Viale Giorgio Ribotta Via Giorgio Ribotta n.21 Roma, Lazio, 00144 ItalyWorldwide Clinical Trials employs more than 1,600 professionals around the world, with offices in North and South America, Eastern and Western Europe, Russia and Asia. Founded by physicians committed to advancing medical science, Worldwide is out to change how the world experiences CROs – in the best possible way. From Early Phase and Bioanalytical Sciences through Late Phase and post approval, we provide world-class, full-service drug development services. With infrastructure and talent spanning 60 countries, we execute predictable, successful studies with operational excellence. We never compromise on science or safety. We’re never satisfied with the status quo. We’re the Cure for the Common CRO.

72 Corso di Porta Romana Milano, Lombardia, 20122 ItalyProductLife offers consulting and support services for life sciences including expertise in regulatory affairs and pharmacovigilance.

via Alfonso Barcaccia 3 Perugia, Umbria, 06134 ItalyUMBRIACHEM s.r.l. offers synthetic organic chemistry, contract research and analytical characterization services for the Life Science, Healthcare and Applied chemistry sectors.

Genoa, Italy

Ravenna, Emilia-Romagna ItalyAgriparadigma S.r.l. is a private laboratory which was created in 1987 and has been accredited by Accredia since 1993 - no. 60 of UNI CEI EN ISO/IEC 17025:2005. Thanks to our long-term experience we can provide analytical testing services as well as technical assistance in many fields. Through continuous investment we are able to have up-to-date instrumentation constantly tailored to the client’s specific needs. Our training and education programme keeps our workforce highly specialized. That’s why we have been able to widen our speciality service range increasing both the quality and the responsiveness Our company is divided into specific fields and departments and a qualified operating officer is typically in charge of each of these divisions and allows a direct relationship with customers by also giving them quick response to their needs. This cooperation and support structure, acknowledged and appreciated by customers, as well as the quality of our analytical testing services, have allowed us to grow and develop considerably.

34 Via di Grotte Portella Lazio, 00044 ItalyParticle Measuring Systems offers particle counting, microbial monitors, gas analysis, and laboratory testing.

17 Piazza della Vetra Milano, Lombardia, 20123 ItalyCegedim Health Data is a division of Cegedim Group, an innovative technology and services group specializing in healthcare for more than 50 years. Cegedim Health Data provides real-world data (RWD) cohorts and real-world evidence (RWE) to drive research and improvements in patient outcomes in compliance with current regulations, including GDPR. The THIN®️ databases cover millions of electronic health record extracts across seven countries: the UK, France, Germany, Italy, Spain, Belgium and Romania. Cegedim Health Data works with researchers, health authorities, healthcare practitioners, pharma and medical device companies. It supports them in R&D, market access, medical affairs with the aim of improving public health.

a Castagnetta 7 00040 Pomezia (Rome), ItalyInjectalia offers manufacturing for vials, syringes, hard capsules, tablets, powder and sachets.

Via Della cooperazione 29 Medicina, Bologna, 40059 ItalyThe integration of our CRO knowledge and CDMO capabilities places PolyCrystalLine as an excellent partner in the production of intermediates and APIs in GMP compliance. Our team can support you in the optimization and in the synthesis of challenging molecules from gram to kilogram scale with consistency and optimized physical and bulk properties. As Polycrystalline CDMO we see ourselves as your strategic partners, with our reliability and our full commitment to meet your need into the development of new APIs and HPAPIs we want to unlock the full potential of our partnership going beyond the classic client/supplier relationship. Our recent investment is aimed to meet and outmach your expectations, our innovative technologies, our custom made plant , our highly skilled scientisst and our continuous reaserch to reach the excellence are just some of the keys of Polycrystalline CDMO. We look forward to have the chance to be your partner and join Polycrystalline in the journey from a small start-up to a fully integrated CDMO.

Via Fantoli 16/15 20138 Milano - Italy

Regione Gonzole, 10 Orbassano, Torino, 10043 ItalyS&P BRAIN is an academic spinoff located in Orbassano, few kilometers away from Turin, in the heart of an excellent environment that hosts two universities of applied sciences, several research institutes and the Biotechnological park of Ivrea. S&P BRAIN’s headquarter and preclinical research unit are located in NICO, a new research center devoted to Neurosciences that gathers the complementary experiences of eight research groups sharing of knowledge, expertise, capabilities and facilities, thereby creating a very collaborative and highly stimulating scientific atmosphere. We offer preclinical studies in small animals spanning from a wide range of behavioral tests to models of neurological injuries to cardiovascular, endocrine and metabolic measures. S&P BRAIN combines the power of a preclinical start-up to draw on scientific faculty to solve the most complex problem. Our experience will help pharmaceutical, biotechnology and medical device companies and research centers to establish the proof-of-efficacy of new drugs or pilot in vivo studies.

Via Alberto Falck 15, Milan, 20099, ItalyPierrel offers packaging, labeling, stability studies, clinical phase studies, and clinical trial material storage.

291 Viale Regina Elena, Roma, Lazio 00161, ITThe IIT@Sapienza laboratory, born after a Research Project CLNS submitted in 2010, revolves around two topics of biomedical interest where technological innovation is key to reach the goals. The first regards neurodegenerative disorders, hereditary and sporadic conditions characterized by progressive nervous system dysfunction. The focus of the second will be brain tumours, the most life-threatening diseases of adulthood and childhood. These challenging projects benefit from the establishment and convergence of common technological platforms. They avail themselves of state-of-the-art commercial equipment and, at the same time, foster and support the development of new techniques and instrumentation.

Largo Donegani 4/A Novara, NO 28100 ItalyProge Farm offers microbiological analysis services and conducts research for probiotic bacteria.

299 Viale Regina Elena, Roma, Lazio 00161, ITThe Institute's main entrance is located in Viale Regina Elena n. 299, Rome, in front of the Campus. Secondary entrances are located in Via del Castro Laurentian n. 10 and n. 25 and in Piazzale Valerio Massimo n. 5. A headquarters is located in Via Giano della Bella n. 34.

Via della Chimica, 9 36100 - Vicenza ItalyZambon offers contract manufacturing as well as products for pain management, respiratory needs, women's healthcare.

Viale Taramelli, 6 27100 Pavia ItalyThe Department brings together teachers and researchers from disciplines that are involved in research and drug development in all its aspects. The scientific activity of the Department is divided into the following areas of research with a high innovation content: Pharmaceutical Chemistry, Pharmaceutical Technology, Pharmaceutical Analysis, Pharmacology, Microbiology, Organic Chemistry, Food Chemistry, Pharmaceutical Biotechnology. The Department has in place profitable collaborations and with other national and international universities, both with research institutions and major industries in the sector, which give it the characteristics of a cutting-edge facility in research on the drug. at the Department of pharmaceutical Sciences are part of a Doctorate in Chemistry and Pharmaceutical technologies and numerous master. These postgraduate initiatives result in a stimulating climate of confrontation between young people interested in issues of departmental research.

Viale Taramelli, 12 Pavia, 27100 ItalyThe Department brings together teachers and researchers from disciplines that are involved in research and drug development in all its aspects. The scientific activity of the Department is divided into the following areas of research with a high innovation content: Pharmaceutical Chemistry, Pharmaceutical Technology, Pharmaceutical Analysis, Pharmacology, Microbiology, Organic Chemistry, Food Chemistry, Pharmaceutical Biotechnology. The Department has in place profitable collaborations and with other national and international universities, both with research institutions and major industries in the sector, which give it the characteristics of a cutting-edge facility in research on the drug. at the Department of pharmaceutical Sciences are part of a Doctorate in Chemistry and Pharmaceutical technologies and numerous master. These postgraduate initiatives result in a stimulating climate of confrontation between young people interested in issues of departmental research.

16 Via Adamello, Milano, Lombardia 20139, ITThe Center for Genomic Science of IIT@SEMM applies modern genomic technologies towards a better understanding of complex biological processes and diseases, with particular emphasis on Cancer. The Center is located within the IFOM-IEO Campus in Milan, one of the largest and most vibrant cancer research communities in Europe. The Center provides state-of-the art technological platforms for functional as well as structural genomics, and benefits from all the infrastructure, technological platforms and didactic activities already present in the IFOM-IEO Campus. Our PhD program is integrated with that of SEMM, the European School of Molecular Medicine. The mission of our Center is to identify changes in the genome that underlie the development of cancer, as well as its susceptibility to therapeutic intervention. Our general aim is to reduce pathological traits into their molecular components, which might correspond to disease markers or potential targets for pharmacological intervention. We will exploit these molecular markers and targets in order to build up strategic programs for disease prevention, early detection and treatment. Our scientists work together in teams, using cutting-edge instrumentation and novel conceptual approaches. Groups in the Experimental Genomics program utilize cellular and animal models to classify genetic and epigenetic states in development and cancer. A Computational Biology program is developing in-house methods for the generation and analysis of genomic and epigenomic data from next generation sequencing platforms, operated by the Genomic Unit. Finally, our Screening Unit harnesses the power of siRNA technology to execute discovery biology projects.

2 Via VIII Febbraio, Padova, Veneto 35122, ITThe University of Padova was established in 1222, after a group of students and teachers decided to come here from Bologna. They set up a free body of scholars, who were grouped according to their place of origin into nationes, in which students approved statutes, elected the rettore (rector, or chancellor) and chose their teachers, who were paid with money the students collected. Defending freedom of thought in study and teaching became a distinctive feature which today lives on in the University motto: Universa Universis Patavina Libertas. The introduction of empirical and experimental methods together with the teaching of theory marked the dawn of a golden age. In the 16th and 17th centuries, Padova became a workshop of ideas and the home to figures who changed the cultural and scientific history of humanity. They included Andrea Vesalio, who founded modern anatomy, as well as the astronomer Copernicus, and Galileo, who observed the skies here. Padova also vaunts the world’s first university botanical garden and a permanent anatomical theatre, which was built by Girolamo Fabrici d’Acquapendente. William Harvey, who became famous for describing the circulation of the blood, studied in Padova, and in 1678 Elena Lucrezia Cornaro Piscopia became the first woman in the world to be awarded a university degree. The fall of the Serenissima Republic of Venice in 1797 marked the beginning of a dark age. Padova fell under the rule of first the French and then the Austrians, passing through Italy’s tumultuous Risorgimento, which also affected the University. Between the late 19th and early 20th centuries, the University expanded to include the faculties of Engineering, Pharmacy, and Political Sciences together with its traditional faculties of Law, Medicine, Arts and Philosophy, and Sciences. The advent of Fascism curtailed the University’s values of free thought and cultural independence. Its professors swore allegiance to the regime, after which the approval of Italy’s racial laws and the expulsion of Jewish professors opened one of the darkest periods in the University’s history. Rector Concetto Marchesi shook the University from its slumber and, at the height of the German occupation made a courageous appeal to the students to fight for the freedom of Italy. For its sacrifices in the name of Liberation, the University of Padova was awarded a gold medal for military valour, the only university to receive such an honour. During the post-war period, the University opened faculties of Education, Agricultural Sciences, and Psychology and, in the 1990s, faculties of Veterinary Medicine, and Economics and Business Administration. In the 20th century, the University of Padova produced great literary figures such as Diego Valeri and Concetto Marchesi; engineers of the stature of Giuseppe Colombo, the “master of celestial mechanics”; mathematicians such as Tullio Levi Civita; jurists Alfredo Rocco and Livio Paladin; philosophers Luigi Stefanini and Enrico Opocher; and doctors like Vincenzo Gallucci, who carried out the first heart transplant in Italy. The new millennium opened with some important new discoveries, particularly in medicine, biomedicine, engineering and aerospace technology.

Via 8 Febbraio, 2 Padova, 35122 ItalyThe University of Padova was established in 1222, after a group of students and teachers decided to come here from Bologna. They set up a free body of scholars, who were grouped according to their place of origin into nationes, in which students approved statutes, elected the rettore (rector, or chancellor) and chose their teachers, who were paid with money the students collected. Defending freedom of thought in study and teaching became a distinctive feature which today lives on in the University motto: Universa Universis Patavina Libertas. The introduction of empirical and experimental methods together with the teaching of theory marked the dawn of a golden age. In the 16th and 17th centuries, Padova became a workshop of ideas and the home to figures who changed the cultural and scientific history of humanity. They included Andrea Vesalio, who founded modern anatomy, as well as the astronomer Copernicus, and Galileo, who observed the skies here. Padova also vaunts the world’s first university botanical garden and a permanent anatomical theatre, which was built by Girolamo Fabrici d’Acquapendente. William Harvey, who became famous for describing the circulation of the blood, studied in Padova, and in 1678 Elena Lucrezia Cornaro Piscopia became the first woman in the world to be awarded a university degree. The fall of the Serenissima Republic of Venice in 1797 marked the beginning of a dark age. Padova fell under the rule of first the French and then the Austrians, passing through Italy’s tumultuous Risorgimento, which also affected the University. Between the late 19th and early 20th centuries, the University expanded to include the faculties of Engineering, Pharmacy, and Political Sciences together with its traditional faculties of Law, Medicine, Arts and Philosophy, and Sciences. The advent of Fascism curtailed the University’s values of free thought and cultural independence. Its professors swore allegiance to the regime, after which the approval of Italy’s racial laws and the expulsion of Jewish professors opened one of the darkest periods in the University’s history. Rector Concetto Marchesi shook the University from its slumber and, at the height of the German occupation made a courageous appeal to the students to fight for the freedom of Italy. For its sacrifices in the name of Liberation, the University of Padova was awarded a gold medal for military valour, the only university to receive such an honour. During the post-war period, the University opened faculties of Education, Agricultural Sciences, and Psychology and, in the 1990s, faculties of Veterinary Medicine, and Economics and Business Administration. In the 20th century, the University of Padova produced great literary figures such as Diego Valeri and Concetto Marchesi; engineers of the stature of Giuseppe Colombo, the “master of celestial mechanics”; mathematicians such as Tullio Levi Civita; jurists Alfredo Rocco and Livio Paladin; philosophers Luigi Stefanini and Enrico Opocher; and doctors like Vincenzo Gallucci, who carried out the first heart transplant in Italy. The new millennium opened with some important new discoveries, particularly in medicine, biomedicine, engineering and aerospace technology.

Palazzo Fedrigotti Corso Bettini 31 Rovereto (TN), 38068 ItalyThe Center for Neuroscience and Cognitive Systems (CNCS) of IIT@UniTn focuses on a multidisciplinary approach to understanding the computational abilities of the brain. Currently the Center studies with systems level neuroscience in human subjects an in animal models, including psychophysical techniques, functional imaging, trans-cranial stimulation and computational approaches. Research includes examining how sensory cues and active movements of the body are integrated to support perception, studying brain mechanisms for attention and timing, studying functional connectivity in the brain, devising advanced methods for decoding/encoding neurophysiological signals.

PI/CF 12410660158 Via Pretorio 4 - C.P. 70 Magenta (MI), 20013 Italytebubio is a leading European distributor of innovative life science research reagents and lab services. Our extensive network of local offices and sales representatives spanning 9 countries daily assists researchers from universities, pharma, cosmetic and biotech companies in choosing and optimally using the products suited to their research programs . For almost 20 years now, tebu-bio’s own laboratories provide R&D contract services and are an active member of recognized professional networks and clusters (Medicen, Cosmetic Valley... Lab services: tebu-bio ISO9001 certified laboratory possesses 4 major platforms: Biomarkers, Protein Production, Molecular Biology and Cell culture. Biomarkers services: tebu bio provides protein quantification and profiling services, gene and miRNA profiling. For protein quantification, the offer includes quantitative measurement of multiple cytokines, chemokines, adipokines, MMPs... in a wide variety of sample types (cell/tissue lysates, serum/plasma, cell culture supernatants...) on robust assays: antibody array or multiplex ELISA format. In addition, we provide one stop pathway focused or broad profiling services including both sample processing and data analysis. If you don't have the expertise or resources to process array data, tebu-bio's biostatistics and bioinformatics partners can do this for you and provide a full report (heat map, cluster and pathway analysis, biomarker selection...). Application examples: inflammation, apoptosis, obesity biomarker monitoring, signalling pathway identification with broad profiling phosphorylation arrays, glycans or glycan/protein interactions detection, miRNA/gene expression profiling... Human Biological samples & Prospective collections: tebu-bio holds an import/export/handling/storage HBS permit and strictly follows regulatory and ethics guidelines related to human biospecimens collection. -Healthy and Diseased blood derived samples (whole blood, plasma, serum, buffy coat, PBMC, platelets...). -Any type of biofluids -Fresh or frozen tissues, healthy or diseased with mutation characterization possibilities -Broad Primary cells offer (healthy or diseased): Human cryo-preserved Hepatocytes, individual donors or pools, Human Hepatic Stellate Cells, Human dermal fibroblast and keratinocytes, Fresh pancreatic human Islets, Human pre-adipocytes, Human Mesenchymal Stem Cells, Peripheral Blood Mononulear Cells (PBMCs), Peripheral Blood Monocytes CD14+, Bone marrow derived CD34+ cells, Tenocytes, Chondrocytes and Synoviocytes, Primary cells from Lung, kidney, Intestine tissues, iPSC derived cardiomyocytes, iPSC derived neurons. Ready to use QC tested specialized media for every primary cell type. Now tebu-bio is the exclusive European distributor of Japanese Collection of Research Bioresources Cell Bank (JCRB), which is one of the most comprehensive cell banks (more than 1 300 cell lines) for Life Scientists and collects high quality cell lines from numerous species such as animal and humans including cancer and genetically modified cells. Protein production (E. coli, HEK293) : tebu-bio provides services from A to Z: gene synthesis, cloning, small scale protein expression to optimize production conditions, large production batches. Our experts have extensive experience and expertise in protein purification and characterization, they will accompany you all along your project. Other services: cell biology (cell amplification & differentiation, cell-line engineering, Spheroids production...); 3D cell culture; hypoxia and normoxia culture conditions; molecular biology, bio-assays (gene reporter & nuclear receptor assays, outsourcing of any assays commercialised by tebu-bio...) Products offer: research antibodies, ELISAs, arrays, proteins & peptides, cell-based & functional assays, primary cells & media (incl. cytokines and growth factors), stem cells and iPS cells, characterized cell lines (ex. melanoma, brain- and stem-cell derived, cell line engineering tools (si/shRNA,CRISPR), biochemicals & compounds, functional assays (actin, tubulin, lipid research tools...).

Via Redipuglia 21A, 35131 Padova, ItaliaBMR Genomics provides molecular biology, genomic and sequencing services.

Via Fantoli, 16/15 Milan, 20138 ItalyBioRep offers biorepository and cell banking services.

Tuscany ItalyInalco Pharmaceuticals manufactures Active Pharmaceutical Ingredients, intermediates, high purity enzyme substrates, and other biochemicals.

Via Ludovico Ariosto, 21, 20091 Bresso Milan ItalyISB Ion Source & Biotechnologies Srl . Was founded in 2006 as a spin-off of the ' University of Milan itself as a' center of excellence 'in the field of biomedical research , to develop innovative strategies to apply mass spectrometry . Today THE MISSION OF ISB is to provide its know-how: in the development of analytical methods , in the realization of KIT for analysis (for example for drugs of abuse in the urine and hair, immunosuppressants), in helping to ' application , in the writing and implementation of research projects with public and private entities, biomarker discovery In addition, the company sells its patented products and operates as a laboratory third parties. This team ISB consists of researchers with a wide range of skills relating to chemistry, biology, pharmacology, life sciences, bioinformatics and engineering. The different skills available in the ISB are integrated with each other in the discovery and development of new methodologies in different fields of application.

Via Ludovico Ariosto, 21 Bresso, Milan, 20091 ItalyISB Ion Source & Biotechnologies Srl . Was founded in 2006 as a spin-off of the ' University of Milan itself as a' center of excellence 'in the field of biomedical research , to develop innovative strategies to apply mass spectrometry . Today THE MISSION OF ISB is to provide its know-how: in the development of analytical methods , in the realization of KIT for analysis (for example for drugs of abuse in the urine and hair, immunosuppressants), in helping to ' application , in the writing and implementation of research projects with public and private entities, biomarker discovery In addition, the company sells its patented products and operates as a laboratory third parties. This team ISB consists of researchers with a wide range of skills relating to chemistry, biology, pharmacology, life sciences, bioinformatics and engineering. The different skills available in the ISB are integrated with each other in the discovery and development of new methodologies in different fields of application.

Via Moretto da Brescia 25 Milano, 20133 ItalyHMGBiotech offers their expertise in HMGB1, a component of the cell nucleus functioning in the organization and expression of the genome, and provides reagents, assay development, and cell migration studies.

Via Trieste, 9 20067 Tribiano, Milano Italy"If you want to build a ship don't drum up people together to collect wood, and don't assign them tasks and work, but rather teach them to long for the endless immensity of the sea". Antoine de Saint Exupérie Agricola 2000 was supported in its development, and for this reason, in turn, it supports some institutions that care for the enhancement of the value of the single person. Some examples are Obra Padre Mario Pantaleo, Father Ignazio Lastrico priest of the parish of Risen Christ in Salvador de Bahia, Father Gabriele Foti of Fraternità S. Carlo, Social Cooperative Il Carro, Fondazione Rosangela D'Ambrosio, Association Incontro e Presenza, Porto Franco Abbiategrasso e Association Sostieni il Sostegno.

Via S. Allende Baronissi , 84081 Italy

2 Via Aldo Moro Siena, Toscana, 53100 Italy

Piancavallo, VerbaniaItalian Institute for Auxology (Istituto Auxologico Italiano) offers genotyping and clinical research services.

Via Calabria, 15 Segrate, MI, 20054 United StatesFounded by world-leading experts in biomolecular analysis, Ultivue is a venture-backed company developing reagent-driven solutions for high-definition biological imaging in situ, combining unlimited multiplexing at high speed with high spatial resolution. Ultivue’s proprietary reagents, instruments, and bioinformatics tools will enable researchers and clinicians to realize the promise of personalized medicine through better matching of patients to therapeutic options. In 2017, the company is launching products and services that seamlessly integrate into existing workflows for biomarker discovery, assay validation, and companion diagnostic applications.

Via Calabria, 15 Segrate, (Milan), 20054 ItalyFounded by world-leading experts in biomolecular analysis, Ultivue is a venture-backed company developing reagent-driven solutions for high-definition biological imaging in situ, combining unlimited multiplexing at high speed with high spatial resolution. Ultivue’s proprietary reagents, instruments, and bioinformatics tools will enable researchers and clinicians to realize the promise of personalized medicine through better matching of patients to therapeutic options. In 2017, the company is launching products and services that seamlessly integrate into existing workflows for biomarker discovery, assay validation, and companion diagnostic applications.

Via Ribes 5 Colleretto Giacosa, TO, I-10010 ItalyThe research at the Department focuses on molecular events underlying pathophysiological processes, and takes a translational medicine approach. Combining basic research and clinical research to develop translational paradigms, the Department seeks to develop advanced diagnostic technologies and innovative therapeutic strategies for clinical practice. Main Research Areas - Molecular and cellular mechanism of metabolic diseases, cardiovascular, oncologie and degenerative diseases - Stem cells and regenerative medicine - Computational genomics - New diagnostic imaging technologies and advanced chemical methodologies - Pre-clinical and clinica! testing of new therapeutic protocols

Via Nizza 52 Colleretto Giacosa, TO, I-10010 ItalyThe research at the Department focuses on molecular events underlying pathophysiological processes, and takes a translational medicine approach. Combining basic research and clinical research to develop translational paradigms, the Department seeks to develop advanced diagnostic technologies and innovative therapeutic strategies for clinical practice. Main Research Areas - Molecular and cellular mechanism of metabolic diseases, cardiovascular, oncologie and degenerative diseases - Stem cells and regenerative medicine - Computational genomics - New diagnostic imaging technologies and advanced chemical methodologies - Pre-clinical and clinica! testing of new therapeutic protocols

Corso Gastaldi, 55 13100 Vercelli ItalyValOryza was founded in 2012 by a group of agronomist and researchers with the aims to: strengthen the knowledge of cultivation methods, particularly in rice; evaluate new strategies and solutions related to agriculture; transfer the know-how among stakeholders dealing with agriculture; consulting for growers, companies, dealers, and public entities work in the direction of sustainability for both the farmer and the environment.

Viale Roma 120 Guidonia Montecelio, 00012 ItalyCliniSciences is a French company headquartered in Paris. CliniSciences is a distributor products & services from suppliers based all around the world. CliniSciences owns 10 other companies (Anawa, Biotrend, Generon, Hexabiogen, Kyvobio, Quimigen) based throughout Europe including the United Kingdom, Germany, Spain, Italy, The Netherlands & Switzerland. Through these companies we offer life science reagents, services and instruments. We sell products & services for research and diagnostic use. Products include reagents, cells, human samples and more. Services include antibody development, peptide synthesis, bulk manufacture, humanization and more.

Via Fossignano Fossignano, Lazio, 04011 ItalyIstituto Biochimico Italiano (ibi) provides manufacturing of recombinant proteins and pharmaceutical products.

Viale San Pietro 43 / C 079-228530 , Italy

Via Anguillarese, 301 Rome, 00123 ItalyGenechron offers DNA sequencing, next generation sequencing, custom primer synthesis, metabonomic profiling, and bioinformatics services.

Via Tito Speri, 12 Rome I-00040 ItalyResearch Toxicology Centre offers mammalian toxicology, kinetic studies, bioavailability, dose studies, and histopathology.

ItalyReact4life has developed MIVO® - Multi In Vitro Organ, an innovative organ on chip able to emulate portions of the human body. MIVO® is a patented, fully industrialized platform for more reliable 3D fluid-dynamic assays which provides a multiple fluidic circulation and multi-chamber system for culturing cells in vitro resembling the real tissues complexity. It can be used as (i) bioreactor for improving tissues conditions and prolonging cells lifetime, as (ii) microfluidic device for accelerating drug testing on 3D human tissues without involving animal use, and as (iii) reliable human disease models for basic research. React4life may both (i) sell the MIVO platform and support the customer during the first adoption, with video tutorial, scientific calls etc, (ii) provide MIVO based in vitro service activities for exploratory assays, drug efficacy assays, cytotoxicity, or permeation assays. In particular, the R&D team has deep experience in cellular biology, cancer biology and immunology.

Via Greto Di Cornigliano Genova, GE, 16152 ItalyReact4life has developed MIVO® - Multi In Vitro Organ, an innovative organ on chip able to emulate portions of the human body. MIVO® is a patented, fully industrialized platform for more reliable 3D fluid-dynamic assays which provides a multiple fluidic circulation and multi-chamber system for culturing cells in vitro resembling the real tissues complexity. It can be used as (i) bioreactor for improving tissues conditions and prolonging cells lifetime, as (ii) microfluidic device for accelerating drug testing on 3D human tissues without involving animal use, and as (iii) reliable human disease models for basic research. React4life may both (i) sell the MIVO platform and support the customer during the first adoption, with video tutorial, scientific calls etc, (ii) provide MIVO based in vitro service activities for exploratory assays, drug efficacy assays, cytotoxicity, or permeation assays. In particular, the R&D team has deep experience in cellular biology, cancer biology and immunology.

via Bruno Buozzi 2 Vimodrone, Milan, 20090 ItalyReact4life has developed MIVO® - Multi In Vitro Organ, an innovative organ on chip able to emulate portions of the human body. MIVO® is a patented, fully industrialized platform for more reliable 3D fluid-dynamic assays which provides a multiple fluidic circulation and multi-chamber system for culturing cells in vitro resembling the real tissues complexity. It can be used as (i) bioreactor for improving tissues conditions and prolonging cells lifetime, as (ii) microfluidic device for accelerating drug testing on 3D human tissues without involving animal use, and as (iii) reliable human disease models for basic research. React4life may both (i) sell the MIVO platform and support the customer during the first adoption, with video tutorial, scientific calls etc, (ii) provide MIVO based in vitro service activities for exploratory assays, drug efficacy assays, cytotoxicity, or permeation assays. In particular, the R&D team has deep experience in cellular biology, cancer biology and immunology.

Via XX Settembre 30/12 Genova, GE, 16121 ItalyHippocrates Research (HR) is a Private Limited Company, as a company of Hippocrates Group qualified since 1995 as a CRO (Contract Research Organization). Our management has more than 20 years of experience in pharmaceutical world. It is supported by a complete training and professional updating program carried out at national and international level (training and refresher courses, problem solving, organization, communication). It includes medical expertise, pharmaceutical skills, Quality Assurance and regulatory, operational flexibility, aimed at achieving the objectives in order to reach the Customer satisfaction. HR supports studies in Italy, from phase 1 (including first-in-human) to phase 4. Moreover, more than 40% of the HR total turnover is focused on NIS, including PASS and about 13% on medical devices and food supplements. Furthermore, HR has access to a broad and reliable domestic network of GPs, well trained in GCPs and suitable to carry out interventional (phase 3 and 4) and NIS studies. HR has a recognized cutting-edge expertise for studies in Cardiology, Onco-haematology, Gastroenterology, Urology, Sexual Health and Dermatology. HR expertise is also recognised in Rare Diseases, Paediatrics and Ophthalmology. FormaResults of many studies conducted by HR have been published in important scientific journals. In total, the results of about 60 projects where HR was involved, have been published in international scientific journals and 4 of them in the New England Journal of Medicine

Via Barsanti 73010 Arnesano, Lecce, ItalyHiQ-Nano is a nanotechnology oriented company arisen from Italian Institute of Technology, focused on the design, fabrication and characterization of high-quality nanoparticles.

Viale Europa, 5 21040 Origgio (VA) ItalyArchimica offers API, building blocks, intermediates, nucleoside modification, purification, and custom synthesis services.

Via Salvador Allende Baronissi, Campania, 84081 Italy

Via Zamboni, 33 - 40126 BolognaThe University of Bologna, an overview The Alma Mater Studiorum, the oldest Unversity in the Western world: looking toward the future since 1088.

via Ungaretti 6i Genoa, GE, 16157 ItalyReact4life has developed MIVO® - Multi In Vitro Organ, an innovative organ on chip able to emulate portions of the human body. MIVO® is a patented, fully industrialized platform for more reliable 3D fluid-dynamic assays which provides a multiple fluidic circulation and multi-chamber system for culturing cells in vitro resembling the real tissues complexity. It can be used as (i) bioreactor for improving tissues conditions and prolonging cells lifetime, as (ii) microfluidic device for accelerating drug testing on 3D human tissues without involving animal use, and as (iii) reliable human disease models for basic research. React4life may both (i) sell the MIVO platform and support the customer during the first adoption, with video tutorial, scientific calls etc, (ii) provide MIVO based in vitro service activities for exploratory assays, drug efficacy assays, cytotoxicity, or permeation assays. In particular, the R&D team has deep experience in cellular biology, cancer biology and immunology.

33 Via dei Vestini Abruzzo, 66100 Italy

Via Nizza 52 Torino, I-10126 ItalyThe research at the Department focuses on molecular events underlying pathophysiological processes, and takes a translational medicine approach. Combining basic research and clinical research to develop translational paradigms, the Department seeks to develop advanced diagnostic technologies and innovative therapeutic strategies for clinical practice. Main Research Areas - Molecular and cellular mechanism of metabolic diseases, cardiovascular, oncologie and degenerative diseases - Stem cells and regenerative medicine - Computational genomics - New diagnostic imaging technologies and advanced chemical methodologies - Pre-clinical and clinica! testing of new therapeutic protocols

via G. Matteotti, 249Procos offers custom synthesis, generic API, intermediates, and manufacturing services.

6A Via Gaetano de Castillia Milano, Lombardia, 20124 ItalyThink about over 4,200 highly skilled professionals operating in the oil & gas processing, petrochemicals and fertilizer industries. This is Maire Tecnimont Group. An industrial leader in Engineering & Construction, Technology & Licensing, and Energy Business Development and Ventures. Listed on the Milan Stock Exchange, the Group is among the top-ranking worldwide engineering contractors.

12 Strada dell'Università, Parma, Emilia-Romagna 43121, ITThe University of Parma is a State University. As such, it is self-governing and has administrative, organisational, and accountancy autonomy, while providing tailored services for students. Its centuries-old history dates back to 13th March 962, when Emperor Ottonian I conferred on Uberto, the Bishop of Parma, the initiation of the University in the 'Diploma': this document, which granted the Bishop the power to order and elect legal leaders ('eligere et ordinare notarios'), was the foundation for an educational institution that would last centuries later, and is still preserved in the Bishop's Archives in Parma today. The University holds 18 Departments, 36 First Cycle Degree Courses, 6 Single Cycle Degree Courses, 38 Second Cycle Degree Courses, as well as many Postgraduate schools, Postgraduate Teacher Training courses, several Master Programmes and PhD Research Projects. The ideal size of the University (30,000 students, with more than 5,000 graduates per year and about 2,000 faculty and staff members), together with the quality of life in Parma has always attracted a large number of students from all over Italy. More than two-thirds of our registered students come from outside of Parma and its Province: for this reason the University deserves top ranking for attracting the most non-resident students nationwide. The different locations of the University allow students to study in comfortable, efficient structures even near green areas, such as the Campus: a 77-hectare area in the south of the city hosting scientific departments, modern and well-equipped lecture halls, comfortable study areas, technologically advanced laboratories, and a CNR centre - as well as several sports facilities, a conference centre, and a canteen. In the heart of the city, the University's central building houses the rector's office, administrative offices and Law. The Medical school is also in the city, located in the Hospital, while Economics and the Political Sciences are next to the Parco Ducale. The Arts and Philosophy and Psychology have their campuses in the old city centre, and Veterinary Medicine is located in the immediate north-western outskirts of the city.

via Università, 12 Parma, 43121 ItalyThe University of Parma is a State University. As such, it is self-governing and has administrative, organisational, and accountancy autonomy, while providing tailored services for students. Its centuries-old history dates back to 13th March 962, when Emperor Ottonian I conferred on Uberto, the Bishop of Parma, the initiation of the University in the 'Diploma': this document, which granted the Bishop the power to order and elect legal leaders ('eligere et ordinare notarios'), was the foundation for an educational institution that would last centuries later, and is still preserved in the Bishop's Archives in Parma today. The University holds 18 Departments, 36 First Cycle Degree Courses, 6 Single Cycle Degree Courses, 38 Second Cycle Degree Courses, as well as many Postgraduate schools, Postgraduate Teacher Training courses, several Master Programmes and PhD Research Projects. The ideal size of the University (30,000 students, with more than 5,000 graduates per year and about 2,000 faculty and staff members), together with the quality of life in Parma has always attracted a large number of students from all over Italy. More than two-thirds of our registered students come from outside of Parma and its Province: for this reason the University deserves top ranking for attracting the most non-resident students nationwide. The different locations of the University allow students to study in comfortable, efficient structures even near green areas, such as the Campus: a 77-hectare area in the south of the city hosting scientific departments, modern and well-equipped lecture halls, comfortable study areas, technologically advanced laboratories, and a CNR centre - as well as several sports facilities, a conference centre, and a canteen. In the heart of the city, the University's central building houses the rector's office, administrative offices and Law. The Medical school is also in the city, located in the Hospital, while Economics and the Political Sciences are next to the Parco Ducale. The Arts and Philosophy and Psychology have their campuses in the old city centre, and Veterinary Medicine is located in the immediate north-western outskirts of the city.

Pontina, 5 km 29 - 00040 Pomezia - Rome - ItalyItalchimici specializes in the manufacturing and marketing of prescription medicines.

Urbino, Marche, 61029 ItalyUniversity of Urbino provides flow cytometry and cytomorphology services.

Piancavallo, Piemonte, 28824 ItalyItalian Institute for Auxology (Istituto Auxologico Italiano) offers genotyping and clinical research services.

Via della Moscova 6/8 20121 Milan (ItalyBio3 Research develops new proprietary compounds up to Phase I/Phase IIA for cardiovascular field, tissue regeneration and nephrology.

4 Via Chieti Leverano, Puglia, 73045 ItalyMedBioteQ Language Services is a global language services provider to the pharmaceutical, biotechnology and medical device industries. We specialise in the life science translation sector by always delivering hight quality services thanks to daily activity exclusively focused on the medical, clinical, pharmaceutical, veterinary and more in general life science and health care sector. Our services cover (but are not limited to): ✔️ Medical Translations, Clinical Translations, Pharma Translations & Life Science Translations ✔️ Linguistic Validations ✔️ Editing and Proofreading ✔️ Project Management

STra del Petriccio e Belriguardo n.35 SIena , Siena, 53100 ItalyEstablished in 2009 from the founders’ past experiences in bioanalytical testing for influenza vaccines and their network of contacts accumulated over time within the Molecular Epidemiology Laboratory of the University of Siena, the company currently receives orders worldwide in the field of vaccines, where it conducts analytical testing of biological samples and validation of bioanalytical methods for the pharmaceutical industry. VisMederi possesses laboratories and research facilities necessary to completely cover all procedures required for the development of phase II, III, and IV of clinical trials and avails of the synergy it has with laboratories and research facilities and international research centers for the development of pre-clinical protocols and phase I studies. Since its conception, it has invested much of its resources in the optimization of laboratory assays for the evaluation of immune responses. Recently, it has specialized in cell immune response testing and the development of specific methods aimed at efficacy studies. In addition, VisMederi has developed expertise in the design and evaluation of animal models In 2013 the company developed a new line of research aimed at quality control analysis for food, water and various types of environment. VisMederi operates in this area of research with the sponsorship of public institutions, corporations and private individuals and avails of the collaboration with qualified companies for the development of its own research. VisMederi laboratories are located in Siena inside the Toscana Life Sciences Foundation (TLS) incubator building (active link at www.toscanalifesciences.org where it has been since March 2010. VisMederi headquarter is located in Via Franco Ferrini 53, Loc. Tognazza – San Martino – 53035 Monteriggioni – Siena, Italy

Via Franco Ferrini n.53 Monteriggioni , Siena, 53035 ItalyEstablished in 2009 from the founders’ past experiences in bioanalytical testing for influenza vaccines and their network of contacts accumulated over time within the Molecular Epidemiology Laboratory of the University of Siena, the company currently receives orders worldwide in the field of vaccines, where it conducts analytical testing of biological samples and validation of bioanalytical methods for the pharmaceutical industry. VisMederi possesses laboratories and research facilities necessary to completely cover all procedures required for the development of phase II, III, and IV of clinical trials and avails of the synergy it has with laboratories and research facilities and international research centers for the development of pre-clinical protocols and phase I studies. Since its conception, it has invested much of its resources in the optimization of laboratory assays for the evaluation of immune responses. Recently, it has specialized in cell immune response testing and the development of specific methods aimed at efficacy studies. In addition, VisMederi has developed expertise in the design and evaluation of animal models In 2013 the company developed a new line of research aimed at quality control analysis for food, water and various types of environment. VisMederi operates in this area of research with the sponsorship of public institutions, corporations and private individuals and avails of the collaboration with qualified companies for the development of its own research. VisMederi laboratories are located in Siena inside the Toscana Life Sciences Foundation (TLS) incubator building (active link at www.toscanalifesciences.org where it has been since March 2010. VisMederi headquarter is located in Via Franco Ferrini 53, Loc. Tognazza – San Martino – 53035 Monteriggioni – Siena, Italy

Via Zamboni, 33 Bologna, 40126 ItalyThe University of Bologna, an overview The Alma Mater Studiorum, the oldest Unversity in the Western world: looking toward the future since 1088.

Via Menabrea, 20 20159 - Milano (Italy)Miat provides active ingredients, intermediates and finished products.

Via G. Galilei, 7 - 20016 Pero (MI) - ItalyMontefarmaco manufactures and develops pharmaceutical and dietetic products.

via Giuseppe Garibaldi 5 int 16 San Giovanni Lupatoto 37057 VeronaAGREA is an indipendent Contract Research Organization in agriculture and services in phytoiatric, entomology and plant pathology, biological and integrated pest management. AGREA also provides advising in urban entomology and pest control, entomology and pathology of ornamental plants, plant management of parks and gardens. AGREA is also officially recognized by the Ministry of Health and Agriculture to conduct GLP and GEP field studies of efficacy, residues and side effects on beneficial organisms. In the pages of this site you can find detailed information and download updated documents.

Via Corti 5, CH - 6828 Balerna, SwitzerlandApplied Pharma Research (APR) is specialized in the development of oral and topical formulations in all healthcare regulatory fields.

Balerna, TI SwitzerlandApplied Pharma Research (APR) is specialized in the development of oral and topical formulations in all healthcare regulatory fields.

Via 7/F Porcellasco Cremona, 26100 ItalyAvantea offers technologies and expertise for animal breeding.

Via Guglielmo Marconi 8 Popoli, Pescara, 65026 Italy4AChem S.r.l. is a start up of the Department of Chemistry and Biology of the University of Salerno and it is located in FiscianoScience Campus (Salerno), Italy. The core business of 4AChem S.r.l. is the development of efficient, innovative and sustainable chemistry processes for the production of fine and bulk chemicals by organic synthesis as well as the marketing of these products and their derivatives

ISPE Srl - Via Bruschetti, 1 - 20125 Milan - Italy

79 San Pietro San Pietro, Trentino-Alto Adige, 39040 Italy

Via Indipendenza 11 Calco, 23885 ItalyFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

Via Luigi Einaudi 7 Guidonia di Montecelio Rome, 00012 ItalyAdaltis offers diagnostic reagent kits such as tests for hormones, tumour markers, fertility, autoimmune, and infectious disease.

Rome, Lazio ItalyAdaltis offers diagnostic reagent kits such as tests for hormones, tumour markers, fertility, autoimmune, and infectious disease.

Via Olgettina, 58 Milano 20132 (MI) ItalyMolMed provides medical biotechnology, cell-based therapy, clinical trials, and a focus on anticancer therapeutics.

CH-6996 Ponte Cremenaga Lugano - SwitzerlandMicro-Sphere offers spray drying of APIs/HPAPIs, micro-encapsulation, formulation development and analytical services.

VIA INDIPENDENZA 11 Calco, Lecco, 23885 ItalyFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

Via del Molin Nuovo 10 Vernio, PO 59024 ItalyArgus Chemicals

viale Bruno Buozzi, 59 - 00197 Roma - ItalyVI.REL Pharma offers phase II-IV clinical research services including clinical development, regulatory affairs, quality assurance, and scientific writing.

V.LE L. PASTEUR 10 NERVIANO, MILANO, 20014 ItalyAccelera offers formulation development, drug safety profiling, metabolism, bioanalysis and pharmacokinetic (PK) services.

5 Via Balbi, Genova, Liguria 16126, ITScientific research, in the head departments , affects 13 of the 14 subject areas identified by the National University Council. Mainly divided into publications, projects, patents , spin off consulted here . The University of Genoa is located in a good position among the Italian universities of medium to large size.

Via Giuseppe di Vittorio, 21 b/3 Castel Maggiore (BO), 40013 ItalyWelcome to Silicon Biosystems! Our mission and our passion is to facilitate advances in healthcare and personalized medicine by creating technologies and products that help uncover the biological complexities of disease at the level of each single cell. Silicon Biosystems’ proprietary technologies offers an unprecedented capability to study rare cells and determine the biological significance of distinct subpopulations of cells within a sample. With this knowledge, our customers are developing new diagnostic and therapeutic strategies to improve patient outcomes and address unmet medical needs. Silicon Biosystems is a wholly owned and operated subsidiary of the Menarini Group, a multinational pharmaceutical, biotechnology and diagnostics company. Silicon Biosystems is based in Bologna, Italy.

Via di Grotte Portella, 34 Frascati, Roma, 00044 ItalyParticle Measuring Systems offers particle counting, microbial monitors, gas analysis, and laboratory testing.

Viale Piceno 137/F Fano, 61032 ItalyDiatheva focuses on development, production and marketing of new and innovative products (antibodies, recombinant proteins, immunoassays and SNPs detection kits) for diagnostics, research and therapeutic applications in the filed of: Cancer, Microbial Infection and Pharmacogenetics.

Via Bissone, 5 20021 Baranzate (MI) - ItalyDipharma offers manufacturing of generic APIs as well as custom synthesis.

Via Bissone, 5 20021 Baranzate (MI) - Italy Tel. + 39 02 38228.1 Fax +39 02 38201075Dipharma offers manufacturing of generic APIs as well as custom synthesis.

Lombardy, 20021 ItalyDipharma offers manufacturing of generic APIs as well as custom synthesis.

Via Ferrata, 9 - 27100 Pavia, Italy.UB-CARE S.r.l. is an official academic spin-off of the University of Pavia, born from the desire of a group of researchers, professors and graduate students to spread in the market their scientific knowledge gained through years of experience in the cosmetic and pharmaceutical area. The team has a strong background in various fields of scientific research (cellular and molecular biology, tumor biology, cell cycle, inflammation, immunology, recombinant proteins and antibodies), and its strength is the ability to apply this knowledge to address and solve the demands and needs of the society and of the cosmetic, pharmaceutical, food and bio-medical markets, with particular regard to the biosafety issues , of pivotal importance in the daily lives of persons. Thanks to academic origin, our company is oriented towards innovation, to increase the relationships between research centers and therefore to introduce in the industrial world of the field the results obtained by the scientific research. In particular, because of the new EU ban to animal testing in laboratories, only two types of tests are now allowed in cosmetics to ensure safety prior to marketing of a product: those on men the in vitro ones. The latter type of analysis is constantly spreading in a more significant manner due to the high standards of reliability and to a greater safety for general health. UB-CARE aims to work in the research and development of new in vitro methods alternative to animal experiments for testing cosmetic products, their raw materials, medical devices and food products, including their supplements, in order to define the safety for the health of the final user. It is, therefore, an important area in the life sciences, directed to the definition of the biosafety of products constantly put in the market.

6928 Manno (Lugano) SwitzerlandDevelopharma provides pharmaceutical development services.

VIA G. DI VITTORIO, 2 GEMONIO, VA, 21036 ItalyManufacturer of instruments for biological reserach

Via Fossignano, 2 04011 Aprilia (LT) ItaliaIstituto Biochimico Italiano (ibi) provides manufacturing of recombinant proteins and pharmaceutical products.

Via Industria, 13 CH-6814 - Cadempino SwitzerlandZambon offers contract manufacturing as well as products for pain management, respiratory needs, women's healthcare.

Largo dei Lombardi 4 Rome, 00186 ItalyISIS, the Institute of Studies for the Integration of Systems, is an independent Italian research institute supporting international, national and local public bodies for the analysis, the design, the implementation and the evaluation of sustainable policies in the fields of energy, environment, transport and mobility, urban planning, and knowledge society. For more than four decades ISIS has supplied expertise and solved complex problems for a variety of public and private organisations, and notably for the European Commission. Founded in 1971, ISIS relies on the expertise of a multi-disciplinary team – including engineers, statisticians, experts in information technology, social scientists, and economists – and avails itself of state-of-the-art information technologies, also developing its own interactive and user-friendly software applications. ISIS has extensive experience in the management of and participation in EU funded projects in FP4, FP5, FP6 and FP7, and has a well-established network of alliances currently active in the Europe and beyond. ISIS has extensively worked in the field of policy impact assessment, with particular reference to socio-economic impacts and through the development and application of forward looking analysis (FLA) methods and tools. ISIS has played an important role in the conception and implementation of some of the most significant projects carried out in Europe, partecipating, both as leader and as partner, in over 80 European projects. The global mind-set of our staff and the ability to work in several languages provide a unique added value to both our international and Italian clients.

Ribes 5-10010 Colleretto Giacosa (TO) Bioindustry Park Canavese, Ivrea (Turin) ItalySpider Biotech offers antibiotic development using gram-negative bacteria.

da Vinci European BioBank Fondazione Farmacogenomica FiorGen Onlus Polo Scientifico di Sesto Fiorentino Via Luigi Sacconi 6 - 50019 Sesto Fiorentino (Firenze, Italy)The da Vinci European BioBank (daVEB) is a research infrastructure which belongs to the Farmacogenomics Foundation FiorGen Onlus. The da Vinci European BioBank is a multicenter biobank with a centralized IT infrastructure and a main repository located at the Polo Scientifico (Scientific Campus of the University of Florence) in Sesto Fiorentino (Florence, Italy), hosted by CERM (Magnetic Resonance Center), focused on protein structure and metabolomics.

Lugano, TI SwitzerlandIBSA Institut Biochimque manufacture pharmacetuicals with a specialization of topical formulations from technologies for transdermal drug delivery.

Via 42 Martiri 213/b Verbania Fondotoce, ItalyABICH offers cellular and microbiological in vitro assay development services.

ItalyABLE Biosciences is a trademark of Bioindustry Park Silvano Fumero S.p.A. which offers quantitative and qualitative analysis of small molecules, peptides, proteins, including protein biomarkers.

Via Lavino, 265-D Monte San Pietro, Bologna 40050 ItalyACZON develops, manufactures and markets NanoProbes (for diagnostic and clinical),Silica nanoparticles for various applications, and antibodies/tandem dyes.

Bologna, Emilia-Romagna ItalyACZON develops, manufactures and markets NanoProbes (for diagnostic and clinical),Silica nanoparticles for various applications, and antibodies/tandem dyes.

Largo Barsanti e Matteucci, 53 Napoli, 80125 ItalyThe Center for Advanced Biomaterials for Healthcare@CRIB develops materials and technologies to engineer bio-logically inspired platforms and systems for applications in the biomedical sector. The control and the guidance of the interactions between synthetic materials and biological entities is the leitmotif of the research activities. The interactions range from individual biomolecules, cells up to tissues and organs and might occur in a broad range of timescales. Specific combinations of these are of crucial importance in various applications such as biomaterial design, tissue engineering and regenerative medicine, drug delivery, diagnostics. The Center has built up a solid know-how in the design and fabrication of materials displaying bioactive signals at the biologic-synthetic interface. Such functional interfaces are able to actively guide and control recognition events, which ultimately elicit specific responses. Within this context, the research activities are organized according to specific platforms, namely Cell Instructive Materials, Tissues and Organs-on-Chip, Theranostic Nanoshuttles and Molecular Sensing Materials. These activities address relevant issues of the biotechnological, pharmaceutical and clinical sectors and stimulate interdisciplinary joint collaborations of researchers belonging to both the academic and industrial field. The center possesses more than 1200 m2 of laboratories equipped with cutting-edge instrumentation enabling synthesis, fabrication and characterization of material platforms and devices, along with state-of-art cell culture facilities for in vitro testing and organotypic tissue fabrication. Labs are located in the beautiful frame of the “Mostra d’Oltremare” exhibition park, close to the Polytechnique School of the University of Naples.

Via Meucci, n° 36 Pisa, Ospedaletto 56121 ItalyAbiogen Pharma provides contract manufacturing for drug products, clinical trial supply, and drug development services.

Via Martiri delle Foibe, 1 29016 Cortemaggiore (PC), ItalyDoppel Farmaceutici offers research and development as well as manufacturing of pharmaceutical and alimentary products.

Via Lillo del Duca, 10 20091 - Bresso ItalyZambon offers contract manufacturing as well as products for pain management, respiratory needs, women's healthcare.

VIALE ADDETTA 4/12 20067 TRIBIANO (MILAN - ITALY)ACS DOBFAR provides APIs, finished dosage forms, and packaging.

Milan, Lombardy ItalyPierrel offers packaging, labeling, stability studies, clinical phase studies, and clinical trial material storage.

Vicenza, Veneto, 36100 ItalyZambon offers contract manufacturing as well as products for pain management, respiratory needs, women's healthcare.

53 Largo Barsanti E. e Matteucci C., Napoli, Campania 80125, ITThe Center for Advanced Biomaterials for Healthcare@CRIB develops materials and technologies to engineer bio-logically inspired platforms and systems for applications in the biomedical sector. The control and the guidance of the interactions between synthetic materials and biological entities is the leitmotif of the research activities. The interactions range from individual biomolecules, cells up to tissues and organs and might occur in a broad range of timescales. Specific combinations of these are of crucial importance in various applications such as biomaterial design, tissue engineering and regenerative medicine, drug delivery, diagnostics. The Center has built up a solid know-how in the design and fabrication of materials displaying bioactive signals at the biologic-synthetic interface. Such functional interfaces are able to actively guide and control recognition events, which ultimately elicit specific responses. Within this context, the research activities are organized according to specific platforms, namely Cell Instructive Materials, Tissues and Organs-on-Chip, Theranostic Nanoshuttles and Molecular Sensing Materials. These activities address relevant issues of the biotechnological, pharmaceutical and clinical sectors and stimulate interdisciplinary joint collaborations of researchers belonging to both the academic and industrial field. The center possesses more than 1200 m2 of laboratories equipped with cutting-edge instrumentation enabling synthesis, fabrication and characterization of material platforms and devices, along with state-of-art cell culture facilities for in vitro testing and organotypic tissue fabrication. Labs are located in the beautiful frame of the “Mostra d’Oltremare” exhibition park, close to the Polytechnique School of the University of Naples.

Viale delle Idee, 22 Sesto Fiorentino, 50019 ItalyProtEra supplies proteins, antibodies, chemicals, and other reagents in addition to offering custom protein production, custom synthesis, and peptide synthesis.

Tuscany, 50019 ItalyProtEra supplies proteins, antibodies, chemicals, and other reagents in addition to offering custom protein production, custom synthesis, and peptide synthesis.

Piazzale Aldo Moro 5 Roma, 00185 Italy

Via Ticino nr. 9 Desenzano del Garda (BS), ITALY 25015

10 Via Antonio Panizzi Milano, Lombardia, 20146 ItalyBIO BASIC EUROPE S.r.l. was founded in 1996 by a team of specialists working in the cosmetic and pharmacological fields. After a first experience as technical consultancy, our company signed several contracts with University Institutes to perform safety tests on cosmetic products. Then BIO BASIC EUROPE S.r.l. acquired instruments and resources to carry out a research activity on its own. Today with the collaboration of its customers, BIO BASIC EUROPE S.r.l. develops processes for the evaluation of cosmetic products.

Via Puglie, 12 47853 Coriano (RN) ItalySince 1973 Akema Fine Chemicals has been manufacturing raw materials for the cosmetic and pharmaceutical industry, specializing in the production of allantoin, allantoin derivatives and preservatives. Akema is an independent family-owned company located in north-eastern Italy with a well established distribution network over the five continents. All the production activities are strictly based on its own factory in Italy, near Rimini. Akema has always proudly kept the manufacturing operations for its products in-house. Over its 30 years of activity Akema has partnered with the leading cosmetic and pharmaceutical companies and has built up a strong reputation throughout the world as a reliable manufacturer of high-quality allantoin. An exclusive range of allantoin derivatives is also produced, which offers cosmetic formulators a valuable group of functional compounds for specific applications. With a long experience in the manufacturing of preservatives for personal care, particularly Imidazolidinyl Urea, Diazolidinyl Urea and DMDM Hydantoin, during the years the company has developed a complete range of preservative systems able to satisfy the challenging requirements of modern cosmetics worldwide.

via Giovanni Paolo II 132 Stecca 7, lab 37 Fisciano, Salerno, 84084 Italy4AChem S.r.l. is a start up of the Department of Chemistry and Biology of the University of Salerno and it is located in FiscianoScience Campus (Salerno), Italy. The core business of 4AChem S.r.l. is the development of efficient, innovative and sustainable chemistry processes for the production of fine and bulk chemicals by organic synthesis as well as the marketing of these products and their derivatives

Rizzoli Orthopaedic Institute via GCPupilli, 1 40136 Bologna

ItalyBouty meets market and consumers' needs with a five (5) division division structure; Healthcare, Diagnostics, Biotechnology, Drug Delivery Systems, International.

via Gaudenzio Fantoli 16/15 Milano, Milano, 20138 ItalyISENET Biobanking is a Biobank Service Provider, offering a wide range of integrated biobanking services, from cryopreservation of biological samples to lab processing including Quality Control services, in a state-of-the-art facility. Part of Air Liquide group, ISENET Biobanking is member of the Air Liquide European Biobanking Network composed by four biobank facilities around Europe (Germany, France and Italy).

Lombardy ItalyAccelera offers formulation development, drug safety profiling, metabolism, bioanalysis and pharmacokinetic (PK) services.

Via Sommarive 18 Trento, Trento, 38123 ItalyAs “The ribosome company” we develop sophisticated tools to capture ribosomes in an active state and characterize their components. Our unique technologies are first-in-class systems allowing for simultaneous measurement of newly synthesized proteins and the RNA template from which they are produced for delivering the highest level of correlation between gene expression and the proteome. The present platform includes IP covering our technologies and is dedicated to research-use-only (RUO) products with the potential to accelerate the path toward the discovery of novel therapeutic strategies in cancer, other human diseases, and congenital disorders. IMMAGINA is expected to fully underpin the immense diagnostic potential of our growing product portfolio to guide better decisions in precision medicine, working together with our partners towards better health for all.

Via Cellaimo, 3532 47032 Bertinoro (FC) ItalyBiosphere offers intermediates, biomass development, and quality control.

Cesena, Emilia-Romagna ItalyBiosphere offers intermediates, biomass development, and quality control.

132 Via Giovanni Paolo II Campania, 84084 Italy

via camporeale snc Ariano Irpino, Avellino, 83031 ItalyBiogem is an Italian no-profit private research Institute located in Ariano Irpino (AV), in the South of Italy. Biogem has a long-standing expertise in cellular and molecular biology, and genetics, mainly focused on Oncology and Nephrology fields. Its activities span over different fields of life sciences, and it offers highly specialized services in in Pre-clinical Research, Experimental Pharmacology, Analytical Biochemistry, Pathology, Bioanalytics, Proteins and Antibodies Production, Nutraceutics, and Functional Genomics. Importantly, Biogem has an advanced animal facility which can house up to 10.000 animals (rat, mice, rabbits, medaka, and zebrafish). Among other things, Biogem has developed innovative cancer cell models (i.e., orthotopic mesothelioma), and it has a GLP certified Test Facility, for the execution of toxicity, biocompatibility, and PK studies both in vitro and in vivo. The test facility has a dedicated animal facility area, analytical laboratories for histopathology processing, hematological and biochemical evaluations, and HPLC-MS/MS analyses. In Biogem, there is a team of scientists that monitor all the steps of each research project, including its conception, its implementation, the anticipation of possible unexpected outcomes, and the exploitation of emerging results. Thus, Biogem can offer a flexible range of services, that may be adapted to the needs of the partner as well as to the different, emerging steps of the process. Biogem also includes different research laboratories: Molecular Oncology and Precision Medicine, Translational Nephrology, Staminality and Tissue Regeneration, Genes and Environment, Medical Epigenetics, Bioethics, Bioinformatics and Computational Biology. For a more detailed description of Biogem please visit https://www.biogem.it/index.php/en/

Viale Decumano 41 Milano, Milano, 20157 ItalyBiomimX S.r.l. is a pioneer in proposing the next generation of clinically relevant in–vitro models: human, dynamic, 3D. BiomimX offers high-content, controlled and reliable in vitro setups (Beating Organs on Chip) to achieve a deeper insight on human biology, pivotal for the effective discovery of new therapies. Every tissue in the body is subjected to motion: Beating Organs on Chip provide controlled mechanical stimulation to 3D cell culture, developing more reliable, fast responsive, and predictive in vitro physiological or pathological models to profile, expand and explore new therapies for complex diseases.

via Vittorio Alfieri, 28b - 10024 Moncalieri (TO) - ItalyVI.REL Pharma offers phase II-IV clinical research services including clinical development, regulatory affairs, quality assurance, and scientific writing.

Piedmont, 10024 ItalyVI.REL Pharma offers phase II-IV clinical research services including clinical development, regulatory affairs, quality assurance, and scientific writing.

P.le Giulio Cesare, 17 20145 Milano - ItalyVitroScreen is a privately owned, independent, international CRO providing in vitro pre-clinical and regulatory toxicological services for Pharmaceuticals, Medical Devices, Cosmetics, Food supplements, Biocides, Plant Protection Products, Engineered nanomaterials, Chemicals. VitroScreen has a quality-oriented approach for research studies and it is a flexible partner open to innovation challenges.

Department of Pharmaceutical Sciences Viale Taramelli 12 27100, Pavia ItalyEtichub srl is a spin-off of the University of Pavia who was born in 2013 after the experience gained over the years in the Department of Pharmaceutical Sciences. The close bond that still maintains with the world of research provides a strong scientific and continuous upgrading of skills. Etichub Ltd. offers its clients a process "end to end" to turn an idea a reality, providing a personalized service created by the customer and for the customer with high standards of quality and reliability built on the concepts of ethics and scientific rigor as intended pillars of the work company.

Via Castelfidardo, 8, 00185 Roma

via Pacinotti, 3 Corlo di Formigine (Mo) ItalyOpocrin offers research and development of new drugs as well as product line of active ingredients.

Formigine, Emilia-Romagna, 41043 ItalyOpocrin offers research and development of new drugs as well as product line of active ingredients.

12 Via Altiero Spinelli Emilia-Romagna, 44028 ItalySPF is a company for testing in plant protection and services, officially recognized as a Testing Organization for the production of data to support registration of pesticides in Italy and the EC. The company was founded in 1993 by staff with previous long experience in a Centre for Research in plant protection. Since 1993 the activity of SPF is growing quickly, expanding and updating its experiences in all areas of testing in accordance with Good Experimental Practice (GEP) and Good Laboratory Practice (GLP). In addition to experimentation, SPF offers: Service Provider for post-harvest protection and conservation Preparation of Biological Assessment Dossiers (Annex IIII) Consulting in phytoiatry

Via Sestri, 37 16154 Genova Sestri PonenteWe provide a high content screening service for evidence based acute general toxicity and neurotoxicity. We exploit alternative test methods in respect of the international principles of the 3Rs - Replacement, Refinement and Reduction and our predictive technology can be used to test toxicity and assess safety of chemicals.

Via G.B. Cassinis 7, 20139 Milano, ItalyShimadzu offers analytical technology, laboratory instruments, testing machines, and scales.

Parkinson Institute Istituti Clinici di Perfezionamento Via Bignami 1 20126 Milano, ItalyThe Biobank of the Parkinson Institute is a collection biological samples from a large number of patients affected by Parkinson Disease or Parkinsonisms, all attending the Parkinson Institute located in the Hospital ""Istituti Clinici di Perfezionamento"" in Milan, Italy. All biological samples and the matching clinical and follow-up information are anonymized and are freely available to the research community for scientific investigations on neurodegenerative diseases.

Via San Sudario, 15 Castagnito d'Alba CN 12050 ItaliaSAGEA SR Centro di Saggio s.r.l. is a private and independent Contract Research Organisation (CRO) providing research, product development and regulatory services to the agrochemical, biocide, biopesticide and seed industries.

Remembrane Srl, C/O Centuria Agenzia per l’Innovazione della Romagna Soc. Cons. a r.l., Via Granarolo 62, 48018 Faenza (RA), ItalyRemembrane leads the cell culture technology a step forward, by envisaging the cell membrane network as a fundamental and indispensable actor of most cellular processes.

Centro di Diagnostica Genetica e Biochimica delle Malattie Metaboliche Istituto Giannina Gaslini - Edificio 16, 3° Piano Via Gerolamo Gaslini, 5 - 16147 Genova, ItalyThe "Cell line and DNA Biobank from patients affected by Genetic Diseases" is situated at the "Centro di Diagnostica Genetica e Biochimica delle Malattie Metaboliche", part of the Diagnostic and Research Department of Istituto Giannina Gaslini and has been operating since 1975.

Viale Morgagni 85University of Florence focuses on pharmacological research.

Viale del'Industria 47 Pergine Valsugana (TN), Trento, 38057 ItalyAs “The ribosome company” we develop sophisticated tools to capture ribosomes in an active state and characterize their components. Our unique technologies are first-in-class systems allowing for simultaneous measurement of newly synthesized proteins and the RNA template from which they are produced for delivering the highest level of correlation between gene expression and the proteome. The present platform includes IP covering our technologies and is dedicated to research-use-only (RUO) products with the potential to accelerate the path toward the discovery of novel therapeutic strategies in cancer, other human diseases, and congenital disorders. IMMAGINA is expected to fully underpin the immense diagnostic potential of our growing product portfolio to guide better decisions in precision medicine, working together with our partners towards better health for all.

School of Medicine of the University of Catania Catania, ItalySchool of Med. of the Univ. of Catania provides animal models of disease and pharmacokinetic services.

Via Podgora 7 Milano, 20122 ItalyKos Genetic offers genotyping and sequencing services based on Illumina technology.

Medical Suite 209BVermaak and Partners Pathologists provides clinical pathology services and consulting.

Via Pontina Km 30,600 Pomezia, 00071 ItalyIRBM is a scientific contract research organization (CRO) that stands at the forefront of drug discovery, leveraging a single, unified research facility to accelerate team-based breakthroughs and improve efficiencies from concept to candidate. With a history of contributing to several approved drugs, and its own internal pipeline of oncology and other therapeutic assets, IRBM is powered by deep collaborations and decades of expertise from leading global institutions. Their comprehensive in-house capabilities assist partners in achieving key milestones and progressing toward clinical readiness, positioning IRBM as a major player in driving innovation in the pharmaceutical and biotech fields. We Make Drugs. IRBM's team has a notable track record, developing 3 marketed therapeutics: ISENTRESS®, the first-in-class HIV integrase inhibitor Grazoprevir, part of the HCV ZEPATIER® combination therapy ZEJULA®, a PARP inhibitor for the treatment of ovarian cancer

Strada Due Ponti 12 Novara, 28100 ItalyCRO developing processes for making active pharmaceutical ingredients

Via Figino, 20/22 Pero, Milano 20016 ItalyEuroClone supplies reagents and products for applications in cell biology, proteomics, genomics, and cytogenetics.

Via Olgettina 58, 20132, Milano,ItalyPrimm Biotech offers custom antibody production(monoclonal, polyclonal, phospho-specific), peptide synthesis including BioActive peptides, recombinant protein production, protein sequencing, proteomic services, Yomics antibody library

Via Sestri, 37 16154 Genua, ItalyThe ETT - ‘ALTERNATIVE TOXICITY SERVICES’ platform provides a high content screening services for evidence based acute general toxicity and neurotoxicity, taking advantage of alternative test methods in compliance with the international principles of the 3Rs - Replacement, Refinement and Reduction.

Genoa, Liguria ItalyThe ETT - ‘ALTERNATIVE TOXICITY SERVICES’ platform provides a high content screening services for evidence based acute general toxicity and neurotoxicity, taking advantage of alternative test methods in compliance with the international principles of the 3Rs - Replacement, Refinement and Reduction.

C.so Svizzera 164 Pad. Q, Amedeo di Savoia Hospital Turin, Turin, 10149 ItalyWe develop analytical methods and diagnostic kit (CE-IVD) for the quantification of molecules in biological samples (responding to the current demand of monitoring of analytes of biological interest in patient) and in non biological samples. We are expert in LC-MS and pharmacogenomics for therapy personalization (TDM and PG). We carry out specific analytical test according to customer requirements. We write, submit to the Ethics Committees and manage clinical trials for the validation of diagnostic kits (according to 13485: 2016) for CE-IVD marking. CoQua Lab srl and his partner (Laboratory of Clinical Pharmacology and Pharmacogenetics, University of Turin, UNI EN ISO 13485:2016 certified) are ready to help your company with the CLINICAL VALIDATION of your in-vitro diagnostic medical device (In Vitro Diagnostic Device Regulations (EU 2017/746)). Direct access to biological samples of patients (blood, plasma, liquor, etc.) for IVD validation.

Corso Svizzera 185 bis Fabbricato 3, Scala C, 3° Piano Torino, TO, 10122 ItalyWe develop analytical methods and diagnostic kit (CE-IVD) for the quantification of molecules in biological samples (responding to the current demand of monitoring of analytes of biological interest in patient) and in non biological samples. We are expert in LC-MS and pharmacogenomics for therapy personalization (TDM and PG). We carry out specific analytical test according to customer requirements. We write, submit to the Ethics Committees and manage clinical trials for the validation of diagnostic kits (according to 13485: 2016) for CE-IVD marking. CoQua Lab srl and his partner (Laboratory of Clinical Pharmacology and Pharmacogenetics, University of Turin, UNI EN ISO 13485:2016 certified) are ready to help your company with the CLINICAL VALIDATION of your in-vitro diagnostic medical device (In Vitro Diagnostic Device Regulations (EU 2017/746)). Direct access to biological samples of patients (blood, plasma, liquor, etc.) for IVD validation.

6 Via Luigi Sacconi Zona Osmannoro, Toscana, 50019 ItalyCERM is a center for research, knowledge transfer, and higher education of the University of Florence, located at the Polo Scientifico (Scientific Campus) in Sesto Fiorentino. The Center is a research infrastructure for NMR in the Life Sciences supported by the European Community. CERM TT and Bio-Enable are infrastructures which provide innovative services to companies in the field of Life Sciences.

20 Viale Isonzo Rozzano, Lombardia, 20089 Italy

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, ItalyExtensive information about the sequence of both human and mouse DNA suggests that mouse and human genes are similar and appear to serve similar functions to the extent that changes in the equivalent gene usually leads to similar inherited diseases. Our unit provides services for the production of genetically modified mice to be used as models to understand human diseases. The creation of genetically altered mice requires specialized techniques and central provision has significant advantages by providing a pool of experience and expertise that reduce and refine the numbers of mice required to generate new genetically altered lines. At the Transgenic Service Facility of EMBL-Monterotondo, many gene targeting projects, DNA injection projects and mouse line rederivations are completed every year and for such purpose, our Transgenic Service unit provides a wide spectrum of standard and advanced alternative techniques. Our service produces many lines of mice and many more are imported from centres around the world.

32 Via Ercole Ramarini Monterotondo, Lazio, 00015 ItalyExtensive information about the sequence of both human and mouse DNA suggests that mouse and human genes are similar and appear to serve similar functions to the extent that changes in the equivalent gene usually leads to similar inherited diseases. Our unit provides services for the production of genetically modified mice to be used as models to understand human diseases. The creation of genetically altered mice requires specialized techniques and central provision has significant advantages by providing a pool of experience and expertise that reduce and refine the numbers of mice required to generate new genetically altered lines. At the Transgenic Service Facility of EMBL-Monterotondo, many gene targeting projects, DNA injection projects and mouse line rederivations are completed every year and for such purpose, our Transgenic Service unit provides a wide spectrum of standard and advanced alternative techniques. Our service produces many lines of mice and many more are imported from centres around the world.

Via Marabini 14/A 40013 Castel Maggiore Bologna - ItalyAgri 2000 was founded in 1985 by a group of agricultural science graduates. Currently over 50 researchers and technicians work for Agri2000. Agri 2000 is in a position to tackle issues regarding the development of the agrofood sector and urban green spaces thanks to the specialized, multidisciplinary approach of its 3 Divisions. Our long-standing experience and our response to the needs of the sector have enabled us to develop unique exclusive services for the different categories of clients. Furthermore, Agri 2000 invests in research in various aspects of the agrofood chain and it participates actively in the Innovation Observatory in agricultural enterprises founded by Agri2000. It also writes and publishes studies and publications on company competitiveness (Competitive rating, Entrepreneurial management rating, etc).

Via Cucchiari, 17 20155 Milan, ItalyCambrex offers a range of specialist drug substance technologies and capabilities including biocatalysis, continuous flow, controlled substances, solid state science, material characterization and highly potent APIs. In addition, Cambrex can support conventional dosage forms including oral solids, semi-solids and liquids and has the expertise to manufacture specialist dosage forms such as modified-release, fixed dose combination, pediatric, bi-layer tablets, stick packs, topicals, controlled substances, sterile and non-sterile ointments.

Località Prulli 103/c Reggello, Florence, 50066 ItalyPQE Group is an ISO 9001 certified technology solutions and compliance consulting services company with global capabilities deliverable throughout the entire product quality life cycle.

Via Ranco, 112 - 47899 Serravalle (RSM) San MarinoValpharma offers formulation, developoment, scale-up and manufacturing of a wide range of pharmaceutical and nutraceuticals.

ItalyValagro was founded in Abruzzo and brings into the world of today the same passion for nature that produces its solutions for the care and nurture of plants. Today, our company is able to globally respond to the specific needs of the Customer, needs that reflect new and increasing requirements, in a context of increasingly scarce and precious resources. For this reason, here at Valagro, we have decided to accept a challenge: to bring development and prosperity using fewer resources, or rather to produce more and better for the needs of the world, using less land, less water and less technical means. To do this, we have placed research and innovation in the service of nature, understanding that taking care of the future means working together while respecting the environment and protecting the health of everyone.

Via Morolense 87 03013 Ferentino (FR) ItalyPatheon is the leading publicly listed provider of drug development and manufacturing services to global pharmaceutical, biotechnology and specialty pharmaceutical companies.

Viale G.B. Stucchi, 110 I-20900 Monza (MB) ItalyPatheon is the leading publicly listed provider of drug development and manufacturing services to global pharmaceutical, biotechnology and specialty pharmaceutical companies.

Cosmo Pharmaceuticals S.p.A. Via C. Colombo 1 I – 20020 Lainate, ItalyCosmo offers specialty pharmaceutical for gastro-intestinal diseases as well as contract manufacturing

Via Gandine 4 29121 Piacenza ItalyEratech offers development of inhalable drug products for the treatment of respiratory and systemic diseases.

Trento, Trentino-Alto Adige/South Tyrol ItalyE-Pharma offers specialization and experience in developing, formulating and manufacturing effervescent and soluble formulations.

Viale Monza, 249 Milan, 20128 ItalyElettracqua manufactures water treatment and purification systems.

Via Gelasio Adamoli 513 16165 GENOVA GE ItalyElettracqua manufactures water treatment and purification systems.

Via XXV Aprile, 2 20097 San Donato Milanese (Mi) ItalyWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

Via F.lli Beltrami 15 - 20026 Novate Milanese (MI), ItalyChemService S.r.l. Controlli e Ricerche is an analytical laboratory providing a complete and tailor-made range of testing services (chemical, chemical-physical, microbiological, ecotoxicological, genetic and environmental analyses) as well as regulatory/registration consulting for food, plant protection products, biocides, chemicals (REACH), cosmetics and veterinary products.

Via F.lli Beltrami, 15 - 20026 Novate Milanese (MI)ChemService S.r.l. Controlli e Ricerche is an analytical laboratory providing a complete and tailor-made range of testing services (chemical, chemical-physical, microbiological, ecotoxicological, genetic and environmental analyses) as well as regulatory/registration consulting for food, plant protection products, biocides, chemicals (REACH), cosmetics and veterinary products.

Via Privata Goito, 8 Paderno Dugnano, MI, 20037 ItalyChemService S.r.l. Controlli e Ricerche is an analytical laboratory providing a complete and tailor-made range of testing services (chemical, chemical-physical, microbiological, ecotoxicological, genetic and environmental analyses) as well as regulatory/registration consulting for food, plant protection products, biocides, chemicals (REACH), cosmetics and veterinary products.

S.S.16 – Zona Industriale 73010 Zollino (LE) ItalyLachifarma offers research, technological development, and health service.

Via Cittadella della Ricerca snc Mesagne, Brindisi, 72023 ItalyThe integration of our CRO knowledge and CDMO capabilities places PolyCrystalLine as an excellent partner in the production of intermediates and APIs in GMP compliance. Our team can support you in the optimization and in the synthesis of challenging molecules from gram to kilogram scale with consistency and optimized physical and bulk properties. As Polycrystalline CDMO we see ourselves as your strategic partners, with our reliability and our full commitment to meet your need into the development of new APIs and HPAPIs we want to unlock the full potential of our partnership going beyond the classic client/supplier relationship. Our recent investment is aimed to meet and outmach your expectations, our innovative technologies, our custom made plant , our highly skilled scientisst and our continuous reaserch to reach the excellence are just some of the keys of Polycrystalline CDMO. We look forward to have the chance to be your partner and join Polycrystalline in the journey from a small start-up to a fully integrated CDMO.

Ivrea, Piedmont, 10015 ItalyABC Farmaceutici is committed to research, development, manufacturing and commercialization of pharmaceutical products and active ingredients.

Via F.S. Fabri 127/1 Medicina, Bologna, 40059 ItalyThe integration of our CRO knowledge and CDMO capabilities places PolyCrystalLine as an excellent partner in the production of intermediates and APIs in GMP compliance. Our team can support you in the optimization and in the synthesis of challenging molecules from gram to kilogram scale with consistency and optimized physical and bulk properties. As Polycrystalline CDMO we see ourselves as your strategic partners, with our reliability and our full commitment to meet your need into the development of new APIs and HPAPIs we want to unlock the full potential of our partnership going beyond the classic client/supplier relationship. Our recent investment is aimed to meet and outmach your expectations, our innovative technologies, our custom made plant , our highly skilled scientisst and our continuous reaserch to reach the excellence are just some of the keys of Polycrystalline CDMO. We look forward to have the chance to be your partner and join Polycrystalline in the journey from a small start-up to a fully integrated CDMO.

Via Saragat Baricella, BO 18-I-40052 ItalyAlchemy is a custom chemistry services provider. We offer: Custom synthesis of scaffolds, intermediates, metabolites, and impurities, Purification and isolation by HPLC-prep for unknown impurities identification

Via Palermo, 26/A Parma, 43100 ItalyChiesi farmaceutici offers drug development, drug discovery, and clinical trials.

Division of Neuromuscular Diseases, Istituto Nazionale Neurologico "C. Besta", Laboratori Bicocca, Via L. Temolo 4 - 20126 Milano

Via G.Saragat, 18- fraz.San Gabriele Italia SAN GABRIELE, BO, 43122 ItalyAlchemy is a custom chemistry services provider. We offer: Custom synthesis of scaffolds, intermediates, metabolites, and impurities, Purification and isolation by HPLC-prep for unknown impurities identification

Via S. Pellico, 48 20900 Monza - ItaliaBioRep offers biorepository and cell banking services.

Strada Savonesa, 9 - 15050. Tortona - ItalyChimete offers API services, analytical services, natural product analysis, stability studies, and structural analysis.

Private Bag X09Parexel provides bioequivalence studies as well as clinical services across Phase I to Phase III of drug development including dose escalation, drug-drug interaction, biomarkers, first-in-man studies, ADME, imaging, and clinical research services.

Via Germania 2 37135 Verona – ItalyCROS offers biostatistics, clinical data management, medical communication, pharmacovigilance, and technology solutions to the life science industry.

Via Dovaro 36045 Almisano di Lonigo (VI) - ItalyZach System offers custom synthesis, APIs, intermediates and process development.

Via Lillo Del Duca, 10 20091 Bresso (MI) - ItalyZach System offers custom synthesis, APIs, intermediates and process development.

Bresso, Lombardy, 20091 ItalyZach System offers custom synthesis, APIs, intermediates and process development.

Via Filippo Turati, 28Parexel provides bioequivalence studies as well as clinical services across Phase I to Phase III of drug development including dose escalation, drug-drug interaction, biomarkers, first-in-man studies, ADME, imaging, and clinical research services.

Via Cento, 5/3 40016 San Giorgio di Piano (BO)An important established presence in the territory. Connective junction between the world of agriculture and the food processing industry, the Agricultural Consortium of Emilia is able to guarantee to each member an optimal enhancement of its production potential in the global market through a strategy of supply chain. In this 'optical CAEmilia the offers, to farms of different types specialized assistance and customized high-level, from design to marketing. The CAEmilia is an integral part of the production chains of the territory under its control The system of chain allows to address agricultural production in function of the needs of the consumer The "production regulations" guide the socio obtaining products of quality, which will be guaranteed by the precise tracking of agronomic made In the livestock sector, as in agriculture, optimize the quality is to remain competitive on the international market Integrated pest management, biological control, use of pesticides targeted, recycling of raw materials: these are the guidelines for the environmentally sound management of agriculture CAEmilia Guardians of the ancient gastronomic traditions of the territory, the CAEmilia plays a vital role in protecting the equilibrium of the ecosystem hydro-geological hillside

41 Via 2 Agosto San Giorgio di Piano, Emilia-Romagna, 40016 ItalyAn important established presence in the territory. Connective junction between the world of agriculture and the food processing industry, the Agricultural Consortium of Emilia is able to guarantee to each member an optimal enhancement of its production potential in the global market through a strategy of supply chain. In this 'optical CAEmilia the offers, to farms of different types specialized assistance and customized high-level, from design to marketing. The CAEmilia is an integral part of the production chains of the territory under its control The system of chain allows to address agricultural production in function of the needs of the consumer The "production regulations" guide the socio obtaining products of quality, which will be guaranteed by the precise tracking of agronomic made In the livestock sector, as in agriculture, optimize the quality is to remain competitive on the international market Integrated pest management, biological control, use of pesticides targeted, recycling of raw materials: these are the guidelines for the environmentally sound management of agriculture CAEmilia Guardians of the ancient gastronomic traditions of the territory, the CAEmilia plays a vital role in protecting the equilibrium of the ecosystem hydro-geological hillside

Via Ravasi, 2 - 21100University of Insubria focuses on research in their departments of chemical sciences, structural/functional biology, and surgical sciences.

Varese, Lombardy, 21100 ItalyUniversity of Insubria focuses on research in their departments of chemical sciences, structural/functional biology, and surgical sciences.

Branch of Bioggio Centro Nord-Sud Bioggio 6934 SwitzerlandMultipharma provides clinical trial supply, distribution, pre-marketing, and market intelligence.

Via Dei Sette Santi 1/3 50131 Florence, ItalyMenarini Biotech provides recombinant protein development and production using mammalian and microbial cell culture.

12 Via Virgilio Ranzato Milano, Lombardia, 20128 Italy500 sqm facility fully equipped with the most advanced technologies available: Luminex/Multiplex platform, NGS capability and Sequencing, FACS, IHC platform. Hubs in the most vibrant area Milano, San Diego and Oxford, of the Life Science community. We are a laboratory service provider delivering Luminex Assay Service -IHC Pathology - Microbiome - RNA Profiling ... and more Labospace is an hub where professionals from different backgrounds (MD, PhD and MSc graduates with in depth experience) meet at the service of scientific research. We offer Biomarker Testing Assay services on Luminex, Meso Scale, ELISA and multiplex ELISA, Human Mouse Pathology Service, Microbioma Testing Service, Transcriptome Testing service and offer innovative products in the market

Strada Statale 14 - km 163,5 AREA Science Park 34149 Basovizza, Trieste ITALYCBM (Cluster in Biomedicine) offers biomarker, bioinformatics, gene expression, NMR, genotyping, proteomics, DNA extraction, and optical imaging services.

Via Nerviano 31/b Lainate, Milan 20020 ItalyGenomnia offers deep sequencing and bioinformatic analysis services covering genomics, transcriptomics and epigenetics projects.

Via Paracelso 22 Agrate Brianza, 20864 Italy

Milan, Lombardy ItalyHMGBiotech offers their expertise in HMGB1, a component of the cell nucleus functioning in the organization and expression of the genome, and provides reagents, assay development, and cell migration studies.

Via della Carboneria 30/32 Solomeo di Corciano - PG, 06073, ItalySterling S.N.I.F.F. Italia provides API synthesis, steroid research, and process optimization.

VIA LUIGI SACCONI 6 Sesto Fiorentino, 50019 Italy

Italy

6 Via Madonna del Piano Toscana, 50019 Italy

Via Manzoni 56, Rozzano Milan ItalyHumanitas is a highly specialized teaching and research hospital. Accredited by the National Health Service, Humanitas combines specialized centers for the treatment of cancers, cardiovascular diseases, neurological and orthopedic disorders, as well as an Ophthalmology Centre and a Fertility Center. The hospital is also equipped with Emergency and Radiotherapy areas. The Italian Ministry of Health granted Humanitas the status “Research Hospital” (IRCCS) with a main focus on diseases of the immune system, ranging from cancer to rheumatoid arthritis. Humanitas is considered one of the most technologically advanced hospitals in Europe. The hospital is equipped with: The latest generation of linear accelerators that are used in radiation therapy for the treatment of cancer Highly developed robotic instruments that are used in less invasive surgeries The latest generation of lasers that are used in Ophthalmology Systems (such as DoseWatch) that automatically collect and analyze patient radiation and iodine exposure Imaging technologies such as CAT scans that are used in Neurosurgery Humanitas believes that it is essential to unite organizational efficiency and clinical quality. For this reason, it was the first Italian general hospital and one of the few in Europe, to be certified for quality by the International Joint Commission (2002, 2006, 2009, 2012 and 2015). Considered by Harvard University as one of the four most innovative hospitals in the world, Humanitas is a case study of the Harvard Business School for its organizational model, which combines economic, developmental and social responsibility. The hospital promotes health care, early detection and prevention of diseases (primary and secondary prevention) through its outpatient clinics and its advanced and innovative services. It encourages a winning strategy for staying healthy by continuously promoting regular exercise and a healthy way of living. Humanitas has always played an active role in campaigns that highlight the importance of a healthy lifestyle. Humanitas Research Hospital is the flagship of a hospital group also present in Bergamo, Turin, Catania, Castellanza (Varese) and Milan.

Istituto Neurologico Carlo Besta Fondazione IRCCS - Milano Via Giovanni Celoria, 11, 20133 Milano, Italia

Via Puglie, 12 Coriano (RN), 47853 ItalySince 1973 Akema Fine Chemicals has been manufacturing raw materials for the cosmetic and pharmaceutical industry, specializing in the production of allantoin, allantoin derivatives and preservatives. Akema is an independent family-owned company located in north-eastern Italy with a well established distribution network over the five continents. All the production activities are strictly based on its own factory in Italy, near Rimini. Akema has always proudly kept the manufacturing operations for its products in-house. Over its 30 years of activity Akema has partnered with the leading cosmetic and pharmaceutical companies and has built up a strong reputation throughout the world as a reliable manufacturer of high-quality allantoin. An exclusive range of allantoin derivatives is also produced, which offers cosmetic formulators a valuable group of functional compounds for specific applications. With a long experience in the manufacturing of preservatives for personal care, particularly Imidazolidinyl Urea, Diazolidinyl Urea and DMDM Hydantoin, during the years the company has developed a complete range of preservative systems able to satisfy the challenging requirements of modern cosmetics worldwide.

Strada del Petriccio e Belriguardo n.35 SIena , Siena, 53100 ItalyEstablished in 2009 from the founders’ past experiences in bioanalytical testing for influenza vaccines and their network of contacts accumulated over time within the Molecular Epidemiology Laboratory of the University of Siena, the company currently receives orders worldwide in the field of vaccines, where it conducts analytical testing of biological samples and validation of bioanalytical methods for the pharmaceutical industry. VisMederi possesses laboratories and research facilities necessary to completely cover all procedures required for the development of phase II, III, and IV of clinical trials and avails of the synergy it has with laboratories and research facilities and international research centers for the development of pre-clinical protocols and phase I studies. Since its conception, it has invested much of its resources in the optimization of laboratory assays for the evaluation of immune responses. Recently, it has specialized in cell immune response testing and the development of specific methods aimed at efficacy studies. In addition, VisMederi has developed expertise in the design and evaluation of animal models In 2013 the company developed a new line of research aimed at quality control analysis for food, water and various types of environment. VisMederi operates in this area of research with the sponsorship of public institutions, corporations and private individuals and avails of the collaboration with qualified companies for the development of its own research. VisMederi laboratories are located in Siena inside the Toscana Life Sciences Foundation (TLS) incubator building (active link at www.toscanalifesciences.org where it has been since March 2010. VisMederi headquarter is located in Via Franco Ferrini 53, Loc. Tognazza – San Martino – 53035 Monteriggioni – Siena, Italy

Stradra del Petriccio e Belriguardo n.35 SIena , Siena, 53100 ItalyEstablished in 2009 from the founders’ past experiences in bioanalytical testing for influenza vaccines and their network of contacts accumulated over time within the Molecular Epidemiology Laboratory of the University of Siena, the company currently receives orders worldwide in the field of vaccines, where it conducts analytical testing of biological samples and validation of bioanalytical methods for the pharmaceutical industry. VisMederi possesses laboratories and research facilities necessary to completely cover all procedures required for the development of phase II, III, and IV of clinical trials and avails of the synergy it has with laboratories and research facilities and international research centers for the development of pre-clinical protocols and phase I studies. Since its conception, it has invested much of its resources in the optimization of laboratory assays for the evaluation of immune responses. Recently, it has specialized in cell immune response testing and the development of specific methods aimed at efficacy studies. In addition, VisMederi has developed expertise in the design and evaluation of animal models In 2013 the company developed a new line of research aimed at quality control analysis for food, water and various types of environment. VisMederi operates in this area of research with the sponsorship of public institutions, corporations and private individuals and avails of the collaboration with qualified companies for the development of its own research. VisMederi laboratories are located in Siena inside the Toscana Life Sciences Foundation (TLS) incubator building (active link at www.toscanalifesciences.org where it has been since March 2010. VisMederi headquarter is located in Via Franco Ferrini 53, Loc. Tognazza – San Martino – 53035 Monteriggioni – Siena, Italy

Viale Padre Pio, 71013 San Giovanni Rotondo - FGThe Genomic Disorders Biobank (GDB) located at the “Medical Genetic Unit”, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, establishes and stores biological samples (DNA, RNA and tissue cell lines) from a number of individuals affected by human rare genomic and genetics diseases. The Biobank includes also molecular and cytogenetics characterization of all samples achieved by cytogenetics and molecular analyses.

9 Via Arturo Toscanini, 40055 Villanova di Castenaso Villanova, Emilia-Romagna 40055, ITVETSPIN is a Contract Research Organization specialized in pharmaceutical studies required for Drug Registration, founded in 2004 as a spinoff of the University of Bologna, based in Ozzano Emilia (Bologna), Italy. VETSPIN performs Pharmacokinetics studies, Residue studies, Drug Methabolism studies, Biostatistics and Medical Writing, Research Expertise, Publishing. The research team of VETSPIN supplies the highest level of scientific knowledge, quality standards and regulatory competence to their customer's requests, whether for routine studies or specific complex and innovative projects. VETSPIN works in compliance with GLP guidelines and the facilities are subjected to regular GLP inspections by Italian authorities. The VETSPIN research facilities are located in Ozzano Emilia (Bologna), Italy.

Via della Ricerca Scientifica Edificio PP2 Rome, 00133 ItalyC4T offers computation chemistry, custom synthesis, and analytical chemistry services.

Via Gian Battista Camozzi, Ranica, Lombardia 24020, ITThe Mario Negri Institute for Pharmacological Research was the result of Silvio Garattini, then a young professor at Milan University Institute of Pharmacology, meeting Mario Negri, a jeweler and philanthropist. Silvio Garattini had spent some time visiting companies in the United States, and had been struck by how differently scientific research was done there, compared to Italy. He was particularly interested in the idea of a foundation, an organization with the flexibility of a private body which, with its non-profit aims, could work in the interests of the public. Mario Negri (1891-1960) was the Milanese philanthropist who made it possible, in his will, to establish the Institute. He had always been interested in medicine and biology, and in the 1950s he acquired a small pharmaceutical company, called Farmacosmici. Then, personally following its scientific programs, he contacted Silvio Garattini, who at the time was coordinating a group of young pharmacologists doing research work at the Milan University Institute of Pharmacology. Over the years, Mario Negri financed several research programs, and soon realized how restrictive and rigid was the university – which was going through a major crisis at the time - with all its inadequacies. In 1960 Mario Negri died of cancer. His will specified that part of his estate should go to found a research institute, and he specified its features and aims in detail. Professor Silvio Garattini was nominated as its director, as chief of the group. Before he died Mario Negri had agreed with Garattini on how the new institute should be established. Once all the necessary burocratic and legal permits had been obtained (for recognition as a no-profit institution – now a foundation) as required under Decree No. 361 of the President of the Italian Republic, dated 5 April 1961, work started on a building in Quarto Oggiaro, a suburb of Milan, and on 1 February 1963 the new organization began working, with a ‘historic core’ or 22 people. Just to mention a few of the outstanding group, there was Luigi Valzelli, Valentino Palma, Emilio Mussini, Luciano Morasca, Lella Bizzi and, in particular, Alfredo Leonardi. The Mario Negri Institute was the first private Italian foundation dedicated entirely to biomedical research. It was an agile structure, like a private body, but dedicated to the public interest as its earnings were always ploughed back for research.

87 Via Stezzano, , Lombardia 24126, ITThe Mario Negri Institute for Pharmacological Research was the result of Silvio Garattini, then a young professor at Milan University Institute of Pharmacology, meeting Mario Negri, a jeweler and philanthropist. Silvio Garattini had spent some time visiting companies in the United States, and had been struck by how differently scientific research was done there, compared to Italy. He was particularly interested in the idea of a foundation, an organization with the flexibility of a private body which, with its non-profit aims, could work in the interests of the public. Mario Negri (1891-1960) was the Milanese philanthropist who made it possible, in his will, to establish the Institute. He had always been interested in medicine and biology, and in the 1950s he acquired a small pharmaceutical company, called Farmacosmici. Then, personally following its scientific programs, he contacted Silvio Garattini, who at the time was coordinating a group of young pharmacologists doing research work at the Milan University Institute of Pharmacology. Over the years, Mario Negri financed several research programs, and soon realized how restrictive and rigid was the university – which was going through a major crisis at the time - with all its inadequacies. In 1960 Mario Negri died of cancer. His will specified that part of his estate should go to found a research institute, and he specified its features and aims in detail. Professor Silvio Garattini was nominated as its director, as chief of the group. Before he died Mario Negri had agreed with Garattini on how the new institute should be established. Once all the necessary burocratic and legal permits had been obtained (for recognition as a no-profit institution – now a foundation) as required under Decree No. 361 of the President of the Italian Republic, dated 5 April 1961, work started on a building in Quarto Oggiaro, a suburb of Milan, and on 1 February 1963 the new organization began working, with a ‘historic core’ or 22 people. Just to mention a few of the outstanding group, there was Luigi Valzelli, Valentino Palma, Emilio Mussini, Luciano Morasca, Lella Bizzi and, in particular, Alfredo Leonardi. The Mario Negri Institute was the first private Italian foundation dedicated entirely to biomedical research. It was an agile structure, like a private body, but dedicated to the public interest as its earnings were always ploughed back for research.

Via Mario Negri 2 Milan, MI, 20156 ItalyThe Mario Negri Institute for Pharmacological Research was the result of Silvio Garattini, then a young professor at Milan University Institute of Pharmacology, meeting Mario Negri, a jeweler and philanthropist. Silvio Garattini had spent some time visiting companies in the United States, and had been struck by how differently scientific research was done there, compared to Italy. He was particularly interested in the idea of a foundation, an organization with the flexibility of a private body which, with its non-profit aims, could work in the interests of the public. Mario Negri (1891-1960) was the Milanese philanthropist who made it possible, in his will, to establish the Institute. He had always been interested in medicine and biology, and in the 1950s he acquired a small pharmaceutical company, called Farmacosmici. Then, personally following its scientific programs, he contacted Silvio Garattini, who at the time was coordinating a group of young pharmacologists doing research work at the Milan University Institute of Pharmacology. Over the years, Mario Negri financed several research programs, and soon realized how restrictive and rigid was the university – which was going through a major crisis at the time - with all its inadequacies. In 1960 Mario Negri died of cancer. His will specified that part of his estate should go to found a research institute, and he specified its features and aims in detail. Professor Silvio Garattini was nominated as its director, as chief of the group. Before he died Mario Negri had agreed with Garattini on how the new institute should be established. Once all the necessary burocratic and legal permits had been obtained (for recognition as a no-profit institution – now a foundation) as required under Decree No. 361 of the President of the Italian Republic, dated 5 April 1961, work started on a building in Quarto Oggiaro, a suburb of Milan, and on 1 February 1963 the new organization began working, with a ‘historic core’ or 22 people. Just to mention a few of the outstanding group, there was Luigi Valzelli, Valentino Palma, Emilio Mussini, Luciano Morasca, Lella Bizzi and, in particular, Alfredo Leonardi. The Mario Negri Institute was the first private Italian foundation dedicated entirely to biomedical research. It was an agile structure, like a private body, but dedicated to the public interest as its earnings were always ploughed back for research.

Via Winckelmann 2Premier Research, a midsize clinical research company, is dedicated to helping biotech, specialty pharma, and device innovators transform life-changing ideas and breakthrough science into new medical treatments. As a global company, Premier Research specializes in the use of innovative technologies for smart study design and trial management to deliver clean, conclusive data to sponsors. Whether it’s developing product lifecycle strategies, reducing clinical development cycle times, securing access to patients, navigating global regulations, maximizing the impact of limited rare disease data, or providing expertise in specific therapeutic areas, Premier Research is committed to helping its customers answer the unmet needs of patients across a broad range of medical conditions.

Clinical Research and Bioengineering Institute Viale Cesare Battisti 38
 I-20900 Monza (MB)Derming is a private and independent research company specialised in clinical trials for skin, hair and nail products.

 Our mission is to provide our trial participants with excellent medical care, and provide our sponsors with the highest quality research services. At Derming, we provide clinical evaluations on the tolerance and activity of skin care products based on scientific tests. We carry out dermatological studies and develop protocols which are tailored to our customer’s needs.

Stradello Aggazzotti, 104 41126 MODENA -ITALYNeotron is a Global Player in the market of analytical and consultancy services for food production and distribution companies. In fact Neotron has been operating in the field of chemical, biochemical, microbiological and sensory analysis in the food sector for 30 years, supplying an essential technical support for control and development of new products. NEOTRON services are addressed to a wide range of companies : from production and distribution companies to trade associations and public and private institutions, having worked with the main Italian and foreign food groups for many years.

Viale Pasteur 10 P.O.Box 11 20014 Nerviano, MI ItalyAccelera offers formulation development, drug safety profiling, metabolism, bioanalysis and pharmacokinetic (PK) services.

Corso Umberto I, Napoli, Campania 80138, ITWe are making every effort to combine teaching and research excellence with the warm and friendly atmosphere of the Neapolitan character. We are convinced that achieving such integration makes the university a much nicer place to learn and work. Proud of the nearly eight-century history of our Institution, we are striving to keep pace with the ever-faster changes of the modern world as we look to the future. We accept the challenge of training competent, open-minded professionals, aware of the rapidly changing needs of a collective human society, for we are all but convinced that knowledge is the most rewarding achievement for mankind. In allegiance to these principles, we are pursuing excellence, making every effort to improve our academic and research standards. We are tirelessly reassessing our current standings pushing changes through, whenever needed. It isn’t easy! But, we feel that the greater the challenge, the greater the reward. We work hard to create a vibrant intellectual environment as the appropriate milieu for world class research and training. This, combined with the many attractions of our very special city, will make the time spent in Naples and at our university a most rewarding one. We hope to have the privilege of assisting you and helping you to enjoy what we can offer. prof. Gaetano Manfredi Rector

Corso Umberto I Napoli, 80138 ItalyWe are making every effort to combine teaching and research excellence with the warm and friendly atmosphere of the Neapolitan character. We are convinced that achieving such integration makes the university a much nicer place to learn and work. Proud of the nearly eight-century history of our Institution, we are striving to keep pace with the ever-faster changes of the modern world as we look to the future. We accept the challenge of training competent, open-minded professionals, aware of the rapidly changing needs of a collective human society, for we are all but convinced that knowledge is the most rewarding achievement for mankind. In allegiance to these principles, we are pursuing excellence, making every effort to improve our academic and research standards. We are tirelessly reassessing our current standings pushing changes through, whenever needed. It isn’t easy! But, we feel that the greater the challenge, the greater the reward. We work hard to create a vibrant intellectual environment as the appropriate milieu for world class research and training. This, combined with the many attractions of our very special city, will make the time spent in Naples and at our university a most rewarding one. We hope to have the privilege of assisting you and helping you to enjoy what we can offer. prof. Gaetano Manfredi Rector

10010 Colleretto GiacosaNoray Bioinformatics provides bioinformatics and software for scientific studies.

Via Sac. Benedetto Cozzolino c/o Mercato dei Fiori 80056 - Ercolano (NA) - ItalyBiofarm is a testing centre officially recognized by the Italian Ministry of Agricultural, Food and Forestry Policies. Biofarm carries out official field tests of registered and/or under registration plant protection products and it generates the data required for the approval process concerning the marketing and the use of plant protection products. Tests are aimed at evaluating usefulness and biological efficacy of active substances. The testing centre assesses any development of resistance in the target pest and toxicity to other plants as well as to non-target arthropods, and it determines the presence of residues affecting human and animal health. Biofarm is entitled to carry out field tests aimed at providing information concerning: Plant protection products efficacy Effects on yield and/or quality Phytotoxicity to plants and target plant products Determination and analysis of residues Appearance or possible development of resistance The Ministry accreditation concerns efficacy field tests and tests for the detection and determination of residues of plant protection products in the following activity sectors: Tree crops, Herbaceous Crops, Horticultural Crops, Weeding, Entomology, Nematology, Plant Pathology. Biofarm is GLP (Good Laboratory Practice) and GEP (Good Experimental Practice) certified. Both these quality standards guarantee that the results generated in terms of biology (GEP) and residues (GLP) are accepted by the Member States of the European Union in the approval process of plant protection products. We conduct outdoor (field) and indoor (green house) tests. Field tests are carrying out in our own farm which covers around one hectare of surface area. Biofarm also relies on the collaboration of many selected and qualified third-party companies. In this regard, it has signed an agreement with a trial laboratory for residues testing and chemical analysis.

Via Giustiniani 5 35128 Padova, ItalyThe ""Neuromuscular Tissue Bank"" (NMTB) at the Regional Neuromuscular Center of the University of Padova was started in 1978. Cases of genetic and acquired muscle diseases have been collected from the linked clinical units and from many other Neurological and Pediatric Centres throughout Italy.

Seconda Università di Napoli - Napoli

Via Roberto Lepetit, 34 21040 Gerenzano (VA) ItalyAreta International offers process development, batch manufacturing, consulting, filling, and cell-based tests.

Via G. Fantoli, 16/15 20138 Milano, ItalyKtedoGen provides microbial strains for compound and catalyst discovery.

Via Monte Morone snc, 21046 Malnate, (VA), ItalyKtedoGen provides microbial strains for compound and catalyst discovery.

Milan, Lombardy ItalyKtedoGen provides microbial strains for compound and catalyst discovery.

Via da Erba Edoari, 29 - 43123 Parma - ItalyGEA Niro Soavi offers homogenization technical and product testing services.

Parma, Emilia-Romagna ItalyGEA Niro Soavi offers homogenization technical and product testing services.

via dei Lavoratori, 54 20092 Cinisello Balsamo (MI) - ItalyChemi offers manufacture of APIs, cytotoxics, peptide, phospholipids and nutraceuticals.

Via Gaudenzio Fantoli 16/15NeED Pharmaceuticals supports discovery research and antimicrobial discovery by providing MIC/MBC, microbial quantitation, and resistance development services.

Milan, Lombardy ItalyNeED Pharmaceuticals supports discovery research and antimicrobial discovery by providing MIC/MBC, microbial quantitation, and resistance development services.

Via Torino, 107 IT30172 – Mestre Venezia ItalyEXPLORA S.r.l. is a privately owned Italian company established in 2006 at the Technological Park “Tecnopolo Tiburtino” in Rome by a pool of young researchers and the support of a French seed capital organization INVENT SaS. EXPLORA is committed to the development of enabling technologies for biological engineering Vision Biology is going through a radical paradigm shift over the last decade evolving from a qualitative/descriptive science to quantitative/engineering one. It’s now possible to “(a) design and construct new biological parts, devices and systems and (b) re-design existing, natural biological systems for useful purposes” in a rational and systematic way. This forward biological engineering approach may be applied at all levels of the hierarchy of biological structures: from individual molecules to whole cells, tissues, organisms and populations. This approach, also known as synthetic or constructive biology, has already revolutionized technology and production paradigms fostering the development of innovative medicines, redesign environmental friendly chemical processes and generate new sources of energy. Mission Our mission is to develop innovative enabling technologies to unlock the full potential of forward biological engineering. Our ultimate goal is to develop a comprehensive and coherent bio-engineering platform to allow scientist to pursue their ambitious goals. Strategy Our strategy is built around the following words: research-develop-deliver. Since inception we have been constantly investing in R&D to develop next generation technology through tailored partnerships. We are currently involved in several research projects and we constantly seek scientific partnerships to broaden and strengthen our expertise.

Via G. Peroni, 386 Loc. Tecnopolo Tiburtino 00131 – Roma ItalyEXPLORA S.r.l. is a privately owned Italian company established in 2006 at the Technological Park “Tecnopolo Tiburtino” in Rome by a pool of young researchers and the support of a French seed capital organization INVENT SaS. EXPLORA is committed to the development of enabling technologies for biological engineering Vision Biology is going through a radical paradigm shift over the last decade evolving from a qualitative/descriptive science to quantitative/engineering one. It’s now possible to “(a) design and construct new biological parts, devices and systems and (b) re-design existing, natural biological systems for useful purposes” in a rational and systematic way. This forward biological engineering approach may be applied at all levels of the hierarchy of biological structures: from individual molecules to whole cells, tissues, organisms and populations. This approach, also known as synthetic or constructive biology, has already revolutionized technology and production paradigms fostering the development of innovative medicines, redesign environmental friendly chemical processes and generate new sources of energy. Mission Our mission is to develop innovative enabling technologies to unlock the full potential of forward biological engineering. Our ultimate goal is to develop a comprehensive and coherent bio-engineering platform to allow scientist to pursue their ambitious goals. Strategy Our strategy is built around the following words: research-develop-deliver. Since inception we have been constantly investing in R&D to develop next generation technology through tailored partnerships. We are currently involved in several research projects and we constantly seek scientific partnerships to broaden and strengthen our expertise.

Via G. Peroni, 386 Loc. Tecnopolo Tiburtino Roma, 00131 ItalyEXPLORA S.r.l. is a privately owned Italian company established in 2006 at the Technological Park “Tecnopolo Tiburtino” in Rome by a pool of young researchers and the support of a French seed capital organization INVENT SaS. EXPLORA is committed to the development of enabling technologies for biological engineering Vision Biology is going through a radical paradigm shift over the last decade evolving from a qualitative/descriptive science to quantitative/engineering one. It’s now possible to “(a) design and construct new biological parts, devices and systems and (b) re-design existing, natural biological systems for useful purposes” in a rational and systematic way. This forward biological engineering approach may be applied at all levels of the hierarchy of biological structures: from individual molecules to whole cells, tissues, organisms and populations. This approach, also known as synthetic or constructive biology, has already revolutionized technology and production paradigms fostering the development of innovative medicines, redesign environmental friendly chemical processes and generate new sources of energy. Mission Our mission is to develop innovative enabling technologies to unlock the full potential of forward biological engineering. Our ultimate goal is to develop a comprehensive and coherent bio-engineering platform to allow scientist to pursue their ambitious goals. Strategy Our strategy is built around the following words: research-develop-deliver. Since inception we have been constantly investing in R&D to develop next generation technology through tailored partnerships. We are currently involved in several research projects and we constantly seek scientific partnerships to broaden and strengthen our expertise.

Via Volta 6, 16128 Genova, ItalyThe Galliera Genetic Bank (GGB) of the Human Genetic Laboratory at Galliera Hospital in Genoa has started in 1983. Several cases of human genetic diseases have been collected from the linked laboratory and from many other centres throughout Italy. To date in the bank are stored: IL-2 activated lymphocytes, EBV transformed B cell lines, parted lymphocytes, fibroblast cell cultures, amniotic fluid cell lines, trophoblast cells, chorionic villi, tissue samples and DNAs of subjects affected by different genetic diseases. Data on each subjects are collected in a database with information referring to code number, personal data, clinical history diagnostic status and sending institution. The appropriate consent is obtained from patients or their parents and personal details remain confidential. The Galliera Genetic Bank is supported by Telethon Italian Foundation.

9/6 Via Tommaso da Cazzaniga Milano, Lombardia, 20121 ItalyUnlocking Excellence in Clinical Research Worldwide with Aesculape CRO Aesculape CRO, headquartered in the vibrant heart of Singapore and with strategic offices spanning Belgium, Malaysia, Thailand, Philippines, and Italy, is your passport to precision in clinical research management on a global scale. As a global Clinical Research Organisation (CRO), we specialize in delivering unparalleled quality and comprehensive services spanning the entire clinical trial spectrum, from Phase I to IV. At Aesculape CRO, we boast a COMMITTED team of experts with formidable scientific and medical backgrounds and who seamlessly cover all facets of clinical research, including meticulous clinical operations encompassing site selection, regulatory submissions, and clinical monitoring. But our commitment to your success doesn't stop there. We harness our EXPERTISE in medical writing, pharmacovigilance, and marketing authorization to ensure your trials achieve their full potential. Aesculape CRO stands as your guiding light, embodying knowledge, expertise, robust infrastructure, and unmatched capacity. We are your ALLY, dedicatedly delivering the PRECISE services you need, unwavering in our pursuit of unwavering quality and execution. We offer a TAILORED APPROACH that accelerates the pace of clinical trials, and delivering exceptional, client-centric service. Choose Aesculape CRO, where EXCELLENCE MEETS COMMITMENT and where YOUR SUCCESS IS OUR DESTINATION.

Via Chiesa Sud 156/F 41016 Rovereto s/S, Novi di Modena (MO)*, ItalyLameplast studies, designs and produces primary containers. Manufactures health, beauty, pharma and medical devices as well as produces filling and sealing machines.

2 Corso Valdocco Torino, Piemonte, 10122 ItalyWe, León Research, are a Spanish CRO, providing outsourcing services all over Europe for the Pharma Industry, Biotech companies, Medical Devices Manufacturers, Food Industry and other CROs, with a wide experience on clinical research, developing Phase I to IV clinical trials, medical devices, observational and food studies. As a full service Contract Research Organization, our solutions include all the activities from design, setting up and monitoring of clinical trials and research studies, up to the management of data, statistical analysis and medical writing, covering the whole process to introduce new medical devices and pharmacy products on the market. In Leon research, we promote intelligence and creativity as the two key factors on scientist research and we also believe that quality, in the framework of the GCP/ICH, as well as flexibility to adapt our services, are what warranties the success. We know better how to manage global studies, because by conducting local clinical trials, we can offer a better local knowledge which accelerates and facilitates the final result.

Rome, Lazio ItalyGenechron offers DNA sequencing, next generation sequencing, custom primer synthesis, metabonomic profiling, and bioinformatics services.

Via Decembrio 28Promega Tailored R&D solutions offers comprehensive solution to client drug discovery needs. https://www.promega.com/custom-solutions/tailored-solutions/ Currently we are offering our data only, compound profiling services through the platform. Our kinase selectivity profiling services use NanoBRET™ Target Engagement Intracellular Kinase Assays to test your supplied compounds. It includes a diverse panel of 192 or 240 full-length kinases. https://www.promega.com/custom-solutions/tailored-solutions/kinase-profiling-services/ Our Targeted Protein Degradation Services include; compound degradation profiling, permeability and affinity services, ternary complex formation assays, and Neosubstrate degradation panel. https://www.promega.com/applications/small-molecule-drug-discovery/protein-degradation-drug-discovery/targeted-protein-degradation-services/

Parco Area delle Scienze Tecnopolo Padiglione 33 Parma, Parma, 43124 ItalyNext to our core competence, the development of new research models and assays, we offer research services, products and instruments. Our different research activities have a synergistic influence on our work. From molecular biology to stainless steel constructions, we put things together to fulfill complex research projects. preclinics’ headquarter is located in Potsdam, Germany, where the administration is located. The basic and preclinical research for human medicine is located in the Potsdam facility. There we have a modern BSL2 laboratory, where we are able to work with human blood and GMO. In our in vivo laboratory we have our imaging devices (x-ray + bioluminescence) and the Revolyzer unit for non-invasive examination. The experimental unit is equipped with devices for measuring physiological parameters (blood pressure, EMG, EKG grip strength etc.) and for anaesthesia and microsurgery. This is supported from the molecular biology lab with a cell culture cabinet equipped with flow cytometry and a bioanalytic unit for ELISA assays and PCR. As well we have our construction site for the research instruments in Potsdam. In the center of Lower Saxony our preclinics research farm is resident. Here we breed New World camelids (llamas and alpacas), Merino sheep and the preclinics black belly sheep. Next to the breeding species other species like goats, rabbits, turkey and chickens are housed for immunization and production of fresh biological products. A special feature of this facility is the immunization of camelids such as llamas and alpacas for the production of heavy chain antibody fragments VHH. At the Behring Campus Eystrup, the former Behringinstitute Eystrup, our veterinary research is located. There we have the facilities to house farm animals for veterinary projects. As well a part of the preclinics research farm is located on the 36000 sqm area. If you want to know more about the Behring Campus Eystrup please follow this link to get the BCE-Homepage: www.behringcampus.org We also possess an Italian facility, highly specialized in VHH/nanobody selection and modification. In addition to being our bacterial/yeast production hub, an entire Phage Display lab has been set up to support our customers in their VHH projects. Besides selecting the best VHH candidates after immunization we are able to modify them for your research purposes conjugating them to Fc regions, reporter enzymes and fluorescent proteins. www.preclinics.com/it

Parco Area delle Scienze 23/a Parma, 43124 ItalyNext to our core competence, the development of new research models and assays, we offer research services, products and instruments. Our different research activities have a synergistic influence on our work. From molecular biology to stainless steel constructions, we put things together to fulfill complex research projects. preclinics’ headquarter is located in Potsdam, Germany, where the administration is located. The basic and preclinical research for human medicine is located in the Potsdam facility. There we have a modern BSL2 laboratory, where we are able to work with human blood and GMO. In our in vivo laboratory we have our imaging devices (x-ray + bioluminescence) and the Revolyzer unit for non-invasive examination. The experimental unit is equipped with devices for measuring physiological parameters (blood pressure, EMG, EKG grip strength etc.) and for anaesthesia and microsurgery. This is supported from the molecular biology lab with a cell culture cabinet equipped with flow cytometry and a bioanalytic unit for ELISA assays and PCR. As well we have our construction site for the research instruments in Potsdam. In the center of Lower Saxony our preclinics research farm is resident. Here we breed New World camelids (llamas and alpacas), Merino sheep and the preclinics black belly sheep. Next to the breeding species other species like goats, rabbits, turkey and chickens are housed for immunization and production of fresh biological products. A special feature of this facility is the immunization of camelids such as llamas and alpacas for the production of heavy chain antibody fragments VHH. At the Behring Campus Eystrup, the former Behringinstitute Eystrup, our veterinary research is located. There we have the facilities to house farm animals for veterinary projects. As well a part of the preclinics research farm is located on the 36000 sqm area. If you want to know more about the Behring Campus Eystrup please follow this link to get the BCE-Homepage: www.behringcampus.org We also possess an Italian facility, highly specialized in VHH/nanobody selection and modification. In addition to being our bacterial/yeast production hub, an entire Phage Display lab has been set up to support our customers in their VHH projects. Besides selecting the best VHH candidates after immunization we are able to modify them for your research purposes conjugating them to Fc regions, reporter enzymes and fluorescent proteins. www.preclinics.com/it

Strada Crescentino 13040 Saluggia (Vc) ItalyGIPHARAMA manufactures injectables, freeze dried products and specializes in radiopharmaceutical products.

Via Giovanni Paolo II, 132 Fisciano, 84084 Italy

Via Epifanio Ferdinando, 41 Mesagne, Brindisi, 72023 ItalyOur mission is to support our clients during drug development, helping them to reduce batch failure, avoiding costly crystallisation issues and overall offering greater confidence in drug quality during manufacturing. We can support you from early-phase drug discovery to kilogram supply. We are a high performing cohesive team of trained chemists and analysts, with more than 10 years of experience in the development and optimization of APIs crystallization. We care about results and innovation based on sound science and the use of modern technologies.

Via F.S. Fabri, 127/1 – 40059 – Medicina, Bologna, ItalyOur mission is to support our clients during drug development, helping them to reduce batch failure, avoiding costly crystallisation issues and overall offering greater confidence in drug quality during manufacturing. We can support you from early-phase drug discovery to kilogram supply. We are a high performing cohesive team of trained chemists and analysts, with more than 10 years of experience in the development and optimization of APIs crystallization. We care about results and innovation based on sound science and the use of modern technologies.

Via F. S. Fabri, 127/1 Mendicina, BO, 40059 ItalyOur mission is to support our clients during drug development, helping them to reduce batch failure, avoiding costly crystallisation issues and overall offering greater confidence in drug quality during manufacturing. We can support you from early-phase drug discovery to kilogram supply. We are a high performing cohesive team of trained chemists and analysts, with more than 10 years of experience in the development and optimization of APIs crystallization. We care about results and innovation based on sound science and the use of modern technologies.

Viale Decumano Milano, Lombardia, 20157 ItalyNeuro-Zone s.r.l. supports drug discovery programs by providing well controlled physiologically relevant primary cell models and a multiparametric cell-based assay platform in order to increase efficiency of lead optimization projects

Open Zone, Via Ariosto 21, 20091 Bresso (MI), ItalyNeuro-Zone s.r.l. supports drug discovery programs by providing well controlled physiologically relevant primary cell models and a multiparametric cell-based assay platform in order to increase efficiency of lead optimization projects

Via Ariosto 21 Bresso- MI, 20091 ItalyNeuro-Zone s.r.l. supports drug discovery programs by providing well controlled physiologically relevant primary cell models and a multiparametric cell-based assay platform in order to increase efficiency of lead optimization projects

via Toscanini, 9 40055 Villanova di Castenaso Bologna ItalyVETSPIN is a Contract Research Organization specialized in pharmaceutical studies required for Drug Registration, founded in 2004 as a spinoff of the University of Bologna, based in Ozzano Emilia (Bologna), Italy. VETSPIN performs Pharmacokinetics studies, Residue studies, Drug Methabolism studies, Biostatistics and Medical Writing, Research Expertise, Publishing. The research team of VETSPIN supplies the highest level of scientific knowledge, quality standards and regulatory competence to their customer's requests, whether for routine studies or specific complex and innovative projects. VETSPIN works in compliance with GLP guidelines and the facilities are subjected to regular GLP inspections by Italian authorities. The VETSPIN research facilities are located in Ozzano Emilia (Bologna), Italy.

Centro Nord-Sud 2E CH-6934 Bioggio-Lugano, SwitzerlandAccelerate your discovery with exceptional service and innovative, cutting-edge life science products! Founded over 35 years ago, AMSBIO is a premier life sciences supplier dedicated to meeting diverse research needs. AMSBIO’s product lines are carefully curated with top tier products to give high choice and quality control, as well as offering advanced, flexible and tailored custom services. In addition, AMSBIO’s focus on generally underserved areas, such as Glycobiology, highlights a wider mission to advancing niche fields in life science. AMSBIO is ISO9000 Certified to ensure easy partnerships, and with European, US, and UK distribution hubs, global shipping and no minimum order quantities, AMSBIO is committed to making products accessible to researchers worldwide. AMSBIO’s Key Areas: - Biorepository: AMSBIO’s one stop shop for tissues and biospecimens. - Stem Cells: Source, grow, store, differentiate and manufacture stem cells using AMSBIO products from research through to clinical applications. - 3D Cell Culture: Aiding in the creation of cultures that are relevant, robust and reproducible. - Kits and Assays: Extensive range of ready-to-use and custom kits for drug discovery and biomedical research. - Custom Services: Bespoke solutions to meet life science research requirements, especially around viral delivery, aptamers, antibodies, protein expression, CAR-T development, magnetic beads, cryopreservation media, and tissue procurement. - Glycobiology: Specialized products and expertise in glycobiology research, vital for cellular biology and drug discovery. For more information, visit AMSBIO’s website, talk to one of the product team on the online live chat function, talk via email on info@amsbio.com, or follow AMSBIO on LinkedIn.

Via Guiseppe Marcora, 7 20121 Milano ItalyOUR MISSION We are committed to diffuse knowledge to improve quality of life through creativity and integrity. OUR VALUES Being our customers' trusted partner is our reward for innovation and our stimulus for personal fulfilment. THE COMPANY Headquartered in the financial city centre of Milan, CISME, founded in 1987 has grown to become a reliable partner in the research & development, production, and supply of chemicals for the paint & glue, detergency, cosmetic, textile, and drilling industries. CISME implements and maintains a Quality Management System which fulfils the requirements of ISO 9001:2008

Via Guiseppe Marcora, 7 Milano, 20121 ItalyOUR MISSION We are committed to diffuse knowledge to improve quality of life through creativity and integrity. OUR VALUES Being our customers' trusted partner is our reward for innovation and our stimulus for personal fulfilment. THE COMPANY Headquartered in the financial city centre of Milan, CISME, founded in 1987 has grown to become a reliable partner in the research & development, production, and supply of chemicals for the paint & glue, detergency, cosmetic, textile, and drilling industries. CISME implements and maintains a Quality Management System which fulfils the requirements of ISO 9001:2008

Canton Moretti, 29 Località San Bernardo Ivrea, TO 10090 ItalyABC Farmaceutici is committed to research, development, manufacturing and commercialization of pharmaceutical products and active ingredients.

Via Pian Scairolo 6, CH-6917 Barbengo (Lugano), SwitzerlandCerbios offers high potency APIs, recombinant proteins, and manufacturing services.

VIA DELLA PACE, 25/A 41030 S. PROSPERO S/S (MODENA) ItalyLamp San Prospero manufactures and packages pharmaceuticals.

Zona Industriale della Botte 4 Fornacette, PI 56012 ItalyArkè Organics offers custom synthesis and API products.

Rome, Lazio ItalyOkairos develops genetic vaccines and GMP manufacturing services.

Via Tito Speri, 12/14 Pomezia, 00071 ItalyERBC Group is a leading CRO committed to bridge the gap between discovery, preclinical and clinical development by evaluating the efficacy and safety of new compounds including new therapies, drugs, medical devices, chemicals, agro-chemicals and cosmetics. Offering a comprehensive range of innovative models and services, regulatory pre-IND package and consultancy services, ERBC Group allows biopharmaceutical and chemical industry professionals to de-risk innovation and enhance R&D productivity.

2 Via Reno Poggibonsi, Toscana, 53036 ItalyEurofins Biolab provides laboratory testing services and research services to the bio-pharmaceutical and the medical device industries. We are located in Milan, Italy in a single 9.000 square meters facility where the company employees more than 250 people, most of which have an high study degree in chemistry or biology or toxicology. The company was founded in 1971 and is the Italian leader in testing of pharmaceutical finished products. The facility is GMP accredited by the Italian drug agency AIFA, GLP certified by Italian Minister of Health, and EN ISO/IEC 17025 accredited for several tests. The facility has been audited several times by FDA (FDA Facility Establishment Identifier: 3002806530). Complete list of accreditation and downloadable copies of certificates are available at the following webpage: http://www.eurofins.it/servizi/pharma/accreditamenti/accreditations.aspx Eurofins Biolab is fully part of Eurofins Scientific group. With over 35.000 staff in more than 400 laboratories across 44 countries, Eurofins Scientific is the world leader in pharmaceutical products testing. It is also number one in the world in the field of food and environmental laboratory services and one of the global market leaders in agroscience, genomics and central laboratory services.

25 Via Fratta Fratta, Veneto, 31023 ItalyChelab Silliker has more than 30 years of proven experience in analytical services in chemistry, biology and microbiology for food, environmental, pharmaceutical and consumer goods. In addition we offer a wide range of complimentary services that you can trust with confidence: contract research, auditing, consulting service thanks to the know-how, highly experienced and skilled staff and state-of-the- art equipment.

Via Quaranta, 12 20141 Milano ItalyMipharm develops and manufactures new products dedicated to the pharmaceutical industry.

V.le Milano, 86/88- 26900 Lodi, ItalyEuticals offers manufacturing of active pharmaceutical ingredients and also is a leading role in the custom synthesis field.

Adriano Buzzati-Traverso Campus, Via Ramarini 32 00015 Monterotondo, ItalyOur research is focused on the study of critical mammalian physiological phenomena from a molecular perspective in the context of the whole organism. The Unit is composed of independent research groups whose work is bound together by the study of the mouse in vivo as the principle experimental organism and the application of state-of-the-art methods for genetic and epigenetic perturbation of cellular and physiological function. Recent advances in gene delivery and modification technology have dramatically increased the ease and rapidity with which genetic and epigenetic perturbations can be introduced into the mouse genome allowing increasingly sophisticated causal experimental approaches in this organism. Currently research groups at EMBL Monterotondo are investigating the epigenetic control of early development, blood cell development and differentiation, neural circuits and behavior, neural computation, and somatosensation. A major and continuing effort is underway to increasingly centre research activities at the Unit around neurobiology and epigenetics.

Fondazione IRCCS Cà Grande Ospedale Maggiore Policlinico - MilanoThe ” Biobank of skeletal muscle , peripheral nerve , DNA and cell culture ” is part of the UOD and Rare Neuromuscular Diseases and was set up with the aim of collecting and storing biological samples , making them available for research purposes and for possible both for diagnostic purposes when new scientific knowledge allow a nosographic that at the time of storage was not possible . Since 1999 is partly funded by the Telethon Foundation ( Project GTB12001 From 2013 for a period of 5 years – Telethon Network of Genetic Biobanks

Via Don E. servadei, 16 - 47100 FORLI' - ITALYChemifarma specializes in the veterinary industry as well as pharmaceuticals.

ABLE Biosciences Bioindustry Park Silvano Fumero S.p.A. - Bi.P.Ca S.p.A. Via Ribes, 5 10010 Colleretto Giacosa (TO) - ITALYABLE Biosciences is a trademark of Bioindustry Park Silvano Fumero S.p.A. which offers quantitative and qualitative analysis of small molecules, peptides, proteins, including protein biomarkers.

Via Pontina km 30.600, c/o IRBM Science Park Pomezia, Rome, 00071 ItalyAdvaxia Biologics (formerly Advent), part of the IRBM group, is a cGMP Contract Development & Manufacturing Organisation (CDMO), located near Rome (Pomezia) Italy, compliant with the regulatory guidelines of the EMA, MHRA and FDA. Advaxia?s integrated contract services portfolio includes outstanding support in the areas of analytical method development, process development/validation, in-process assay development & qualification, GMP Manufacture, full QC product release, ICH Stability and cell banking. Advaxia is dedicated to the development and production of clinical lots of recombinant adenoviruses to support clinical trials for vaccine and gene therapy applications. The Advaxia team has built an outstanding track record in the production of clinical lots for many infectious diseases, including Ebola, HIV and supported the global effort to expedite delivery of a COVID-19 vaccine.

CLC bio Italy Arcugnano, Vicenza Italy 36057 ItalyCLC Bio provides bioinformatics and sequencing services.

Via Brisa 3 Milan, Milan, 20123 ItalyEvidilya is an innovative global Contract Research Organization (CRO) that specializes in conducting clinical and Real-World Evidence (RWE) studies for the pharmaceutical, consumer healthcare (CHC), medical devices, and food & nutrition industries. Evidilya stands out for its digital approach and technological solutions for Decentralized Clinical Trials (DCTs) and Virtual studies. Evidilya's digital approach involves leveraging cutting-edge technologies to streamline and enhance the conduction of studies offering a platform and e-solutions designed to optimize the entire process, from patient recruitment and engagement to data collection and analysis. This digital infrastructure enhances the efficiency and flexibility of clinical and RWE studies, ultimately leading to more robust and insightful results. Our full-service CRO solutions (Project Management, Start up and Feasibility, Regulatory, Biometrics, Digital&Tech, Monitoring, Med Affairs and Medical Writing) are enriched with Exclusive health tech solutions and excellence services to manage the entire process of Hybrid and de-centralized studies around the globe.

17 Via Fossato di Mortara, Ferrara, Emilia-Romagna 44121, ITThe aim of the Center for Translational Neurophysiology of Speech and Communication CTNSC@UniFe is twofold. On one side we are studying how the brain builds communicative and linguistic representations. On the other side we are designing new brain interfaces, specifically conceived for human use, to record and computationally decode neural signals. A particular focus of the Center is on communication because we believe that many paralyzing pathologies require, at first, the restoring of an efficient communicative flow between the patient and the environment. To this purpose we are studying the way by which the brain processes and understands the communicative behaviors of other individuals in order to efficiently decode the brain signals related to communicative intentions, we are applying innovative and possibly biologically-compatible technologies to the problem of automatic speech and action recognition (Speech and Communication Team) and we are designing a new generation of brain electrodes characterized by reduced invasiveness, improved resolution and sensitivity (Neural Interfaces Team). In summary, with a critical focus on translational methodologies (single unit recordings, Micro-ECoG, fMRI, EEG, TMS), our research goal is to advance knowledge on brain functioning to help building the next generation of brain-computer interfaces. The group research activities span from basic research to applied one along three main research lines: Design of long-term and stable neural-tissue interfaces Research on brain centers and circuits involved in action/speech understanding Research on new efficient methods for automatic speech recognition Collaborations with other National and international labs are fundamental. A particularly intense collaboration is running between CTNSC@UniFe and the Neurosurgery Unit of Udine Hospital (M. Skrap).

via Provinciale Schito 131 Torre Annunziata, Naples, 80058 ItalyAxxam is leading provider of integrated services in early drug discovery across the entire Life Science industries: Pharmaceutical, Crop protection, Animal health, Cosmetics and Nutrition. Our work to identify bioactive molecules with the desired pharmacological activity, such as the modulation of a target or a cellular pathway, is fundamental to pave the way toward the development of new drug compounds. Service overview: - Assay development (biochemical or cell-based, including molecular interactions & PROTAC) and phenotypic assays for compound testing activities and HTS. - Ready for use assays (functional & phenotypic) for compound testing activities and HTS. - High Throughput Screening (HTS) campaigns using client’s own compound collections or our compound collection of around 425.000 diverse small molecules (divided into 6 subsets which can be screened separately according to the project's needs). - High Content Screening (HCS) campaigns (on up to 20.000 compounds) and Phenotypic analysis: autophagy, neurite outgrowth, cell cicle, citotoxicity, mitochondrial analysis, marker localization, DNA damage, translocation, aggregation assays. - Molecular biology: gene editing, gene expression analysis, TaqMan-based screening, splice modulators and promoter activation assays. - iPSC-derived cells (neurons, cardiomyocytes, microglia cells, myotubes, hepatocytes, macrophages): calcium oscillation, aggregation assays, imaging, electrophysiology, cytokine release, citotoxicity, disease models. - Electrophysiology: manual patch clamp, automated patch clamp suitable for HTS, organellar patch clamp (lysosomes, mitochondria, nuclei), automated lysosomal patch clamp, optogenetics. - Hit validation & hit-to-lead: potency determination, mechanism of action studies, cardiac safety, specificity, selectivity, ortholog and orthogonal assays, among others. - Biophysical tools: affinity measurement, Kd determination, spectral shift, molecular interactions, microscale thermophoresis. - Analytical chemistry: LC-MS analysis, in vitro ADME (plasma permeability assay; plasma protein binding; microsomal stability assay); physico-chemical properties (solubility; lipophilicity; chemical stability). - Medicinal Chemistry and computational chemistry (analog synthesis; SAR analysis; IP positioning analysis; database maintenance; etc.). - Compound management: external libraries reformatting & storage. - AXXSense platform (https://axxsense.com/): specialized in the generation and development of novel, natural and synthetic flavour and fragrance compounds for the food and beverage, pet food, animal health, cosmetic and perfume industry. Taste and olfactory receptors, natural product library, aging platform.

70 Via Giovanni Pascoli, Milano, Lombardia 20133, ITThe Center for Nano Science and Technology (CNST) is one node of the network established by the Istituto Italiano di Tecnologia with Italian academies in order to foster synergy in the national research. The mission of the center is "innovation", therefore the goal of the CNST scientific team is to transfer new basic knowledge into new applications. CNST has a focus on material science, and it is able to conduct the complete production line, from conceiving and realizing a new material to its application in devices (solar cells, transistor and LEDs), through a comprehensive characterization. The areas of competence are Material Chemistry, Molecular Electronics, Printed Electronics, Nanotechnology Fabrication and Optical-Photophysical-Morphological and Theoretical Characterization.

Via Pascoli, 70/3 Milano, 20133 ItalyThe Center for Nano Science and Technology (CNST) is one node of the network established by the Istituto Italiano di Tecnologia with Italian academies in order to foster synergy in the national research. The mission of the center is "innovation", therefore the goal of the CNST scientific team is to transfer new basic knowledge into new applications. CNST has a focus on material science, and it is able to conduct the complete production line, from conceiving and realizing a new material to its application in devices (solar cells, transistor and LEDs), through a comprehensive characterization. The areas of competence are Material Chemistry, Molecular Electronics, Printed Electronics, Nanotechnology Fabrication and Optical-Photophysical-Morphological and Theoretical Characterization.

Strada Rivoltana km 6/7 Rodano, Milan, 20053 ItalyGlobal leader in the development and production of active pharmaceutical ingredients (APIs) for CDMO and generic markets, integrating chemical synthesis and biological processes while always embracing the highest international safety, quality, and environmental standards.

Via Provina 2 38123 Ravina di Trento (TN) - ItalyE-Pharma offers specialization and experience in developing, formulating and manufacturing effervescent and soluble formulations.

via A. Fleming, 4 Campus Levi Montalcini Verona, 37135 ItalyEvotec is a global leader in drug discovery and development, offering extensive CRO and CDMO services across all stages of the R&D continuum, from target identification to the clinic, delivering efficient, high-quality, and cost-effective solutions. We integrate deep disease understanding, a multimodality approach, advanced technologies and tailored solutions to enhance the probability of success. Our innovative and flexible approach supports collaboration through standalone CRO/CDMO services, integrated drug discovery and development programs, or strategic partnerships, regardless of your stage in the discovery-development journey. Expertise in Modalities and Therapeutic Areas Our broad capabilities cover small molecules, antibodies, antibody drug conjugates, oligonucleotides, peptides, cell therapy, RNA-targeted therapies and other advanced modalities. With particular strength in pharmacology, toxicology, and preclinical formulation, we help de-risk development and optimize the selection of therapeutic candidates. Our consultative approach ensures partners benefit from our deep expertise in complex disease areas, enabling better outcomes from early discovery to clinical development. Innovative R&D Platforms Our AI-powered proprietary R&D platforms, including PanOmics and iPSC technologies, integrate advanced analytics and automation to enhance disease understanding and ensure human relevance. By leveraging continuous manufacturing and high-throughput platforms, we provide faster, more reliable access to high-quality drug candidates, reducing time to clinic and enabling data-driven decision-making. Global Presence and Flexibility Evotec operates globally with an expansive R&D infrastructure, allowing us to offer flexibility in partnering models and scalability in operations. Our state-of-the-art facilities and diverse scientific team of over 4,000 experts are equipped to handle the most complex challenges across therapeutic areas and modalities, including biologics, small molecules, and cell therapies. Driving Impact through Science In an era of rapid innovation, Evotec’s fully integrated drug development solutions position us as a trusted partner for organizations aiming to accelerate their R&D pipelines. Our commitment to scientific excellence, operational flexibility, and deep therapeutic expertise enables us to deliver the highest quality outcomes—from concept to clinical development and beyond. Together, we are creating medicines that matter.

Via Ardeatina, 306 – 00179 Rome ItalyPreclinical Research and Translational Sciences The Santa Lucia Foundation conducts research in the field of neuroscience. This research is preclinical and translational, meaning designed to result in a rapid implementation of its findings to actual patient care. The research activity is a core element of Santa Lucia’s Mission. Since1992, the Ministry of Health has recognized the Foundation as a fully qualified Institute for Research and Health Care (IRCCS). The activity of individual laboratories is coordinated within six research lines. Laboratories and Scientific Productivity Fifty laboratories are involved in the entire research area of activity of the Foundation. Regarding the scientific productivity, which is calculated by means of the international standard of Impact Factor, Santa Lucia Foundation is ranked number one in Italy in the Neurosciences field (Source: Italian Department of Health). Specifically, the current normalized Impact Factor of scientific production of the Foundation is 2,112.50 scores (2014). CERC The laboratories of the Foundation are both housed within the hospital and its wards, and also at the European Centre for Brain Research (Centro Europeo di Ricerca sul Cervello – CERC), a short distance from the campus of the Foundation. The CERC research activities and collaborations serve to highlight the institutions commitment to providing scientists with the resources, spaces and technologies appropriate to the research mission and objectives. The facility has been made possible to realize important synergies with research centers and universities both in Italy and internationally. Particularly important are the partnerships with Sapienza University of Rome, Tor Vergata University of Rome and Campus Bio-Medico University.

Via Ardeatina, 306 – Rome, 00179 ItalyPreclinical Research and Translational Sciences The Santa Lucia Foundation conducts research in the field of neuroscience. This research is preclinical and translational, meaning designed to result in a rapid implementation of its findings to actual patient care. The research activity is a core element of Santa Lucia’s Mission. Since1992, the Ministry of Health has recognized the Foundation as a fully qualified Institute for Research and Health Care (IRCCS). The activity of individual laboratories is coordinated within six research lines. Laboratories and Scientific Productivity Fifty laboratories are involved in the entire research area of activity of the Foundation. Regarding the scientific productivity, which is calculated by means of the international standard of Impact Factor, Santa Lucia Foundation is ranked number one in Italy in the Neurosciences field (Source: Italian Department of Health). Specifically, the current normalized Impact Factor of scientific production of the Foundation is 2,112.50 scores (2014). CERC The laboratories of the Foundation are both housed within the hospital and its wards, and also at the European Centre for Brain Research (Centro Europeo di Ricerca sul Cervello – CERC), a short distance from the campus of the Foundation. The CERC research activities and collaborations serve to highlight the institutions commitment to providing scientists with the resources, spaces and technologies appropriate to the research mission and objectives. The facility has been made possible to realize important synergies with research centers and universities both in Italy and internationally. Particularly important are the partnerships with Sapienza University of Rome, Tor Vergata University of Rome and Campus Bio-Medico University.

Via Ponte della Fabbrica 3/A 35031 Abano Terme (PD) - ItalyFidia Farmaceutici is a pharmaceutical company that focuses on osteoarticular disorders, tissue repair and genrics.

73 Via Lago Dei Tartari Albuccione, Lazio, 00012 ItalyFarm srl was established from the union of pre-existing companies (FARM sas) and independent professionals whose activity takes off in 1985. Farm srl grows on average 15% per year and invests about 20% of its turnover in new structures, equipments and training. The staff is hired in full with permanent contracts and includes graduates in chemistry, industrial chemistry, environmental engineering, biomedical engineering, chemical engineering, biology and agronomy. The company is divided into the following departments: LAB-01 Water; LAB 02 Emissions and Working/Living Environments; LAB 03 Foods; LAB 04 Wastes and Soils; LAB 05 Raw materials and Fine products for Pharmaceutical, Chemical, Cosmetic and other companies; Engineering and Technical assistance. The laboratory is divided into the following activities: Basic Chemistry, Inorganic Chemistry 1 (Metals, Elementary Analysis), Inorganic Chemistry 2 (Anions, Hydrocarbons), Organic Chemistry, Microbiological and Physical. The instrumentation is at the forefront, and always renewed. Sample registration, their processing, certification and archiving are automated and managed by a specific software. Customers are able to consult and export their own analytical results by means a virtual platform. Beside the analytical controls Farm srl ensures qualified technical assistance directly in the field owing to its Engineering and Technical assistance departments.

Amelia, Umbria, 05022 ItalyFarm srl was established from the union of pre-existing companies (FARM sas) and independent professionals whose activity takes off in 1985. Farm srl grows on average 15% per year and invests about 20% of its turnover in new structures, equipments and training. The staff is hired in full with permanent contracts and includes graduates in chemistry, industrial chemistry, environmental engineering, biomedical engineering, chemical engineering, biology and agronomy. The company is divided into the following departments: LAB-01 Water; LAB 02 Emissions and Working/Living Environments; LAB 03 Foods; LAB 04 Wastes and Soils; LAB 05 Raw materials and Fine products for Pharmaceutical, Chemical, Cosmetic and other companies; Engineering and Technical assistance. The laboratory is divided into the following activities: Basic Chemistry, Inorganic Chemistry 1 (Metals, Elementary Analysis), Inorganic Chemistry 2 (Anions, Hydrocarbons), Organic Chemistry, Microbiological and Physical. The instrumentation is at the forefront, and always renewed. Sample registration, their processing, certification and archiving are automated and managed by a specific software. Customers are able to consult and export their own analytical results by means a virtual platform. Beside the analytical controls Farm srl ensures qualified technical assistance directly in the field owing to its Engineering and Technical assistance departments.

Via Pian Scairolo, 11 6915 Lugano, SwitzerlandFLARER offers independent marketing and sales organization as well as pre-formulation / formulation studies, development and validation.

Via G.B. Oliva 8, 56121, Pisa, ItalyFarmigea provides research, production, promotion and distribution of pharmaceutical products.

Via Sile 6/2 Roncade, 31056 ItalyAt Officinae Bio we're developing a platform to support the future of biologically designed therapeutics. By developing breakthroughs in AI-enabled methodologies for nucleic manufacture we’re supporting pioneering research in Gene-modified Cell therapy, Gene therapy and RNA therapeutic research. How can you work with us? DNA Platform An automated platform for streamlined development of plasmids and libraries for viral vector and mRNA. CDS libraries Precise variant control and representation of codons for protein expressing sequences. Specify an exact combination of codons, a precise percentage of desired amino acids and reduce frameshift mutations for the best mutant integrity. Or introduce singular mutations in a user-defined region or truncate a sequence to characterize and optimize the desired protein features and function. Combinatorial Libraries A powerful tool for determining and optimizing biomolecule function from a parent sequence. Create a library of randomized, partially randomized or specifically designated mutants with multiple, different combinations of genetic elements. Precisely create codon or DNA part variants in combination to efficiently explore the vast design space. Complex construct synthesis Design DNA for functionality while we handle the construction. With DNA construct synthesis up to 50kbp and none of the complexity limits of traditional manufacture methods, you concentrate on design while we bring your creations to life. RNA Platform Our industry leading mRNA development and manufacturing solutions support rapid turnaround, advanced transcription capabilities and precision control over regulatory sequences design. In Vitro RNA Transcription Our foundry capabilities allow for in vitro RNA transcription from any DNA template to eliminate traditional constraints faced in research. Complex sequences, flexibility over capping and precise length polyA tail all delivered with high fidelity, purity, and yield allows you to explore a limitless range of research applications. UTR Libraries Explore and optimise regulatory sequences with in vitro verified DNA parts and targeted sequence variants of 3' and 5' untranslated regions. Why Choose Us? Complex design as standard Explore a near limitless sequence space with industry leading standards on GC content (15-85%), long stretches of repeating sequences and homopolymers (150bp), Work with collections Mix and match de novo synthesis of your target sequences with in vivo verified parts from our collections. Or synthesise, store and reuse your own frequently used parts. That way you can save time and budget on your projects. Precise Codon and Amino Acid representation Control precisely the codon and amino acid representation in your library to match requirements for your research. Our precision synthesis services lets you balance or bias representation as needed. Highly Diverse, Highly Complex Our precision DNA synthesis platform allows you to explore the entire sequence space, without compromise.  Library diversity up to 10^9 and capabilities to produce highly complex libraries with variants across multiple non-contiguous sequences of interest effectively multiples your discovery potential. Precise control over Poly A tails Our unique Modular Assembly Protocols allow for sequence- and length-perfect polyA tails for DNA templates, giving you unprecedented control over mRNA in vivo stability and translation efficiency. Choose from our flexible length options of Sanger-verified 40, 80, or 120bp to tailor your project to perfection.

Via Verdi 32 Venice, Italy, VE, IT-30174 ItalyAt Officinae Bio we're developing a platform to support the future of biologically designed therapeutics. By developing breakthroughs in AI-enabled methodologies for nucleic manufacture we’re supporting pioneering research in Gene-modified Cell therapy, Gene therapy and RNA therapeutic research. How can you work with us? DNA Platform An automated platform for streamlined development of plasmids and libraries for viral vector and mRNA. CDS libraries Precise variant control and representation of codons for protein expressing sequences. Specify an exact combination of codons, a precise percentage of desired amino acids and reduce frameshift mutations for the best mutant integrity. Or introduce singular mutations in a user-defined region or truncate a sequence to characterize and optimize the desired protein features and function. Combinatorial Libraries A powerful tool for determining and optimizing biomolecule function from a parent sequence. Create a library of randomized, partially randomized or specifically designated mutants with multiple, different combinations of genetic elements. Precisely create codon or DNA part variants in combination to efficiently explore the vast design space. Complex construct synthesis Design DNA for functionality while we handle the construction. With DNA construct synthesis up to 50kbp and none of the complexity limits of traditional manufacture methods, you concentrate on design while we bring your creations to life. RNA Platform Our industry leading mRNA development and manufacturing solutions support rapid turnaround, advanced transcription capabilities and precision control over regulatory sequences design. In Vitro RNA Transcription Our foundry capabilities allow for in vitro RNA transcription from any DNA template to eliminate traditional constraints faced in research. Complex sequences, flexibility over capping and precise length polyA tail all delivered with high fidelity, purity, and yield allows you to explore a limitless range of research applications. UTR Libraries Explore and optimise regulatory sequences with in vitro verified DNA parts and targeted sequence variants of 3' and 5' untranslated regions. Why Choose Us? Complex design as standard Explore a near limitless sequence space with industry leading standards on GC content (15-85%), long stretches of repeating sequences and homopolymers (150bp), Work with collections Mix and match de novo synthesis of your target sequences with in vivo verified parts from our collections. Or synthesise, store and reuse your own frequently used parts. That way you can save time and budget on your projects. Precise Codon and Amino Acid representation Control precisely the codon and amino acid representation in your library to match requirements for your research. Our precision synthesis services lets you balance or bias representation as needed. Highly Diverse, Highly Complex Our precision DNA synthesis platform allows you to explore the entire sequence space, without compromise.  Library diversity up to 10^9 and capabilities to produce highly complex libraries with variants across multiple non-contiguous sequences of interest effectively multiples your discovery potential. Precise control over Poly A tails Our unique Modular Assembly Protocols allow for sequence- and length-perfect polyA tails for DNA templates, giving you unprecedented control over mRNA in vivo stability and translation efficiency. Choose from our flexible length options of Sanger-verified 40, 80, or 120bp to tailor your project to perfection.

Via Ribes, 5 10010 Coleretto Giacosa (TO) ItalyBioMan offers feasibility studies, industrial development, and pilot processes of bacteria biomass and yeast production.

Zeni 8 Rovereto, TN ItalyBiomat supplies HTS microplates and immunoassay products and offers plate coating services.

Via Scuderlando Verona, 10 - 37135 ItalyCROMSOURCE offers clinical research services and staffing solutions.

Via Angelini,21 27028 S. Martino Siccomario (PV)We are a company providing all the services to assess security, safety, tolerability, sensory aspects, efficacy of cosmetic products (skin care, hair care, make-up, solar care, personal care), nutritional products and medical devices. Acting as a close partner to your R&D and Marketing divisions, we provide our support and expertise for the realization of your scientific projects by: • performing in-vitro, ex-vivo and in-vivo studies, • proposing standard assays and designing innovative protocols, • testing both your finished products and raw materials. With the objective of strengthening its internal procedures and internal control system, Farcoderm Srl adopted, on 25 July 2013, a new Management, Organization and Control System pursuant to Legislative Decree no. 231/2001 (so-called, Model 231/2001). This Management System, that is integrated with existing Management Systems, is an additional tool for monitoring and ensuring compliance with the requirements of legality, fairness and transparency in its relations with all stakeholders that relate to the Company.

Via Ing. Comotto 36 Caluso, To, 10071 ItalyGEM FORLAB is an R&D service provider devoted to supporting companies belonging to the life science field. GEM FORLAB is the partner of choice for companies which require to manage and solve complex problems according to regolatory requirements. Its strenght is based on scientific and technological platforms, quality system, competences, flexibility and versatility in meeting costumer's needs. A wide range of services, provided in compliance with GLP and GCP, is available to support R&D programs of NCEs, NBEs and PPP from preclinical to advanced clinical phases (I-III).

25 Via Maestri del Lavoro P.i.p. Roata Raffo, Piemonte, 12022 ItalyGEM FORLAB is an R&D service provider devoted to supporting companies belonging to the life science field. GEM FORLAB is the partner of choice for companies which require to manage and solve complex problems according to regolatory requirements. Its strenght is based on scientific and technological platforms, quality system, competences, flexibility and versatility in meeting costumer's needs. A wide range of services, provided in compliance with GLP and GCP, is available to support R&D programs of NCEs, NBEs and PPP from preclinical to advanced clinical phases (I-III).

Via Maestri del Lavoro, 25 Busca, 12022 ItalyGEM FORLAB is an R&D service provider devoted to supporting companies belonging to the life science field. GEM FORLAB is the partner of choice for companies which require to manage and solve complex problems according to regolatory requirements. Its strenght is based on scientific and technological platforms, quality system, competences, flexibility and versatility in meeting costumer's needs. A wide range of services, provided in compliance with GLP and GCP, is available to support R&D programs of NCEs, NBEs and PPP from preclinical to advanced clinical phases (I-III).

Via Vetreria, 1 22070 Grandate (CO) ItalyFarmaka provides high-quality services in the fields of pharmaceuticals, consumer health products and medical devices.

Grandate, Lombardy, 22070 ItalyFarmaka provides high-quality services in the fields of pharmaceuticals, consumer health products and medical devices.

Via Castelli Romani, 22 00040 Pomezia RM ItalySo.Se.PHARM provides discovery, development and sale of pharmaceutical products.

Piazza Umberto I, 1 70121 Bari, Italy 080 571 1111BioForDrug offers metabolic stability studies, biochemical assays, radioligand binding assays, and synthesis services.

Via Orabona 4 Bari, 70125 ItalyBioForDrug offers metabolic stability studies, biochemical assays, radioligand binding assays, and synthesis services.

C/O Innovami Via Selice 84/a Imola , BO, 40026 ItalyRemembrane leads the cell culture technology a step forward, by envisaging the cell membrane network as a fundamental and indispensable actor of most cellular processes.

Via Berlino, 39 - 24040 Verdellino (Bg) , ItalyFine Foods NTM provides products and services to the pharmaceutical, nutraceutical and food industry.

Via di Castel Romano,100 Rome, 00128 ItalyLeveraging on the long standing experience of our scientists in the Pharma sector, Takis as CRO provides high quality services in Oncology, Immunology and Infectious Diseases. Custom antibodies generation and production, protein production, animal models, drug discovery and development services are our daily activities.

Via Corfu, 71 Brescia, 25124 ItalyBioUniVet specializes in veterinary research and offers molecular biology, serology, clinical chemistry, and pathology services in application of clinical veterinary analysis.

Via A. Einstein snc 26900, Lodi (Italy)FlowMetric, Inc., is a niche contract research organization (CRO), focused on providing polychromatic flow cytometry and cell sorting services to bio-pharma and drug discovery companies. FlowMetric is committed to providing independent, unbiased, comprehensive and precise test services as part of the pre-clinical and clinical trial process for its clients. FlowMetric offers integrated, cost-effective, and specialized polychromatic flow cytometry services delivered with an uncompromising commitment to quality.

Via Einstein Lodi 26900 ItalyTransgenic Operative Products offers vector generation, PET, NMR, and optic imaging.

217 Via Cascina Secchi Isso, Lombardia, 24040 ItalyFLAMMA is a CDMO with Headquarters near Milan, Italy. As a fully integrated CDMO, we can leverage our 100% self-owned, self-managed facilities, in Italy, China and the USA to deliver a stable, reliable supply chain. We specialize in the cGMP manufacturing of: • APIs • NCEs • RSMs • Advanced intermediates (NCEs and generics). We use our expertise in high value chiral materials (specifically amino acid related materials) to provide solutions to customers who not only have need for chiral materials but also clients who have other requirements with a various type of chemistries. In addition, we also manufacture specialty compounds and advanced intermediates for the nutraceutical and cosmetic industries, and we have a variety of niche generic products. FLAMMA has four state of the art cGMP manufacturing facilities, each with its own R&D staff and labs. Italy 1. Flamma Chignolo has 120 m3 capacity 2. Flamma Isso has 130 m3 capacity 3. Flamma Bulciago has 650 m3 of capacity China 4. Flamma Honkai is located outside of Dalian, China with 200 m3 of capacity - Flamma Honkai provides the security of constant Italian management & oversight. It is like having an Italian facility in China. USA 5. Flamma USA is located in Malvern, PA outside of Philadelphia- perfect for early stage drug development in the USA - Flamma-delpia features a cGMP Pilot Plant, 5 standard cGMP kilo lab suites, 1 cGMP HPAPI kilo lab suite, 22 fume hoods, an analytical development lab as well as a QC lab, and additional space for future expansion for any necessary analytical, chemistry, and/or warehouse needs. Flamma works on both early stage pre-clinical development of small molecules (multi-kilo) as well as large-scale commercial manufacturing (MT) bringing value to those in the pharmaceutical industry. With over 700 employees and a total capacity of 1,100 m3 and the flexibility to use five different manufacturing sites and four different R&D labs, see why Flamma is the “go to” contract manufacturer of the pharma industry. Experience the FLAMMA difference today! FLAMMA- The Thinking CDMO™ http://www.flammagroup.com

Flamma Via Bedeschi 22 Chignolo d’Isola, Lombardia, 24040 ItalyFLAMMA is a CDMO with Headquarters near Milan, Italy. As a fully integrated CDMO, we can leverage our 100% self-owned, self-managed facilities, in Italy, China and the USA to deliver a stable, reliable supply chain. We specialize in the cGMP manufacturing of: • APIs • NCEs • RSMs • Advanced intermediates (NCEs and generics). We use our expertise in high value chiral materials (specifically amino acid related materials) to provide solutions to customers who not only have need for chiral materials but also clients who have other requirements with a various type of chemistries. In addition, we also manufacture specialty compounds and advanced intermediates for the nutraceutical and cosmetic industries, and we have a variety of niche generic products. FLAMMA has four state of the art cGMP manufacturing facilities, each with its own R&D staff and labs. Italy 1. Flamma Chignolo has 120 m3 capacity 2. Flamma Isso has 130 m3 capacity 3. Flamma Bulciago has 650 m3 of capacity China 4. Flamma Honkai is located outside of Dalian, China with 200 m3 of capacity - Flamma Honkai provides the security of constant Italian management & oversight. It is like having an Italian facility in China. USA 5. Flamma USA is located in Malvern, PA outside of Philadelphia- perfect for early stage drug development in the USA - Flamma-delpia features a cGMP Pilot Plant, 5 standard cGMP kilo lab suites, 1 cGMP HPAPI kilo lab suite, 22 fume hoods, an analytical development lab as well as a QC lab, and additional space for future expansion for any necessary analytical, chemistry, and/or warehouse needs. Flamma works on both early stage pre-clinical development of small molecules (multi-kilo) as well as large-scale commercial manufacturing (MT) bringing value to those in the pharmaceutical industry. With over 700 employees and a total capacity of 1,100 m3 and the flexibility to use five different manufacturing sites and four different R&D labs, see why Flamma is the “go to” contract manufacturer of the pharma industry. Experience the FLAMMA difference today! FLAMMA- The Thinking CDMO™ http://www.flammagroup.com

Via Industria 3 6963 MUZZANO Muzzano, Ticino, 6933 SwitzerlandFounded in 2013 in Muzzano (Switzerland), FEMTOprint is a pioneer and market leader in high-precision, 3D printing of custom-designed glass microdevices. The business activities focus on the Contract Manufacturing and Development of microsystems, from rapid prototyping to industrial series manufacturing at wafer-level. The groundbreaking FEMTOPRINT® microfabrication platform, based upon a two-step manufacturing process of ultrafast laser exposure and wet etching development, enable truly free-form surface/volume definition, welding, polishing, and ablative solutions in glass, creating a large variety of 3D microdevices in many different applications, such as in micro-optics, photonics, microfluidics, micromechanics, and microelectronics. With a monolithic approach to avoid challenging assembly and alignment steps, it enables the integration of optical, mechanical and microfluidic functionalities with a process resolution down to one-micron, high aspect-ratios, geometrical accuracy and surface quality. The company employs 40 highly skilled professionals and is certified ISO13485, having its manufactured products being used in over 25 countries by leading international entities and fast-paving tech companies in biotechnology, life sciences, medical, watchmaking, automotive, aerospace, semiconductors, and other domains.

35 Strada del Petriccio e Belriguardo Siena, Toscana, 53100 ItalyExosomics is a company located in Siena (Italy), founded in 2011 with the aim to leverage the EV potential for diagnostic purposes. In 2019, Exosomics acquired HansaBioMed Life Sciences a company entirely focused on the research in the field of exosomes, extracellular vesicles (EVs) and nanoparticles. With a team of more than 30 employees between its two Sites in Italy and Estonia, our group provide a wide range of high-quality services dedicated to the field of extracellular vesicles both for research and diagnostic purposes. Our services include scalable and automated purification of exosomes and extracellular vesicles from conditioned media, biofluids, plant and microbe cultures, characterization and phenotyping of bulk or single EVs. Additionally, we provide a range of customizable pre-analytical solutions able to enrich different EVs and exosomes subpopulations (e.g.: tumor-derived) from human biofluids and analyze their biomarker content. Our technology can be used for early detection of disease-associated biomarker in liquid biopsy assays and enables the next generation of disease screening, staging, profiling and monitoring tests. Amongst our range of services we employ a versatile and powerful platform - Flow NanoAnalyzer for the multiparameter analysis of individual EVs down to 40nm. Exosomics Laboratories have been appointed as Worldwide Reference Centre for the execution of services in the exosome space, employing this cutting-edge Flow Cytometry Technique.

Via Zante 14New Brunswick Scientific offers optimization, cell expertise, computer-controlled strategies, and media formulation.

Via San Gregorio, 34 Milano, 20124 ItalyBioDigitalValley is dedicated to invent, develop and commercialize new solutions and services in the bioinformatics field.

Ligornetto, SwitzerlandInstitute for PK and Analytical Studies provides clinical pharmacology, genetic analysis, ADME studies, regulatory affairs, and biochemistry.

Viale Pasteur, 10, 20014, Nerviano, Milan, ItalyNerviano Medical Sciences is an oncology-focused, integrated discovery and development company.

Milan, Lombardy ItalyNerviano Medical Sciences is an oncology-focused, integrated discovery and development company.

Via Milano 37/C - 20064 Gorgonzola (MI) , ItalyNova Argentia develops and produces branded pharmaceutical products.

Ligornetto, TI SwitzerlandInstitute for PK and Analytical Studies provides clinical pharmacology, genetic analysis, ADME studies, regulatory affairs, and biochemistry.

19 Via Antonio Canova Tortoreto Lido, Abruzzo, 64018 Italyfield trials

14 Via dell'Industria Zona Industriale, Veneto, 36045 ItalyREPROS is a company dedicated to agricultural services. Since it was founded in 1985, its core business has involved field testing on the most important crops in Northern Italy. Over the years, REPROS has broadened its range of services for farming operators, becoming an important landmark for seed and agrochemical companies, public authorities and agricultural associations. REPROS is a dynamic and flexible company: its target is to find the best possible solution for each client, offering tailored services in a short time with the utmost professionalism and expertise. The company also collaborates with Public Research Authorities as well as state universities and institutions, REPROS works with these institutions as an effective partner in planning joint projects and tests.

Via Appia km. 65,561 04013 Latina Scalo (Lt) - ItalyBSP Pharmaceuticals specializes in the development and manufacturing of cytotoxic drugs.

Latina Scalo, Lazio ItalyBSP Pharmaceuticals specializes in the development and manufacturing of cytotoxic drugs.

2 Via Bruno Buozzi Vimodrone, Lombardia, 20090 ItalyEurofins Biolab provides laboratory testing services and research services to the bio-pharmaceutical and the medical device industries. We are located in Milan, Italy in a single 9.000 square meters facility where the company employees more than 250 people, most of which have an high study degree in chemistry or biology or toxicology. The company was founded in 1971 and is the Italian leader in testing of pharmaceutical finished products. The facility is GMP accredited by the Italian drug agency AIFA, GLP certified by Italian Minister of Health, and EN ISO/IEC 17025 accredited for several tests. The facility has been audited several times by FDA (FDA Facility Establishment Identifier: 3002806530). Complete list of accreditation and downloadable copies of certificates are available at the following webpage: http://www.eurofins.it/servizi/pharma/accreditamenti/accreditations.aspx Eurofins Biolab is fully part of Eurofins Scientific group. With over 35.000 staff in more than 400 laboratories across 44 countries, Eurofins Scientific is the world leader in pharmaceutical products testing. It is also number one in the world in the field of food and environmental laboratory services and one of the global market leaders in agroscience, genomics and central laboratory services.

Via Bruno Buozzi, 2 VIMODRONE, 20055 ItalyEurofins Biolab provides laboratory testing services and research services to the bio-pharmaceutical and the medical device industries. We are located in Milan, Italy in a single 9.000 square meters facility where the company employees more than 250 people, most of which have an high study degree in chemistry or biology or toxicology. The company was founded in 1971 and is the Italian leader in testing of pharmaceutical finished products. The facility is GMP accredited by the Italian drug agency AIFA, GLP certified by Italian Minister of Health, and EN ISO/IEC 17025 accredited for several tests. The facility has been audited several times by FDA (FDA Facility Establishment Identifier: 3002806530). Complete list of accreditation and downloadable copies of certificates are available at the following webpage: http://www.eurofins.it/servizi/pharma/accreditamenti/accreditations.aspx Eurofins Biolab is fully part of Eurofins Scientific group. With over 35.000 staff in more than 400 laboratories across 44 countries, Eurofins Scientific is the world leader in pharmaceutical products testing. It is also number one in the world in the field of food and environmental laboratory services and one of the global market leaders in agroscience, genomics and central laboratory services.

Via XXV Aprile 19 40016 San Giorgio di Piano (BO)Renolab is an italian owned laboratory for analysis provided with extensive experience in the analytical world in accordance with good laboratory practice(GLP). For several years RENOLAB has been offering its services to chemical industry, throught trained personnel and sophisticated and modern equipment. The Renolab laboratory follows up with the Certification of the Italian Ministry of Health for the physico-chemical characterization and the residue studies of plant protection/biocide products, in compliance with the GLP principles of the OECD and according to the European Directives implemented by the Italian laws. RENOLAB srl is a fully Italian laboratory succeeding to GAB Analisi srl keeping all the existing activities, personnel, structures and equipment in order to continue the analytical services.

Via Sant'Ignazio Da Laconi 13 Cagliari, Italy, 09123 ItalyReGenFix provides a complete regeneration service for Fplc-type prepacked chromatography columns, such as affinity columns (e.g. NiNTA, Talon), size exclusion columns (e.g. Superdex, Superose, Sephacryl), ion exchange columns (e.g. Q, S, SP, DEAE sepharose) and many others. The ReGenFix procedure is much more than just an “in-place cleaning” of your columns. After the ReGenFix treatment, your column will perform like a brand-new one. This means that the ReGenFix treatment will be extremely useful in procedures of protocols’ standardization either for low-scale production, such as the ones in laboratories, or industrial-scale productions. Wherever your lab is located around the world, within 15 days you will receive your regenerated, completely standardized, and ready-to-use columns at a fraction of the price of a brand-new one. Don’t throw out your used, old, and exhausted pre-packed column (or resin) for protein and nucleic acid chromatography! Send them to us instead! We will regenerate them and bring them back to life again.

Milan, ItalyItalfarmaco provides drug delivery systems, selective inhibitors, and slow-release parenteral drug delivery.

30 Via Morego, Genova, Liguria 16163, ITThe main goal of the Istituto Italiano di Tecnologia (IIT) is to promote excellence in both basic and applied research and to facilitate the development of the national economy. The central Research Lab is a 30,000 sqm facility located in Genova, close to the airport and to the entrance of the main highways. It is a large-scale infrastructure hosting approximately 1,000 people, equipped with state-of-the-art instruments, including the following laboratories: Organic Chemistry Materials characterizations: mechanical, thermal, electric, structural, chemical Nanocomposites and Material processing: chemistry, laser writing, patterning, extrusion etc. Optical Microscopy: confocal, STED, super-resolution microscopy Nikon-IIT Imaging Center Graphene laboratories for graphene synthesis and characterization, graphene ink, ink jet printing, spraying technologies, graphene composites, etc. Optical spectroscopies: including ultrafast, low temperature, micro-probe spectroscopies TEM/SEM facility Raman and Plasmon spectroscopy laboratory Clean room (approx. 600 sqm, class 100/1000/10000) equipped with e-beam lithography, dual ion beam lithography, processing and packaging Pharmacology laboratory, including Mass spectroscopy facility, chemistry, NMR facility, etc.. Neuroscience laboratory, including optogenetics lab, neurophysiology laboratories, stem cell lab, virus lab, biochemistry facility etc. Microelectrode array laboratory and bioelectronics laboratory Robotics laboratories: humanoids lab, quadruped labs (hydraulic), robotic surgery, Robotic rehabilitation laboratory Human machine interaction laboratory Machine learning, Artificial intelligence laboratories Nanochemistry laboratories, including colloidal synthesis, biochemistry lab, chemical characterizations.

Via Morego, 30 Genova, 16163 ItalyThe main goal of the Istituto Italiano di Tecnologia (IIT) is to promote excellence in both basic and applied research and to facilitate the development of the national economy. The central Research Lab is a 30,000 sqm facility located in Genova, close to the airport and to the entrance of the main highways. It is a large-scale infrastructure hosting approximately 1,000 people, equipped with state-of-the-art instruments, including the following laboratories: Organic Chemistry Materials characterizations: mechanical, thermal, electric, structural, chemical Nanocomposites and Material processing: chemistry, laser writing, patterning, extrusion etc. Optical Microscopy: confocal, STED, super-resolution microscopy Nikon-IIT Imaging Center Graphene laboratories for graphene synthesis and characterization, graphene ink, ink jet printing, spraying technologies, graphene composites, etc. Optical spectroscopies: including ultrafast, low temperature, micro-probe spectroscopies TEM/SEM facility Raman and Plasmon spectroscopy laboratory Clean room (approx. 600 sqm, class 100/1000/10000) equipped with e-beam lithography, dual ion beam lithography, processing and packaging Pharmacology laboratory, including Mass spectroscopy facility, chemistry, NMR facility, etc.. Neuroscience laboratory, including optogenetics lab, neurophysiology laboratories, stem cell lab, virus lab, biochemistry facility etc. Microelectrode array laboratory and bioelectronics laboratory Robotics laboratories: humanoids lab, quadruped labs (hydraulic), robotic surgery, Robotic rehabilitation laboratory Human machine interaction laboratory Machine learning, Artificial intelligence laboratories Nanochemistry laboratories, including colloidal synthesis, biochemistry lab, chemical characterizations.

Frazione Pantalla di Todi - 06059 Perugia - ItalyBioTecnologie BT, with its 2 GLP and GEP Research Centres, is able to provide its Customers with a complete and competitive range of activities and studies, in order to support the registration dossier of different kinds of products: Plant Protection Products Veterinary Medicinal Products Biocides Pharmaceutical Products All tests are performed in compliance with current International Guidelines (OECD, IOBC/WPRS, ESCORT, CIPAC, ICH etc). BioTecnologie BT, thanks to a long experience, consolidated know-how and highly qualified staff, can guarantee a quality performance to suit customer needs. The Company, with its 2 Research Centres situated in Central and Northern Italy, offers cuttingedge equipment extending over a total area of 3000 m2 including laboratories, greenhouses and an Insectarium, amongst the largest in Europe.

24 Corso di Porta Nuova 20121 Milano, Lombardia, 20121 ItalyAnalytica LASER is a scientific consultancy that specialises in Real World Data, Analytics and HEOR and Market Access services. A significant portion of this work involves developing rigorous, evidence-based materials to help guide research and healthcare decisions. Our international team is a diverse group of experts with a breadth of experience, including high level (MSc and PhD) researchers, former payers, pharmaceutical industry leaders, noted academics, and highly experienced industry consultants. Our diverse scientific team includes statisticians, epidemiologists, mathematicians, economists, physicians, pharmacists and other pertinent expertise that assures the development of scientifically rigorous, insightful and actionable deliverables for our customers. PGRx Real World Datasets are targeted case registries that operate in multiple disease areas. PGRx provides quality data for most real world studies required by our HEOR and market access clients such as burden of illness, treatment patterns, drug utilisation, health resource use and quality of life studies. Programs for new pathologies can be rapidly deployed as a result of the validated protocol/tools and the extensive network of specialists created over the years that PGRx has been operating. PGRx uniquely links detailed medical data and HRU information from the physician with extensive patient-reported data on drug usage, adherence, quality of life and productivity impact. This gives a rich source of ‘deep’ data on patients, their management, possible drivers of effectiveness and the associated patient outcomes. Our other Real World Data solutions services include electronic database analytics, chart reviews, patient/physician surveys and advanced outcomes research and pharmacoepidemiology studies. Analytica LASER has been at the forefront of advising clients on market access issues with strategic consultancy, development of global value dossiers, evidence synthesis amongst other services.

Via Mastri 36 6853 Ligornetto SwitzerlandA Highly Specialised Company Covering Phase I Clinical Studies.

Via Mastri 36 Ligornetto, 6853 SwitzerlandA Highly Specialised Company Covering Phase I Clinical Studies.

Turin, ItalyThe growing rate of available data generated by Next-Generation sequencing isn't counterbalanced by efficient data analysis. NGI is a platform for Next Generation Sequencing data analysis kindly provided by the Epigenetics Unit of the Human Genetics Foundation (HuGeF). We offer a wide range of bioinformatics tools and an experienced and professional collaboration service for any type of biological data analysis. We provide both standard and customized analysis, custom softwares and pipelines development and post-sequencing support. We'll enhance and make easier your discovery process.

Piedmont ItalyThe growing rate of available data generated by Next-Generation sequencing isn't counterbalanced by efficient data analysis. NGI is a platform for Next Generation Sequencing data analysis kindly provided by the Epigenetics Unit of the Human Genetics Foundation (HuGeF). We offer a wide range of bioinformatics tools and an experienced and professional collaboration service for any type of biological data analysis. We provide both standard and customized analysis, custom softwares and pipelines development and post-sequencing support. We'll enhance and make easier your discovery process.

Via Olgettina, 60 c/o DIBIT 2 - Palazzina San Michele 20132 Milan - Italy

Via Einstein Lodi, 26900 ItalyBiotrack offers novel cell based analysis based on new proteomic technologies.

Via del piano, PO Box 266 6915 Pambio-Noranco SwitzerlandIBSA Institut Biochimque manufacture pharmacetuicals with a specialization of topical formulations from technologies for transdermal drug delivery.

Viale Ortles, 22/4 Milano, 20139 Milano ItalyMacrogen Europe is a leading sequencing provider. We provide DNA and RNA sequencing for all types of samples using technology provided by our partnerships Illumina, PacBio, and Oxford Nanopore Technologies among others. However, what is most important for us is to provide high-quality data together with committed customer service. From assisting you in sending samples to us, a personal following of your project, and data delivery.

Via I Maggio, 6 - 21020 BUGUGGIATE (VA) ItalyTecniplast offers animal care products, such as cages, tanks, and washing systems.

Via Costarica, 20/22 - 00040 Pomezia (Roma) ItalyTubilux Pharma specializes in designing, developing and producing ophthalmic drugs.

Pomezia, Lazio, 00040 ItalyTubilux Pharma specializes in designing, developing and producing ophthalmic drugs.

Via Giosuè Carducci 34 Sardara (SU), Italy, 09030 ItalyReGenFix provides a complete regeneration service for Fplc-type prepacked chromatography columns, such as affinity columns (e.g. NiNTA, Talon), size exclusion columns (e.g. Superdex, Superose, Sephacryl), ion exchange columns (e.g. Q, S, SP, DEAE sepharose) and many others. The ReGenFix procedure is much more than just an “in-place cleaning” of your columns. After the ReGenFix treatment, your column will perform like a brand-new one. This means that the ReGenFix treatment will be extremely useful in procedures of protocols’ standardization either for low-scale production, such as the ones in laboratories, or industrial-scale productions. Wherever your lab is located around the world, within 15 days you will receive your regenerated, completely standardized, and ready-to-use columns at a fraction of the price of a brand-new one. Don’t throw out your used, old, and exhausted pre-packed column (or resin) for protein and nucleic acid chromatography! Send them to us instead! We will regenerate them and bring them back to life again.

Via Varese 16b Roma, 00185 ItalyThe Telethon Network of Genetic Biobanks (TNGB) has been founded in 2008 by 7 Biobanks supported by Telethon Foundation, whose purpose is to collect, preserve and offer to the Scientific Community biological samples and related clinical data from individuals affected by genetic diseases, from their relatives or from healthy control individuals. TNGB also offers its services to Patients’ Associations. At present, the Network is constituted of 11 Biobanks. The aim of the Network is to coordinate and manage the Biobanks' activities in order to enhance synergy and provide scientists with an effective service responding to the highest quality standards, according to rigorous ethical principles complying with Italian laws and International Recommendations. Over the years, national and international scientists have extensively used the TNGB with different purposes. The complete list of the scientific publications acknowledging the TNGB services is available here. At the European level, TNGB is partnering with EuroBioBank Network and since its inception the Network has joined as associated member the pan-European research infrastructure BBMRI. Since 2014, all Biobanks of the Network have been admitted to the Italian Node (BBMRI-IT) and have signed the BMMRI-IT Partner Charter. TNGB also is one of the associated partners of the European RD-connect project aimed at connecting databases, registries, biobanks and clinical bioinformatics for rare disease research.

Via Maestri del Lavoro, 90 - 48014 Castel Bolognese (RA) ItalyComecer provides nuclear medicine, isolation technology, and nuclear power plant equipment.

Cereal Research Centre S.S. 673, km 25,200 71122 FOGGIA (ITALY)The Cereal Research Centre deals with genetics, genetic improvement, breeding and agronomy of cereals for human and animal consumption, with particular attention to the aspects related to the resistance to biotic and abiotic stresses, the sustainability of cultivation and the quality of products in relation to the cereal chain, differentiation of selections depending on the needs of diffe rent traditional and industrial uses,care and maintenance of collections of cereal varieties suitable for the cultivation in the Mediterranean area for the preservation and enhancement of biodiversity.

Via Meucci 3, Bresso 20091, Milano, ItalyAxxam is leading provider of integrated services in early drug discovery across the entire Life Science industries: Pharmaceutical, Crop protection, Animal health, Cosmetics and Nutrition. Our work to identify bioactive molecules with the desired pharmacological activity, such as the modulation of a target or a cellular pathway, is fundamental to pave the way toward the development of new drug compounds. Service overview: - Assay development (biochemical or cell-based, including molecular interactions & PROTAC) and phenotypic assays for compound testing activities and HTS. - Ready for use assays (functional & phenotypic) for compound testing activities and HTS. - High Throughput Screening (HTS) campaigns using client’s own compound collections or our compound collection of around 425.000 diverse small molecules (divided into 6 subsets which can be screened separately according to the project's needs). - High Content Screening (HCS) campaigns (on up to 20.000 compounds) and Phenotypic analysis: autophagy, neurite outgrowth, cell cicle, citotoxicity, mitochondrial analysis, marker localization, DNA damage, translocation, aggregation assays. - Molecular biology: gene editing, gene expression analysis, TaqMan-based screening, splice modulators and promoter activation assays. - iPSC-derived cells (neurons, cardiomyocytes, microglia cells, myotubes, hepatocytes, macrophages): calcium oscillation, aggregation assays, imaging, electrophysiology, cytokine release, citotoxicity, disease models. - Electrophysiology: manual patch clamp, automated patch clamp suitable for HTS, organellar patch clamp (lysosomes, mitochondria, nuclei), automated lysosomal patch clamp, optogenetics. - Hit validation & hit-to-lead: potency determination, mechanism of action studies, cardiac safety, specificity, selectivity, ortholog and orthogonal assays, among others. - Biophysical tools: affinity measurement, Kd determination, spectral shift, molecular interactions, microscale thermophoresis. - Analytical chemistry: LC-MS analysis, in vitro ADME (plasma permeability assay; plasma protein binding; microsomal stability assay); physico-chemical properties (solubility; lipophilicity; chemical stability). - Medicinal Chemistry and computational chemistry (analog synthesis; SAR analysis; IP positioning analysis; database maintenance; etc.). - Compound management: external libraries reformatting & storage. - AXXSense platform (https://axxsense.com/): specialized in the generation and development of novel, natural and synthetic flavour and fragrance compounds for the food and beverage, pet food, animal health, cosmetic and perfume industry. Taste and olfactory receptors, natural product library, aging platform.

Via Meucci 3 Bresso, 20091 ItalyAxxam is leading provider of integrated services in early drug discovery across the entire Life Science industries: Pharmaceutical, Crop protection, Animal health, Cosmetics and Nutrition. Our work to identify bioactive molecules with the desired pharmacological activity, such as the modulation of a target or a cellular pathway, is fundamental to pave the way toward the development of new drug compounds. Service overview: - Assay development (biochemical or cell-based, including molecular interactions & PROTAC) and phenotypic assays for compound testing activities and HTS. - Ready for use assays (functional & phenotypic) for compound testing activities and HTS. - High Throughput Screening (HTS) campaigns using client’s own compound collections or our compound collection of around 425.000 diverse small molecules (divided into 6 subsets which can be screened separately according to the project's needs). - High Content Screening (HCS) campaigns (on up to 20.000 compounds) and Phenotypic analysis: autophagy, neurite outgrowth, cell cicle, citotoxicity, mitochondrial analysis, marker localization, DNA damage, translocation, aggregation assays. - Molecular biology: gene editing, gene expression analysis, TaqMan-based screening, splice modulators and promoter activation assays. - iPSC-derived cells (neurons, cardiomyocytes, microglia cells, myotubes, hepatocytes, macrophages): calcium oscillation, aggregation assays, imaging, electrophysiology, cytokine release, citotoxicity, disease models. - Electrophysiology: manual patch clamp, automated patch clamp suitable for HTS, organellar patch clamp (lysosomes, mitochondria, nuclei), automated lysosomal patch clamp, optogenetics. - Hit validation & hit-to-lead: potency determination, mechanism of action studies, cardiac safety, specificity, selectivity, ortholog and orthogonal assays, among others. - Biophysical tools: affinity measurement, Kd determination, spectral shift, molecular interactions, microscale thermophoresis. - Analytical chemistry: LC-MS analysis, in vitro ADME (plasma permeability assay; plasma protein binding; microsomal stability assay); physico-chemical properties (solubility; lipophilicity; chemical stability). - Medicinal Chemistry and computational chemistry (analog synthesis; SAR analysis; IP positioning analysis; database maintenance; etc.). - Compound management: external libraries reformatting & storage. - AXXSense platform (https://axxsense.com/): specialized in the generation and development of novel, natural and synthetic flavour and fragrance compounds for the food and beverage, pet food, animal health, cosmetic and perfume industry. Taste and olfactory receptors, natural product library, aging platform.

Via Campestre 33 Bresso, MI, 20091 ItalyAxxam is leading provider of integrated services in early drug discovery across the entire Life Science industries: Pharmaceutical, Crop protection, Animal health, Cosmetics and Nutrition. Our work to identify bioactive molecules with the desired pharmacological activity, such as the modulation of a target or a cellular pathway, is fundamental to pave the way toward the development of new drug compounds. Service overview: - Assay development (biochemical or cell-based, including molecular interactions & PROTAC) and phenotypic assays for compound testing activities and HTS. - Ready for use assays (functional & phenotypic) for compound testing activities and HTS. - High Throughput Screening (HTS) campaigns using client’s own compound collections or our compound collection of around 425.000 diverse small molecules (divided into 6 subsets which can be screened separately according to the project's needs). - High Content Screening (HCS) campaigns (on up to 20.000 compounds) and Phenotypic analysis: autophagy, neurite outgrowth, cell cicle, citotoxicity, mitochondrial analysis, marker localization, DNA damage, translocation, aggregation assays. - Molecular biology: gene editing, gene expression analysis, TaqMan-based screening, splice modulators and promoter activation assays. - iPSC-derived cells (neurons, cardiomyocytes, microglia cells, myotubes, hepatocytes, macrophages): calcium oscillation, aggregation assays, imaging, electrophysiology, cytokine release, citotoxicity, disease models. - Electrophysiology: manual patch clamp, automated patch clamp suitable for HTS, organellar patch clamp (lysosomes, mitochondria, nuclei), automated lysosomal patch clamp, optogenetics. - Hit validation & hit-to-lead: potency determination, mechanism of action studies, cardiac safety, specificity, selectivity, ortholog and orthogonal assays, among others. - Biophysical tools: affinity measurement, Kd determination, spectral shift, molecular interactions, microscale thermophoresis. - Analytical chemistry: LC-MS analysis, in vitro ADME (plasma permeability assay; plasma protein binding; microsomal stability assay); physico-chemical properties (solubility; lipophilicity; chemical stability). - Medicinal Chemistry and computational chemistry (analog synthesis; SAR analysis; IP positioning analysis; database maintenance; etc.). - Compound management: external libraries reformatting & storage. - AXXSense platform (https://axxsense.com/): specialized in the generation and development of novel, natural and synthetic flavour and fragrance compounds for the food and beverage, pet food, animal health, cosmetic and perfume industry. Taste and olfactory receptors, natural product library, aging platform.

Via Varese 16b - 00185 Roma, ItaliaThe Telethon Network of Genetic Biobanks (TNGB) has been founded in 2008 by 7 Biobanks supported by Telethon Foundation, whose purpose is to collect, preserve and offer to the Scientific Community biological samples and related clinical data from individuals affected by genetic diseases, from their relatives or from healthy control individuals. TNGB also offers its services to Patients’ Associations. At present, the Network is constituted of 11 Biobanks. The aim of the Network is to coordinate and manage the Biobanks' activities in order to enhance synergy and provide scientists with an effective service responding to the highest quality standards, according to rigorous ethical principles complying with Italian laws and International Recommendations. Over the years, national and international scientists have extensively used the TNGB with different purposes. The complete list of the scientific publications acknowledging the TNGB services is available here. At the European level, TNGB is partnering with EuroBioBank Network and since its inception the Network has joined as associated member the pan-European research infrastructure BBMRI. Since 2014, all Biobanks of the Network have been admitted to the Italian Node (BBMRI-IT) and have signed the BMMRI-IT Partner Charter. TNGB also is one of the associated partners of the European RD-connect project aimed at connecting databases, registries, biobanks and clinical bioinformatics for rare disease research.

Piazza Cavour, 1 - 20121 Milano, ItaliaThe Telethon Network of Genetic Biobanks (TNGB) has been founded in 2008 by 7 Biobanks supported by Telethon Foundation, whose purpose is to collect, preserve and offer to the Scientific Community biological samples and related clinical data from individuals affected by genetic diseases, from their relatives or from healthy control individuals. TNGB also offers its services to Patients’ Associations. At present, the Network is constituted of 11 Biobanks. The aim of the Network is to coordinate and manage the Biobanks' activities in order to enhance synergy and provide scientists with an effective service responding to the highest quality standards, according to rigorous ethical principles complying with Italian laws and International Recommendations. Over the years, national and international scientists have extensively used the TNGB with different purposes. The complete list of the scientific publications acknowledging the TNGB services is available here. At the European level, TNGB is partnering with EuroBioBank Network and since its inception the Network has joined as associated member the pan-European research infrastructure BBMRI. Since 2014, all Biobanks of the Network have been admitted to the Italian Node (BBMRI-IT) and have signed the BMMRI-IT Partner Charter. TNGB also is one of the associated partners of the European RD-connect project aimed at connecting databases, registries, biobanks and clinical bioinformatics for rare disease research.

VIA COLUMBIA, 2 ROMA LAZIO, RM, 00133 Italy

Via Pinerolo 2 Roma, Roma, 00182 ItalyLearn how we ignite Clinical and Professional Development in the Life Sciences industry. At the heart of CRES lies a mindset to stay open to cooperating with everyone, from patient association representatives to clinicians, life science companies and policy and decision-makers. We aim to foster innovation in healthcare and fill the gap in access to medical treatments and healthcare services. A track record of successful services & training: CRES was born from the merger between Cres Academy and Cres Trials, CRES supports companies in their approach to clinical research and commercialization, allowing them to modernize and speed up the identification of impactful solutions.

Via passerini 2 Monza, Italy, 20900 ItalyRhemaStem, a biotech company specialising in the research and development of innovative drugs for colorectal cancer and other solid cancers. We provide an advanced and unique platform technology to address critical shortcomings in existing methods of isolation and production of tumour and normal stem cells for drug discovery and development. Our goal? To cure colorectal cancer and other solid cancers with our unique expertise and skills in the field of cancer and normal stem cells – an approach we champion with unwavering conviction. RhemaStem also offers consulting services in the area of solid cancer stem cells, encompassing colon, lung, breast, prostate, ovary, brain, circulating blood cells, and other cancers.

Corso Susa 299/A, 10098 Rivoli, Torino, ItalyTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

Via E. De Amicis 53 20123 Milano, ItalyTheorem Clinical Research offers full service clinical research solutions including DM, biostatistics, programming including CDISC, PM, clinical operations, and regulatory affairs.

Via Tito Speri 12/14 Rome, Lazio, 00071 ItalyResearch Toxicology Centre offers mammalian toxicology, kinetic studies, bioavailability, dose studies, and histopathology.

Via Greto di Cornigliano 6R c/o BIC Genoa, Italy, 16152 ItalyReact4life has developed MIVO® - Multi In Vitro Organ, an innovative organ on chip able to emulate portions of the human body. MIVO® is a patented, fully industrialized platform for more reliable 3D fluid-dynamic assays which provides a multiple fluidic circulation and multi-chamber system for culturing cells in vitro resembling the real tissues complexity. It can be used as (i) bioreactor for improving tissues conditions and prolonging cells lifetime, as (ii) microfluidic device for accelerating drug testing on 3D human tissues without involving animal use, and as (iii) reliable human disease models for basic research. React4life may both (i) sell the MIVO platform and support the customer during the first adoption, with video tutorial, scientific calls etc, (ii) provide MIVO based in vitro service activities for exploratory assays, drug efficacy assays, cytotoxicity, or permeation assays. In particular, the R&D team has deep experience in cellular biology, cancer biology and immunology.

Villaggio Cogne 57/A 11012 Cogne, ITALIAWe have access to an extensive network of talented translators and writers and are able to provide additional expertise and resources if required for specific projects.

Villaggio Cogne 57/A 11012 Cogne AO ItalyWe have access to an extensive network of talented translators and writers and are able to provide additional expertise and resources if required for specific projects.

Via Santa Maria Valle 3At PRA Health Sciences, providing innovative solutions for our clients is what we do. But innovation just for the sake of innovation isn’t why we do it. Side-by-side with our clients, we strive to move drug discovery forward, to help them develop life-saving and life- improving drugs. We help change people’s lives for the better every single day. It’s who we are. Innovating to help people is at the heart of our process, but it’s even more than that. It’s also our privilege.

7 Via Penninazzo Viagrande, Sicilia, 95029 Italy• 2.5 million plus archived human tissue samples with pathology, molecular and clinical data • High density TMAs • Assay transfer and development in IHC/FISH/PCR/Sanger & NGS • Target profiling in tumor & normal samples via TMAs with matched large sections or directly on large sections • Pathology expertise - 5 MD Pathologists (one from Large Pharma & 4 academic) • Digital Image Analysis • Biomarker-positive and negative samples • Validated assays in >20 immune oncology related markers • Monoplex & multiplex IHC • Ventana, Dako & Leica Bond platforms

Strada Statale 17, 67100, L'Aquila (AQ), Italy L'Aquila, Italy, 67100 ItalyDante Genomics is a leading global genomics and precision medicine company working to deliver better healthcare and save lives with a more human approach to health. We provide advanced genomics sequencing, transcriptomics, proteomics and advanced multiomic and data analysis to biotech companies, pharma, life science companies and clinics. We have customers in North America, Europe, MENA and the rest of the world.

Via Ribes 5 10010 Colleretto Giacosa Torino - ItalyEPHORAN Multi Imaging Solutions, a Contract Research Organization based in Italy, provides a complete solution toolset for non-invasive in vivo preclinical imaging to study, develop, and promote the application of imaging technologies in pre-clinical drug research and development. EPHORAN offers in vivo imaging and pharmaco-toxicological testing services, using serial/longitudinal imaging experiments during pharmacology and toxicology animal studies. Ephoran can provide preclinical imaging services covering all imaging techniques from those extensively used in clinical phases (e.g. MRI, PET, CT, SPECT, US, Opto-US) to Optical Imaging (OI, visible light and Near Infra Red – NIR), to assure a link between the preclinical and clinical studies. Our facility is quipped with a 1, 3, ad 7T MRI imagers, hybrid PET/SPECT/CT and SPECT/PET imagers, ultrasound equipmet coupled to Photoacustic imaging system, bioluminescence, and fluorescence imaging instruments, along with radiochemistry and radiotherapy capabilities. For situation where one modality will not answer all your biological questions Ephoran is capable of combining funcional and anatomical data using a multimodal imaging system (PET/SPECT/CT system). Our pre-clinical in vivo imaging systems offer solution for quantitation, deep tissue targeting, such as lung, heart, liver, kidney, GI, and brain in order to monitor and quantify in real time biological targets and pathways, giving a deeper understanding of the biology underlying disease mechanism and therapeutic response. Furthermore Ephoran provides a great variety of in vivo testing services including subcutaneous tumor models (xenograft tumor models), orthotopic tumor models, inflammation, CNS, hematoma, and others.

Via Ribes 5 10010 Colleretto Giacosa Torino - ItalyEPHORAN Multi Imaging Solutions, a Contract Research Organization based in Italy, provides a complete solution toolset for non-invasive in vivo preclinical imaging to study, develop, and promote the application of imaging technologies in pre-clinical drug research and development. EPHORAN offers in vivo imaging and pharmaco-toxicological testing services, using serial/longitudinal imaging experiments during pharmacology and toxicology animal studies. Ephoran can provide preclinical imaging services covering all imaging techniques from those extensively used in clinical phases (e.g. MRI, PET, CT, SPECT, US, Opto-US) to Optical Imaging (OI, visible light and Near Infra Red – NIR), to assure a link between the preclinical and clinical studies. Our facility is quipped with a 1, 3, ad 7T MRI imagers, hybrid PET/SPECT/CT and SPECT/PET imagers, ultrasound equipmet coupled to Photoacustic imaging system, bioluminescence, and fluorescence imaging instruments, along with radiochemistry and radiotherapy capabilities. For situation where one modality will not answer all your biological questions Ephoran is capable of combining funcional and anatomical data using a multimodal imaging system (PET/SPECT/CT system). Our pre-clinical in vivo imaging systems offer solution for quantitation, deep tissue targeting, such as lung, heart, liver, kidney, GI, and brain in order to monitor and quantify in real time biological targets and pathways, giving a deeper understanding of the biology underlying disease mechanism and therapeutic response. Furthermore Ephoran provides a great variety of in vivo testing services including subcutaneous tumor models (xenograft tumor models), orthotopic tumor models, inflammation, CNS, hematoma, and others.

Via Ribes 5, c/o Bioindustry Park Silvano Fumero Italia Colleretto Giacosa, Torino, 10010 ItalyEPHORAN Multi Imaging Solutions, a Contract Research Organization based in Italy, provides a complete solution toolset for non-invasive in vivo preclinical imaging to study, develop, and promote the application of imaging technologies in pre-clinical drug research and development. EPHORAN offers in vivo imaging and pharmaco-toxicological testing services, using serial/longitudinal imaging experiments during pharmacology and toxicology animal studies. Ephoran can provide preclinical imaging services covering all imaging techniques from those extensively used in clinical phases (e.g. MRI, PET, CT, SPECT, US, Opto-US) to Optical Imaging (OI, visible light and Near Infra Red – NIR), to assure a link between the preclinical and clinical studies. Our facility is quipped with a 1, 3, ad 7T MRI imagers, hybrid PET/SPECT/CT and SPECT/PET imagers, ultrasound equipmet coupled to Photoacustic imaging system, bioluminescence, and fluorescence imaging instruments, along with radiochemistry and radiotherapy capabilities. For situation where one modality will not answer all your biological questions Ephoran is capable of combining funcional and anatomical data using a multimodal imaging system (PET/SPECT/CT system). Our pre-clinical in vivo imaging systems offer solution for quantitation, deep tissue targeting, such as lung, heart, liver, kidney, GI, and brain in order to monitor and quantify in real time biological targets and pathways, giving a deeper understanding of the biology underlying disease mechanism and therapeutic response. Furthermore Ephoran provides a great variety of in vivo testing services including subcutaneous tumor models (xenograft tumor models), orthotopic tumor models, inflammation, CNS, hematoma, and others.

Via Alessandro Volta 12-14 Piane AN, Ancona, 60020 ItalyKymos Group is an analytical CRO devoted to bioanalysis and CMC services for small molecules, biologics and nucleic acids. We are GMP and GLP certified and we have been inspected by EMA and FDA. We work for biotechnology, pharmaceutical, veterinary, fine chemistry, cosmetics and nutraceutical industries. We are located in Cerdanyola del Vallès (Technology Park) where we have a two stand alone buildings: one of 1,500 m2 for laboratories and a second one of 1,000 m2 for offices. Our labs are fully equipped with state-of-the-art technology. The company has two subsidiaries: Pharmaprogress s.r.l. in Italy and Prolytic GMbH in Germany, as well as partnership agreements and collaborations with a wide range of local and multinational companies. Our main areas of activity are: BIOANALYSIS: - Full bioequivalence studies for generics - Bioanalysis of preclinical and clinical samples by mass spec (pK, PD, TK) - Bioanalysis by ELISA and ECLA for biologics and biosimilars - Immunogenicity studies - Cell based assays - Enzyme activity - Nucleic acid bioanalysis by qPCR - Full Preclinical studies CMC: - Analytical Method development and Validation - API analysis (compendial and non-compendial methods) - Stability studies - Characterization of biologics following the ICH Q6B - Microbiology testing - Batch Testing & Batch Release

22036 Erba (Como) - Italia - Via LicinioLisapharma manufactures dosage forms, including medical devices and veterinary products.

12 Via Virgilio Ranzato Via Ranzato 12 Milano, Lombardia, 20128 Italy500 sqm facility fully equipped with the most advanced technologies available: Luminex/Multiplex platform, NGS capability and Sequencing, FACS, IHC platform. Hubs in the most vibrant area Milano, San Diego and Oxford, of the Life Science community. We are a laboratory service provider delivering Luminex Assay Service -IHC Pathology - Microbiome - RNA Profiling ... and more Labospace is an hub where professionals from different backgrounds (MD, PhD and MSc graduates with in depth experience) meet at the service of scientific research. We offer Biomarker Testing Assay services on Luminex, Meso Scale, ELISA and multiplex ELISA, Human Mouse Pathology Service, Microbioma Testing Service, Transcriptome Testing service and offer innovative products in the market

Via Ignazio Guidi n. 3 Rome, RM, 00147 Italy

Via Ignazio Guidi n. 3 ROMA, RM, 00147 Italy