as a way to improve and industrialize processes. It is our in-depth knowledge of pharmaceutical R&D which allows us to transform these tools to support a real advance in your clinical projects. Contact us to get started : +33 1 6 62 89 32 58

6 rue Jean-Pierre Timbaud Le Campus Bât A1 Sud Montigny-le-Bretonneux, Île-de-France, 78930 FrancePopsi Cube has a unique profile for an international Clinical Research Organisation providing distinctive and innovative dual expertise by combining clinical research implementation with the development of customized IT applications specific to the pharmaceutical industry, using agile method and digital iot for data capture optimization. Our expertise stems from many years of experience spent inside the largest CRO or pharmaceutical companies. We always considered IT as a valuable tool and as a way to improve and industrialize processes. It is our in-depth knowledge of pharmaceutical R&D which allows us to transform these tools to support a real advance in your clinical projects. Contact us to get started : +33 1 6 62 89 32 58

161 rue de CourcellesAt PRA Health Sciences, providing innovative solutions for our clients is what we do. But innovation just for the sake of innovation isn’t why we do it. Side-by-side with our clients, we strive to move drug discovery forward, to help them develop life-saving and life- improving drugs. We help change people’s lives for the better every single day. It’s who we are. Innovating to help people is at the heart of our process, but it’s even more than that. It’s also our privilege.

Level 6, Block 8Q-Pharm offers phase I clinical research services including bioanalysis, assay development/validation, pharmacokinetic analysis, data analysis, PK analysis, and bioequivalence.

200 Rue Leonard de VinciParexel provides bioequivalence studies as well as clinical services across Phase I to Phase III of drug development including dose escalation, drug-drug interaction, biomarkers, first-in-man studies, ADME, imaging, and clinical research services.

Plan-les-Ouates, GE SwitzerlandSelexis offers mammalian cell line development and cell line technology products and services.

Chemin du Vallon de Maire 13240 Septemes-Les Vallons FranceSPI Pharma provides development of drug delivery systems, anatacid actives and supplies excipients for tablets, soft gels and effervescents.

45 Boulevard Pagnol Grasse Biotech Grasse, Choisir une province, 06130 FrancePKDERM is a French private company that provides smart innovative solutions for in vitro safety and efficacy testing. Created in 2018, PKDERM relies on the expertise of more than 20 years of its founder, Dr. Hanan Osman-Ponchet. As a former leader in metabolism and pharmacokinetics for large pharmaceutical companies, PKDERM’s CEO has developed and tested many alternatives to animal experiment models allowing a reliable and secure evolution from in-vivo experimentation to in-vitro experimentation. The company is located in Grasse, in the south of France and aims to support partners in the area of cosmetics/Personal care, dermatology, pharmaceutical, chemical, agro/petrochamical, and medical device industries. At PKDERM, we are familiar with an array of different assay systems to evaluate the safety and efficacy of new products. This allows us to work with our clients to determine the optimum assay that best fit their needs. Our acknowledged experience with our worldwide network of multidisciplinary partners enable us to rapidly support our customers confronted with new urgent testing needs. Our biological models include but not limited to: 2D culture of human skin cells (keratinocytes, fibroblasts, melanocytes), 3D human skin equivalent models, excised human skin, 2D and 3D human hepatocytes, 2D and 3D human lung models. Our in vitro safety testing includes but not limited to: dermal absorption, skin irritation, eye irritation, skin sensitization, cytotoxicity, phototoxicity, endocrine properties, metabolism, drug transporters and drug-drug interactions. Our in vitro pharmacology/efficacy testing includes but not limited to: dermal and nail absorption, anti-inflammatory properties, pigmentation, ageing, wound healing, ... We provide personalized service for every client and every project and we support the development of new products from the initial reflection and conceptualization to the data promotion and publication. We perform standard testing services as well as optimizing and validating new alternative assays. On the other hand, PKDERM offers scientific and project management services related to alternative methods to animal testing and provides workshops and practical training on the use of in vitro methods. Please do not hesitate to contact us if you need further assistance, have questions or need to place an order.

28, Corniche Valmare Antibes, 06600 FrancePKDERM is a French private company that provides smart innovative solutions for in vitro safety and efficacy testing. Created in 2018, PKDERM relies on the expertise of more than 20 years of its founder, Dr. Hanan Osman-Ponchet. As a former leader in metabolism and pharmacokinetics for large pharmaceutical companies, PKDERM’s CEO has developed and tested many alternatives to animal experiment models allowing a reliable and secure evolution from in-vivo experimentation to in-vitro experimentation. The company is located in Grasse, in the south of France and aims to support partners in the area of cosmetics/Personal care, dermatology, pharmaceutical, chemical, agro/petrochamical, and medical device industries. At PKDERM, we are familiar with an array of different assay systems to evaluate the safety and efficacy of new products. This allows us to work with our clients to determine the optimum assay that best fit their needs. Our acknowledged experience with our worldwide network of multidisciplinary partners enable us to rapidly support our customers confronted with new urgent testing needs. Our biological models include but not limited to: 2D culture of human skin cells (keratinocytes, fibroblasts, melanocytes), 3D human skin equivalent models, excised human skin, 2D and 3D human hepatocytes, 2D and 3D human lung models. Our in vitro safety testing includes but not limited to: dermal absorption, skin irritation, eye irritation, skin sensitization, cytotoxicity, phototoxicity, endocrine properties, metabolism, drug transporters and drug-drug interactions. Our in vitro pharmacology/efficacy testing includes but not limited to: dermal and nail absorption, anti-inflammatory properties, pigmentation, ageing, wound healing, ... We provide personalized service for every client and every project and we support the development of new products from the initial reflection and conceptualization to the data promotion and publication. We perform standard testing services as well as optimizing and validating new alternative assays. On the other hand, PKDERM offers scientific and project management services related to alternative methods to animal testing and provides workshops and practical training on the use of in vitro methods. Please do not hesitate to contact us if you need further assistance, have questions or need to place an order.

62 RN 113 30620 Bernis FRANCEPhylogene SA is an R&D and servicing lab in genomics, transcriptomics, (PCR, rtPCR, NGS) proteomics, metabolomics (LC-MS/MS and immunotechniques) dedicated bioinformatics. These applications are mainly services to food, cosmetics and health industries including in vitro diagnostics, and environment industry.

Z.A. de Glatigne Le Genest-Saint-Isle, 53940 FrancePorsolt is a global preclinical CRO with almost 40 years of experience providing preclinical discovery, efficacy, and safety pharmacology services. We provide GLP services in multiple species (including rodents, rabbits, guinea pigs, ferrets, minipigs, and dogs) in a variety of disease areas including CNS, Oncology, Drug Abuse, CV, Pain, Inflammation, GI, Dermatology, Metabolism and Medical Devices. We also provide biomarker analysis, in vitro screening, predictive toxicology and efficacy services with High Content Analysis, Live Content Imaging, and High Content Histology, using of the latest technologies. Please access our online catalog for more detailed information about our services and capabilities: https://www.porsolt.com/wp-content/uploads/2023/Catalog/catalog_interactive_Porsolt.pdf

10 rue Henri Regnault Castres, Occitanie, 81100 FrancePhysioStim is a French preclinical CRO dedicated to cardiovascular pharmacology and electrophysiology from discovery stages to clinical development. Whatever the therapeutic areas, we ensure robust and valuable preclinical data on cardiovascular activities and secondary pharmacology to secure in-vivo development and bring new safe therapies to patients. Thanks to our predictive and translational models, we define the POC of drug discovery, we investigate secondary pharmacology with on and off-target liabilities, and we address the safety purpose in order to build and support your IND submission (with mandatory and not mandatory assays). Physiostim senior scientific team is evolving in a GLP environment, the reactivity and accuracy are our best “signature” for more than 20 years. Let’s bridge the preclinical gap together, for the success of your clinical applications.

ZI DE BRENAS LAUTREC, NA, 81440 FrancePhysioStim is a French preclinical CRO dedicated to cardiovascular pharmacology and electrophysiology from discovery stages to clinical development. Whatever the therapeutic areas, we ensure robust and valuable preclinical data on cardiovascular activities and secondary pharmacology to secure in-vivo development and bring new safe therapies to patients. Thanks to our predictive and translational models, we define the POC of drug discovery, we investigate secondary pharmacology with on and off-target liabilities, and we address the safety purpose in order to build and support your IND submission (with mandatory and not mandatory assays). Physiostim senior scientific team is evolving in a GLP environment, the reactivity and accuracy are our best “signature” for more than 20 years. Let’s bridge the preclinical gap together, for the success of your clinical applications.

5, allée d’Helsinki BP 50043 – Schiltigheim Strasbourg cedex, Strasbourg cedex, 67012 FrancePhoenix Pharmaceuticals Inc. specializes in Obesity, Cardiovascular, and Diabetes, providing over 7,000 peptide related products to researchers worldwide.

3 quai Kleber, Tour Sebastopol, 67000, Strasbourg, FrancePhoenix Pharmaceuticals Inc. specializes in Obesity, Cardiovascular, and Diabetes, providing over 7,000 peptide related products to researchers worldwide.

11 Rue Watt, Paris-13E-Arrondissement, Île-de-France 75013, FRPathoQuest SAS, a spin off of Institut Pasteur, is a biotechnology company offering a game changing metagenomics approach to improving the breadth of pathogen detection. The company’s proprietary next generation sequencing (NGS) based testing approach delivers actionable reports to clinicians, biologists and biopharmaceutical quality assurance managers/production managers. PathoQuest’s proprietary sample preparation, and its comprehensive database of pathogens genomic information, enables clinicians and biopharma companies to overcome the current limitation of infectious agent detection. PathoQuest’s Viral Safety testing service, directed towards biopharmaceutical companies, is the company’s first commercial application of its testing approach and has quickly established a revenue stream for the company from several major biopharma companies.

Pathoquest France Paris, 75, 75013 FrancePathoQuest SAS, a spin off of Institut Pasteur, is a biotechnology company offering a game changing metagenomics approach to improving the breadth of pathogen detection. The company’s proprietary next generation sequencing (NGS) based testing approach delivers actionable reports to clinicians, biologists and biopharmaceutical quality assurance managers/production managers. PathoQuest’s proprietary sample preparation, and its comprehensive database of pathogens genomic information, enables clinicians and biopharma companies to overcome the current limitation of infectious agent detection. PathoQuest’s Viral Safety testing service, directed towards biopharmaceutical companies, is the company’s first commercial application of its testing approach and has quickly established a revenue stream for the company from several major biopharma companies.

GrasseBiotech 45 Boulevard Marcel Pagnol Grasse, 06130 FrancePhenocell is a research-based biotechnology company specialized in the creation, production, and commercialization of cellular models and bioassays for the dermo-cosmetic and pharmaceutical industry through the Noble Prize-winnning technology of iPSC. We specialize in dermatology and ophthalmology, with specific bioassays for skin pigmentation, acne (hyper seborrhea), skin dryness (hypo seborrhea), CBD testing and inflammation, and for diseases that involve retinal degeneration. Phenocell is here to help you improve and accelerate your research and discovery programs with highly relevant in vitro tools.

4, rue Pierre Fontaine Evry cedex, F-91058 FrancePhenocell is a research-based biotechnology company specialized in the creation, production, and commercialization of cellular models and bioassays for the dermo-cosmetic and pharmaceutical industry through the Noble Prize-winnning technology of iPSC. We specialize in dermatology and ophthalmology, with specific bioassays for skin pigmentation, acne (hyper seborrhea), skin dryness (hypo seborrhea), CBD testing and inflammation, and for diseases that involve retinal degeneration. Phenocell is here to help you improve and accelerate your research and discovery programs with highly relevant in vitro tools.

Fort Foch, Niederhausbergen FranceSilabe offers a large range of NonHuman Primate bioproducts to academic research institutes and companies in the field of Science and Health. Samples from our biobank (blood, serum, plasma…) are collected from healthy captive-bred monkeys housed in Europe, with respect to animal welfare and regulations in force. Sampling is performed under veterinary supervision; the quality and the traceability are guaranteed by the certificate provided with the products. Silabe delivers worldwide, respecting all international rules including CITES permits and sanitary requirements. Biological products of primates from different species (Cynomolgus and Rhesus Macaques, Marmosets…), origin, sex and age are currently available, and we can also provide customized primate products.

80 Chemin de Riboulin 26270 LORIOL SUR DROME (Drôme, France)

80 Chemin de Riboulin Loriol-sur-Drôme, Auvergne-Rhône-Alpes, 26270 France

132 Rue Andre Bisiaux Maxeville, 54320 FranceWhen renting medical devices at Quipment TM, you not only get your investigator sites equipped on time. You also get leading-edge tools to pilot your study equipment like never before. Quipment is setting new standards in equipment rental and management. With Quipsite®, the most integrated platform on the market, Quipment brings a unique technology that allows its customers to deploy and manage study equipment with unparalleled efficiency.

8, RUE VERNIER 75017 PARIS FRANCEQuinten is a pioneer in data science and the strategic application of data in business.

8 Rue Vernier Paris, Île-de-France, 75017 FranceQuinten is a pioneer in data science and the strategic application of data in business.

2 allée du Doyen Georges Brus Pessac, 33370 FranceQuantaCell is a pioneering firm specializing in data analysis and artificial intelligence tailored for the life sciences industry. Established in 2014, our headquarters are now located at St Eloi Hospital in Montpellier, France. At QuantaCell, we are deeply immersed in addressing biomedical inquiries and are keenly attuned to the evolving needs of clinical research units. Our dynamic team excels in delivering cutting-edge software solutions rooted in artificial intelligence and image analysis technology. We specialize in quantifying and analyzing various data and image types, including virtual slides, confocal/electron microscopy images, videos, and medical imaging for both patients and small animals. Our comprehensive services encompass: - Cellular Analysis: Nuclear and cellular counting Nucleic acid and protein analysis Neuronal network detection Viability assessments Cellular type segregation Protein translocation analysis Kinetics studies (e.g., metastasis invasion) - Histological Analyses: H&E, IHC, immune-fluorescence, FISH, TMA, and more Detection of cellular structures and specific organs Organ segmentation for small organisms Tumor detection and lesion identification Angiogenesis and vascularization analysis Fibers detection (e.g., collagen, elastin) Adipocyte analysis - Medical Imaging: CT scan (e.g., invasive nodule detection in the chest), MRI, ultrasounds Correlation with histological data Organ segmentation Image restoration - Statistics and Bioinformatics: Statistical tests, data normalization, multi-parametric studies Machine learning and deep learning algorithms (CNN, RNN, RCNN, YOLO, SSD, GAN) In addition, QuantaCell develops bespoke scientific applications for biomedical labs, including scripts, desktop applications, and websites. Our proficiency spans various programming languages and technologies, including Python, Matlab, R, C/C++, C#, Docker, JavaScript, databases, Flask, CSS, and automatic report generation (e.g., PDF, LaTeX). At QuantaCell, we pride ourselves on our flexibility and commitment to providing top-notch consulting, technical studies, and software development services tailored to the unique needs of our clients.

QuantaCell, IRMB, Hopital St Eloi 80 av Augustin Fliche Montpellier CEDEX 5, Occitanie, 34295 FranceQuantaCell is a pioneering firm specializing in data analysis and artificial intelligence tailored for the life sciences industry. Established in 2014, our headquarters are now located at St Eloi Hospital in Montpellier, France. At QuantaCell, we are deeply immersed in addressing biomedical inquiries and are keenly attuned to the evolving needs of clinical research units. Our dynamic team excels in delivering cutting-edge software solutions rooted in artificial intelligence and image analysis technology. We specialize in quantifying and analyzing various data and image types, including virtual slides, confocal/electron microscopy images, videos, and medical imaging for both patients and small animals. Our comprehensive services encompass: - Cellular Analysis: Nuclear and cellular counting Nucleic acid and protein analysis Neuronal network detection Viability assessments Cellular type segregation Protein translocation analysis Kinetics studies (e.g., metastasis invasion) - Histological Analyses: H&E, IHC, immune-fluorescence, FISH, TMA, and more Detection of cellular structures and specific organs Organ segmentation for small organisms Tumor detection and lesion identification Angiogenesis and vascularization analysis Fibers detection (e.g., collagen, elastin) Adipocyte analysis - Medical Imaging: CT scan (e.g., invasive nodule detection in the chest), MRI, ultrasounds Correlation with histological data Organ segmentation Image restoration - Statistics and Bioinformatics: Statistical tests, data normalization, multi-parametric studies Machine learning and deep learning algorithms (CNN, RNN, RCNN, YOLO, SSD, GAN) In addition, QuantaCell develops bespoke scientific applications for biomedical labs, including scripts, desktop applications, and websites. Our proficiency spans various programming languages and technologies, including Python, Matlab, R, C/C++, C#, Docker, JavaScript, databases, Flask, CSS, and automatic report generation (e.g., PDF, LaTeX). At QuantaCell, we pride ourselves on our flexibility and commitment to providing top-notch consulting, technical studies, and software development services tailored to the unique needs of our clients.

Synelvia - Prologue Biotech 516 rue Pierre et Marie Curie Labège, 31670 FranceQIMA Life Sciences (previously Bioalternatives and Synelvia) is a Contract Research Organization (CRO) established in 1996 and specializing in cellular and molecular pharmacology. We offer assays ranging from in silico screening to non-invasive clinical sample bioanalysis, as well as in vitro and ex vivo assays. QIMA Life Sciences contributes to the development of in vitro methods as an alternative to animal experimentation, by offering solutions dedicated to preclinical research and to the development of drug candidates and to cosmetic active ingredients and formulations. Beyond this activity of product evaluation and development and thanks to our offer of customized competitive services based on collaborative innovation, QIMA Life Sciences can assist the health industry with its new strategic choices. Our assays are performed on our two French sites, in Gençay (Vienne) and Labège (Haute-Garonne). With 60 experts and two 1000 square meter laboratories, our firm helps the marketing and R&D departments of big European and American cosmetic and pharmaceutical groups to innovate in the field of project conceptualization and to substantiate and support their product claims.

1bis Rue des Plantes Gençay, Aquitaine-Limousin-Poitou-Charentes, 86160 FranceQIMA Life Sciences (previously Bioalternatives and Synelvia) is a Contract Research Organization (CRO) established in 1996 and specializing in cellular and molecular pharmacology. We offer assays ranging from in silico screening to non-invasive clinical sample bioanalysis, as well as in vitro and ex vivo assays. QIMA Life Sciences contributes to the development of in vitro methods as an alternative to animal experimentation, by offering solutions dedicated to preclinical research and to the development of drug candidates and to cosmetic active ingredients and formulations. Beyond this activity of product evaluation and development and thanks to our offer of customized competitive services based on collaborative innovation, QIMA Life Sciences can assist the health industry with its new strategic choices. Our assays are performed on our two French sites, in Gençay (Vienne) and Labège (Haute-Garonne). With 60 experts and two 1000 square meter laboratories, our firm helps the marketing and R&D departments of big European and American cosmetic and pharmaceutical groups to innovate in the field of project conceptualization and to substantiate and support their product claims.

1bis Rue des Plantes Gencay, Vienne, 86160 FranceQIMA Life Sciences (previously Bioalternatives and Synelvia) is a Contract Research Organization (CRO) established in 1996 and specializing in cellular and molecular pharmacology. We offer assays ranging from in silico screening to non-invasive clinical sample bioanalysis, as well as in vitro and ex vivo assays. QIMA Life Sciences contributes to the development of in vitro methods as an alternative to animal experimentation, by offering solutions dedicated to preclinical research and to the development of drug candidates and to cosmetic active ingredients and formulations. Beyond this activity of product evaluation and development and thanks to our offer of customized competitive services based on collaborative innovation, QIMA Life Sciences can assist the health industry with its new strategic choices. Our assays are performed on our two French sites, in Gençay (Vienne) and Labège (Haute-Garonne). With 60 experts and two 1000 square meter laboratories, our firm helps the marketing and R&D departments of big European and American cosmetic and pharmaceutical groups to innovate in the field of project conceptualization and to substantiate and support their product claims.

27 rue de la VilletteREGISTRAT-MAPI offers clinical research services including project management, site management, data management, quality assurance, and regulatory assessment with expertise in late phase.

190 Route de Gap 04200 SISTERONRaison’Alpes est une société de prestation de services en agriculture, dont les travaux ont pour objectif l’amélioration de la performance économique et environnementale des systèmes de production. Implantée au cœur des Alpes du Sud, les services développés concernent essentiellement les filières arboricoles, céréalières et les plantes à parfum.

45, rue Saint-Philippe - 06000 - NICESkinEthic Laboratories offers in vitro and in vivo skin model services.

Mulhouse, Alsace-Champagne-Ardenne-Lorraine FranceRhenovia Pharma offers drug discovery optimzation services, case studies, first operational services and life science consulting.

ZAC du Moulin, 24-26 Rue du Noyer, BP40, 95700 Roissy en FranceRandox Laboratories, through its business units, offer diagnostic services, life science reagents, biomarker testing services, antibody/drug assay development, and toxicology services.

1 Avenue de la gare, 26300 Alixan, FranceFormed in April 2014 Rovaltain Research Company is a newly established private contract research organisation providing expert services for ecotoxicology and environmental toxicology. Our company philosophy is to provide in all its activities and communications: Scientific excellence Quality and timeliness of result Cost effectiveness We pride ourselves in being able to offer a new and exciting innovative service within the realms of ecotoxicology and environmental toxicology to both our academic and industrial clients.

102, Avenue Gaston RousselRoowin offers API synthesis, custom compound synthesis, and cheminformatic services.

60 rue Carnot F-92100Research Pharmaceutical Services offers manufacturing, formulation, regulatory affairs, quality assurance, molecular modeling, and clinical management.

2 Allée du Doyen Georges Brus Pessac, Nouvelle-Aquitaine, 33600 FranceResonance Pharma is a CRO specialized in the study of in vivo preclinical pharmacology (drug efficacy and toxicity). Our expertise in Nuclear Magnetic Resonance Imaging (MRI) and Nuclear Magnetic Resonance Spectroscopy (MRS) is proposed to study the efficacy and toxicity of drug candidates in animal models. The proposed methods aim at highlighting the functional effects of drug candidates. As such, we have developed and developed methods and biomarkers adapted to functional studies.

104 avenue du général Leclerc Palaiseau, Essonne, 91120 FranceRime Bioinformatics is a research and development biotechnology company with a focus on bioinformatics. We develop services to speed up medical, agronomic and veterinary research. Our technologies grant in-depth view of bacterial and bacteriophage genomes, which is an essential prerequisite in the R&D process that leads a phage to market. We work hard to make high-performance bioinformatics accessible and promote a safe use of phage therapy for the patients and the environment ! Our technology enables us to considerably improve our knowledge of gene functions, we are 6 times faster and 100 times more accurate than current techniques. We want to make high-performance bioinformatics accessible to biologists. Our in silico studies enable us to detect the presence of genes for lysogenesis, virulence and antibiotic resistance in phages, using regulation-compliant techniques.

1682 Rue de la valsière CAP DELTA Grabels, 34790 FranceR&H Discovery is a CRO ofering its expertise in the synthesis and discovery of new drug candidate molecules. Its founders, with 20 years of experience in pharmaceutical research (Pierre-Fabre, Idenix, MSD), co-inventors of 15 patents and co-authors of 10 publications use their expertise in medicinal chemistry, analytical chemistry and purification to serve R&D projects.

3, Rue Henri Baigue 25000 Besançon, FRANCEA French company founded in 2002, RD-Biotech has a complete technical platform and a high-level scientific expertise in molecular biology, recombinant proteins, antibody and cellular engineering. Customized services tailored to the needs of R & D, preclinical and clinical projects: Plasmid DNA biomanufacturing (up to 20 grams) : from research to clinical and commercial applications - R&D, High Quality and GMP Grades Bioproduction & purification: monoclonal antibodies (up to several grams) recombinant antibodies and recombinant proteins (several expression systems: CHO, HEK cells, E. Coli, in vitro system, Yeasts...), cells - Standard quality, endofree or high grade quality (GMP Like) Development of expression vectors, gene design, cell lines and stable pools, murine hybridomas Recombinant antibodies: Antibody Sequencing, Chimerization and Humanization, characterization and validation (specificity, affinity, bioactivity) Analytical platform: ELISA, Blotting, Cytometry, OCTET, PCR and qPCR ...: development of methods, validation of procedures, analysis and quality control A range of FastELISA kits for the quantification of human, mouse, rat, and contaminant Ig (bovine Ig, protein A, etc.). Antibodies anti rabies for ELISA applications RD-Biotech is a company of the mAbexperts group (www.mabexperts.com)

18 rue Françoise Dolto Besançon, 25000 FranceA French company founded in 2002, RD-Biotech has a complete technical platform and a high-level scientific expertise in molecular biology, recombinant proteins, antibody and cellular engineering. Customized services tailored to the needs of R & D, preclinical and clinical projects: Plasmid DNA biomanufacturing (up to 20 grams) : from research to clinical and commercial applications - R&D, High Quality and GMP Grades Bioproduction & purification: monoclonal antibodies (up to several grams) recombinant antibodies and recombinant proteins (several expression systems: CHO, HEK cells, E. Coli, in vitro system, Yeasts...), cells - Standard quality, endofree or high grade quality (GMP Like) Development of expression vectors, gene design, cell lines and stable pools, murine hybridomas Recombinant antibodies: Antibody Sequencing, Chimerization and Humanization, characterization and validation (specificity, affinity, bioactivity) Analytical platform: ELISA, Blotting, Cytometry, OCTET, PCR and qPCR ...: development of methods, validation of procedures, analysis and quality control A range of FastELISA kits for the quantification of human, mouse, rat, and contaminant Ig (bovine Ig, protein A, etc.). Antibodies anti rabies for ELISA applications RD-Biotech is a company of the mAbexperts group (www.mabexperts.com)

3 rue Henri Baigue Besançon, 25000 FranceA French company founded in 2002, RD-Biotech has a complete technical platform and a high-level scientific expertise in molecular biology, recombinant proteins, antibody and cellular engineering. Customized services tailored to the needs of R & D, preclinical and clinical projects: Plasmid DNA biomanufacturing (up to 20 grams) : from research to clinical and commercial applications - R&D, High Quality and GMP Grades Bioproduction & purification: monoclonal antibodies (up to several grams) recombinant antibodies and recombinant proteins (several expression systems: CHO, HEK cells, E. Coli, in vitro system, Yeasts...), cells - Standard quality, endofree or high grade quality (GMP Like) Development of expression vectors, gene design, cell lines and stable pools, murine hybridomas Recombinant antibodies: Antibody Sequencing, Chimerization and Humanization, characterization and validation (specificity, affinity, bioactivity) Analytical platform: ELISA, Blotting, Cytometry, OCTET, PCR and qPCR ...: development of methods, validation of procedures, analysis and quality control A range of FastELISA kits for the quantification of human, mouse, rat, and contaminant Ig (bovine Ig, protein A, etc.). Antibodies anti rabies for ELISA applications RD-Biotech is a company of the mAbexperts group (www.mabexperts.com)

2bis rue Tête d'Or Lyon, 69006 FranceRTI Health Solutions is the place you turn when you need substantiated, authoritative evidence and advice. We are scientists first—academically-trained, credentialed researchers who know how and when to apply the appropriate research methodologies to your real-world applications and situations. We care about doing what’s right and what’s relevant, so you can make good, safe, and timely decisions about your pharmaceutical, medical device, or diagnostic products. Full range provider of health economics and outcomes research (HEOR), RWE, market access and pharmacoepidemiology services. Also a niche provider of GI clinical trials. Multinational & Multidisciplinary: A global perspective Located across the US and Europe, our staff have led projects in approximately 70 countries. Their experience is diverse; encompasses economics, public health, psychology, epidemiology, statistics, engineering, and other disciplines; and spans both developed and emerging markets, so we can help you with an array of projects in any region of interest. Expertise: Access to key thought leaders We attract and retain top talent across each of our practice areas, so you always have access to key thought leaders in drug development, commercialization, and safety. Nearly 80% of our researchers hold master's or doctorate degrees. Nearly all are published in their fields, many serve as peer-reviewers and editors for research journals, and several maintain university and industry advisory appointments.

6 rue Dr Jean-Francois-Xavier Girod BP 1985 Besancon, Cedex, F-25020 FranceScientist.com is the world’s largest marketplace for medical research. We help pharmaceutical scientists discover life-saving medicines in less time and at lower cost. Our mission is to make it possible to cure all human disease by 2050. By connecting scientists and enabling them to exchange ideas and transact seamlessly online, Scientist.com is speeding up and reducing the cost of medical research. We were founded in 2007, launched our first research outsourcing marketplace in 2008 and built our first enterprise marketplace for Pfizer in 2009. Today, we operate enterprise marketplaces for 24 of the world’s top 30 pharmaceutical companies, 100+ biotechnology companies and the US National Institutes of Health (NIH).

746, avenue Ambroise Croizat Crolles, 38920 FranceScientist.com is the world’s largest marketplace for medical research. We help pharmaceutical scientists discover life-saving medicines in less time and at lower cost. Our mission is to make it possible to cure all human disease by 2050. By connecting scientists and enabling them to exchange ideas and transact seamlessly online, Scientist.com is speeding up and reducing the cost of medical research. We were founded in 2007, launched our first research outsourcing marketplace in 2008 and built our first enterprise marketplace for Pfizer in 2009. Today, we operate enterprise marketplaces for 24 of the world’s top 30 pharmaceutical companies, 100+ biotechnology companies and the US National Institutes of Health (NIH).

17 square Edouard VII Paris, 75009 FranceScienomics is a software company specialized in molecular modeling and simulations of materials.

Paris, Île-de-France FranceScienomics is a software company specialized in molecular modeling and simulations of materials.

2 Rue Paul Milleret Besançon, Bourgogne Franche-Comté, 25000 FranceBesançon is the capital of microtechniques and has acquired international recognition in the field of skin biometrology following the works initiated by Professor Pierre AGACHE and pursued by Professor Philippe HUMBERT. Privileged and long-term collaborations and relationships have been developed with many other laboratories and the resulting achievements have enhanced the knowledge of physiological and physiopathological mechanisms, in particular with regard to the microcirculation and the optical and physico-chemical properties of the skin. SKINEXIGENCE S.A.S. was created by Sophie MAC on February 2nd, 2006, in Besançon (France), a city with a rich past, and its premises are located within the University Hospital. The company is therefore very close to the Department of Dermatology directed by Professor Philippe HUMBERT.

Racing Park 19 rue des rosiéristes Champagne au Mont d'Or, 69410 France

6-8 RUE BELLECOMBE LYON, 69006 France

516 rue Pierre et Marie Curie Prologue Biotech Labège cedex, 31670 FranceSynelvia is a CRO dedicated to the analysis of biomarkers and evaluation of drugs effects in the areas of cardio-metabolic, dermatology and cosmetology using innovating technologies

29 Route Nationale Ennetières-en-Weppes, Hauts-de-France, 59320 FranceSPM-Biocameltec is an R&D service provider for Pharmaceutical Industry, Biotech Companies, University Researchers and Government Agencies. SPM-Biocamaltec provides high quality R&D service across a number of disciplines including pharmacology, toxicology and antibody development and production. We offer a wide variety of animal species, such as rabbits, dogs, cats and other largest animals such as pigs, sheeps, horses, camels….. SPM-Biocameltec has designed dedicated facilities in compliance with all applicable animal welfare and housing requirements. All our work with animals is carryout strictly in accordance with the national regulations, legislation and guidelines and those of the countries of our customers (e.g. 2010/63/EU). SPM-Biocameltec’s mission is to offer the highest quality R&D services within short deadlines to advance our customers projects in a timely and cost effective manner.

23, Rue de Moeuvres - 62860 INCHY EN ARTOIS - FRANCEThe STAPHYT company was created in France in 1989 to answer the customers´ needs in the field of agronomical research. Thanks to the experience of its 230 employees and the access to 67 stations in Europe, STAPHYT positions itself as a main company in plant protection products, seeds, as well as the management of products registration on the market for our clients. STAPHYT’s ambition is to take up one of the worldwide challenges essential to us all: To feed the population of the world while protecting the environment and getting the means to work for Plant Health as part of a modern and innovative agriculture.

4 rue Charles Bried BESANCON, 25000 FranceSMALTIS is a company created by two doctors in bacteriology, Sophie GUENARD and Cédric MULLER. Its team is composed of experts in microbiology, who aim to support various public and private actors in their health product development projects, from research to clinical studies. SMALTIS thus, offers tailor-made solutions with high added value, to fight against antibiotic resistance, to explore microbiota, and to optimize bioprocesses through bacterial strain engineering and vector optimization. SMALTIS’ services and products allow, for example, to assess the risk of antimicrobial resistance of a new antimicrobial candidate, to understand the interactions between a compound and the intestinal microbiota, or to build a modified bacterial strain to simplify a bioproduction process. Catalogues of clinical strains, well characterized, are also available, as well as analytical services. In order to ensure a high level of quality for its customers, the laboratory is certified ISO 9001.

2 Rue Paul Milleret BESANCON, 25000 FranceSMALTIS is a company created by two doctors in bacteriology, Sophie GUENARD and Cédric MULLER. Its team is composed of experts in microbiology, who aim to support various public and private actors in their health product development projects, from research to clinical studies. SMALTIS thus, offers tailor-made solutions with high added value, to fight against antibiotic resistance, to explore microbiota, and to optimize bioprocesses through bacterial strain engineering and vector optimization. SMALTIS’ services and products allow, for example, to assess the risk of antimicrobial resistance of a new antimicrobial candidate, to understand the interactions between a compound and the intestinal microbiota, or to build a modified bacterial strain to simplify a bioproduction process. Catalogues of clinical strains, well characterized, are also available, as well as analytical services. In order to ensure a high level of quality for its customers, the laboratory is certified ISO 9001.

3 allée Thérésa CS 10009 92665 Asnières sur Seine Cedex FranceThe Stago Group has therefore developed and acquired its expertise over many years, accompanying, and often leading, the rapid growth of this Haematology-related scientific discipline. Which is why Stago is today the only independent international group in the In Vitro Diagnostics industry dedicated to Haemostasis and Thrombosis exploration.

Champigneulles, Grand Est FranceSeparex provides supercritical and high pressure technology applications and systems.

Résidence Boissy, 4STE Engipharm installs clean rooms and designs pharmaceutical process systems including water production plants.

238 Rue Giraudeau Tours, Centre-Val de Loire, 37000 FranceLaboratoire spécialisé dans les tests d'efficacité et de tolérance de tout produit à vocation cosmétique, Spincontrol vous propose des protocoles ""sur-mesure"" des plus classiques aux plus originaux. Spincontrol is specialised in efficacy and safety tests of every claimed cosmetic products and can suggest you ""tailor-made"" protocols from the most standard to the most creative.

41-43 rue PergolèseSogeti offers information technology support as well as software and systems development.

59, avenue sainte victoire Zac Saint Charles Fuveau, 13710 FranceSynprosis specializes in peptide manufacturing to develop and produce a synthetic vaccine designed to fight against HIV.

ZI Avenue Jean Foucault CS621, 34500 Beziers, FranceOur mission: Our formulation facilities and our development, piloting and technical know-how are available to the leading crop protection firms. Our ambition is to be the major European service provider for the crop protection industry, by offering innovative solutions for sustainable agriculture. Our values: Delivering high-quality development, industrialization and formulation services to our customers is our priority and our core value. We also emphasize the transparency of our industrial activities, resulting from our responsible behaviour. We pay particular attention to the health and safety of our employees, the protection of the local population and respect for the environment.

Guy Môquet 94800 66 rue Villejuif France

Institut Polytechnique National de Lorraine 2 avenue de la Forêt des Haye 54500 Vandœuvre-lès-Nancy, FranceProviding clients with acutely induced phenotypic models of proteopathic neurodegenerative diseases, accelerating drug discovery of symptomatic and disease-modifying therapeutics.

24-30, rue Lionnois 54000 Nancy, FranceProviding clients with acutely induced phenotypic models of proteopathic neurodegenerative diseases, accelerating drug discovery of symptomatic and disease-modifying therapeutics.

Saint-Genis-l'Argentière, Auvergne-Rhône-Alpes, 69610 FranceStem Alpha offers custom manufacturing and media for the cornea, hematopoietic cells, murine cells, and other research activities.

23 Boulevard François Mitterrand Laboraoire SABNP - Bat. Maupertuis - Université d'Évry Évry, Île-de-France, 91000 FranceCreated in 2013, SYNSIGHT is a game changer in drug discovery by developing the first platform combining cell-based microscopy that train AI models, to generate new chemical entities. The benefits are to increase the productivity of your R&D and secure your drug discovery programs. Its innovative platform and technologies can be directly applied to RNA-protein and protein-protein interactions. Its cellular assay is unique and is able to qualify and quantify directly in human cells these challenging interactions. The MTBench characterizes the efficacy of small molecule modulators in cell (Hit identification and IC50 measurement). This cellular assay, easy to setup as medium or high-throughput screening level combined to biophysical assays, are then able to train our multiparametric AI models to select and generate new chemical entities.

4 Rue Pierre Fontaine Genopole Entreprises Évry, Île-de-France, 91058 FranceCreated in 2013, SYNSIGHT is a game changer in drug discovery by developing the first platform combining cell-based microscopy that train AI models, to generate new chemical entities. The benefits are to increase the productivity of your R&D and secure your drug discovery programs. Its innovative platform and technologies can be directly applied to RNA-protein and protein-protein interactions. Its cellular assay is unique and is able to qualify and quantify directly in human cells these challenging interactions. The MTBench characterizes the efficacy of small molecule modulators in cell (Hit identification and IC50 measurement). This cellular assay, easy to setup as medium or high-throughput screening level combined to biophysical assays, are then able to train our multiparametric AI models to select and generate new chemical entities.

9 Allée Charles Cros Colomiers, Occitanie, 31770 FranceThe Scanelis laboratory is specialised in molecular diagnostics in the field of animal health. Specialist in real-time PCR (Polymerase Chain Reaction), Scanelis offers approximately 45 real-time PCR assays, for the detection/quantification of infectious agents in many animal species (dogs, cats, birds, ferrets, exotics, cattle, sheep and goats, poultry and rabbits, horses, fishes). Scanelis also provides support to industry, biotechs, lab animal suppliers and research labs: * health monitoring for laboratory animals * real-time PCR genetic testing * quality control of biopharmaceuticals by real-time PCR testing * diagnostics performed in accordance with a customer’s specifications or prescribed quality plan, for instance with the European Pharmacopoeia recommendations. * custom-designed investigations: molecular typing of isolates or strains, infection monitoring and epidemiological monitoring, pathogens or mRNA quantification, cloning and DNA quantification

Bd Salvador AllendeShimadzu offers analytical technology, laboratory instruments, testing machines, and scales.

19 Rue de Verdun Suresnes, Île-de-France, 92150 FranceSocosur specializes in chemicals distribution.

Route de Saint-Bris Augy, Bourgogne Franche-Comté, 89290 FranceSAFE (Scientific Animal Food & Engineering) designs, formulates and produces lab diets and custom diets for the international research community.

Alès, Occitanie FranceAgate Bioservices offers cloning, plasmid purification, mutagenesis, PCR, recombinant protein production and purification services.

185 Rue André Ampère L'Isle-sur-la-Sorgue, Provence-Alpes-Côte d'Azur, 84800 France

100, rue Petit 75019 Paris FranceSince the year 2000, our teams of industry experts have created the world's largest online professional network dedicated to chemicals and materials. This network includes more than 500,000 engineers, formulators, product developers, marketers, applicators and brand owners across the globe. Through our vertical industry websites, these professionals have unlimited access to Universal Selectors aimed at gathering all chemicals & materials in the world, and the knowledge to select them through high value content such as Product Selection Guides and Online Courses.

100 rue 75019 FranceSince the year 2000, our teams of industry experts have created the world's largest online professional network dedicated to chemicals and materials. This network includes more than 500,000 engineers, formulators, product developers, marketers, applicators and brand owners across the globe. Through our vertical industry websites, these professionals have unlimited access to Universal Selectors aimed at gathering all chemicals & materials in the world, and the knowledge to select them through high value content such as Product Selection Guides and Online Courses.

2 Route de Créon, 33370 Sadirac, France

155, rue du Faubourg Saint-Denis Paris, 75010 FranceCerom provides cardiovascular analytical service.

2 rue André Citroen Franconville, 95130 FranceSTERIGENE offers process and cleanroom equipment.

8, rue John Grasset CH 1205 Geneva SwitzerlandAt Solid Drug Development, we offer you a broad spectrum of drug development services, including technology transfer operations. Our expertise ranges across CMC, non-clinical, clinical, regulatory and strategic concerns and we strive to provide you with the best possible solutions.

47, Rue De Longvic - B.P. 50Synkem offers API and intermediate synthesis services.

FranceThe Virtual Tumour Bank of the Cancéropôle Grand Sud-Ouest allows access to an inventory of the samples stored in each tumour bank of the Greate South-West region, of the University Hospital Centres and Cancer Centres of Bordeaux, Limoges, Montpellier, Nîmes and Toulouse.

3 Rue Châteaubriand Orléans, Centre-Val de Loire, 45100 FranceSOTAX leads the way in the development and manufacture of high-quality pharmaceutical testing equipment and associated services. Our equipment is used worldwide in the development and production processes of our customers and the pharmaceutical and science industries. SOTAX develops, produces and markets system solutions for pharmaceutical testing and does so in close cooperation with pharmaceutical and scientific partners. Our extensive market and process know-how enables us to meet our customers’ requirements and comply with the key directives relevant to them. We are also open to cooperation with new industries. SOTAX is a leading independent company for pharmaceutical testing equipment. The company owes its independence to its sustained economic success. The SOTAX Group is a global success story and has subsidiaries around the world that are familiar with local needs and practices. We maintain our competitive edge by excelling in flexibility, performance, quality and safety.

Cap Sigma 1682 rue de la Valsière Grabels, 34790 FranceStem Genomics is a biotech company, located in France and in the USA, specialized in the design of innovative testing technologies for stem cells. A spin-out of the Institute for Regenerative Medicine & Biotherapy (IRMB) and co-founded by Prof. John de Vos and Dr. Said Assou, experts in stem cell genomic integrity, Stem Genomics has emerged from a prestigious scientific environment. Located at the heart of the University Hospital Centre of Montpellier, the IRMB houses research groups working on basic stem cell research and innovative applications for regenerative therapy with the aim of facilitating the transfer from research to clinical applications. Founded in 2018, we work with +150 clients worldwide, from academic institutions to biotech companies and core facilities. We service our North American clients from our laboratory based in the Research Triangle in Durham, North Carolina, and our European and other international clients from our headquarters in Montpellier, France. Stem Genomics is a team of passionate and committed individuals whose aim is to support research scientists in achieving qualitative and reliable cell lines for their work. We have developed in-house expertise in stem cells and in innovative genetic stability assay technologies which enable us to perform most of our tests on our own platform. In parallel, our R&D team is continuously developing latest generation quality controls assays. We pride ourselves on our reactivity and availability in our relationship with our clients throughout the process. Technologies we have selected for stem cell characterization: - Digital PCR (dPCR) is the most accurate PCR method for assessing the genetic integrity of stem cells through the detection of Copy Number Variants (CNVs). It is ideal for regular in-process controls and fast clone screening. - G-banding karyotyping is helpful in providing an exhaustive structural and numerical variant analysis. - Next-Generation Sequencing (NGS) offers a hypothesis-free approach that does not require prior knowledge of sequence information. NGS enables the simultaneous analysis of numerous genes, making it both feasible and cost effective. It is particularly well-suited to key stages in the workflow such as cell line acquisition, banking and/or end of workflow.

5 avenue du Grand Sablon Grenoble, 38700 FranceSynthelis is a French biotech company specialized in production, purification and characterization of any type of proteins including difficult-to-express ones such as ion channels, membrane transporters, GPCRs, membrane enzymes and antigens. Based on our proprietary cell-free technology, we offer products and services to deliver functional proteins as proteoliposomes, nanodiscs or in a soluble format. As a result we can support pharmaceutical companies, biotech companies and academic teams in applications such as vaccine development, antibody development, drug discovery, protein delivery, in vitro diagnostics and structural biology.

55 rue du Montmurier Saint-Quentin-Fallavier, 38070 FranceSkyepharma is an expert CDMO specialized in formulating, developing and producing complex oral dosage forms, with complex and tailor-made modified release profiles. We offer a full range of services, from early stage development to industrial manufacturing and packaging. Our scientific expert team, supported by our patented technologies, has a solid track-record of successful development, reformulation and transfer projects. Our GMP site located in France, FDA, ANVISA, Korean MSDS approved, serve worldwide customers, with a recognized high level of service.

39, Impasse de la Bégude DOMAZAN, Gard, 30390 FranceUV disinfection expert, STERIXENE assists you along your innovative project. From the right idea through to the creation of the technical solution, STERIXENE develops two dry and clean technologies, compact and efficient : Pulsed light and UV LED.

10 rue du compagnonnage LES ANGLES, Gard, 30133 FranceUV disinfection expert, STERIXENE assists you along your innovative project. From the right idea through to the creation of the technical solution, STERIXENE develops two dry and clean technologies, compact and efficient : Pulsed light and UV LED.

128 RUE LA BOETIE Paris, 75008 FrancePromote and connect with best health experts in the life sciences ecosystem identify and rank KOLs, clinical sites, investigators for scientific projects (clinical trials, advisory boards)

7, rue de la Gratiole Larçay, 37270 FranceSciempath Labo (previously Biodoxis) is a company specialized in molecular pathology, created in 2000 to provide expertise in tissue analysis using molecular pathology approaches supporting experimental and translational research. We provide scientific and technical expertise to support your projects through the entire drug development process. Our pathologists and project managers are available to set up investigative and translational pathology studies based on your needs. With both experience of Dr Virgile Richard (DVM, PhD, DES Vet.Path.) and Dr Jacques Bosq (MD), Sciempath Labo has an integrated competence in biology and histopathology for human and translational research. Our mission is to provide expertise in molecular pathology: molecular histopathology combined to biochemistry, genetics and proteomic are necessary to understand molecular alterations and responses to drug therapies.

1 MAIL DU PARV DU PR GEORGES MATHE VILLEJUIF, ILE DE FRANCE, 94800 FranceSvar Life Science is a Swedish group of companies that invents, develops, and applies the best assay technology for drug development and clinical diagnostics with the goal of delivering new solutions tailored to customer requirements. Our multiple locations worldwide and experience in assay development, bioanalysis, and clinical diagnostics make us an ideal partner for pharma, biotech, and CROs. Svar Life Science offers a comprehensive portfolio of products and solutions: ● Functional and biomarker assays that can be used to explore every angle of complement system-involved in a wide range of application areas. ●The iLite® cell-based solutions that are based on the iLite technology, a cleverly engineered cell-based assay system with a dual reporter gene readout. ●Cell-based custom development services including an assay-ready cell service and master cell bank development. ●CRO Services include Bioanalytical Services, Biomarker Discovery Services, and GMP QC Testing Services. Our GMP, GCP, GLP, and ISO 15189-compliant laboratory is designed to offer assay development, validation, and sample analysis for pre-clinical as well as clinical studies. We have experience with various immunoassays including ELISA, MSD, SIMOA, Olink Proteomics technology, and cell-based assays. We work to deliver the right answers at the right time to improve patient care and accelerate drug development. Our subsidiaries: ●Wieslab is our diagnostic laboratory services offering a comprehensive range of clinical diagnostic tests within neuro-immunology, nephrology, rheumatology, and gastroenterology for clinicians and laboratories worldwide. ●Calpro AS is our Norwegian based bio-tech company dedicated to research and development of Calprotectin based diagnostic tests. Focussing on one specific biomarker, the company has a knowledge base unlike any other.

Zone Industrielle Les Paluds Auenue de Jouques- CS 91051 Aubagne, 13781 FranceSartorius Stedim BioOutsource Ltd. is a leading provider of contract testing services to the global biopharmaceutical and biotechnology industries. BioOutsource has operations in both Europe and the USA, with testing laboratories in Glasgow, UK, and Cambridge, MA, USA. BioOutsource was founded in 2007 and was acquired by Sartorius Stedim Biotech in 2015. We are accredited for cGMP, GLP and GCP and provide contract testing services to assess the quality and safety of biologic drugs and vaccines including: A range of off-the-shelf assays for biosimilar characterization and comparability Biosafety testing of cell banks and bulk harvest as well as cell line stability and lot release At Sartorius, we don’t just perform contract testing services; we are committed to delivering service excellence, with an in-house R&D department, we are constantly adding to our existing portfolio of services to address market demands. Our innovative approach and client management model ensure’s projects are managed efficiently, cost-effectively and delivered on-time.

Rue de la Chimie Saint-Martin-d'Hères, Auvergne-Rhône-Alpes, 38400 FranceSB-PEPTIDE (Formely Smart Bioscience), is a French company specialized in peptide synthesis, peptide engineering and peptide analysis. Peptides are 100% made in France in the company facilities located in the Grenoble area. SB-PEPTIDE is a subdivisary of the worldwide renowned company Smartox Biotechnology for its expertise in animal venom research. Smartox Biotechnology offers compound libraries for screening, analytical services and synthetic peptide toxins in more than 40 countries to pharmaceutical, biotech and academic research laboratories. Smartox Biotechnology has developed an extensive expertise in peptide synthesis, engineering and analysis which is now accessible through SB-PEPTIDE to every scientist requiring peptide services. SB-PEPTIDE offers quality, flexible and reliable services, focused on the satisfaction of our clients. Peptide synthesis services from the Smartox group have been cited in various scientific publications and patents (see section Citations & achievements). SB-PEPTIDE supplies public, pharmaceutical and biotech laboratories, agroscience & cosmetic companies as well as CRO in antibody production for example. The company has already successfully synthesized peptides with up to 120 amino acids in acceptable quantity and purity, with up to 5 disulfide bridges, performed double labeling…

570 rue de la chimie, Saint Martin d’Hères, 38400 FranceSB-PEPTIDE (Formely Smart Bioscience), is a French company specialized in peptide synthesis, peptide engineering and peptide analysis. Peptides are 100% made in France in the company facilities located in the Grenoble area. SB-PEPTIDE is a subdivisary of the worldwide renowned company Smartox Biotechnology for its expertise in animal venom research. Smartox Biotechnology offers compound libraries for screening, analytical services and synthetic peptide toxins in more than 40 countries to pharmaceutical, biotech and academic research laboratories. Smartox Biotechnology has developed an extensive expertise in peptide synthesis, engineering and analysis which is now accessible through SB-PEPTIDE to every scientist requiring peptide services. SB-PEPTIDE offers quality, flexible and reliable services, focused on the satisfaction of our clients. Peptide synthesis services from the Smartox group have been cited in various scientific publications and patents (see section Citations & achievements). SB-PEPTIDE supplies public, pharmaceutical and biotech laboratories, agroscience & cosmetic companies as well as CRO in antibody production for example. The company has already successfully synthesized peptides with up to 120 amino acids in acceptable quantity and purity, with up to 5 disulfide bridges, performed double labeling…

6 rue des platanes Saint-Egrève, 38120 FranceSB-PEPTIDE (Formely Smart Bioscience), is a French company specialized in peptide synthesis, peptide engineering and peptide analysis. Peptides are 100% made in France in the company facilities located in the Grenoble area. SB-PEPTIDE is a subdivisary of the worldwide renowned company Smartox Biotechnology for its expertise in animal venom research. Smartox Biotechnology offers compound libraries for screening, analytical services and synthetic peptide toxins in more than 40 countries to pharmaceutical, biotech and academic research laboratories. Smartox Biotechnology has developed an extensive expertise in peptide synthesis, engineering and analysis which is now accessible through SB-PEPTIDE to every scientist requiring peptide services. SB-PEPTIDE offers quality, flexible and reliable services, focused on the satisfaction of our clients. Peptide synthesis services from the Smartox group have been cited in various scientific publications and patents (see section Citations & achievements). SB-PEPTIDE supplies public, pharmaceutical and biotech laboratories, agroscience & cosmetic companies as well as CRO in antibody production for example. The company has already successfully synthesized peptides with up to 120 amino acids in acceptable quantity and purity, with up to 5 disulfide bridges, performed double labeling…

3B Rue de l' Isère Saint-Égrève, Auvergne-Rhône-Alpes, 38120 FranceSmartox Biotechnology is specialised in animal venom research. Smartox offers a catalog of synthetic toxins which modulate ion channels, GPCR and integrins. Smartox has developed an innovative compound library named "VenomScreen" made of 40,000 peptides from animal venoms. This library allows to access a unique chemical space composed of constrained peptides targetting preferentially GPCRs, ion channels, integrins and some of them also demonstrate potent bioinsecticidal and antimicrobial properties. Animal venom toxins have been involved in a wide range of therapeutic area such as autoimmune disease, diabetes, pain, cardiovascular disorders, cancer..

Bât BIOPOLIS 5, avenue du Grand Sablon La Tronche, 38700 FranceSmartox Biotechnology is specialised in animal venom research. Smartox offers a catalog of synthetic toxins which modulate ion channels, GPCR and integrins. Smartox has developed an innovative compound library named "VenomScreen" made of 40,000 peptides from animal venoms. This library allows to access a unique chemical space composed of constrained peptides targetting preferentially GPCRs, ion channels, integrins and some of them also demonstrate potent bioinsecticidal and antimicrobial properties. Animal venom toxins have been involved in a wide range of therapeutic area such as autoimmune disease, diabetes, pain, cardiovascular disorders, cancer..

570 rue de la chimie saint martin d'hères, 38400 FranceSmartox Biotechnology is specialised in animal venom research. Smartox offers a catalog of synthetic toxins which modulate ion channels, GPCR and integrins. Smartox has developed an innovative compound library named "VenomScreen" made of 40,000 peptides from animal venoms. This library allows to access a unique chemical space composed of constrained peptides targetting preferentially GPCRs, ion channels, integrins and some of them also demonstrate potent bioinsecticidal and antimicrobial properties. Animal venom toxins have been involved in a wide range of therapeutic area such as autoimmune disease, diabetes, pain, cardiovascular disorders, cancer..

4 Rue du Commandant d’Estienne d’Orves Villeneuve-la-Garenne, 92390 FranceSGS helps pharmaceutical, biopharmaceutical, and medical device companies by providing services along the entire drug development pathway. As a global contract research organization, our global Health Science team provides integrated solutions from preclinical activities to Phase I-IV clinical trials, bioanalytical, pharmaceutical development, biologics characterization, biosafety, and quality control testing of small and large molecules, raw materials, containers and finished products. In an ever-changing world, with technological change reaching breakneck speed, SGS helps navigate the sometimes complex process to successfully deliver high quality, safe and medical devices to market. SGS boasts a wealth of global health science expertise. We will support you every step of the way as you deliver first-class, fully compliant biopharmaceutical, pharmaceutical and medical device products. Our expert staff is trained to the highest standards and has an in-depth knowledge of their fields and your business needs.

Health Science Division, with laboratory at 14, chemin des Aulx Plan-Les-Ouates, CH-1228 SwitzerlandSGS helps pharmaceutical, biopharmaceutical, and medical device companies by providing services along the entire drug development pathway. As a global contract research organization, our global Health Science team provides integrated solutions from preclinical activities to Phase I-IV clinical trials, bioanalytical, pharmaceutical development, biologics characterization, biosafety, and quality control testing of small and large molecules, raw materials, containers and finished products. In an ever-changing world, with technological change reaching breakneck speed, SGS helps navigate the sometimes complex process to successfully deliver high quality, safe and medical devices to market. SGS boasts a wealth of global health science expertise. We will support you every step of the way as you deliver first-class, fully compliant biopharmaceutical, pharmaceutical and medical device products. Our expert staff is trained to the highest standards and has an in-depth knowledge of their fields and your business needs.

Oignies 2 Rue George Sand ZA Pierre Loti, Oignies, 62590 FranceSGS helps pharmaceutical, biopharmaceutical, and medical device companies by providing services along the entire drug development pathway. As a global contract research organization, our global Health Science team provides integrated solutions from preclinical activities to Phase I-IV clinical trials, bioanalytical, pharmaceutical development, biologics characterization, biosafety, and quality control testing of small and large molecules, raw materials, containers and finished products. In an ever-changing world, with technological change reaching breakneck speed, SGS helps navigate the sometimes complex process to successfully deliver high quality, safe and medical devices to market. SGS boasts a wealth of global health science expertise. We will support you every step of the way as you deliver first-class, fully compliant biopharmaceutical, pharmaceutical and medical device products. Our expert staff is trained to the highest standards and has an in-depth knowledge of their fields and your business needs.

29 Avenue Aristide Briand Arcueil , 94110 FranceSGS helps pharmaceutical, biopharmaceutical, and medical device companies by providing services along the entire drug development pathway. As a global contract research organization, our global Health Science team provides integrated solutions from preclinical activities to Phase I-IV clinical trials, bioanalytical, pharmaceutical development, biologics characterization, biosafety, and quality control testing of small and large molecules, raw materials, containers and finished products. In an ever-changing world, with technological change reaching breakneck speed, SGS helps navigate the sometimes complex process to successfully deliver high quality, safe and medical devices to market. SGS boasts a wealth of global health science expertise. We will support you every step of the way as you deliver first-class, fully compliant biopharmaceutical, pharmaceutical and medical device products. Our expert staff is trained to the highest standards and has an in-depth knowledge of their fields and your business needs.

SYNERGY Building ZAC ISIPARC SAINT ISMIER, Isère, 38330 France1. About SynapCell Since 2005, SynapCell’s mission has been to accelerate the discovery of new treatments for patients with brain disorders. True partners of the pharmaceutical industry, we unlock the potential of drug candidates in vivo with our state-of-the-art EEG platform called Cue®. We upgrade the predictive power of rodent models with objective EEG biomarkers of neurological disorders for a smooth translation to the clinic. We study compounds’ pharmacodynamics out of any brain structure and deliver decision-enabling outcomes from off-the-shelf screening, dose-response, phenotyping, or customized exploratory protocols. Striving to advance our understanding of the brain’s pathophysiology, our team engages in authentic collaborative approach with our clients, who recognize SynapCell for its excellent quality of work from project start to finish. 2. Specific Skillsets Supporting Pharmaceutical Neuroscience SynapCell’s cross-functional team of experts possesses know-how in: - Stereotaxic surgery i.e. in cortical and subcortical electrodes implantation for the recording of electrophysiological activities (electrocorticogram and local field potential), - EEG data acquisition: recording spontaneous and evoked EEG activities, - Signal processing, - Data analysis and interpretation, - Pharmacology. 3. Background Knowledge: Applications for drug discovery - Off-the-shelf or customized assays designed for drug discovery applications. - Functional EEG phenotyping and biomarker identification - In vivo Pharmacological testing of neuroactive compounds in freely-moving rodents: - Compound pharmaco-EEG profiling - Head to head drug comparison - Identification of a compound most effective dosing and peak time

11 Av. des Tropiques Les Ulis, 91940 FranceSeqens, with more than 30 years-experience in the pharma industry, are the undisputed Europe-based CDMO leader in the Small molecule Drug substance space. Seqens are a partner of choice for more than 1,000 customers around the world backed by the highest level of service and commitment thanks to strong CMC project management team while acting ethically in accordance with a strong Environmental, Social and Governance program. State-of-the-art R&D facilities (in Europe and in the US) and an extensive network of 10 Western manufacturing sites (both GMP and nonGMP) permit Seqens to offer the widest range of solutions to innovative pharmas. Seqens support their customer from the very early stage of the development of their assets until commercial production: - Preclinical R&D work (route scouting, non GMP tox batches…) - Process and analytical development, QBD, kilo-lab and pilot production - cGMP clinical supply - nonGMP / GMP intermediates, RSMs and APIs manufacturing - Standalone analytics (Nitrosamines quantification, solid state studies…) - Pre-formulation work

70 Allée Graham Bell Nîmes, 30000 FranceSeqens, with more than 30 years-experience in the pharma industry, are the undisputed Europe-based CDMO leader in the Small molecule Drug substance space. Seqens are a partner of choice for more than 1,000 customers around the world backed by the highest level of service and commitment thanks to strong CMC project management team while acting ethically in accordance with a strong Environmental, Social and Governance program. State-of-the-art R&D facilities (in Europe and in the US) and an extensive network of 10 Western manufacturing sites (both GMP and nonGMP) permit Seqens to offer the widest range of solutions to innovative pharmas. Seqens support their customer from the very early stage of the development of their assets until commercial production: - Preclinical R&D work (route scouting, non GMP tox batches…) - Process and analytical development, QBD, kilo-lab and pilot production - cGMP clinical supply - nonGMP / GMP intermediates, RSMs and APIs manufacturing - Standalone analytics (Nitrosamines quantification, solid state studies…) - Pre-formulation work

ZI de Limay 8 Rue de Rouen, Porcheville, 78440 FranceSeqens, with more than 30 years-experience in the pharma industry, are the undisputed Europe-based CDMO leader in the Small molecule Drug substance space. Seqens are a partner of choice for more than 1,000 customers around the world backed by the highest level of service and commitment thanks to strong CMC project management team while acting ethically in accordance with a strong Environmental, Social and Governance program. State-of-the-art R&D facilities (in Europe and in the US) and an extensive network of 10 Western manufacturing sites (both GMP and nonGMP) permit Seqens to offer the widest range of solutions to innovative pharmas. Seqens support their customer from the very early stage of the development of their assets until commercial production: - Preclinical R&D work (route scouting, non GMP tox batches…) - Process and analytical development, QBD, kilo-lab and pilot production - cGMP clinical supply - nonGMP / GMP intermediates, RSMs and APIs manufacturing - Standalone analytics (Nitrosamines quantification, solid state studies…) - Pre-formulation work

21, Chemin de la Sauvegarde, Écully, Lyon, Auvergne-Rhône-Alpes, 69130 FranceSeqens, with more than 30 years-experience in the pharma industry, are the undisputed Europe-based CDMO leader in the Small molecule Drug substance space. Seqens are a partner of choice for more than 1,000 customers around the world backed by the highest level of service and commitment thanks to strong CMC project management team while acting ethically in accordance with a strong Environmental, Social and Governance program. State-of-the-art R&D facilities (in Europe and in the US) and an extensive network of 10 Western manufacturing sites (both GMP and nonGMP) permit Seqens to offer the widest range of solutions to innovative pharmas. Seqens support their customer from the very early stage of the development of their assets until commercial production: - Preclinical R&D work (route scouting, non GMP tox batches…) - Process and analytical development, QBD, kilo-lab and pilot production - cGMP clinical supply - nonGMP / GMP intermediates, RSMs and APIs manufacturing - Standalone analytics (Nitrosamines quantification, solid state studies…) - Pre-formulation work

2 Rue Marie Hamm Strasbourg, Bas-Rhin, 67000 FranceSPARTHA Medical is the result of 20 years of research in microbiology and biomaterials. SPARTHA Medical offers testing and coating services, ranging from proof of concept (PoC) to licensing agreements. Some non-exhaustive examples: • Accelerated aging tests • Antimicrobial efficacy tests after our antimicrobial coating • Artificial Intelligence services • Automatic robot services • Biocompatibility tests • Coating test application on the surface with our antimicrobial product • Consulting with our experts in microbiology, biofilm, biomaterials, regulatory • Contamination tests by pathogens (bacteria, viruses, yeasts, etc.) on various materials • Culture cells tests • Cytotoxicity tests • Microbiology tests • Sterilization tests (antimicrobial resistance) • Writing of scientific reports

2 Rue Marie Hamm Strasbourg, Please select...., 67000 FranceSPARTHA Medical is the result of 20 years of research in microbiology and biomaterials. SPARTHA Medical offers testing and coating services, ranging from proof of concept (PoC) to licensing agreements. Some non-exhaustive examples: • Accelerated aging tests • Antimicrobial efficacy tests after our antimicrobial coating • Artificial Intelligence services • Automatic robot services • Biocompatibility tests • Coating test application on the surface with our antimicrobial product • Consulting with our experts in microbiology, biofilm, biomaterials, regulatory • Contamination tests by pathogens (bacteria, viruses, yeasts, etc.) on various materials • Culture cells tests • Cytotoxicity tests • Microbiology tests • Sterilization tests (antimicrobial resistance) • Writing of scientific reports

7 Rue du Lac Saint-Egrève, 38120 France STEMCELL Technologies provides products and services to support life sciences research, including human primary cells, specialized culture media, cell separation technologies, instruments, accessories, and scientific services. Find out more about our featured tools and resources Limited-Time Offer: Get a Complimentary Lab Timer When You Request an Easysep™ Sample What more could you achieve if you spent less time isolating cells and more time getting results? EasySep™ is an efficient technology that can isolate cells in as little as 8 minutes, helping you move your research forward faster. For a limited time only, get a free 3-channel timer when you request an EasySep™ sample. Request your free sample using this link. Save up to 25% on Fresh or Frozen Peripheral Blood Leukopaks* Until September 15, 2023, you can save up to 25% on fresh, frozen or mobilized peripheral blood leukopaks and begin your large-scale studies confidently. You can now save even more by also bundling your leukopaks with the right EasySep™ cell isolation kits* To take advantage of this offer, please visit this form page. A member of our team will contact you to follow up. **Excludes fresh whole peripheral blood and isolated cells, LRS cones, mobilized peripheral blood isolated cell products, bone marrow products, cord blood products, and disease-sourced blood products. Discount does not apply to fees and may require a minimum purchase amount. Offer valid on orders placed between August 1, 2024, and September 15, 2024. Offer is only valid in Austria, Belgium, Canada (excluding Quebec), Denmark, Finland, Germany, Iceland, Ireland, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, the United Kingdom and the United States. Certain products are only available in select territories. Please contact your Sales representative or Product & Scientific Support at techsupport@stemcell.com for further information. Void where prohibited or restricted by federal, state, provincial, or local laws or regulations, or agency/institutional policy. Other conditions or restrictions may apply. About STEMCELL Technologies Inc. Get the Cells You Need from STEMCELL Technologies Driven by science and a passion for quality, STEMCELL Technologies supports life sciences research with more than 2500 specialized cell culture media, cell separation technologies, instruments, accessory products, and scientific services. Scientists performing stem cell, immunology, cancer, regenerative medicine, and cellular therapy research are among those who rely on our products and services. At STEMCELL, we are dedicated to improving lives through advanced knowledge and scientific discovery, our commitment to fostering diversity and inclusion in STEM, and our investments in sustainability, community, and social responsibility. We are a company of Scientists Helping Scientists, and we care deeply about making the world a better place. About Our Offerings on Scientist.com Partner with the Right Primary Cell Supplier The success of your primary cell-based research depends on partnering with the right cell supplier. Having a dependable source of quality human primary cells that consistently meet your requirements can reduce experimental uncertainty and increase confidence in your results. STEMCELL’s human primary cell products are ethically sourced using Informed Consent Forms (ICFs) and protocols approved by either an Institutional Review Board (IRB), the Food and Drug Administration (FDA), the U.S. Department of Health and Human Services, and/or an equivalent regulatory authority. You can choose human primary cells based on donor specifications that include sex, age range, BMI range, ethnicity, blood type, smoker status, and more. Ensure you get the cells you need by placing multiple lots on hold for testing, and save time by using our characterization services, including high-resolution HLA typing (Class I and II), CMV status, EBV status, vaccination status, genotyping, phenotyping, and FACS analysis. Visit STEMCELL.com/PrimaryCells to learn more about human primary cells. Our portfolio* of ready-to-use, fresh or cryopreserved human primary cells from blood, cord blood, and bone marrow includes: Induced pluripotent stem cells Leukopaks LRS cones Mobilized peripheral blood Mononuclear cells (MNCs) Purified immune cells (e.g. NK, T cells, monocytes, B cells, macrophages, pan-T cells, dendritic cells) Serum-free cultured immune cell subsets (e.g. dendritic cells, macrophages) Hematopoietic stem and progenitor cells (e.g. CD34+ cells) Stromal cells (MSCs) STEMCELL also offers a wide range of disease-state samples and customizations for your needs. Schedule the collection and delivery of fresh cells* at your convenience, or reserve multiple lots of cryopreserved cells while you test them in your assays. If you have a question about ready-to-use fresh or frozen human primary cells from STEMCELL, please contact us. Your Contract Research Organization Partner Contract Assay Services (CAS) is a contract research organization (CRO) established within STEMCELL that performs assay services based on in vitro and in vivo primary cell assays. The use of primary cells in our in vitro assays can provide more physiologically relevant results than cell line-based assays. We specialize in the various applications of the in vitro hematopoietic colony-forming unit (CFU) assay, also known as the colony-forming cell (CFC) assay. In addition, we perform standardized and customized immunological and mesenchymal cell-based assays for use at a variety of points in the drug discovery and development pathway. We combine STEMCELL Technologies' specialized media and reagents with the practical knowledge of our scientists, to provide both standardized and customized assay services that help researchers obtain the high-quality data they require. To explore our full product listing or educational and scientific resources, visit www.stemcell.com. *Certain products are only available in select territories. Please contact your sales representative or the Product & Scientific Support team at techsupport@stemcell.com for further information. STEMCELL employs over 1,400 people worldwide and operates in nine countries. Three locations are in North America: our headquarters in Vancouver, Canada, a sales support office in Cambridge, MA, and a distribution center in Seattle, WA. As well as three European offices, we have five Asia Pacific offices to serve our customers. We provide direct sales and support in more than 30 countries throughout North America, Europe, Asia, and Australia, as well as through a network of distributors. For full contact information worldwide, visit our locations page for specific details.

7 rue du lac St Egrève, 38120 France STEMCELL Technologies provides products and services to support life sciences research, including human primary cells, specialized culture media, cell separation technologies, instruments, accessories, and scientific services. Find out more about our featured tools and resources Limited-Time Offer: Get a Complimentary Lab Timer When You Request an Easysep™ Sample What more could you achieve if you spent less time isolating cells and more time getting results? EasySep™ is an efficient technology that can isolate cells in as little as 8 minutes, helping you move your research forward faster. For a limited time only, get a free 3-channel timer when you request an EasySep™ sample. Request your free sample using this link. Save up to 25% on Fresh or Frozen Peripheral Blood Leukopaks* Until September 15, 2023, you can save up to 25% on fresh, frozen or mobilized peripheral blood leukopaks and begin your large-scale studies confidently. You can now save even more by also bundling your leukopaks with the right EasySep™ cell isolation kits* To take advantage of this offer, please visit this form page. A member of our team will contact you to follow up. **Excludes fresh whole peripheral blood and isolated cells, LRS cones, mobilized peripheral blood isolated cell products, bone marrow products, cord blood products, and disease-sourced blood products. Discount does not apply to fees and may require a minimum purchase amount. Offer valid on orders placed between August 1, 2024, and September 15, 2024. Offer is only valid in Austria, Belgium, Canada (excluding Quebec), Denmark, Finland, Germany, Iceland, Ireland, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, the United Kingdom and the United States. Certain products are only available in select territories. Please contact your Sales representative or Product & Scientific Support at techsupport@stemcell.com for further information. Void where prohibited or restricted by federal, state, provincial, or local laws or regulations, or agency/institutional policy. Other conditions or restrictions may apply. About STEMCELL Technologies Inc. Get the Cells You Need from STEMCELL Technologies Driven by science and a passion for quality, STEMCELL Technologies supports life sciences research with more than 2500 specialized cell culture media, cell separation technologies, instruments, accessory products, and scientific services. Scientists performing stem cell, immunology, cancer, regenerative medicine, and cellular therapy research are among those who rely on our products and services. At STEMCELL, we are dedicated to improving lives through advanced knowledge and scientific discovery, our commitment to fostering diversity and inclusion in STEM, and our investments in sustainability, community, and social responsibility. We are a company of Scientists Helping Scientists, and we care deeply about making the world a better place. About Our Offerings on Scientist.com Partner with the Right Primary Cell Supplier The success of your primary cell-based research depends on partnering with the right cell supplier. Having a dependable source of quality human primary cells that consistently meet your requirements can reduce experimental uncertainty and increase confidence in your results. STEMCELL’s human primary cell products are ethically sourced using Informed Consent Forms (ICFs) and protocols approved by either an Institutional Review Board (IRB), the Food and Drug Administration (FDA), the U.S. Department of Health and Human Services, and/or an equivalent regulatory authority. You can choose human primary cells based on donor specifications that include sex, age range, BMI range, ethnicity, blood type, smoker status, and more. Ensure you get the cells you need by placing multiple lots on hold for testing, and save time by using our characterization services, including high-resolution HLA typing (Class I and II), CMV status, EBV status, vaccination status, genotyping, phenotyping, and FACS analysis. Visit STEMCELL.com/PrimaryCells to learn more about human primary cells. Our portfolio* of ready-to-use, fresh or cryopreserved human primary cells from blood, cord blood, and bone marrow includes: Induced pluripotent stem cells Leukopaks LRS cones Mobilized peripheral blood Mononuclear cells (MNCs) Purified immune cells (e.g. NK, T cells, monocytes, B cells, macrophages, pan-T cells, dendritic cells) Serum-free cultured immune cell subsets (e.g. dendritic cells, macrophages) Hematopoietic stem and progenitor cells (e.g. CD34+ cells) Stromal cells (MSCs) STEMCELL also offers a wide range of disease-state samples and customizations for your needs. Schedule the collection and delivery of fresh cells* at your convenience, or reserve multiple lots of cryopreserved cells while you test them in your assays. If you have a question about ready-to-use fresh or frozen human primary cells from STEMCELL, please contact us. Your Contract Research Organization Partner Contract Assay Services (CAS) is a contract research organization (CRO) established within STEMCELL that performs assay services based on in vitro and in vivo primary cell assays. The use of primary cells in our in vitro assays can provide more physiologically relevant results than cell line-based assays. We specialize in the various applications of the in vitro hematopoietic colony-forming unit (CFU) assay, also known as the colony-forming cell (CFC) assay. In addition, we perform standardized and customized immunological and mesenchymal cell-based assays for use at a variety of points in the drug discovery and development pathway. We combine STEMCELL Technologies' specialized media and reagents with the practical knowledge of our scientists, to provide both standardized and customized assay services that help researchers obtain the high-quality data they require. To explore our full product listing or educational and scientific resources, visit www.stemcell.com. *Certain products are only available in select territories. Please contact your sales representative or the Product & Scientific Support team at techsupport@stemcell.com for further information. STEMCELL employs over 1,400 people worldwide and operates in nine countries. Three locations are in North America: our headquarters in Vancouver, Canada, a sales support office in Cambridge, MA, and a distribution center in Seattle, WA. As well as three European offices, we have five Asia Pacific offices to serve our customers. We provide direct sales and support in more than 30 countries throughout North America, Europe, Asia, and Australia, as well as through a network of distributors. For full contact information worldwide, visit our locations page for specific details.

40 rue des Berges Miniparc Polytec, Bâtiment Sirocco Grenoble, France, 38000 France STEMCELL Technologies provides products and services to support life sciences research, including human primary cells, specialized culture media, cell separation technologies, instruments, accessories, and scientific services. Find out more about our featured tools and resources Limited-Time Offer: Get a Complimentary Lab Timer When You Request an Easysep™ Sample What more could you achieve if you spent less time isolating cells and more time getting results? EasySep™ is an efficient technology that can isolate cells in as little as 8 minutes, helping you move your research forward faster. For a limited time only, get a free 3-channel timer when you request an EasySep™ sample. Request your free sample using this link. Save up to 25% on Fresh or Frozen Peripheral Blood Leukopaks* Until September 15, 2023, you can save up to 25% on fresh, frozen or mobilized peripheral blood leukopaks and begin your large-scale studies confidently. You can now save even more by also bundling your leukopaks with the right EasySep™ cell isolation kits* To take advantage of this offer, please visit this form page. A member of our team will contact you to follow up. **Excludes fresh whole peripheral blood and isolated cells, LRS cones, mobilized peripheral blood isolated cell products, bone marrow products, cord blood products, and disease-sourced blood products. Discount does not apply to fees and may require a minimum purchase amount. Offer valid on orders placed between August 1, 2024, and September 15, 2024. Offer is only valid in Austria, Belgium, Canada (excluding Quebec), Denmark, Finland, Germany, Iceland, Ireland, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, the United Kingdom and the United States. Certain products are only available in select territories. Please contact your Sales representative or Product & Scientific Support at techsupport@stemcell.com for further information. Void where prohibited or restricted by federal, state, provincial, or local laws or regulations, or agency/institutional policy. Other conditions or restrictions may apply. About STEMCELL Technologies Inc. Get the Cells You Need from STEMCELL Technologies Driven by science and a passion for quality, STEMCELL Technologies supports life sciences research with more than 2500 specialized cell culture media, cell separation technologies, instruments, accessory products, and scientific services. Scientists performing stem cell, immunology, cancer, regenerative medicine, and cellular therapy research are among those who rely on our products and services. At STEMCELL, we are dedicated to improving lives through advanced knowledge and scientific discovery, our commitment to fostering diversity and inclusion in STEM, and our investments in sustainability, community, and social responsibility. We are a company of Scientists Helping Scientists, and we care deeply about making the world a better place. About Our Offerings on Scientist.com Partner with the Right Primary Cell Supplier The success of your primary cell-based research depends on partnering with the right cell supplier. Having a dependable source of quality human primary cells that consistently meet your requirements can reduce experimental uncertainty and increase confidence in your results. STEMCELL’s human primary cell products are ethically sourced using Informed Consent Forms (ICFs) and protocols approved by either an Institutional Review Board (IRB), the Food and Drug Administration (FDA), the U.S. Department of Health and Human Services, and/or an equivalent regulatory authority. You can choose human primary cells based on donor specifications that include sex, age range, BMI range, ethnicity, blood type, smoker status, and more. Ensure you get the cells you need by placing multiple lots on hold for testing, and save time by using our characterization services, including high-resolution HLA typing (Class I and II), CMV status, EBV status, vaccination status, genotyping, phenotyping, and FACS analysis. Visit STEMCELL.com/PrimaryCells to learn more about human primary cells. Our portfolio* of ready-to-use, fresh or cryopreserved human primary cells from blood, cord blood, and bone marrow includes: Induced pluripotent stem cells Leukopaks LRS cones Mobilized peripheral blood Mononuclear cells (MNCs) Purified immune cells (e.g. NK, T cells, monocytes, B cells, macrophages, pan-T cells, dendritic cells) Serum-free cultured immune cell subsets (e.g. dendritic cells, macrophages) Hematopoietic stem and progenitor cells (e.g. CD34+ cells) Stromal cells (MSCs) STEMCELL also offers a wide range of disease-state samples and customizations for your needs. Schedule the collection and delivery of fresh cells* at your convenience, or reserve multiple lots of cryopreserved cells while you test them in your assays. If you have a question about ready-to-use fresh or frozen human primary cells from STEMCELL, please contact us. Your Contract Research Organization Partner Contract Assay Services (CAS) is a contract research organization (CRO) established within STEMCELL that performs assay services based on in vitro and in vivo primary cell assays. The use of primary cells in our in vitro assays can provide more physiologically relevant results than cell line-based assays. We specialize in the various applications of the in vitro hematopoietic colony-forming unit (CFU) assay, also known as the colony-forming cell (CFC) assay. In addition, we perform standardized and customized immunological and mesenchymal cell-based assays for use at a variety of points in the drug discovery and development pathway. We combine STEMCELL Technologies' specialized media and reagents with the practical knowledge of our scientists, to provide both standardized and customized assay services that help researchers obtain the high-quality data they require. To explore our full product listing or educational and scientific resources, visit www.stemcell.com. *Certain products are only available in select territories. Please contact your sales representative or the Product & Scientific Support team at techsupport@stemcell.com for further information. STEMCELL employs over 1,400 people worldwide and operates in nine countries. Three locations are in North America: our headquarters in Vancouver, Canada, a sales support office in Cambridge, MA, and a distribution center in Seattle, WA. As well as three European offices, we have five Asia Pacific offices to serve our customers. We provide direct sales and support in more than 30 countries throughout North America, Europe, Asia, and Australia, as well as through a network of distributors. For full contact information worldwide, visit our locations page for specific details.

2-4, rue Jean Baptiste HuetTransgenic Rabbit Models offers transgenic rabbit models for the study of atherosclerosis, ophtalmology, hypertrophic myopathies, diabetes, obesity, hemostasis, respiratory diseases, AIDS, and cancer.

28Rue Claude BernardTelstar Life Science Solutions designs, manufactures, sell and support of high technology equipment solutions for the pharmaceutical, biotech and related industries

Bidart, Aquitaine-Limousin-Poitou-Charentes, 64210 FranceTechnoflex offers design and production of flexible bags and medical devices.

ZA de Bassilour 64210 BIDART FranceTechnoflex offers design and production of flexible bags and medical devices.

IRS-UN 8, quai Moncousu BP 70721 Nantes Cedex 1, 44007 FranceTherassay offers animal models, in vivo, ex vivo, and in vitro testing in various therapeutic areas including metabolism, cardiac, pulmonary, motor, digestive, and oncology.

8è étage, 26 rue d’Ulm Paris, 75005 FranceThe genomics platform provides to basic, translational, and medical research teams with high throughput technological tools for analyzing gene structure and expression in various organisms, cellular models, and tumors. Structural alterations in genomes, such as mutations, gains, amplifications, loss of genomic regions, polymorphisms, allelic imbalances, loss of heterozygosity are identified using SNP arrays, Nanostring analysis, Sanger sequencing, or qPCR. Gene expression is complex and may be addressed at multiple levels. Coding and non-coding transcript for proteins can be quantified using Affymetrix chip for a pangenomic analysis, or using NanoString tools, or via qPCR depending on the number of samples and markers to quantify. The platform analyses the regulation of gene expression by quantifying microRNA, non-coding functional RNA, and other specific types of RNA, which modulate gene expression at various levels (transcription and translation). Such quantifications are performed by using Affymetrix chips or via NanoString multiplexing tools. Technics for quantifying certain epigenetic markers are currently being tested to meet internal demand (OxBS method developed by Cambridge Epigenetix).Other technics to analyse the chromatin conformation are being setup (in situ HiC, Uveal Melanoma project, with Pr. E. Heard) to enrich our portfolio of activities

26 rue d’Ulm Paris , 75248 FranceThe NGS Platform of the Institut Curie has greatly evolved since 2012 mainly with the financial support of ICGEx grant obtained in the frame of the EQUIPEX « investissement d’avenir » competitive call. This grant allowed to purchase high throughput NGS sequencers, to fully equip a dedicated lab at the 7th floor of the hospital and expand the staff in charge of running sequencing projects. Under the supervision of Olivier Delattre and Alain Nicolas, the NGS platform provides state of the art services in sequencing. This includes the organization of pre-run meetings where the choice of the most appropriate technical strategy is defined in order to best address the biological question of collaborators. Multiple sequencing protocols have been developed and routinely used in the platform to cover most commonly used applications in genetics and epigenetics (Genome, Exome and targeted resequencing, RNA sequencing, DNA methylation sequencing, ChIP-seq …). Furthermore, we are also willing to co-develop more specific protocols according to the need of research teams of the Institute.

Voie de l’innovation Pharma Parc II Chaussée du Vexin Val de Reuil, 27100 FranceTFChem specializes in fluorochemistry and offers synthesis of fluorinated molecules.

14 Rue Ambroise Croizat Croissy-Beaubourg, 77183 FranceWith more than 25 years experience of developing, manufacturing, and marketing innovative in-vitro diagnostics, Theradiag is now strengthening its presence in theranostics. Our new name, Theradiag, illustrates this approach. With CE marking in 2010 and the launch in 2011 of the first Lisa-Tracker kits, we are expanding this panel by developing and launching new kits. Our goal is to offer clinicians and patients a wide range of biotherapy monitoring kits. We have built the foundations for this new activity based on our knowledge of autoimmune diseases. In the coming months, we will be extending our offer to assist in the monitoring of biotherapies in other treatment areas, such as infectious diseases and cancer. We will also continue to develop our traditional activity in IVD, and specifically autoimmunity and innovative oncogenetic diagnostics. This technological and innovative evolution will allow Theradiag to better serve its clients and contribute to improving the bio-therapeutic treatments of today and the future.

Halle 13, Bio-Ouest Ile de NantesTcLand Expression provides immunological tests, biomarkers, and personalized medicine.

Esplanade de la paix CS 14032 CAEN cedex 5, 14032 France

140bis, Rue de RennesTripos provides natural product and informatics technology services.

109, rue des Cotes Maisons-Laffitte 78600 FranceFounded in 1989, Thorlabs has its headquarters in Newton, NJ. This location is also home to our mechanics, optics, fiber, advanced systems technology, and advanced applications teams as well as one of our three distribution warehouses. On-site manufacturing allows us to customize our products quickly and efficiently to meet specialized customer requests. Our technical support team, call center, marketing, and web development teams make their homes in Newton as well, and are dedicated to providing comprehensive customer support and services.

4, rue des Terreaux-du-Temple Geneva, CH-1201 SwitzerlandTriskel Integrated Services provides a strategic complement to contract research organisations (CROs), contract manufacturers (CMOs) or other classical service providers, offering consulting services throughout the product's lifespan – from discovery through to the post-authorisation phase.

37th-39th, Ledru-Rollin Avenue Office 710 Paris 75012 FranceTheorem Clinical Research offers full service clinical research solutions including DM, biostatistics, programming including CDISC, PM, clinical operations, and regulatory affairs.

1 Rue Pierre Fontaine Evry, 91000 FranceTexcell-North America, Inc. is a global contract research organization based in the Maryland/Virginia biotech corridor specializing in custom cell culture, virus propagation, virus concentration, viral clearance services, and viral safety testing in support of biopharmaceutical applications submitted to the FDA and other regulatory authorities. Since 2002, our team has cultivated an ever-increasing range of experience performing viral clearance studies for a wide variety of purification steps including chromatography, filtration, and inactivation methods, as well as evaluations of column age and sanitization, or cleaning efficacy. We offer our clients a personalized and tailored approach to study design with the advantage of an extensive historical viral clearance database of over 9,000 studies performed by our global organization. Through partnerships with other Texcell facilities around the world, we have expanded our services portfolio to include cGMP cell bank production, cell bank characterization and GMP compliant animal studies. We are proud to support research that continues to improve global quality of life.

34 rue de la Croix de Fer CS 30158 Saint-Germain-en-Laye, 78100 FranceTakara Bio Europe provides kits, reagents, instruments, and services that enable life sciences researchers to achieve their experimental objectives. As a member of the Takara Bio Group, Takara Bio Europe is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Going forward, Takara Bio Europe will continue to develop high-quality, innovative tools and services that accelerate scientific discovery. For researchers in the USA, please visit "Takara Bio USA's profile here":https://app.scientist.com/domain_switcher?redirect=/providers/ba5e2593-0a26-4dda-93b6-b07ddb7823b1

54 rue de Londres 75008 PARIS, IDF, 75008 FranceTox by Design is a leading European toxicological expertise company specializing in impurity risk assessments. Our services cover a wide range of pharmaceutical sectors, including APIs, cosmetics and medical devices. Our expert team thoroughly reviews all ICH and EMA requirements to ensure your products and manufacturing processes align with the latest industry standards. We have extensive access to tox literature and validated in-silico solutions in order to provide our clients with the most relevant information to support the research, development, and validation of their products. We take pride in recruiting top-of-the-class, European registered toxicologists who deliver outstanding service. Learn more at our website www.toxby.design and get a quotation today to see how your company can benefit from our toxicology and regulatory compliance expertise.

54 Rue de Londres Paris, Île-de-France, 75008 FranceTox by Design is a leading European toxicological expertise company specializing in impurity risk assessments. Our services cover a wide range of pharmaceutical sectors, including APIs, cosmetics and medical devices. Our expert team thoroughly reviews all ICH and EMA requirements to ensure your products and manufacturing processes align with the latest industry standards. We have extensive access to tox literature and validated in-silico solutions in order to provide our clients with the most relevant information to support the research, development, and validation of their products. We take pride in recruiting top-of-the-class, European registered toxicologists who deliver outstanding service. Learn more at our website www.toxby.design and get a quotation today to see how your company can benefit from our toxicology and regulatory compliance expertise.

39 Rue de Houdan Le Perray en Yvelines, Yvelines, 78610 Francetebubio is a leading European distributor of innovative life science research reagents and lab services. Our extensive network of local offices and sales representatives spanning 9 countries daily assists researchers from universities, pharma, cosmetic and biotech companies in choosing and optimally using the products suited to their research programs . For almost 20 years now, tebu-bio’s own laboratories provide R&D contract services and are an active member of recognized professional networks and clusters (Medicen, Cosmetic Valley... Lab services: tebu-bio ISO9001 certified laboratory possesses 4 major platforms: Biomarkers, Protein Production, Molecular Biology and Cell culture. Biomarkers services: tebu bio provides protein quantification and profiling services, gene and miRNA profiling. For protein quantification, the offer includes quantitative measurement of multiple cytokines, chemokines, adipokines, MMPs... in a wide variety of sample types (cell/tissue lysates, serum/plasma, cell culture supernatants...) on robust assays: antibody array or multiplex ELISA format. In addition, we provide one stop pathway focused or broad profiling services including both sample processing and data analysis. If you don't have the expertise or resources to process array data, tebu-bio's biostatistics and bioinformatics partners can do this for you and provide a full report (heat map, cluster and pathway analysis, biomarker selection...). Application examples: inflammation, apoptosis, obesity biomarker monitoring, signalling pathway identification with broad profiling phosphorylation arrays, glycans or glycan/protein interactions detection, miRNA/gene expression profiling... Human Biological samples & Prospective collections: tebu-bio holds an import/export/handling/storage HBS permit and strictly follows regulatory and ethics guidelines related to human biospecimens collection. -Healthy and Diseased blood derived samples (whole blood, plasma, serum, buffy coat, PBMC, platelets...). -Any type of biofluids -Fresh or frozen tissues, healthy or diseased with mutation characterization possibilities -Broad Primary cells offer (healthy or diseased): Human cryo-preserved Hepatocytes, individual donors or pools, Human Hepatic Stellate Cells, Human dermal fibroblast and keratinocytes, Fresh pancreatic human Islets, Human pre-adipocytes, Human Mesenchymal Stem Cells, Peripheral Blood Mononulear Cells (PBMCs), Peripheral Blood Monocytes CD14+, Bone marrow derived CD34+ cells, Tenocytes, Chondrocytes and Synoviocytes, Primary cells from Lung, kidney, Intestine tissues, iPSC derived cardiomyocytes, iPSC derived neurons. Ready to use QC tested specialized media for every primary cell type. Now tebu-bio is the exclusive European distributor of Japanese Collection of Research Bioresources Cell Bank (JCRB), which is one of the most comprehensive cell banks (more than 1 300 cell lines) for Life Scientists and collects high quality cell lines from numerous species such as animal and humans including cancer and genetically modified cells. Protein production (E. coli, HEK293) : tebu-bio provides services from A to Z: gene synthesis, cloning, small scale protein expression to optimize production conditions, large production batches. Our experts have extensive experience and expertise in protein purification and characterization, they will accompany you all along your project. Other services: cell biology (cell amplification & differentiation, cell-line engineering, Spheroids production...); 3D cell culture; hypoxia and normoxia culture conditions; molecular biology, bio-assays (gene reporter & nuclear receptor assays, outsourcing of any assays commercialised by tebu-bio...) Products offer: research antibodies, ELISAs, arrays, proteins & peptides, cell-based & functional assays, primary cells & media (incl. cytokines and growth factors), stem cells and iPS cells, characterized cell lines (ex. melanoma, brain- and stem-cell derived, cell line engineering tools (si/shRNA,CRISPR), biochemicals & compounds, functional assays (actin, tubulin, lipid research tools...).

39 rue de Houdan BP 15 Le Perray-en-Yvelines, 78612 Francetebubio is a leading European distributor of innovative life science research reagents and lab services. Our extensive network of local offices and sales representatives spanning 9 countries daily assists researchers from universities, pharma, cosmetic and biotech companies in choosing and optimally using the products suited to their research programs . For almost 20 years now, tebu-bio’s own laboratories provide R&D contract services and are an active member of recognized professional networks and clusters (Medicen, Cosmetic Valley... Lab services: tebu-bio ISO9001 certified laboratory possesses 4 major platforms: Biomarkers, Protein Production, Molecular Biology and Cell culture. Biomarkers services: tebu bio provides protein quantification and profiling services, gene and miRNA profiling. For protein quantification, the offer includes quantitative measurement of multiple cytokines, chemokines, adipokines, MMPs... in a wide variety of sample types (cell/tissue lysates, serum/plasma, cell culture supernatants...) on robust assays: antibody array or multiplex ELISA format. In addition, we provide one stop pathway focused or broad profiling services including both sample processing and data analysis. If you don't have the expertise or resources to process array data, tebu-bio's biostatistics and bioinformatics partners can do this for you and provide a full report (heat map, cluster and pathway analysis, biomarker selection...). Application examples: inflammation, apoptosis, obesity biomarker monitoring, signalling pathway identification with broad profiling phosphorylation arrays, glycans or glycan/protein interactions detection, miRNA/gene expression profiling... Human Biological samples & Prospective collections: tebu-bio holds an import/export/handling/storage HBS permit and strictly follows regulatory and ethics guidelines related to human biospecimens collection. -Healthy and Diseased blood derived samples (whole blood, plasma, serum, buffy coat, PBMC, platelets...). -Any type of biofluids -Fresh or frozen tissues, healthy or diseased with mutation characterization possibilities -Broad Primary cells offer (healthy or diseased): Human cryo-preserved Hepatocytes, individual donors or pools, Human Hepatic Stellate Cells, Human dermal fibroblast and keratinocytes, Fresh pancreatic human Islets, Human pre-adipocytes, Human Mesenchymal Stem Cells, Peripheral Blood Mononulear Cells (PBMCs), Peripheral Blood Monocytes CD14+, Bone marrow derived CD34+ cells, Tenocytes, Chondrocytes and Synoviocytes, Primary cells from Lung, kidney, Intestine tissues, iPSC derived cardiomyocytes, iPSC derived neurons. Ready to use QC tested specialized media for every primary cell type. Now tebu-bio is the exclusive European distributor of Japanese Collection of Research Bioresources Cell Bank (JCRB), which is one of the most comprehensive cell banks (more than 1 300 cell lines) for Life Scientists and collects high quality cell lines from numerous species such as animal and humans including cancer and genetically modified cells. Protein production (E. coli, HEK293) : tebu-bio provides services from A to Z: gene synthesis, cloning, small scale protein expression to optimize production conditions, large production batches. Our experts have extensive experience and expertise in protein purification and characterization, they will accompany you all along your project. Other services: cell biology (cell amplification & differentiation, cell-line engineering, Spheroids production...); 3D cell culture; hypoxia and normoxia culture conditions; molecular biology, bio-assays (gene reporter & nuclear receptor assays, outsourcing of any assays commercialised by tebu-bio...) Products offer: research antibodies, ELISAs, arrays, proteins & peptides, cell-based & functional assays, primary cells & media (incl. cytokines and growth factors), stem cells and iPS cells, characterized cell lines (ex. melanoma, brain- and stem-cell derived, cell line engineering tools (si/shRNA,CRISPR), biochemicals & compounds, functional assays (actin, tubulin, lipid research tools...).

39 Rue de Houdan Le Perray-en-Yvelines, Île-de-France, 78610 Francetebubio is a leading European distributor of innovative life science research reagents and lab services. Our extensive network of local offices and sales representatives spanning 9 countries daily assists researchers from universities, pharma, cosmetic and biotech companies in choosing and optimally using the products suited to their research programs . For almost 20 years now, tebu-bio’s own laboratories provide R&D contract services and are an active member of recognized professional networks and clusters (Medicen, Cosmetic Valley... Lab services: tebu-bio ISO9001 certified laboratory possesses 4 major platforms: Biomarkers, Protein Production, Molecular Biology and Cell culture. Biomarkers services: tebu bio provides protein quantification and profiling services, gene and miRNA profiling. For protein quantification, the offer includes quantitative measurement of multiple cytokines, chemokines, adipokines, MMPs... in a wide variety of sample types (cell/tissue lysates, serum/plasma, cell culture supernatants...) on robust assays: antibody array or multiplex ELISA format. In addition, we provide one stop pathway focused or broad profiling services including both sample processing and data analysis. If you don't have the expertise or resources to process array data, tebu-bio's biostatistics and bioinformatics partners can do this for you and provide a full report (heat map, cluster and pathway analysis, biomarker selection...). Application examples: inflammation, apoptosis, obesity biomarker monitoring, signalling pathway identification with broad profiling phosphorylation arrays, glycans or glycan/protein interactions detection, miRNA/gene expression profiling... Human Biological samples & Prospective collections: tebu-bio holds an import/export/handling/storage HBS permit and strictly follows regulatory and ethics guidelines related to human biospecimens collection. -Healthy and Diseased blood derived samples (whole blood, plasma, serum, buffy coat, PBMC, platelets...). -Any type of biofluids -Fresh or frozen tissues, healthy or diseased with mutation characterization possibilities -Broad Primary cells offer (healthy or diseased): Human cryo-preserved Hepatocytes, individual donors or pools, Human Hepatic Stellate Cells, Human dermal fibroblast and keratinocytes, Fresh pancreatic human Islets, Human pre-adipocytes, Human Mesenchymal Stem Cells, Peripheral Blood Mononulear Cells (PBMCs), Peripheral Blood Monocytes CD14+, Bone marrow derived CD34+ cells, Tenocytes, Chondrocytes and Synoviocytes, Primary cells from Lung, kidney, Intestine tissues, iPSC derived cardiomyocytes, iPSC derived neurons. Ready to use QC tested specialized media for every primary cell type. Now tebu-bio is the exclusive European distributor of Japanese Collection of Research Bioresources Cell Bank (JCRB), which is one of the most comprehensive cell banks (more than 1 300 cell lines) for Life Scientists and collects high quality cell lines from numerous species such as animal and humans including cancer and genetically modified cells. Protein production (E. coli, HEK293) : tebu-bio provides services from A to Z: gene synthesis, cloning, small scale protein expression to optimize production conditions, large production batches. Our experts have extensive experience and expertise in protein purification and characterization, they will accompany you all along your project. Other services: cell biology (cell amplification & differentiation, cell-line engineering, Spheroids production...); 3D cell culture; hypoxia and normoxia culture conditions; molecular biology, bio-assays (gene reporter & nuclear receptor assays, outsourcing of any assays commercialised by tebu-bio...) Products offer: research antibodies, ELISAs, arrays, proteins & peptides, cell-based & functional assays, primary cells & media (incl. cytokines and growth factors), stem cells and iPS cells, characterized cell lines (ex. melanoma, brain- and stem-cell derived, cell line engineering tools (si/shRNA,CRISPR), biochemicals & compounds, functional assays (actin, tubulin, lipid research tools...).

ArchParc, Le Forum 1 260 Avenue Marie Curie Archamps, 74160 FranceTransCure BioServices is the only CRO specialized in preclinical studies using full human immune system (CD34 engrafted and PBMC engrafted) and humanized liver mouse models. We provide predictive in vivo pharmacology tools to accelerate preclinical drug development in: Immuno-Oncology (CDX/PDX/Leukemia) Infectious Diseases: HIV, HBV Inflammation: IBD/Colitis, NASH/MASH, lung fibrosis Toxicity/Immuno-toxicity Our state-of-the-art facilities based in France include BSL-2 and -3 labs, advanced flow cytometry, and customized protocols, ensuring flexibility and adaptability to your project’s needs. With over 12 years of expertise, an AAALAC-accredited facility , and affordable pricing, we help save you time and budget while offering robust and predictive data for IND filing.

BioPark le Forum 1-2 260 avenue Marie Curie Archamps, Haute-Savoie, 74160 FranceTransCure BioServices is the only CRO specialized in preclinical studies using full human immune system (CD34 engrafted and PBMC engrafted) and humanized liver mouse models. We provide predictive in vivo pharmacology tools to accelerate preclinical drug development in: Immuno-Oncology (CDX/PDX/Leukemia) Infectious Diseases: HIV, HBV Inflammation: IBD/Colitis, NASH/MASH, lung fibrosis Toxicity/Immuno-toxicity Our state-of-the-art facilities based in France include BSL-2 and -3 labs, advanced flow cytometry, and customized protocols, ensuring flexibility and adaptability to your project’s needs. With over 12 years of expertise, an AAALAC-accredited facility , and affordable pricing, we help save you time and budget while offering robust and predictive data for IND filing.

Grenoble, 38041 FranceUniversity Joseph Fourier focuses on research in various areas.

55 avenue de ParisUniversity of Versailles Saint Quentin en Yvelines (UVSQ) focuses on research with laboratories for cellular biology, microbiology, pathology, oncology, and pharmacology.

1 Rue Michel-Servet Genève, GE, 1206 Switzerland

62127 AverdoingtFlexible packaging solutions across Europe and West Africa UNI Packaging manufactures innovative and quality based flexible packaging solutions for an ever changing and highly demanding international market place. Continual investment has seen its presence grow in over fifteen countries throughout Europe and West Africa, based on a firm commitment to provide flexible packaging of the highest standard at optimum cost.

1 chemin du Thil Amiens, 80025 FranceThe international is a priority in the strategy of development of the University of Picardie Jules Verne. Its presence on the international scene is manifested by the expansion of its network of partner universities, its participation in major exchange programmes and its accession to the Agence Universitaire de la Francophonie and the Agency National Campus France.

4 Boulevard du Pont-d'Arve, Genève, GE 1205, CH

Bd du Pont-d'Arve 40 Bureau R050 GENEVA 4, CH-1211 Switzerland

25 Rue Becquerel 25 Rue Becquerel Strasbourg, Grand Est, 67087 FranceThe LSMBO focuses on research in the field of mass spectrometry based- proteomics and protein characterization.

LSMBO ECPM Building R5-0, 25 Rue Becquerel Strasbourg, France FranceThe LSMBO focuses on research in the field of mass spectrometry based- proteomics and protein characterization.

43 boulevard du 11 Novembre 1918Université Claude Bernard Lyon 1 (Claude Bernard University) focuses on research.

5 Rue Blaise Pascal Strasbourg, Grand Est, 67000 France

5 Rue Blaise Pascal Strasbourg, 67084 United States

UPR 9002 IBMC 15 rue René Descartes 67 084 Strasbourg FranceLes thèmes de recherche développés dans l’Unité 9002 du CNRS portent sur la biologie du monde de l’ARN. Les ARN sont en effet à la base de nombreuses fonctions biologiques (régulation de l’expression génique, traduction, ou infection virale). Ils remplissent leurs fonctions notamment en adoptant des structures spatiales particulières qui leur permettent d'interagir avec leurs partenaires de manière coordonnée. Ces structures contrôlent de nombreux processus biologiques par des mécanismes d’interaction très sélectifs qui sont loin d'être élucidés et dont l'étude ouvre de multiples perspectives tant fondamentales qu’appliquées.

60 Rue du Plat d'Étain Tours, Centre-Val de Loire, 37000 FranceWelcome to the PST Animaleries website of the University of Tours Scientific and Technical Platform Animal experiments enable us to analyze the functioning of the biological systems of the animal kingdom, based on studies on a living animal which is endowed with sensibility. Most of our basic knowledge in biochemistry, physiology, endocrinology or pharmacology is derived from initial studies in animal models; These studies could not have been carried out in man for ethical and religious considerations. Since 1901, more than 80% of Nobel Prizes in medicine or physiology have been obtained for discoveries based on animal models. Animal experimentation is a legal practice that takes place within a precise regulatory framework defining a field of action, the competencies required, an authority and control mechanisms. Its actors have put in place the means of its evaluation. Recently, a regulatory ethics framework has added to this framework an assessment of the 'why' and 'how' by representatives of the social body. All animal facilities or user establishments (EU) of the University of Tours are grouped together in a Scientific and Technical Platform (PST) 'Pet Shops'. This platform makes available to researchers many conventional pathological and / or transgenic animal models in rodent, rabbit or primate species. PST allows to develop a large number of methods: From minimally invasive methods based on imaging to classical in vivo procedures including surgery, from maintaining conventional lines to breeding specific lines. Already involved in research work with more than fifteen local teams and with external partners, PST Petries has the optimum conditions for the development of university research themes, while offering state-of-the-art equipment Projects in partnership with industry. PST Animaleries also provides regulatory training. Already involved in research work with more than 15 local teams and with external partners, PST Petries has the optimum conditions for the development of university research themes, while offering state-of-the-art equipment Projects in partnership with industry. PST Animaleries also provides regulatory training. Already involved in research work with more than 15 local teams and with external partners, PST Petries has the optimum conditions for the development of university research themes, while offering state-of-the-art equipment Projects in partnership with industry. PST Animaleries also provides regulatory training.

60 rue du Plat D'Etain Tours cedex 1 , 37020 FranceWelcome to the PST Animaleries website of the University of Tours Scientific and Technical Platform Animal experiments enable us to analyze the functioning of the biological systems of the animal kingdom, based on studies on a living animal which is endowed with sensibility. Most of our basic knowledge in biochemistry, physiology, endocrinology or pharmacology is derived from initial studies in animal models; These studies could not have been carried out in man for ethical and religious considerations. Since 1901, more than 80% of Nobel Prizes in medicine or physiology have been obtained for discoveries based on animal models. Animal experimentation is a legal practice that takes place within a precise regulatory framework defining a field of action, the competencies required, an authority and control mechanisms. Its actors have put in place the means of its evaluation. Recently, a regulatory ethics framework has added to this framework an assessment of the 'why' and 'how' by representatives of the social body. All animal facilities or user establishments (EU) of the University of Tours are grouped together in a Scientific and Technical Platform (PST) 'Pet Shops'. This platform makes available to researchers many conventional pathological and / or transgenic animal models in rodent, rabbit or primate species. PST allows to develop a large number of methods: From minimally invasive methods based on imaging to classical in vivo procedures including surgery, from maintaining conventional lines to breeding specific lines. Already involved in research work with more than fifteen local teams and with external partners, PST Petries has the optimum conditions for the development of university research themes, while offering state-of-the-art equipment Projects in partnership with industry. PST Animaleries also provides regulatory training. Already involved in research work with more than 15 local teams and with external partners, PST Petries has the optimum conditions for the development of university research themes, while offering state-of-the-art equipment Projects in partnership with industry. PST Animaleries also provides regulatory training. Already involved in research work with more than 15 local teams and with external partners, PST Petries has the optimum conditions for the development of university research themes, while offering state-of-the-art equipment Projects in partnership with industry. PST Animaleries also provides regulatory training.

1919 Route de Mende Montpellier, Occitanie, 34090 FranceWe provide bioinformatics services to the 18 research groups of the institute.

Tour Franklin 92042 Paris La Défense Cedex FranceUnipex distributes specialty products including API, excipients, and other formulations.

75 rue Saint LazareUnither Pharmaceuticals is the world's leading contract manufacturer of sterile, unit dose preparations.

146 Rue Léo Saignat Bordeaux, Nouvelle-Aquitaine, 33000 FranceThe Institute for Interdisciplinary Neuroscience (IINS) is a new research center that has officially opened its doors January 1st, 2011. The IINS is part of the "Centre National de la Recherche Scientifique" & the "Université of Bordeaux". The IINS unites researchers with diverse areas of expertise, and creates a highly synergistic environment to promote: > The development of innovative methods and investigation tools, especially those based on molecular biology, physiology, optics, chemistry, physics and computer science. > The application of such tools to push the boundaries of the study of molecular events underlying the activity of the brain. This will include studying the morpho-dynamic and functional properties of the nervous system to understand the complexity of its molecular assemblies and functions at an integrated level. > The development of the Bordeaux Imaging Center (BIC), a core facility of service, training and R & D in cellular imaging of international stature to permit the transfer to the scientific community and industry of the tools developed in IINS. Currently, the IINS project is home to 8 research teams, comprised of about 130 scientists. The IINS is part of a greater plan to expand Neuroscience research in Bordeaux through the Neurocampus project that will see the construction of 12 000 m² of new lab space dedicated to Neuroscience, with teams ranging from molecular to behavioral and patho-physiological studies. These teams are federated in the Federation of Bordeaux Neurocampus (FBN).

Faculty of Medicine of Lille Lille Cedex , F-59045 FranceThe research teams of the Faculty of Medicine have access to state-of-the-art methodological platforms and common services that optimize technical resources and strengthen synergy between the teams: Methodological Platforms - Molecular and cellular imaging - Genomics, proteomics and bioinformatics platform - Cytometry and cell sorting platform - Platform for therapeutic innovation - Biotherapy platform - Experimental resources platform - Platform Imaging - Clinical evaluation platform

92 rue Pasteur 69361 LYON, cedex 07, CS 30122 FranceThe Université de Lyon is a consortium of higher education and research institutions (COMUE: Communauté d’universités et établissements) located within the two neighboring cities of Lyon and Saint-Étienne. The Université de Lyon is the main French higher education and scientific center outside the Parisian area composed of 4 public universities, 7 grandes écoles and the CNRS (the French National Center for Scientific Research), forming a group of 12 members institutions. The Université de Lyon also assembles 19 associated institutions offering specific disciplinary training programs. Altogether, the Université de Lyon regroups 137,600 students and 168 public laboratories. The Université de Lyon implements and manages large strategic projects with the regional authorities (Région Auvergne-Rhône-Alpes, Métropole de Lyon, Saint-Étienne Métropole) as well as a large network of public and private companies. The Université de Lyon builds its international recognition on the great quality of its faculty members, research teams and teaching departments in various disciplines and more particularly in three strategic domains: Bio health and Society Science and Engineering for Sustainable Society Urbanity and Humanities In cooperation with its network of member and associated institutions, the Université de Lyon implements joint-research centers, offers high-quality targeted internships programs and organizes scientific and academic symposiums. It also coordinates PhD programs for the 17 doctoral schools and fosters strategic international partnerships. The Université de Lyon works as a powerful brand promoting its institutions, academic communities, institutional partners, as well as the Lyon Saint-Étienne area in the same way as renowned international university brands.

1 Rue Michel-Servet Genève, GE, 1206 Switzerland

Mont Saint Aignan, FranceUniversity of Rouen provides academic collaboration.

Canal Biotech II 3 rue des Satellites Toulouse, 31400 FranceUROSPHERE is a leading Contract Research Organization specializing in preclinical urogenital, gastro-intestinal and oncological pharmacology assays. We provide the pharmaceutical and biopharmaceutical industries with a unique experimental research platform combining both in vivo models and in vitro assays on human and animal tissues. UROsphere's headquarters, laboratories and animal housing facilities are located in Toulouse, France.

Nantes, Pays de la Loire FranceVivalis offers contract manufacturing of virus, protein, and media products.

10 boulevard Carnot 2ème étage - Bât Richelieu Dijon, Please select a state/province, 21000 FranceEstablished in 2009, VIVEXIA is a CRO (Contract Research Organization) focusing on life sciences and health. Our actions and motivation are focused on combatting antimicrobial resistant bacteria. To this aim, we specialized in the creation of humanized or non-humanized preclinical infection models that are designed for the evaluation of anti-infective therapies.

Gemeaux, 21120 FranceEstablished in 2009, VIVEXIA is a CRO (Contract Research Organization) focusing on life sciences and health. Our actions and motivation are focused on combatting antimicrobial resistant bacteria. To this aim, we specialized in the creation of humanized or non-humanized preclinical infection models that are designed for the evaluation of anti-infective therapies.

168 Allée des Grands Prés Mérignies, Hauts-de-France, 59710 France Dr. Eve Ramery founded Vetcyt in January 2016. The company provides cytology and hematology diagnostic, continuing education for veterinarians and research support for both university and private environnements. Graduated from Liege Faculty of Veterinary Medicine in 2004, Dr Ramery practiced one year before starting a PhD thesis and becoming assistant in Clinical Pathology in Liege Faculty of Veterinary Medicine (2005-2015). Meanwhile, she underwent her Clinical Pathology residency (2009-2014), multiplying externships in Europe, USA and Canada. In 2014, she became double boarded of the American College of Veterinary Pathology (ACVP, sp. ClinPath) and The European College of Veterinary Clinical Pathology (ECVCP). She authored multiple articles and scientific conferences in France and abroad. (list of publications: https://orbi.uliege.be/simple-search?query=ramery).

Vyoo Agency 10, rue Yvonne Villeurbanne, 69100 FranceWe are a specialized agency in health economics and market access, based in France (Lyon and Paris). Thanks to our know-how and references, Vyoo Agency is a global leader in the field.

Prologue Biotech 516, rue Pierre et Marie Curie 31670 Labège - France Vibiosphen is a French biotechnology company specialized in infectious diseases. • BACTERIA • FUNGI • VIRUS • We combine expertise in microbiology, molecular biology and pharmacology (in vitro and in vivo) with experience in drug R&D in the field of infectious diseases, immunomodulation and host-pathogen interaction Our preclinical services start from in vitro to in vivo testing •In vitro Efficacy and cytotoxicity • Organoids Efficacy and cytotoxicity • In vivo MTD & PK/PD studies and efficacy models• • Efficacy test in vitro : MIC, MBC, TKC, antibiogram, • Host-pathogen interaction, adhesion / invasion assay, • In vitro safety assessment: Cell viability, hemolysis assays, • In vivo MDT and PK/PD studies • In vivo preclinical models: bacteria, viruses, fungi, in house and on demand. BSL2 and BSL3 • Vaccine development support. As a biotechnology company, we conduct research into potential future therapies against multi-resistant bacteria ( E coli, Pseudomona Aeruginosa, Klebsiella, Acinetobacter, Staph aureus..;) fungi and virus including a large panel of predictive models as pulmonary infection, urinary tract infection, gastrointestinal infection, sepsis, septicemia and inflammation. (see included documents for full overview of model and strains) Vibiosphen has at disposal, in this high technical and scientific quality environment with BSL2 and BSL3 laboratories and facilities. Vibiosphen provides services drawing on cutting-edge technology to create predictive and translational models for studying small molecules, vaccine or biologics

Prologue Biotech 516, rue Pierre et Marie Curie LABEGE, 31670 France Vibiosphen is a French biotechnology company specialized in infectious diseases. • BACTERIA • FUNGI • VIRUS • We combine expertise in microbiology, molecular biology and pharmacology (in vitro and in vivo) with experience in drug R&D in the field of infectious diseases, immunomodulation and host-pathogen interaction Our preclinical services start from in vitro to in vivo testing •In vitro Efficacy and cytotoxicity • Organoids Efficacy and cytotoxicity • In vivo MTD & PK/PD studies and efficacy models• • Efficacy test in vitro : MIC, MBC, TKC, antibiogram, • Host-pathogen interaction, adhesion / invasion assay, • In vitro safety assessment: Cell viability, hemolysis assays, • In vivo MDT and PK/PD studies • In vivo preclinical models: bacteria, viruses, fungi, in house and on demand. BSL2 and BSL3 • Vaccine development support. As a biotechnology company, we conduct research into potential future therapies against multi-resistant bacteria ( E coli, Pseudomona Aeruginosa, Klebsiella, Acinetobacter, Staph aureus..;) fungi and virus including a large panel of predictive models as pulmonary infection, urinary tract infection, gastrointestinal infection, sepsis, septicemia and inflammation. (see included documents for full overview of model and strains) Vibiosphen has at disposal, in this high technical and scientific quality environment with BSL2 and BSL3 laboratories and facilities. Vibiosphen provides services drawing on cutting-edge technology to create predictive and translational models for studying small molecules, vaccine or biologics

11 allée des Acacias 01600 TrévouxCreated July 23, 2012, ViroScan3D is a services company and Contract Research, Genomics and Nanogénomique specialized in the service of Infectious Diseases. Spin-off from the University Lyon 1, ViroScan3D comes from the activities of the platform ProfileXpert Lyon-1 University and benefited from the project development Feder P2i -Plateforme Technological Innovation in Infectious Diseases ".

8 avenue Rockefeller Aile 2AH Lyon, 69008 FranceCreated July 23, 2012, ViroScan3D is a services company and Contract Research, Genomics and Nanogénomique specialized in the service of Infectious Diseases. Spin-off from the University Lyon 1, ViroScan3D comes from the activities of the platform ProfileXpert Lyon-1 University and benefited from the project development Feder P2i -Plateforme Technological Innovation in Infectious Diseases ".

8 avenue Rockefeller LYON, Rhone, 69008 FranceCreated July 23, 2012, ViroScan3D is a services company and Contract Research, Genomics and Nanogénomique specialized in the service of Infectious Diseases. Spin-off from the University Lyon 1, ViroScan3D comes from the activities of the platform ProfileXpert Lyon-1 University and benefited from the project development Feder P2i -Plateforme Technological Innovation in Infectious Diseases ".

1 avenue Bourgelat Marcy l'Etoile, 69280 FranceBioVetim is an immunoassay laboratory specialized in hormone and biomarker analysis. BioVetim is a testing laboratory involved in preclinical studies for the pharmaceutical industry, chemical industry and CRO.

42 BOULEVARD JOURDAN PARIS, 75014 France

Pépinière Genopole Entreprises 4 rue Pierre Fontaine 91000 Evry FranceWatchFrog offers in vivo drug efficacy evaluation, high throughput screening, eco-toxicological screening, and target validation services.

Évry, Île-de-France FranceWatchFrog offers in vivo drug efficacy evaluation, high throughput screening, eco-toxicological screening, and target validation services.

94, Quai Charles de Gaulle 69463 Lyon Cedex 06 FranceWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

15 rue Dominique Piazza GEMENOS, France, 13420 FranceXEGEN is a Contrat research organization in bioinformatics / biostatistics specialized in NGS « Next Generation Sequencing» and omics data analysis (WES,WGS, targeted, RNA-Seq etc), applied to virus, bacteria, human, plant, animal. We elaborate customized analysis strategies, and we provide interpretations that drive biotech/pharma R&D projects. We provide as well a customized expert software suite to automate Next generation data analysis able to provide accurate analysis and repeatability for large quantity of data, even on the most complex genomic regions (e.g. HLA typing). XEGEN product activities include software development with ergonomic and easy to used User interface. This solution could be adapted to any medical device purpose (RT PCR, NGS, others). XEGEN is certified ISO 13485 and provide a development environment compliant with CE mark or FDA mark requirements. XEGEN propose support for medical device solution development Our dataflow management solution is also able to process data batches.

4 rue Pierre Fontaine Evry-Courcouronnes, 91000 FranceXenTech is an oncology preclinical CRO specializing in Patient-Derived tumor Xenografts (PDX). We test anticancer drug activity in our PDXs and identify drug response biomarkers. Cell lines derived from our PDX are available for in vitro assays and we also offer Immuno-Oncology PDX (syngeneic and PBMC humanized models) to test I/O checkpoints and combinations with existing or emerging therapies. Our expertise : World-renowned Breast PDX collection, extensively pubished and characterized for all DDR aspects (HRD scores, RAD51 scores, PARP inhibitor responses,...). Special PDX range (Match-R) focusing on Acquired Resistance to the LATEST targeted Therapies (osimetinib, dabrafenib, trametinib, erdafitinib,...) A large collection of Prostate PD models (cRPCs, ...)

4, rue Pierre Fontaine Evry, F 91000 FranceXenTech is an oncology preclinical CRO specializing in Patient-Derived tumor Xenografts (PDX). We test anticancer drug activity in our PDXs and identify drug response biomarkers. Cell lines derived from our PDX are available for in vitro assays and we also offer Immuno-Oncology PDX (syngeneic and PBMC humanized models) to test I/O checkpoints and combinations with existing or emerging therapies. Our expertise : World-renowned Breast PDX collection, extensively pubished and characterized for all DDR aspects (HRD scores, RAD51 scores, PARP inhibitor responses,...). Special PDX range (Match-R) focusing on Acquired Resistance to the LATEST targeted Therapies (osimetinib, dabrafenib, trametinib, erdafitinib,...) A large collection of Prostate PD models (cRPCs, ...)

101, rue de Sèvres Lot 1674 Paris, 75279 CEDEX 06 FranceYOLARX Consultants is a privately-owned company that has successfully provided services in pharmacoepidemiology for almost 20 years. Since its inception in 2006, YOLARX has evolved into a boutique research organization with a North American headquarter in Montreal (Canada) and a European headquarter in Paris (France). A staff of 15 provides services in pharmacoepidemiology, data science, therapeutic risk management and pharmacovigilance, to a global client base of large, medium, and small pharmaceutical companies. YOLARX has conducted projects in all therapeutic areas, including rare diseases, across all regions – critical and literature reviews (systematic, rapid/targeted, scoping, umbrella), data landscaping, feasibility assessment, data analysis, post-authorization safety studies. Our proprietary Yolarx SLRTM platform increases the efficiency of the literature reviews we conduct by leveraging AI technology, including natural language processing, for the selection of sources and data extraction. Our proprietary RWD Tracker© platform is a unique AI-powered online library of real-world data (RWD) sources. For each data landscaping project, YOLARX leads the industry in creating a knowledge base of data sources that is customized to our client’s business needs. Our reputation is derived from well-established values: Quality, Innovation, Commitment, Respect, Collaboration, Responsibility & Reliability. The academic appointments and affiliations held by the members of our organization enhance the credibility of our work and are testimony of the high standards to which we adhere. For additional information about our company and our services, please visit our website at: www.yolarx.com.

101 Rue de Sèvres Lot 1674 Paris, Île-de-France, 75007 FranceYOLARX Consultants is a privately-owned company that has successfully provided services in pharmacoepidemiology for almost 20 years. Since its inception in 2006, YOLARX has evolved into a boutique research organization with a North American headquarter in Montreal (Canada) and a European headquarter in Paris (France). A staff of 15 provides services in pharmacoepidemiology, data science, therapeutic risk management and pharmacovigilance, to a global client base of large, medium, and small pharmaceutical companies. YOLARX has conducted projects in all therapeutic areas, including rare diseases, across all regions – critical and literature reviews (systematic, rapid/targeted, scoping, umbrella), data landscaping, feasibility assessment, data analysis, post-authorization safety studies. Our proprietary Yolarx SLRTM platform increases the efficiency of the literature reviews we conduct by leveraging AI technology, including natural language processing, for the selection of sources and data extraction. Our proprietary RWD Tracker© platform is a unique AI-powered online library of real-world data (RWD) sources. For each data landscaping project, YOLARX leads the industry in creating a knowledge base of data sources that is customized to our client’s business needs. Our reputation is derived from well-established values: Quality, Innovation, Commitment, Respect, Collaboration, Responsibility & Reliability. The academic appointments and affiliations held by the members of our organization enhance the credibility of our work and are testimony of the high standards to which we adhere. For additional information about our company and our services, please visit our website at: www.yolarx.com.

101, rue de Sèvres Lot 1674 Paris, 75279 CEDEX 6 FranceYOLARX Consultants is a privately-owned company that has successfully provided services in pharmacoepidemiology for almost 20 years. Since its inception in 2006, YOLARX has evolved into a boutique research organization with a North American headquarter in Montreal (Canada) and a European headquarter in Paris (France). A staff of 15 provides services in pharmacoepidemiology, data science, therapeutic risk management and pharmacovigilance, to a global client base of large, medium, and small pharmaceutical companies. YOLARX has conducted projects in all therapeutic areas, including rare diseases, across all regions – critical and literature reviews (systematic, rapid/targeted, scoping, umbrella), data landscaping, feasibility assessment, data analysis, post-authorization safety studies. Our proprietary Yolarx SLRTM platform increases the efficiency of the literature reviews we conduct by leveraging AI technology, including natural language processing, for the selection of sources and data extraction. Our proprietary RWD Tracker© platform is a unique AI-powered online library of real-world data (RWD) sources. For each data landscaping project, YOLARX leads the industry in creating a knowledge base of data sources that is customized to our client’s business needs. Our reputation is derived from well-established values: Quality, Innovation, Commitment, Respect, Collaboration, Responsibility & Reliability. The academic appointments and affiliations held by the members of our organization enhance the credibility of our work and are testimony of the high standards to which we adhere. For additional information about our company and our services, please visit our website at: www.yolarx.com.

11 Rue Aristide Berges Le Pont de Claix  Ceder , 33801 FranceZebraSci Inc. was founded in 2009 as a company dedicated to developing novel inspection technologies to ensure quality in parenteral packaging and combination products. Over the years, we have grown substantially by concentrating on scientific expertise, customer service and a strict adherence to regulatory compliance. ZebraSci now works with 100’s of medical device manufacturers, pharmaceutical and biotechnology. Our client’s partner with ZebraSci to resolve technical issues and accelerate “time to market” to support the development of safe and effective products for commercialization around the globe. We treat each client project with the utmost care and attention. We pride ourselves in our craft and develop specific protocols for each client project. We make sure that we validate each method on our equipment to match our individual client testing requirements. ZebraSci. has developed and maintains a robust quality management system to demonstrate our commitment to consistently provide inspection products and laboratory services that adhere to cGMP FDA regulations, ISO 17025 and ISO 13485 standards, and customer Quality System requirements. We operate two locations with over 30,000 ft2 of clean room, laboratory, and office space. Our original location is in California and we recently opened a new east coast location in New Jersey. Both our facilities are FDA registered and FDA audited with 0 observations. ZebraSci has helped our clients commercialize over 30 combination products in multiple geographies over the last decade.

Campus de l'Institut Pasteur de Lille 1 Rue du Professeur Calmette, Lille, 59000 France4P Pharma offers a wide range of preclinical inflammatory models and consultancy expertise in the preclinical inflammatory area. We develop flexible, tailored preclinical programs designed to each therapeutics specificity, from in vitro drug screening to experimental inflammatory models in animals. Acute and chronic inflammation are the cause of severe complications and an established risk factor for life-threatening conditions, including cancer, cardiovascular diseases and stroke. For every R&D studies performed, we ensure an intercross between in vitro, in vivo and ex vivo models along with unbiased laboratory, species and model independency.

28 Rue Laennec 69008 Lyon, CA, 04 78 78 28 28 United StatesThe Léon Bérard Center has three essential missions: care, research and teaching. The vocation of the center is to offer quality care to people suffering from cancer. This care that goes from screening to the most innovative treatments also takes into account the nutritional, psychological and rehabilitation aspects adapted to each individual.

44 Rue d'Alésia Paris, Île-de-France, 75014 FranceThe CTCPA, center of collective research for companies which produce canned and dehydrated foods. The CTCPA achieves its general interest missions thanks to a fiscal contribution paid by French companies working in the canned and dehydrated food sector. These companies represent nearly 40% of the center’s resources. The missions include: collective research programs transfer of technology, expertise, representing the profession, scientific, technical, and regulatory watch technical support to professionals through question and answer service, valorization of the research results The research orientations of the CTCPA and the nature of its general interest missions are established through a contract of objectives and means lasting many years. This contract is defined between the minister in charge of the food sector and the concerned professional syndicate (Fiac). Each year food companies choose their desired research projects for the coming year. The result of each research project is available to any European Union industry with products in the area of competence of TFA, by simple request to the documentation center.

2, The Alley Chavannerie La Ferte Saint Aubin, 45240 FranceAgro-Bio (sub-subsidiary of the diagnostics in vitro company Stago) is one of the French pioneer in the development and production of CUSTOM ANTIBODIES since 1975. REACTIVITY, high QUALITY service at COMPETITIVE PRICING as well as building long term and confidence-based collaboration with our customers are our key engagements. Our mission is to support each client to implement the best strategy for each project. Agro-Bio provides its expertise for public research teams, CRO's, biotech and IVD companies as well as renowned Big-Pharma (ISO9001/ISO13485/CIR). Agro-bio offers a wide range of fully customized services: BIOANALYTICS - ADA reference samples for your immunogenicity tests - Anti-idiotypic and/or neutralizing antibodies for PK/PD and potency tests - BIACORE : afffinity, receptor binding, cynomolgous vs human - Antibody characterization: stability, affinity, epitope mapping, sequencing, aggregation BIOPRODUCTION - Selection and validation of generic assays (preclinical and clinical phase I and II) • Performance study of the generic HCPs ELISA • Determination of ELISA suitability and accuracy: dilutional linearity, specificity, spike recovery, LOD / LOQ • Coverage assessment of the antibodies of the generic HCPs ELISA (Required by the reglementary authorities) - Development of a process specific (required from phase III) • Bulk production/purification of process-specific HCP polyclonal antibodies on rabbit, goat or chicken. • Validation of HCP antibodies: coverage assessment by 2D-DIBE (fluorescent based) and purification by affinity on HCP antigen • Development and validation of process-specific HCPs ELISA kits • Manufacturing of HCP ready-to-use ELISA kits - Mass spectrometry analysis can be implemented as an orthogonal method. IN VITRO DIAGNOSTICS - Large scale mAb production (from mg to 10g-scale) - Large scale pAB production (goat, rabbit, guinea pig, chicken, mice & rat) - mAb & pAb development - BIACORE® analysis: affinity, antibody pairs, stability DISCOVERY - Immunogen design & generation - Target validation and Proof-of-concept antibody-tools - R&D antibodies: mAB & pAb multi-species - Conjugation, Fragmentation, Sequencing

5 rue Vaubenard, 14000 Caen, FranceBorochem provides boron building blocks for chemists

Caen, Normandy, 14000 FranceBorochem provides boron building blocks for chemists

1 place pierre potier Toulouse , 31100 FranceB Molecular provides services around proteins : custom protein development, custom and catalogue molecular tools dedicated to capture of ubiquitylated proteins and LC3/GABARAP proteins, custom protac development. In addition, B Molecular provides Mass spectrometry services for identification of proteins of interest.

12 Avenue des Morgines CH-1213 Petit-Lancy Geneva, SwitzerlandBattelle is a GLP-compliant, IND and BLA-enabling CRO. We provide services that can help move projects from in vitro to in vivo through clinical support. Specifically, our core capabilities are focused around our long-standing experience and expertise in cell-based and biochemical assay development, validation and analytical and bioanalytical sample screening, proteomics, compound synthesis, HTP next generation sequencing, in vivo efficacy, safety pharmacology, toxicology, inhalation toxicology (small and large species), ADME/PK, analytical chemistry, pathology. Battelle also has deep experience developing and manufacturing medical devices, and in conjunction with customer test articles is able to validate both the device and test article together.

Institut Pasteur, Building F. Jacob 28 rue du Docteur Roux Paris, 75015 FranceBIOASTER is a Technology Research Institute dedicated to Microbiology & Infectious Diseases. BIOASTER is a non-profit organization aiming to provide our industrial partners with innovative scientific and technological solutions to accelerate the development of diagnostic, prophylactic, therapeutic or more broadly life science products. We design and implement tailored technological solutions to open new areas of opportunities or tackle technological barriers identified in product developments.

40 avenue Tony Garnier Lyon, 69007 FranceBIOASTER is a Technology Research Institute dedicated to Microbiology & Infectious Diseases. BIOASTER is a non-profit organization aiming to provide our industrial partners with innovative scientific and technological solutions to accelerate the development of diagnostic, prophylactic, therapeutic or more broadly life science products. We design and implement tailored technological solutions to open new areas of opportunities or tackle technological barriers identified in product developments.

5 rue des aqueducs Craponne, 69290 France

Parc D'affaires la Breteche Bldg A4 Saint Gregoire, Ille et Vilaine, 35760 FranceBiopredic International provides human and animal primary cells, cell lines, and tissues for research, drug discovery, and drug development.

72 Boulevard des Belges LYON, 69006 FranceCompany dedicated to research and development, at the interface between healthcare professionals and healthcare industry stakeholders. Based on our biobank &Health data warehouse, we can provide digital slides with histopathological and clinical annotations & unstained FFPE slides, as clinical cohorts of patients We can participate in digital slides annotations for AI algorithm creation or help you to find the good partners to validate your algorithm. We can also conduct research project as a CRO.

Rue Bossuet LYON, 69006 FranceCompany dedicated to research and development, at the interface between healthcare professionals and healthcare industry stakeholders. Based on our biobank &Health data warehouse, we can provide digital slides with histopathological and clinical annotations & unstained FFPE slides, as clinical cohorts of patients We can participate in digital slides annotations for AI algorithm creation or help you to find the good partners to validate your algorithm. We can also conduct research project as a CRO.

Biopolis 5, avenue du Grand Sablon 38700 La Tronche FranceCreaCell provides recombinant cell lines, cytotoxicity testing, efficacy testing, lipolysis, primary cultures, and genome integrity.

Rue Pierre et Marie Curie 516 rue Pierre et marie Curie Labège, Occitanie, 31670 FranceCardiomedex is specialized in cardiovascular diseases and complications (heart failure with reduced or preserved ejection fraction (HFpEF), myocardial infarction, cardiac arrhythmia, cardiac hypertophy, heart failure, hypertension).

6-8 rue du 4 septembre Batiment B - Le Poversy 92130 Issy Les MoulineauxDelpharm provides development and production of pharmaceutical products.

85 avenue philippe auguste France Paris, france, 75011 FranceElveflow® focuses on the development of high performance and Plug and Play flow control systems fitted to microfluidic research. We provide the only microfluidic flow control systems using Piezo technology and that enable blazing fast flow changes in your microdevice. Our team develops microfluidic instruments with unrivaled performances in accordance to researchers’ needs. Our product line is built around the best seller OB1 flow controller and includes all that is needed to control your microfluidic chip. All our instruments can be controlled at once on the same computer, through our software or Standard Development Kits.

Grenoble, Auvergne-Rhône-Alpes FranceEuropean Synchrotron Radiation Facility (ESRF) provides synchrotron radiation source for scientific research.

6 Rue des Champs Godin S, 41220 FranceERBC Group is a leading CRO committed to bridge the gap between discovery, preclinical and clinical development by evaluating the efficacy and safety of new compounds including new therapies, drugs, medical devices, chemicals, agro-chemicals and cosmetics. Offering a comprehensive range of innovative models and services, regulatory pre-IND package and consultancy services, ERBC Group allows biopharmaceutical and chemical industry professionals to de-risk innovation and enhance R&D productivity.

Chemin de Montifault BAUGY, 18800 FranceERBC Group is a leading CRO committed to bridge the gap between discovery, preclinical and clinical development by evaluating the efficacy and safety of new compounds including new therapies, drugs, medical devices, chemicals, agro-chemicals and cosmetics. Offering a comprehensive range of innovative models and services, regulatory pre-IND package and consultancy services, ERBC Group allows biopharmaceutical and chemical industry professionals to de-risk innovation and enhance R&D productivity.

Chemin de Montifault - 18800 Baugy - France BAUGY, 18800 FranceERBC Group is a leading CRO committed to bridge the gap between discovery, preclinical and clinical development by evaluating the efficacy and safety of new compounds including new therapies, drugs, medical devices, chemicals, agro-chemicals and cosmetics. Offering a comprehensive range of innovative models and services, regulatory pre-IND package and consultancy services, ERBC Group allows biopharmaceutical and chemical industry professionals to de-risk innovation and enhance R&D productivity.

Centre de Recherche Langlade 3 Avenue Hubert Curien TOULOUSE, 31100 FranceFlash BioSolutions is a dynamic Contract Development and Manufacturing Organization (CDMO) pioneering the frontier of innovative technologies in biopharmaceuticals. Our foundation is rooted in scientific ingenuity, driving us to discover and produce highly effective RNA and DNA GMP2transfer solutions that redefine possibilities in healthcare. At Flash BioSolutions, we are committed to revolutionising the field of gene and cell therapy by providing high quality viral vectors for research and clinical use. We work closely with biotechnology and pharmaceutical companies to accelerate the development of innovative treatments that have the potential to transform patients’ lives.