6-7-6 Minatojima Minamimachi Chuo-ku Kobe 650-0047 JAPANAllied Laboratories provides customized CMC solutions for development phase Pharma project. We support supply chain management for semi-bulk scale API and intermediates required for development stage. Our consulting service covers all aspects of development issues such as regulatory compliance, development strategy, cGMP compliance, bridging medicinal chemistry to process chemistry with global network and experienced team. Allied Laboratories supports whole elements of CMC issues such as cGMP compliances, Analytical development, Process development and manufacturing strategy. Allied represents globally recognized NY based CMC consulting group Rondaxe Pharma Inc. in Japan. Well experienced and responsible Rondaxe team actively supports our client’s project to maximize efficiency from pre-clinical to commercial phase. Utilizing our own laboratory and extended laboratory alliance, we provide tailor made R&D services such as analytical support for imported APIs, preparation of small-scale samples, quality evaluation for customer’s R&D stage projects. Our chemistry is not limited into Pharmaceutical area but also supports specialty chemicals, chemicals for electronics or other advanced materials. Import and export unique lab and plant equipment is our another expertise. If commercial product doesn’t fit your application, we will design and manufacture custom made equipment or machine to fit your specific needs.

1285, Kurisaki-machi Uto-shi, Kumamoto, 869-0425 Japan[Notice] Mediford Corporation was established on November 1, 2023 by combining the drug development support businesses of LSIM Safety Institute Corporation and LSI Medience Corporation, as a member of PHC Group ( https://www.phchd.com/global ). ******** Mediford Corporation offers services that support a wide range of drug research and development from the exploratory phase to clinical testing, leveraging our testing expertise and experience in advanced analysis, which has been accumulated through our established businesses in clinical trials and non-clinical testing. Our services fall into the following three categories: nonclinical study services, bioanalysis services, and central laboratories services. ・Nonclinical study services: Our services include various safety studies, pharmacodynamic and pharmacokinetic studies for regulatory approval applications as well as exploratory studies in the early stages of research and development at facilities compliant with GLP standards including those for pharmaceuticals, medical devices, regenerative medical products, agricultural chemicals, the Chemical Substances Control Law, etc. We also provide services using PDX (patient-derived xenografts) as well as PDC (patient-derived cells). ・Bioanalysis services: We provide analysis services for drugs, their metabolites, biomarkers, etc. in biological samples. We provide comprehensive support from analytical method development to analytical method validation and measurement of actual samples, from the basic research/exploration stage to the verification/clinical development stage. ・Central laboratory services: We conduct centralized testing for clinical research/ trial/ testing samples from nationwide medical institutions, at LSI Medience, the predecessor of our company. This avoids differences in platforms between institutions, unifies testing methodologies and reference ranges, and facilitates data analysis of testing results. We also leverage our overseas laboratories network to support globalization of drug development, responding to our valuable clients’ demands.

3-30-1, Shimura Itabashi-ku, Tokyo, 174-8555 Japan[Notice] Mediford Corporation was established on November 1, 2023 by combining the drug development support businesses of LSIM Safety Institute Corporation and LSI Medience Corporation, as a member of PHC Group ( https://www.phchd.com/global ). ******** Mediford Corporation offers services that support a wide range of drug research and development from the exploratory phase to clinical testing, leveraging our testing expertise and experience in advanced analysis, which has been accumulated through our established businesses in clinical trials and non-clinical testing. Our services fall into the following three categories: nonclinical study services, bioanalysis services, and central laboratories services. ・Nonclinical study services: Our services include various safety studies, pharmacodynamic and pharmacokinetic studies for regulatory approval applications as well as exploratory studies in the early stages of research and development at facilities compliant with GLP standards including those for pharmaceuticals, medical devices, regenerative medical products, agricultural chemicals, the Chemical Substances Control Law, etc. We also provide services using PDX (patient-derived xenografts) as well as PDC (patient-derived cells). ・Bioanalysis services: We provide analysis services for drugs, their metabolites, biomarkers, etc. in biological samples. We provide comprehensive support from analytical method development to analytical method validation and measurement of actual samples, from the basic research/exploration stage to the verification/clinical development stage. ・Central laboratory services: We conduct centralized testing for clinical research/ trial/ testing samples from nationwide medical institutions, at LSI Medience, the predecessor of our company. This avoids differences in platforms between institutions, unifies testing methodologies and reference ranges, and facilitates data analysis of testing results. We also leverage our overseas laboratories network to support globalization of drug development, responding to our valuable clients’ demands.

14-1, Sunayama, Kamisu-shi, Ibaraki, 314-0255 Japan[Notice] Mediford Corporation was established on November 1, 2023 by combining the drug development support businesses of LSIM Safety Institute Corporation and LSI Medience Corporation, as a member of PHC Group ( https://www.phchd.com/global ). ******** Mediford Corporation offers services that support a wide range of drug research and development from the exploratory phase to clinical testing, leveraging our testing expertise and experience in advanced analysis, which has been accumulated through our established businesses in clinical trials and non-clinical testing. Our services fall into the following three categories: nonclinical study services, bioanalysis services, and central laboratories services. ・Nonclinical study services: Our services include various safety studies, pharmacodynamic and pharmacokinetic studies for regulatory approval applications as well as exploratory studies in the early stages of research and development at facilities compliant with GLP standards including those for pharmaceuticals, medical devices, regenerative medical products, agricultural chemicals, the Chemical Substances Control Law, etc. We also provide services using PDX (patient-derived xenografts) as well as PDC (patient-derived cells). ・Bioanalysis services: We provide analysis services for drugs, their metabolites, biomarkers, etc. in biological samples. We provide comprehensive support from analytical method development to analytical method validation and measurement of actual samples, from the basic research/exploration stage to the verification/clinical development stage. ・Central laboratory services: We conduct centralized testing for clinical research/ trial/ testing samples from nationwide medical institutions, at LSI Medience, the predecessor of our company. This avoids differences in platforms between institutions, unifies testing methodologies and reference ranges, and facilitates data analysis of testing results. We also leverage our overseas laboratories network to support globalization of drug development, responding to our valuable clients’ demands.

千葉県習志野市香澄1-3-7-405 Tokyo, 1-3-7-405 JapanAt Medicilon, we are dedicated to help our clients develop their research and discovery programs from a burst of ideas all the way through the Investigational New Drug (IND) filing phase. Our services span across medicinal chemistry, biology, API, CMC, formulation, and preclinical studies. We provide flexible business models, including stand-alone Fee For Services (FFS) and fully integrated FTE services. In addition, our facilities are GLP/GMP compliant and AAALAC accredited. All study reports can be presented in SEND format, supporting dual filing of IND applications in the US, EU, and China.

Hiroshima University Bisiness Incubation Office #8 Kagamiyama 3-10-31, Higashihiroshima, Hiroshima 739-0046 JapanNeosilk provides recombinant proteins from silkworms and monoclonal antibodies.

S-cube 104 130-42 Nagasone-cho Kita-ku Sakai-shi, 591-8025 JapanABsize offers formulation services for poorly water-soluble molecules without chemical charge.

8-14-5 Ginza Chuo City, Tōkyō-to, 104-0061 JapanNAMSA is a Medical Research Organization (MRO), accelerating product development through integrated laboratory, clinical and consulting services. Driven by our regulatory expertise, NAMSA’s MRO® Approach plays an important role in translational research, applying a unique combination of disciplines—consulting, preclinical, toxicology, microbiology, chemistry, clinical and quality—to move client’s products through the development process, and continue to provide support through commercialization to post-market requirements, anywhere in the world.

JapanABsize offers formulation services for poorly water-soluble molecules without chemical charge.

Business Offices, KOL Building, room 405 Research Labs, KOL Building, 4th floor Komaba Research Campus (Komaba Ⅱ) The University of Tokyo 4-6-1 Komaba, Meguro-ku, Tokyo JAPAN 153–8904Business Offices, KOL Building, room 405 Research Labs, KOL Building, 4th floor Komaba Research Campus (Komaba Ⅱ) The University of Tokyo 4-6-1 Komaba, Meguro-ku, Tokyo JAPAN 153–8904

2-38-5 Nishishimbashi, Minato-ku, Tokyo 105-8433, JapanDevelopment, manufacture and sale of healthcare devices and services ( in vitro diagnostic devices, medical IT solutions, life science devices and services, etc.)

Nippon Roper, K. K. Sakurai Building 2-8-19 Fukagawa, Kotu-Ku Tokyo 135-0033, JAPAN Princeton Instruments (PI) designs and manufactures high-performance CCD, ICCD, EMCCD, emICCD, and InGaAs cameras; spectrographs; and optics-based solutions for the scientific research, industrial imaging, and OEM communities. We take pride in partnering with our customers to solve their most challenging problems in unique, innovative ways. PI operates as a unit of Roper Technologies, a diversified growth company and a constituent of the S&P 500, Fortune 1000, and Russell 1000 indices. Roper provides engineered products and solutions for global niche markets, including water, energy, transportation, medical, education, and SaaS-based information networks. Princeton Instruments has two U.S. manufacturing facilities, one located in New Jersey (Trenton) and one in Massachusetts (Acton). Our worldwide sales and service organizations in Germany, France, the United Kingdom, Japan, China, and Singapore provide sales support and discuss application requirements in addition to being your local contacts for order processing and service. Capabilities: Princeton Instruments possesses core technological capabilities in several key areas: Scientific Imaging: High-performance CCD, ICCD, EMCCD, emICCD, and InGaAs cameras for an expansive range of applications, including astronomy, BEC, combustion, PIV, single-molecule imaging, surface and materials analysis, PSP, and nanotechnology. Spectroscopy: A wide selection of state-of-the-art CCD cameras, spectrographs, monochromators, and integrated systems for Raman, LIBS, absorption, fluorescence, NIR/SWIR, and luminescence spectroscopy. X-ray Imaging: Advanced scientific-grade CCD cameras for x-ray applications such as EUV, lithography, XRS, plasma, diffraction, microscopy, and tomography. Optics & Coatings:

1-7-22 Suehiro-cho, Tsurumi-ku Yokohama 230-0045 JapanRiken provides NMR measurements and sequencing.

5F, G-4(A-7), ATC Bldg, ITM Mune, Nankou-Kita2-1-10, Suminoe-Ku, Osaka, JapanRUNDO-CRONOVA offers clinical trial management, statistics services, regulatory affairs, and consulting.

NihonBashi Core Bldg, Chuou-ku NihonBashi Horidome-Chou 2-8-4, Tokyo, JapanRUNDO-CRONOVA offers clinical trial management, statistics services, regulatory affairs, and consulting.

38 MoroyamaSaitama Medical University focuses on research with departments in molecular biology, biochemistry, pharmacology, immunology, and microbiology.

9-1, Kitasode, Sodegaura, Chiba, 299-0266, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

1-8-34 Oyodonaka, Kita-kuTrimGen specializes in developing innovative molecular assays to provide laboratories with advanced, cost effective tests and services. Using proprietary technologies, we offer unique assays for FFPE tissue DNA/RNA extraction as well as highly sensitive mutation and pathogen detection. Our STA technology has been widely applied to detect multiple mutations in the EGFR pathway including KRAS, BRAF, PIK3CA and other oncogenic mutations.

1-1 Daigaku, Uchinada Kahoku, Ishikawa , 920-0293 JapanKanazawa Medical University was established in Uchinada, near Kanazawa City, in June 1972. Kanazawa City is a historic town, with a long history and tradition of medical education starting as far back as Japan’s feudal era around the year 1600. Kanazawa Medical University was the first private medical university to be built on the Japan Sea side of the country.

G-BASE tamachi, shiba 5-29-11 minato ku, Tokyo, 108-0014 JapanGenequest Research Genequest Inc. has a variety of ongoing genetic studies within our internal research team and with our collaborators at research universities or companies. "Genequest" = "Gene" + "quest" We are accelerating research with ongoing genetic studies to contribute to human health all over the world. Through a challenging large-scale research project with our partners, our quest is to maximize the synergistic effects between research institutes and personal genome services.

582-2 Shioshinden Iwata, Shizuoka, 4371213 Japan

582-2 Shiopshinzen, Shizuoka, 4371213 Japan

75-1, Ono-cho, Leading Venture Plaza 201 Tsurumi-ku, Yokohama 230-0046 JapanIt is our goal to make proteins work! CellFree Sciences is using its own wheat germ cell-free protein expression system to serve protein needs in life sciences and for industrial use. Performing protein synthesis outside of the cell in an in vitro system allows us to separate protein production from other processes required to maintain a cell. Thus, working cell-free opens new opportunities to better adopt protein synthesis to protein needs offering dedicated reagents to make for example membrane proteins in a lipid environment, labeled proteins for use in MS or NMR, or well-folded antigens for antibody production. Our scalable and flexible expression system can serve protein needs from the small amounts used for production of our protein bead arrays presenting up to 23,000 human full-length proteins to individual proteins made on large-scale for use in structural biology, medical research, on-demand product production, and diagnostic tests. Our eukaryotic expression system has a strong record on supporting a wide range of projects working on all kinds of proteins from the kingdoms of life.

shiba 5-29-11 G-BASE tamachi 2F minato ku, Tokyo, 108-0014 JapanGenequest Research Genequest Inc. has a variety of ongoing genetic studies within our internal research team and with our collaborators at research universities or companies. "Genequest" = "Gene" + "quest" We are accelerating research with ongoing genetic studies to contribute to human health all over the world. Through a challenging large-scale research project with our partners, our quest is to maximize the synergistic effects between research institutes and personal genome services.

shiba 5-29-11 G-BASE tamachi 3F minato ku, Tokyo, 108-0014 JapanGenequest Research Genequest Inc. has a variety of ongoing genetic studies within our internal research team and with our collaborators at research universities or companies. "Genequest" = "Gene" + "quest" We are accelerating research with ongoing genetic studies to contribute to human health all over the world. Through a challenging large-scale research project with our partners, our quest is to maximize the synergistic effects between research institutes and personal genome services.

3F Ishikawa EMC Laboratory Bldg. 2-3-18 Namamugi, Tsurumi-ku Yokohama, Kanagawa, 230-0052 JapanGenoMembrane supplies transporter related products including ABC transporter membranes/vesicles and SLC transporter products.

Diaya Yaesu Building 3F 2-2-1 Yaesu Chuo-ku, Tokyo 104-0028 JapanHaploPharma develops technologies to discover genetic biomarkers for the prediction of individual drug response.

Tokyo JapanHaploPharma develops technologies to discover genetic biomarkers for the prediction of individual drug response.

246-2 Mizukami Kakuganji, Tsuruoka, Yamagata 997-0052, JAPANHMT-America develops and offers mass spectrometry-based metabolic profiling services. Our unique CE-MS and LC-MS platforms provide quantitative and untargeted measurements for primary metabolism and profiling for many types of samples and applications. Based on statistical, multivariate and pathway analyses, our research coordinators support the study design and biological interpretation.

1-3-7, Shinmiyakoda, Hamana-ku Hamamatsu, Shizuoka, 431-2103 JapanHamamatsu Pharma Research is a Japan-based preclinical CRO specializing in pharmacological efficacy studies using nonhuman primate (NHP) disease models. As nonhuman primates are phylogenetically and physiologically more similar to human than rodents, our NHP efficacy models will help you to obtain preclinical proof of concept (POC) relevant to clinical efficacy. Hamamatsu Pharma Research is an AAALAC International accredited facility in JAPAN and creates exquisite NHP models, leveraging extensive experience in translational research and animal care. Develop your novel therapeutics with Hamamatsu Pharma research’s nonhuman primate efficacy models with higher efficacy.

Hamamatsu-shi, Shizuoka-ken, 431-2103 JapanHamamatsu Pharma Research is a Japan-based preclinical CRO specializing in pharmacological efficacy studies using nonhuman primate (NHP) disease models. As nonhuman primates are phylogenetically and physiologically more similar to human than rodents, our NHP efficacy models will help you to obtain preclinical proof of concept (POC) relevant to clinical efficacy. Hamamatsu Pharma Research is an AAALAC International accredited facility in JAPAN and creates exquisite NHP models, leveraging extensive experience in translational research and animal care. Develop your novel therapeutics with Hamamatsu Pharma research’s nonhuman primate efficacy models with higher efficacy.

1-3-7 Shin-Miyakoda, Kita-ku Hamamatsu, Shizuoka, 4312103 JapanHamamatsu Pharma Research is a Japan-based preclinical CRO specializing in pharmacological efficacy studies using nonhuman primate (NHP) disease models. As nonhuman primates are phylogenetically and physiologically more similar to human than rodents, our NHP efficacy models will help you to obtain preclinical proof of concept (POC) relevant to clinical efficacy. Hamamatsu Pharma Research is an AAALAC International accredited facility in JAPAN and creates exquisite NHP models, leveraging extensive experience in translational research and animal care. Develop your novel therapeutics with Hamamatsu Pharma research’s nonhuman primate efficacy models with higher efficacy.

Senri Life Science Center Bldg.17F 1-4-2 Shinsenri Higashimachi, Toyonaka Osaka, 560-0082 JapanSince its foundation in 1970, Nagano Science has become the largest provider of services and products for pharmaceutical storage stability testing in Japan. Today all top ten pharmaceutical manufacturers and contract research organizations (CROs) in Japan trust Nagano Science products and services. More than 80% of all Japanese pharmaceutical companies are using our products and services. In addition to storage stability testing chambers, we also provide off-site stability storage space for pharmaceutical products to conduct ICH and GMP compliant storage stability testing. Our facility fulfils all criteria to international inspection and auditing requirements. Using Nagano Science for sample storage results in substantial cost-savings compared to investing in owned storage chambers and related space and / or equipment.

2nd Fl. IFReC Research Building, Osaka University 3-1 Yamadaoka, Suita, 565-0871, Osaka, JapanOsaka University Immunology Frontier Research Center (IFReC), directed by Prof. Shizuo Akira, was selected by the Japanese Ministry of Education, Culture, Sports, Science, and Technology as one of the nation's five exclusive World Premier International (WPI) Research Centers. Since the WPI program was established in 2007, IFReC has engaged in high-level research that is expected to make it an internationally renowned research center in the field of immunology. Immunology explores the mechanisms that protect the body against various pathogens such as bacteria and viruses. Because the immune system is essential for eliminating infectious pathogens from the body, its malfunction gives rise to various immune disorders including allergies, cancers, autoimmune diseases, and allograft rejection during transplantation. The scientific aim of IFReC is to contribute to a more comprehensive understanding of the dynamics of the immune system by employing not only traditional immunology experiments, but also a variety of imaging and bioinformatics technologies. In order to accomplish this goal, IFReC has recruited a diverse team of imaging and informatics scientists. These efforts will enable immunologists to directly track the dynamic behavior of immune cells and their cell-to-cell networks in order to clarify how immune cells respond to pathogens and cancers in vivo.

8-1, Minamisakae-cho, Kasukabe, Saitama 344-0057, JapanNipro Patch provides transdermal therapeutic preparations and products.

Central2, 1-1-1, Umezono, Tsukuba, Ibaraki, 305-8568 JapanResearch Center for Med. Glycoscience offers sugar chain profiling, biomarkers, and diagnostics for drug development.

1-3-1 Kasumigaseki, Chiyoda-ku, Tokyo 100-8921 JapanThe National Institute of Advanced Industrial Science and Technology (AIST), one of the largest public research organizations in Japan, focuses on the creation and practical realization of technologies useful to Japanese industry and society, and on “bridging” the gap between innovative technological seeds and commercialization. For this, AIST is organized into 5 departments and 2 centers that bring together core technologies to exert its comprehensive strength. AIST, as a core and pioneering existence of the national innovation system, has about 2000 researchers doing research and development at 10 research bases across the country, based on the national strategies formulated with the changing environment involving innovation in mind. AIST is also actively building a global network by, for example, signing memorandam of understanding for comprehensive research cooperation (MOUs) with 30 major research institutes around the

1-3-1 Kasumigaseki Chiyoda-ku Tokyo, 100-8921 JapanThe National Institute of Advanced Industrial Science and Technology (AIST), one of the largest public research organizations in Japan, focuses on the creation and practical realization of technologies useful to Japanese industry and society, and on “bridging” the gap between innovative technological seeds and commercialization. For this, AIST is organized into 5 departments and 2 centers that bring together core technologies to exert its comprehensive strength. AIST, as a core and pioneering existence of the national innovation system, has about 2000 researchers doing research and development at 10 research bases across the country, based on the national strategies formulated with the changing environment involving innovation in mind. AIST is also actively building a global network by, for example, signing memorandam of understanding for comprehensive research cooperation (MOUs) with 30 major research institutes around the

Saitama, Saitama Prefecture JapanBushu Pharmaceuticals offers product lifecycle management, drug delivery, manufacturing, packaging, and quality control.

2-7-8 Sumiyoshi, Hatsukaichi, Hiroshima 738-0014, JapanBiostir offers pharmacological testing and animal models for atopic dermatitis and allergens.

4-7-3-101 Ebara, Shinagawa-ku Tokyo 142-0063 JapanBIOBASE Biological Databases offers data collection and analysis, gene expression analysis, pathway modeling, and biological databases.

Tsukuba-shi, Ibaraki, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

Setagaya-ku, Tokyo, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

36-7 Oyama-cho Shibuya-ku, Tokyo, 151-0065 JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

Japan

#2-1-160 & 161, Mangesh Mansion Hyderabad, Telangana India, 500044Vincatis formed by a group of professional business experts with more than four decades of collective experience in delivering small, medium and large scale software applications and IT solutions across different industries

2-6-11 Mejirodai, Hachioji-city, Tokyo, Japan

720-3 Takyo, Izunokuni-shi Shizuoka, 410-2315 JapanAn Integrated Contract Chemistry Service Organisation Since 2010, Bellen Chemistry has been providing chemistry CRO/CDMO services as an integrated Contract Chemistry Service Organization. With years of accumulated technical advantages and experience in chemical synthesis of small molecule compounds, Bellen has built a one-stop-shop chemistry service platform, supporting big pharmas, biotech innovators and new drug development institutions for their research programs from discovery to commercial stage through comprehensive chemistry solutions. Our R&D, production, sales and operation team are based globally and at present, Bellen has nearly 1,000 employees worldwide, of which our technical team accounts for around 50%. Bellen is committed to continuing investing in innovation and state-of-the-art facilities to enable a one-stop-shop chemistry service platform, adding value to your project from library synthesis to API GMP manufactory. Our Key Services & Capabilities: - Key intermediates & RSMs (non-GMP & GMP) - cGMP APIs - Flow chemistry & Biocatalysis - Process development & optimisation - Process safety assessment - Early phase scale up - Late phase API & intermediates manufacturing - Solid Phase & Recrystallisation platforms (New for 2023) Watch our introductory video here: https://www.youtube.com/watch?v=6EoahD-c6WI

University of Tokyo Entrepreneur Plaza 701,7-3-1 Hongo Bunkyo, Tokyo, 113-0033 JapanWe are a biotech company that originated from the University of Tokyo, supporting the preclinical phase of drug discovery using biotechnology and digital technologies, including 3D imaging technology CUBIC and next-generation epitope mapping service DECODE. With CUBIC technology, we can quantitatively analyze the pharmacokinetics and efficacy verification in three dimensions. Furthermore, using DECODE, we can identify the specificity of epitopes recognized by antibodies at the highest global standard. By utilizing our services, we enable the reduction of the drug discovery timeline.

7th building 210, 3-5-8 Saiwai-cho, Fuchu, Tokyo, 183-0054, JapanNoveltec supports study in disease animal models through software and examination systems.

1-1-33, Sumiyoshihigashi-machi, Higashinada-ku, Kobe, Hyogo, 658-0052, JapanNoveltec supports study in disease animal models through software and examination systems.

Level 7, Wakamatsu Blg, 3-3-6 Nihonbashi, Hon-cho Cho-ku, Tokyo, 103-0023 JapanConfocal Science provides protein crystallography.

1-1 Nihonbashi-Muromachi 2-Chome Chuo-ku, Tokyo 103-8324 JAPANThe Chugai Group upholds its mission statement—which consists of its mission, its core values and its envisioned future—in order to be a business that meets a diverse array of stakeholder expectations as it realizes its corporate responsibility to society. It is on the basis of this mission statement that the Chugai Group conducts its business operations. Mission Statement Mission Chugai's mission is to dedicate itself to adding exceptional value through the creation of innovative medical products and services for the benefit of the medical community and human health around the world. Core values The primary focus of all our activities is patients and consumers. In all our activities we are committed to the highest ethical and moral standards. We value employees who develop profound expertise and broad perspectives and pursue innovation and challenges without fear of failure. Wherever we operate around the world we seek to understand and respect people and cultures and to behave as good corporate citizens. We promote an open and active corporate culture that respects individuality, ability and teamwork. We care about the global environment. We aim to achieve a fair return for our shareholders and to disclose information appropriately and in a timely manner. Envisioned Future As a most important member of the Roche group, we aim to become a top Japanese pharmaceutical company by providing a continuous flow of innovative new medicines domestically and internationally.

1-1 Nihonbashi-Muromachi 2-Chome Chuo-ku Tokyo, 103-8324 JapanThe Chugai Group upholds its mission statement—which consists of its mission, its core values and its envisioned future—in order to be a business that meets a diverse array of stakeholder expectations as it realizes its corporate responsibility to society. It is on the basis of this mission statement that the Chugai Group conducts its business operations. Mission Statement Mission Chugai's mission is to dedicate itself to adding exceptional value through the creation of innovative medical products and services for the benefit of the medical community and human health around the world. Core values The primary focus of all our activities is patients and consumers. In all our activities we are committed to the highest ethical and moral standards. We value employees who develop profound expertise and broad perspectives and pursue innovation and challenges without fear of failure. Wherever we operate around the world we seek to understand and respect people and cultures and to behave as good corporate citizens. We promote an open and active corporate culture that respects individuality, ability and teamwork. We care about the global environment. We aim to achieve a fair return for our shareholders and to disclose information appropriately and in a timely manner. Envisioned Future As a most important member of the Roche group, we aim to become a top Japanese pharmaceutical company by providing a continuous flow of innovative new medicines domestically and internationally.

4-14-4, Sendagaya, Shibuya-Ku,Rigaku offers services for electron diffraction crystallography exclusively. Rigaku is furthermore a market-leading manufacturer of instruments for electron diffraction crystallography and x-ray crystallography, x-ray diffraction, x-ray spectrometry, semiconductor metrology, automation, and cryogenics.

Rigaku Corporation 3-9-12, Matsubara-cho Akishima-shi Tokyo, 196-8666 JapanRigaku offers services for electron diffraction crystallography exclusively. Rigaku is furthermore a market-leading manufacturer of instruments for electron diffraction crystallography and x-ray crystallography, x-ray diffraction, x-ray spectrometry, semiconductor metrology, automation, and cryogenics.

448-5 Kajii-cyo Kamigyo-ku Kyoto 607-0841, JapanCosMED Pharmaceuticals offers a range of transdermal delivery systems for nervous system disorder,anti-emetic, hormone therapy and other therapeutic areas.

Kyoto, Kyoto Prefecture JapanCosMED Pharmaceuticals offers a range of transdermal delivery systems for nervous system disorder,anti-emetic, hormone therapy and other therapeutic areas.

Chiba Univ. Innovation Plaza, 1-8-15 Inohana, Chuo-ku, Chiba-shi, Chiba 260-0856, Japan.The goal of ProteinExpress, an R & D oriented company, is to become an important base for proteomics and, as its core business, conduct drug discovery research in the post-genome era. This is possible by making the best use of its fully comprehensive protein expression technology. ProteinExpress focuses its business on exploring and validating seeds of novel drugs as a genome-based drug discovery company. Our business is based on recombinant DNA technology for effective protein production. Genome-based Drug Seed Development Projects Genome-based Drug Discovery Project - Targeting genes for drug discovery - Identifying target proteins by proteomics - Validating drug seeds KIAA Project - Producing antibodies as a proteome analysis tool - Proteomics with the utilization of antibodies

2-7-11 Shimotakaido Suginami-ku Tokyo, Japan 168-0073Plexera provides label-free screening services on the high-throughput PlexArray HT screening platform, providing flexibility in project size and experimental design.

113-0033 2-9-7 Hongo, Bunkyo-ku, Tokyo JapanCellSeed provides safe and advanced tissue-engineering products.

Yokohama, JapanCellaVision offers analyzers, review software, competency software, and blood smearing devices.

ICN Building 5A 2-27-17 Hongo, Bunkyo-ku, Tokyo, 113-0033, JAPANWe contribute to significant advances in medical treatments through our revolutionary 3D tissue-engineering technology. Because our society faces an aging population and increasing prevalence of chronic diseases, regenerative medicine will play a growing and important role in patient care, particularly where satisfaction is low with medical treatments using traditional drugs, devices, and surgery. In addition to cell quality, the performance of cellular products relies on their composition. The conventional approach of injecting cell suspension has proved unsuitable for regenerating solid tissue because it does not introduce sufficient cell numbers while scaffolding, such as with animal-derived collagen, raises safety concerns related to allergies and viral vectors. With our proprietary tissue-engineering technologies, cellular aggregates are assembled into three-dimensional macrostructures without the need for scaffolding materials. The subsequent self-organization/maturation process in our customized bioreactor generates functional tissues/organs. To promote our platform technologies, we successfully developed the BIO 3D PRINTER, Regenova®. Regenova® is a state-of-the-art robotic system that enables fully automated fabrication of three-dimensional artificial tissues/organs from living cells.

Chikusa-ku, Aichi-ken, 464-0848 Japan

1-10-27-5F, Edobori Nishi-ku Osaka 550-0002 JapanCLC Bio provides bioinformatics and sequencing services.

Marunouchi Kitaguchi Building 9F 1-6-5 Marunouchi Chiyoda-ku, Tokyo, 100-005 JapanCaris Life Sciences offers molecular profiling (WES/WTS), clinical trial enrollment, and IVD/CDx development services.

Tokyo, JapanCosmo Bio provides unique services and quality life science products from leading Japanese manufacturers, to laboratories, research institutes, life-science education and testing organizations. We take pride in that our products fill a current need for hard to find reagents and instruments, while being created under the meticulous care of Japanese scientists and researchers. By maximizing our distribution ability and cooperative effort with our headquarters in Tokyo, we uphold the commitment and responsibility befitting that of a company trusted by its valued customers. Custom Drug Discovery Services From Japan https://www.cosmobio.co.jp/c/custom-drug-discovery-services/index.asp

Toyo Ekimae Building 2-20, Toyo2-chome koto-ku, Tokyo, 135-0016 JapanCosmo Bio provides unique services and quality life science products from leading Japanese manufacturers, to laboratories, research institutes, life-science education and testing organizations. We take pride in that our products fill a current need for hard to find reagents and instruments, while being created under the meticulous care of Japanese scientists and researchers. By maximizing our distribution ability and cooperative effort with our headquarters in Tokyo, we uphold the commitment and responsibility befitting that of a company trusted by its valued customers. Custom Drug Discovery Services From Japan https://www.cosmobio.co.jp/c/custom-drug-discovery-services/index.asp

Tokyo, JapanCactus Life Sciences provides cutting-edge solutions for medical affairs, powered by strategic insights and digital enhancements grounded in science. 1. Scientific Publications 2. Medical Communications 3. Medical Information 4. Medical Device Solutions 5. HEOR 6. Digital and Technology solutions 7. Patient centric services

1-13-23 Minami-Ikebukuro Toshima, Tokyo, 171-0022 JapanCROee has over 10 years of experience with patient recruitment in Japan, supporting Phase I to Phase IV studies, as well as other clinical trials. In fact, we enrol more than 20% of patients in studies performed in Japan. Further, CROee’s marketing team are healthcare marketing specialists who take advantage of the 800,000 personal healthcare records in our volunteer database to analyze the patient experience of each targeted disease and provide the optimal solution for our clients. By utilizing our patient database of over 800,000 members, we can bring the best solution of DTC marketing based on patient insights and patient experiences. We can also create an ideal patient experience from trial studies to improve our marketing strategies.

YS Building 2F, 1-13-23 Minami-Ikebukuro, Toshima-Ku TOKYO, Tokyo, 1710022 JapanCROee has over 10 years of experience with patient recruitment in Japan, supporting Phase I to Phase IV studies, as well as other clinical trials. In fact, we enrol more than 20% of patients in studies performed in Japan. Further, CROee’s marketing team are healthcare marketing specialists who take advantage of the 800,000 personal healthcare records in our volunteer database to analyze the patient experience of each targeted disease and provide the optimal solution for our clients. By utilizing our patient database of over 800,000 members, we can bring the best solution of DTC marketing based on patient insights and patient experiences. We can also create an ideal patient experience from trial studies to improve our marketing strategies.

Tokyo, Tokyo Japan

Tokyo, JapanCTL offers products and services for immune assays. These include a library of cryopreserved human PBMC with HLA-typed donors that have established T cell reactivity. We specialize in immune characterization through ELISPOT, providing ImmunoSpot analyzers, ImmunoSpot kits, hands-on wetlab training, consultation, and GLP contract research.

2-10-50 Furukawa-cho Mukai-machi, Hida-shi, Gifu 509-4241 JAPANALPS Pharmaceutical offers manufacture and sale of pharmaceutical raw materials, intermediates, food items and cosmetic ingredients.

Yoshimi-machi Yoshimi, Saitama Prefecture, 355-0166 Japan

Higashimatsuyama, Saitama Prefecture, 355-0071 Japan

31-8, 1-Chome, Takadanobaba Shinjuku-ku, Tokyo, 169-0075 Japan

Room 108, Leading Venture Plaza-2, 75-1, Ono-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0046 JapanDNAFORM offers cDNA libraries, high throughput DNA preparation, and gene expression services.

ASK Sanshin bld. 3F 2-6-29, TurumiChuo, Tsurumi Yokohama, Kanagawa, 230-0051 JapanDNAFORM offers cDNA libraries, high throughput DNA preparation, and gene expression services.

2-18-1, Konan Minato-ku, Tokyo 108-8230, JapanDaicel Chemical Industries offers API, chiral chromatographic separation, and synthesis services.

Mainichi Intecio., 4-5, Umeda 3-chome, Kita-ku, Osaka 530-0001, JapanDaicel Chemical Industries offers API, chiral chromatographic separation, and synthesis services.

Osaka, Osaka Prefecture JapanDaicel Chemical Industries offers API, chiral chromatographic separation, and synthesis services.

3F, Aobadai 4-7-7, Meguro-ku Tokyo 153-0042 JapanEffector Cell Institute provides cell-based drug discovery, regenerative medicine, and assays.

7F, Sumitomo Bldg., Higashi Ikebukuro 1-10-1 Toshima-Ku, Tokyo 170-0013, JapanEurofins EAG Materials Science, LLC has a long history, dating back to the birth of the company in 1978 in California, as Charles Evans & Associates. Over the years we have expanded from a single location offering SIMS only to having over 200 employees offering over 30 different services via 14 locations in 8 different countries. The original focus of the company was supporting semiconductor manufacturing but now we also work with multiple further industries beyond semiconductors, including: solar/PV, lighting, photonics, energy storage, aerospace & defense, medical devices, raw materials, glass, polymers and plastics and consumer products. EAG's analytical expertise is what enables us to help our clients to meet their goals. Our on-demand analytical testing services can help streamline R&D, solve urgent problems during manufacturing and help resolve materials related issues in the global supply chain, both within and between organizations.

Sunrise Mita Bldg. 6F, 3-16-12, Shiba, Minato-ku, Tokyo, 105-0014, JapanThomas Emery (Snr) started a tallow and candle business in 1840. A decade later, The Emery Candle Company offered customers sturdier, whiter, dripless candles made of stearic acid. Soon, the expanded product line also included elaine oil (oleic acid) and sweetwater (glycerine). By 1872, the company was involved in fatty acid exploration while growing an existing product line that included elaine oil (oleic acid) and sweetwater (glycerine). Click here to find more. Today, 174 years later, Emery Oleochemicals is a name synonymous with the production of high quality, natural-based chemicals commonly made from natural oils and fats. Our business is increasingly focused in high-value derivatives. Through our six dedicated business units , we have the ability to provide you with customisable, high-performance, market-based solutions. Backed by an extensive distribution network covering over 50 countries globally, Emery Oleochemicals applies its philosophy, Creating Value with our wide-ranging product portfolio for use in the home and personal care, construction, automotive, lubricants, packaging, food and beverage, pharmaceuticals, textiles, electrical and electronics, furniture and bedding, and agriculture industries. Headquartered in Shah Alam, Malaysia,our manufacturing facilities and sales and marketing offices are located in Asia Pacific, Europe and North America. We are backed by a diverse workforce of more than 1,000 people and an extensive distribution network covering over 50 countries globally.

Tokyo, JapanEnBioTec Laboratories provides screening services, ELISA systems, and PCB detection.

Aoyama Place Canada 1F Place Canada,7-3-37 Akasaka, Minato-ku, Tokyo 107-0052, JapanAt Truven Health Analytics™, our purpose is to make healthcare better — lower costs, improved quality, better results. Simple words. Yet remarkably complex concepts. But that's not stopping us. Or our customers. Every day, we get to work with smart, passionate professionals, from every facet of the industry, as they manage change and implement strategies that will achieve exactly those outcomes. Our customers are healthcare payers and providers. In both the private and public sectors. They're researchers and suppliers. Regulators. Movers and shakers in each piece and part of the healthcare world. With this broad view of healthcare, we're able to see when new challenges are just beginning to emerge. And that's when we begin working on new solutions. Data. We're driven by it. Known for our exacting collection and secure management of data, we've worked with clinical evidence, claims, clinical, and other healthcare data for more than 40 years. We know the challenges to watch for, what to do about them — and how to recognize new ones. Like finding new ways to measure risk for providers who take on more of it, and payers who contract for it. Or integrating data to deliver the solutions today's converging healthcare interests demand. Analytics. Because data alone is just numbers and letters. The need for reliable insights from data demands proven analytics. Our methodologies and algorithms are uniformly trusted across the industry to deliver critical information that leads to confident decisions. Coupled with flexible reporting, integration, and consulting services, our sophisticated analytics enable our customers to make their part of healthcare better, faster. Domain expertise. We have it. We really have walked in our customers' shoes. We've worked in their environments. That level of understanding, plus our leading data management capabilities and advanced analytics, are why our customers turn to us as their partner to deliver quality, reduce costs, and yield greater value in healthcare.

2-26-1, Muraoka-higashi, Shonan-iPark Fujisawa-city, Kanagawa, 2518555 JapanElixirgen Scientific, established in 2016, is a Maryland-based biotechnology firm specializing in iPSC-related technology. Our mission is to dedicate ourselves to quality, innovation, and collaboration, which drives the development of cutting-edge discoveries and therapies through the power of iPSC technology. We are focused on: ● New Cell Type Development Partnership: Engage in a strategic partnership focused on creating clinically relevant and functional cells. These cells find applications in neurodegenerative drug screening and cell therapy, contributing to the evolution of medical solutions. ●Cell Supply Agreement for Drug Screening: Ensure the efficiency of your drug discovery pipeline with our reliable and consistent supply of cells for screening purposes. We prioritize the seamless progression of your research and development initiatives. ●Translational Research Partnership with Patient-Derived Disease Model: Collaborate with us in translational research, benefitting from disease panel assays tailored to your specific needs. Our expertise extends to diseases such as Alzheimer's, Parkinson's, rare diseases and regenerative medicine.

Rm 409, Life Innovation Center 3-25-22, Tonomachi, Kawasaki-ku Kawasaki, Kanagawa, 210-0821 JapanElixirgen Scientific, established in 2016, is a Maryland-based biotechnology firm specializing in iPSC-related technology. Our mission is to dedicate ourselves to quality, innovation, and collaboration, which drives the development of cutting-edge discoveries and therapies through the power of iPSC technology. We are focused on: ● New Cell Type Development Partnership: Engage in a strategic partnership focused on creating clinically relevant and functional cells. These cells find applications in neurodegenerative drug screening and cell therapy, contributing to the evolution of medical solutions. ●Cell Supply Agreement for Drug Screening: Ensure the efficiency of your drug discovery pipeline with our reliable and consistent supply of cells for screening purposes. We prioritize the seamless progression of your research and development initiatives. ●Translational Research Partnership with Patient-Derived Disease Model: Collaborate with us in translational research, benefitting from disease panel assays tailored to your specific needs. Our expertise extends to diseases such as Alzheimer's, Parkinson's, rare diseases and regenerative medicine.

9-7 Hongo 2-Chome, Bunkyo-ku, Tokyo 113-0033 JAPANFunakoshi Co., Ltd. has contributed as a leader to distribute research reagents and instruments for researchers in the life science fields since its foundation. Our corporate mission is to provide products to broad range of customers throughout our worldwide network. We would like to take this opportunity to introduce selected products, which have been getting favorable response from our customers.

Hatano Research Institute, Food and Drug Safety Center 729-5 Ochiai Hadano, Kanagawa 257-8523 JapanFood and Drug Safety Center (FDSC) offers contract research services for safety and quality testing of compounds, materials, foods, drugs, medical devices, and chemical agents.

Hadano, Kanagawa Prefecture JapanFood and Drug Safety Center (FDSC) offers contract research services for safety and quality testing of compounds, materials, foods, drugs, medical devices, and chemical agents.

2-15-1 Tamura,Sawara-ku Fukuoka, 814-0193 JapanFukuoka Dental College, located in the western part of Japan, celebrated its 40th Anniversary in 2012. With its 40 years' firm basis, FDC keeps evolving in order to lead the future of Dentistry as the only one Private Dental College in the west of Japan. Its history shows how dedicated we are to fostering individuals for upcoming era, which requires dentists to have knowledge of both medicine and dentistry. FDC aims to foster competent dentists with virtues and international perspectives, contribute towards social welfare and advance Dental Medicine. In order to achieve our goals, we offer 6-year curriculum that includes ethics, specialized subjects and clinical trainings. We also offer various club activities, international exchanges and support systems for the students to help them achieve their goals. Clinical trainings include not only Dentistry but also Medicine such as Internal Medicine, General Surgery, Pain Clinic, Otorhinolaryngology, Plastic Surgery, Psychosomatic Medicine, Ophthalmology, Pediatrics and Orthopedics. Today, in our super aging society, dentists are required to have knowledge of Medicine in order to meet the needs of the society. For better cooperation between dentists and medical doctors, we are fostering dentists with such knowledge.

Kamiichi, Toyama Prefecture JapanFuji Chemical Industry offers synthesis and manufacturing of pharmaceutical and bulk pharmaceutical products as well as production and sales of food additives.

1-1 Yanagido Gifu Gifu Prefecture , 501-1193 JapanWelcome to the homepage of Gifu University. Please enjoy the contents in our homepage. Gifu University is located in Central Japan, between Tokyo and Kyoto, and has excellent international accessibility. The history of Gifu University dates back to its foundation on May 31, 1949, and the university now consists of five faculties: Education, Regional Studies, Medicine, Engineering, Applied Biological Sciences (agriculture and veterinary). Currently, more than 7,000 students and post-graduate students are studying at Gifu University. One of our major missions is to produce graduates ready to contribute to the region and to engage in active roles throughout the world. Under the motto of "Learning, Exploring, and Contributing", we provide excellent educational courses to produce globally-minded graduates and to train future talent that conduct productive research. We also have several hundred foreign students at our campus and will soon open English-only courses to accept more students from abroad. Gifu University international alumni have been established in Shanghai, China and Dhaka, Bangladesh. Internet lectures are available at http://www.gifu-u.ac.jp/en/about/about_gu/glg.html. Gifu University strives to become a leading, global university. We are open to foreign students willing to interact with Japanese young people as well as to other communities in the world for more profound understanding of both local and world-wide science and culture. We look forward to seeing and talking with you in Gifu. Hisataka Moriwaki

Yokohama, JapanGP Biosciences offers microarray, glycan profiling, genotyping, and gene expression services.

1-3-3 Azamino-minami, Aoba-ku, Yokohama 225-0012, JapanGP Biosciences offers microarray, glycan profiling, genotyping, and gene expression services.

3-2-5-406, Minami-kyujo nishi, Chuo-ku, Sapporo 064-0809, JapanGP Biosciences offers microarray, glycan profiling, genotyping, and gene expression services.

2-2 Kanda-Tsukasa-cho, Chiyoda-ku, Tokyo 101-0048 JapanGlycogene LLC is an advanced biotechnology enterprise founded in Wuhan with a warehouse in Atlanta, USA. We focus our business in the fields of R&D, manufacturing, including Glycan-related compounds, phosphoramidites, nucleotides, nucleosides, customized GalNAc molecular with GMP grade facility. and marketing to help our customers in their evolving needs for higher quality of chemicals. Here at Glycogene, using our biosynthesis, fermentation and organic synthesis techniques, our scientific experts are more than happy to offer the best quality and cost-effective products such as nucleosides, nucleotides, phosphoramidites and carbohydrates. Also, we can provide custom synthesis service for unqiue structures those are not in stock

75-1 Ono-cho, Tsurumi-ku Yokohama, Kanagawa 230-0046 JapanGenoMembrane supplies transporter related products including ABC transporter membranes/vesicles and SLC transporter products.

1-1-1-808 Eifuku, Suginami, Tokyo 168-0064 JAPANAsinex provides chemical library design, compound resupply, along with hit expansion and lead optimization services.

Kita 18, Nishi 9, Kita-ku Sapporo, 060-0818 JapanIn 2005, a Japanese law, Act on Welfare and Management of Animals was revised and the 3Rs concept (Replacement, Reduction, and Refinement) in animal experiments was stipulated in the Act. According to the concept, our Animal Facility has been making a great endeavor to execute animal experiments which satisfy animal welfare and the international standard. The Institutional Animal Care and Use Committee (IACUC) of the School including a ordinal citizen member has been improving the animal care and use program and facility, such as support for planning of appropriate animal experiments, critical review of the experimental protocols, improvement of environments of Animal Facility, application of environmental enrichment, evaluation of appropriate quality and number of animals, reduction or elimination of unpleasantness, suffering, and pain in animals, appropriate choice of sedative, analgesic, and anesthetic drugs, establishment of endpoints, and inspection by attending veterinarians all the year round. To verify that our Animal Facility satisfies high level of animal ethics and the international standard for using animals, we decided that our Facility should be reviewed by The Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International) which is the most well-known NPO for evaluation of animal facilities. In 2007, our Animal Facility obtained the full accreditation from AAALAC International as the first accredited institute among Japanese Universities and has kept the status since then. Our Animal Facility wishes to execute animal experiments by satisfying animal welfare as well as to rear qualified persons who could be a leader for executing the appropriate animal experiment with wide knowledge.

2, Miyanohigashi, Kisshoin Minami-Ku, Kyoto 601-8510 JapanHORIBA provides an extensive array of instruments and systems for applications ranging from automotive R&D, process and environmental monitoring, in-vitro medical diagnostics, semiconductor manufacturing and metrology, to a broad range of scientific R&D and QC measurements.

1-3 Shimoishii 1-chome, Kita-ku Okayama, 700-0907 JapanHayashibara offers products for food, pharmaceuticals, cosmetics and photosensitizing dyes.

Okayama, Okayama Prefecture JapanHayashibara offers products for food, pharmaceuticals, cosmetics and photosensitizing dyes.

# 20 No. 1 chome Higashi-ku Hamamatsu, Shizuoka 431-3192 JapanHamamatsu University School of Medicine focuses on research in clinical areas as well as animal models for research opportunities.

Hamamatsu, Shizuoka Prefecture JapanHamamatsu University School of Medicine focuses on research in clinical areas as well as animal models for research opportunities.

31-2, Kanda Higashi Matsushita-Cho Chiyoda-Ku, Tokyo, 101-0042 JapanWe, Hoshi Corporation, started our business as a raw material trading company in 1975. As well as making use of the strengths of this procurement capability, we also distribute ingredients of cosmetic and health supplements. It is possible for us to source all kinds of raw materials by building a relationship of trust and partnership with other local raw material trading companies. In recent years, we focus on “ocean-origin materials” which is highly evaluated by its effect-efficacy to skin. We offer a broad line of safe and secure ingredients such as Marine Chondroitin and Marine Placenta that has long been loved by Japanese women. Please feel free to contact us for any kinds of raw materials for cosmetics and health supplements – we are able to supply you a variety of them.

Minatojima-minamimachi 5-5-2, Chuo-ku Kobe, 650-0047, JapanHamari Chemicals is specialized in the manufacture of APIs and pharmaceutical intermediates, food additives, amino acid derivatives, nutritional ingredients, peptide, cosmetic substances, dietary supplements

4300-18, 2-Chome, Hachimanpara Yonezawa City, Yamagata 992-1128, JAPANHamari Chemicals is specialized in the manufacture of APIs and pharmaceutical intermediates, food additives, amino acid derivatives, nutritional ingredients, peptide, cosmetic substances, dietary supplements

1-4-29 Kunijima Higashi-Yodogawa-ku, Osaka 533-0024 JapanHamari Chemicals is specialized in the manufacture of APIs and pharmaceutical intermediates, food additives, amino acid derivatives, nutritional ingredients, peptide, cosmetic substances, dietary supplements

Yodogawa Ward, Osaka Prefecture JapanHamari Chemicals is specialized in the manufacture of APIs and pharmaceutical intermediates, food additives, amino acid derivatives, nutritional ingredients, peptide, cosmetic substances, dietary supplements

1 Chome-3-2 Kagamiyama Higashihiroshima, Hiroshima Prefecture , 739-8511 JapanBased on its founding principle “a single unified university, free and pursuing peace” and its five guiding principles, Hiroshima University fulfills its roles as a national university. The Pursuit of Peace To develop intellectual attitudes which always seek peaceful solutions to the problems affecting society and the world at large. The Creation of New Forms of Knowledge To evolve new systems of study which surpass existing frontiers of knowledge and encourage intellectual innovation. The Nurturing of Well-Rounded Human Beings To train graduates with well-developed and multifaceted personalities by means of an education which has breadth as well as depth. Collaboration with the Local, Regional, and International Community To create a university with a strong international awareness which can efficiently disseminate knowledge on a worldwide scale, in collaboration with local and regional communities. Continuous Self-Development To maintain a constant readiness to re-examine established ways of acting, and a constant openness to improvement and innovation.

Fukuoka, JapanHokkaido System Science provides DNA, microarray, protein, and gene related services

Osaka, JapanHokkaido System Science provides DNA, microarray, protein, and gene related services

Ibaraki, JapanHokkaido System Science provides DNA, microarray, protein, and gene related services

Hokkaido, JapanHokkaido System Science provides DNA, microarray, protein, and gene related services

2nd Floor, Hakataekimae Square 1-21-28 Hakataekimae, Hakata-ku, Fukuoka-shi, Fukuoka , 812-0011Acronet offers toxicology, safety pharmacology studies, virus validation, ADME, and phase I clinical trials.

10th Floor, The 3rd Fuji Bldg. 1-3-13 Itachibori, Nishi-ku, Osaka, 550-0012Acronet offers toxicology, safety pharmacology studies, virus validation, ADME, and phase I clinical trials.

1-3-25 Koishikawa, Bunkyou-ku Koishikawa Daikoku Bldg. 6, 7F Tokyo 112-0002 JapanAcronet offers toxicology, safety pharmacology studies, virus validation, ADME, and phase I clinical trials.

Tokyo, JapanHybrigenics Services is a complete service provider of cutting-edge technologies dedicated to the study of proteins and their interactions in 35+ organisms and any research thematic. We offer three main lines of services: • Interactions Discovery: ULTImate Y2H™ to discover novel protein-protein interactions in various tissues/cell types o Several adapted versions allow to identify interactions with transmembrane proteins, DNA and RNA o Associated services: Interaction Domain Mapping, Low binders, super binders • Drug Discovery Services (Adapted from ULTImate Y2H) o Target deconvolution: ULTImate YChemH™ to identify on- and off-targets of small bioactive molecules - mechanism of action, polypharmacology, drug repositioning, prediction of toxicity o Protein-protein interactions induced by molecular glues (protein stabilization, targeted protein degradation) • Nanobody® (or Synthetic Antibodies, VHH) to select and validate high-affinity single-domain antibodies (Hybribody™) - for IF, ELISA, high-resolution microscopy, video-microscopy, target inhibition applications but also for diagnosis and therapeutic purposes Our optimized screening platform in yeast enables the identification of the protein partners of proteins, DNA sequences, RNA and small molecules of therapeutic interest. Highly complex protein domain libraries, prepared from any cell type or tissue, are screened to saturation to identify partners and their interacting domains using a transcriptional read-out. Sophisticated bioinformatics analysis allows to attribute confidence scores to each interaction. With more than 3,200 academic and industrial customers from over 40 countries, Hybrigenics Services is internationally recognized. Among our services, our yeast two-hybrid screening technology, ULTImate Y2H, is extensively used in many research projects. The results obtained at Hybrigenics have been quoted in more than 480 scientific publications to date. Hybribody offers single-domain antibody selection and validation services. We handle the in vitro selection of antibodies against your protein from a fully synthetic humanized VHH library by an optimized Phage Display technology. VHHs have the advantages of being very small (15 kDa), affine and stable molecules. We validate the selected VHHs for in vitro and in vivo applications (ELISA, IF, Intrabody…). We can also fuse the VHH with Fc fragments from the species of your choice to deliver fully functional recombinant antibodies. In addition, Hybrigenics Services provides optimization of nanobodies coming from the Llama using yeast display technology. Nanobody® is a trademark of Ablynx.

Tokyo JapanSeikagaku offers pharmaceuticals and medical devices specifically related to glycoconjugates.

Kanagawa 231-0023 JapanIn Silico Biology provides sequence analysis, cloning, gene analysis, homology analysis, genome analysis, and array analysis software.

Yokohama, Kanagawa Prefecture JapanIn Silico Biology provides sequence analysis, cloning, gene analysis, homology analysis, genome analysis, and array analysis software.

Gotemba-shi, Shizuoka, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

2148-188 Nishiminowa, Ina-shi, Nagano-ken 399-4501 JapanIna Research offers non-clinical and clinical studies including expertise in toxicology, safety pharmacology, drug dependence, drug efficacy, and health food development services.

Nishiwaki, JapanInCROM offers clinical research services including first in human studies, PK/PD studies, and data management.

Hongo 2-1-1Juntendo University School of Medicine focuses on research.

7-6-8 Saito-Asagi, Ibaraki Osaka 567-0085, JAPANJCRB Cell Bank (Japanese Collection of Research Bioresources Cell Bank) supplies and distributes cell lines and tissues.

JapanKyowa Hakko USA provides chemicals, chemical synthesis, and nutraceuticals.

4-31, 2-chome, Kyutaro-machi Chuo-ku, Osaka 541-8581 JapanKURABO supplies various laboratory instruments and reagents for assays and cell culture while offering custom peptide synthesis, antibody production, and microarray analysis services.

53 Kawahara-cho, Shogoin, Sakyo-ku Kyoto , 606-8507 JapanTo serve as the world-first core institute dedicated to leading iPS cell research.

7-5–1, Kusunoki-choKobe University School of Medicine focuses on experimental animal research for infectious disease and myocardial infarction.

2-39-1 KurokamiKumamoto University focuses on life science and natural science research.

Tokyo, JapanChiome Bioscience provides monoclonal antibody products and antibody design.

Tokyo, Tokyo JapanChiome Bioscience provides monoclonal antibody products and antibody design.

19-48, Yoshino, Nagano Prefecture Matsumoto City, , 399-8710Health and happiness are common desires of people around the world. We at Kissei have met the challenge of developing innovative new drugs that can contribute to the health of people around the world under the management philosophy of "making a social contribution through high-quality, innovative pharmaceutical products" and "serving society through the members who constitute the company." "Pharmaceutical companies are worthless without R&D." These words have been passed on at Kissei ever since it was founded. In addition to demonstrating that R&D is the vital core of the company, they convey the ardor and passion of each and every employee towards the creation of new drugs in the hope that new drugs will allow as many people as possible to recover from illness as soon as possible, to lead lives filled with laughter and joy. The brilliant progress of the life sciences has contributed immeasurably to the health and happiness of mankind. Yet there remain many illnesses for which treatments have yet to be established and illnesses for which no satisfactory treatments exist, and highly useful, new drugs are sought. We at Kissei will continue to constantly incorporate the progress made in the field of the life sciences, strengthening our R&D activities to meet the challenges of developing new drugs, and providing superior drugs to people throughout the world as the fruits of our innovations.

, Kōchi-shi, Kōchi-ken 780-8072, JPKochi University, located between the Shikoku Mountains and the Nankai Trough, is a comprehensive university offering education and research under the slogan From Regionality to Globality and from Globality to Regionality. Based on a philosophy of local, relevant decision-making and regional community collaboration, we aim to help develop a safe, sustainable society where people live in harmony with the environment. We strengthen our principle of comprehensive education through regional collaboration and by producing professionals who boast profound problem-solving capabilities. Based on the special features of the Kuroshio Region, our international education and published research contribute both to regional communities and international society.

2-5-1 Akebonocho Kochi, Kochi Prefecture , 780-8072 JapanKochi University, located between the Shikoku Mountains and the Nankai Trough, is a comprehensive university offering education and research under the slogan From Regionality to Globality and from Globality to Regionality. Based on a philosophy of local, relevant decision-making and regional community collaboration, we aim to help develop a safe, sustainable society where people live in harmony with the environment. We strengthen our principle of comprehensive education through regional collaboration and by producing professionals who boast profound problem-solving capabilities. Based on the special features of the Kuroshio Region, our international education and published research contribute both to regional communities and international society.

, Uchinada-machi, Ishikawa-ken 920-0265, JPKanazawa Medical University was established in Uchinada, near Kanazawa City, in June 1972. Kanazawa City is a historic town, with a long history and tradition of medical education starting as far back as Japan’s feudal era around the year 1600. Kanazawa Medical University was the first private medical university to be built on the Japan Sea side of the country.

Yokohama Bio Industry Center 1-6 Suehiro-cho, Tsurumi-ku Yokohama, Kanagawa, 230-0045 JapanIt is our goal to make proteins work! CellFree Sciences is using its own wheat germ cell-free protein expression system to serve protein needs in life sciences and for industrial use. Performing protein synthesis outside of the cell in an in vitro system allows us to separate protein production from other processes required to maintain a cell. Thus, working cell-free opens new opportunities to better adopt protein synthesis to protein needs offering dedicated reagents to make for example membrane proteins in a lipid environment, labeled proteins for use in MS or NMR, or well-folded antigens for antibody production. Our scalable and flexible expression system can serve protein needs from the small amounts used for production of our protein bead arrays presenting up to 23,000 human full-length proteins to individual proteins made on large-scale for use in structural biology, medical research, on-demand product production, and diagnostic tests. Our eukaryotic expression system has a strong record on supporting a wide range of projects working on all kinds of proteins from the kingdoms of life.

23-23 Honcho, Itabashi-ku, Tokyo 173-0001, JapanLinTec provides manufacturing of pressure-sensitive adhesive materials.

Mikura Building 3-21-4 Yushima, Bunkyo-Ku, Tokyo, 113-0034, JapanLutronic provides high-quality, affordable medical lasers.

Shinjuku Sumitomo Building, 2-6-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 163-0227, JapanAC Medical provides one-stop solutions for your clinical development projects by combining a full spectrum of services, including monitoring, electrical data capture (EDC), data management, and statistical analysis. We are a Contract Research Organization (CRO) with a competitive edge in IT, offering efficient yet high-quality services.

2-20-8, Shinkawa, Chuo-ku, Kyowa Shinkawa Bldg 8F, Tokyo, 104-0033 JapanLonza provides advanced cell biology and cell engineering solutions that support customers from discovery to the clinic. We provide primary human cells, specialized media, advanced cell culture and transfection tools, supported by best-in-class quality, regulatory and scientific support. We support customers from basic research through preclinical and process development stages of small molecules, biologics, and cell and gene therapy programs in drug discovery and immuno-oncology. This includes immunogenicity prediction and assessment, manufacturability risk assessment and protein re-engineering.

Kyoto-University Katsura Venture Plaza 1-36 Goryo-Ohara Nishikyo, Kyoto, 615-8425 JapanMiCAN technologies has developed a standardized and ready-to-use human dendritic cells from iPSC for various assays or developing therapeutics/vaccines.

2-5-1 Atago Atago Green Hills MORI Tower Minato-ku, Tokyo, 105-6215 JapanMITSUI KNOWLEDGE INDUSTRY CO., LTD. (MKI) has been providing comprehensive bioinformatics services to public research institutes, universities, and pharmaceutical companies. MKI now offers a contract analysis service for nucleic acid analysis from LC-MS data using its self-developed software "AQXeNA". The advantage of using "AQXeNA" is that it enables the analysis of detailed internal structures of nucleic acid sequences and modified nucleic acids. In addition, it also supports long nucleic acid sequences of several thousand bases. The information from such analyses is required for drug discovery and R&D of nucleic acid medicine as well as mRNA vaccines. If you are interested in or have any concerns about nucleic acid analysis using LC-MS data, please contact us.

Jowa Takanawa Building 8F 1-5-4 Takanawa, Minato-Ku 108-0074 Tokyo - JapanAlpha MOS provides chemical analysis, odor monitoring solutions, and electronic noses, tongue, and eyes.

Chiyoda Japan

7 Kanda Mitoshiro Cho Chiyoda-ku Tokyo, 1010053 Japan

Shin-Yokohama Square Bldg. 14F, 2-3-12 Shin-Yokohama, Kohoku-ku, Yokohama, Kanagawa, 222-0033 JAPANMedinet provides immuno-cell therapy services as well as research and development.

4-2-8, Shibaura, Minato-ku, Tokyo, JapanMitsubishi Chemical Medience Corporation offers genotoxicit, safety pharmacology, efficacy testing, biomarker, proteomics, screening and genotyping services.

1-5-8, KYOBASHI, CHUO-KU, TOKYO 104-8305, JAPANMercian focuses on drug discovery research and offers fermentation services.

Matrix Science K.K. KN-bldg 3F 6-10-12, Sotokanda Chiyoda-ku Tokyo 101-0021 JapanYou are welcome to submit searches to this free Mascot Server. Searches of MS/MS data are limited to 1200 spectra and some functions, such as no enzyme searches, are unavailable. Automated searching of batches of files is not permitted. If you want to automate search submission, perform large searches, search additional sequence databases, or customise the modifications, quantitation methods, etc., you’ll need to license your own, in-house copy of Mascot Server.

1-15-10 Shimura Itabashi-ku Tokyo, 174-0056 Japan[Notice] Mediford Corporation was established on November 1, 2023 by combining the drug development support businesses of LSIM Safety Institute Corporation and LSI Medience Corporation, as a member of PHC Group ( https://www.phchd.com/global ). ******** Mediford Corporation offers services that support a wide range of drug research and development from the exploratory phase to clinical testing, leveraging our testing expertise and experience in advanced analysis, which has been accumulated through our established businesses in clinical trials and non-clinical testing. Our services fall into the following three categories: nonclinical study services, bioanalysis services, and central laboratories services. ・Nonclinical study services: Our services include various safety studies, pharmacodynamic and pharmacokinetic studies for regulatory approval applications as well as exploratory studies in the early stages of research and development at facilities compliant with GLP standards including those for pharmaceuticals, medical devices, regenerative medical products, agricultural chemicals, the Chemical Substances Control Law, etc. We also provide services using PDX (patient-derived xenografts) as well as PDC (patient-derived cells). ・Bioanalysis services: We provide analysis services for drugs, their metabolites, biomarkers, etc. in biological samples. We provide comprehensive support from analytical method development to analytical method validation and measurement of actual samples, from the basic research/exploration stage to the verification/clinical development stage. ・Central laboratory services: We conduct centralized testing for clinical research/ trial/ testing samples from nationwide medical institutions, at LSI Medience, the predecessor of our company. This avoids differences in platforms between institutions, unifies testing methodologies and reference ranges, and facilitates data analysis of testing results. We also leverage our overseas laboratories network to support globalization of drug development, responding to our valuable clients’ demands.

5F Itabashi-Honcho Bldg, 36-1 Shimizu-cho, Itabashi-ku Tokyo, 174-0053 Japan[Notice] Mediford Corporation was established on November 1, 2023 by combining the drug development support businesses of LSIM Safety Institute Corporation and LSI Medience Corporation, as a member of PHC Group ( https://www.phchd.com/global ). ******** Mediford Corporation offers services that support a wide range of drug research and development from the exploratory phase to clinical testing, leveraging our testing expertise and experience in advanced analysis, which has been accumulated through our established businesses in clinical trials and non-clinical testing. Our services fall into the following three categories: nonclinical study services, bioanalysis services, and central laboratories services. ・Nonclinical study services: Our services include various safety studies, pharmacodynamic and pharmacokinetic studies for regulatory approval applications as well as exploratory studies in the early stages of research and development at facilities compliant with GLP standards including those for pharmaceuticals, medical devices, regenerative medical products, agricultural chemicals, the Chemical Substances Control Law, etc. We also provide services using PDX (patient-derived xenografts) as well as PDC (patient-derived cells). ・Bioanalysis services: We provide analysis services for drugs, their metabolites, biomarkers, etc. in biological samples. We provide comprehensive support from analytical method development to analytical method validation and measurement of actual samples, from the basic research/exploration stage to the verification/clinical development stage. ・Central laboratory services: We conduct centralized testing for clinical research/ trial/ testing samples from nationwide medical institutions, at LSI Medience, the predecessor of our company. This avoids differences in platforms between institutions, unifies testing methodologies and reference ranges, and facilitates data analysis of testing results. We also leverage our overseas laboratories network to support globalization of drug development, responding to our valuable clients’ demands.

7-7-20 Asagi,Saito Ibaraki city, osaka, 567-0085 Japanmass spectrometry imaging service We, Miruion CO., LTD., are a venture company established by Osaka University that provides total solutions related to "mass spectrometry imaging," an innovative analysis method that makes unknown distributions known. The most critical step that determines the results of an analysis is sample preparation. Dr. Shimma, who is our CTO, has performed over 1000 pretreatments over the past 15 years. Make use of the abundant know-how to carry out the optimum pretreatment for the properties of the sample. In addition, we offer consulting services for analysis of various samples and interpretation of analysis data, depending on the customer's needs. Please feel free to contact us for samples that are difficult to analyze elsewhere. It is possible to perform MSI of all substances such as plants, insects, foods as well as animal cells. Of course, analysis of cosmetics using 3D skin model can also be performed.

Seven Bldg. 4F ３丁目-７-14 日本橋人形町 中央区 東京都 103-0013 Japan 中央区, 東京都, 103-0013 JapanMP Biomedicals is dedicated to giving scientists and researchers innovative, quality tools and superior service to aid them in their quest for ground-breaking discovery and turning the hope for life-changing solutions into a reality. The company manufactures and sells more than 55,000 products and is one of the only companies in the industry to offer a comprehensive line of life science, fine chemical and diagnostic products. MP Biomedicals is a world-wide corporation, with ISO-certified and FDA-approved manufacturing and distribution facilities throughout the globe and headquartered in Southern California. A vast network of global distributors and satellite facilities and offices throughout Europe, Asia, Australia and the Americas assures customers top quality products delivered when and where needed. No matter how dynamic the evolution of the life science and biotechnology markets, we remain committed to supporting our customers in their efforts to make new discoveries. From basic research, through scale-up, to full-scale production and diagnostic testing, MP Biomedicals serves every industry need – from specialized areas of research to supplying large scale quantities of fine chemicals. Our customers partner with us because they want a long-time player and reliable colleague in the fields of life science research and diagnostics. MP Biomedicals will never rest in our odyssey to remain at the forefront of discovery in the ever-changing biomedical industry.

千葉県習志野市香澄1-3-7-405 Tokyo, MA, 1-3-7-405 JapanAt Medicilon, we are dedicated to help our clients develop their research and discovery programs from a burst of ideas all the way through the Investigational New Drug (IND) filing phase. Our services span across medicinal chemistry, biology, API, CMC, formulation, and preclinical studies. We provide flexible business models, including stand-alone Fee For Services (FFS) and fully integrated FTE services. In addition, our facilities are GLP/GMP compliant and AAALAC accredited. All study reports can be presented in SEND format, supporting dual filing of IND applications in the US, EU, and China.

5-3-13, Mita, Minato-ku Tokyo, JapanNippon Shikizai is a contract cosmetics manufacturing service solution provider.

2nd Mantomi Building, 6th Floor 1-14-4 Kameido, Koto-ku, Tokyo JAPAN 136-0071ATDBio founded in 2005 by Prof. Tom Brown, a leading nucleic acid chemist, is now a part of Biotage. We are experts in oligonucleotide synthesis for therapeutic applications: ASOs, siRNA, RNAi, Aptamers, new chemical modalities.

6136-4, Ohnogo-machi, Joso-city, Ibaraki-ken 300-2521 JapanNemoto Science, a subsidiary of Nemoto, offers custom synthesis, in vivo/in vitro pharmacokinetic and toxicokinetic analysis, and metabolite identification services.

4-10-9, Takaido-higashi, Suginami-ku, Tokyo 168-0072, JapanNemoto Science, a subsidiary of Nemoto, offers custom synthesis, in vivo/in vitro pharmacokinetic and toxicokinetic analysis, and metabolite identification services.

4-10-9, Takaido-higashi Suginami-ku Tokyo, 168-0072 JapanNemoto Science, a subsidiary of Nemoto, offers custom synthesis, in vivo/in vitro pharmacokinetic and toxicokinetic analysis, and metabolite identification services.

2-5-1 HigashigaokaNational Institute of Sensory Organs focuses on research in vision and hearing impairment.

6F, 1-17-24 Shinkawa, Chuo-ku, Tokyo 104-0033Nitto Medic specializes in manufacturing and selling opthalmic drugs.

Keikyu-Sendai-Plaza 101, 3-8-19 Haginomachi Miyagino-ku, Sendai Miyagi 983-0043 JapanNihon Gene Research Laboratories offers DNA/RNA synthesis, chromosome analysis, and gene analysis services.

Furo-cho, Chikusa-ku, Nagoya, 464-8601, JapanNagoya University Institute for Advanced Research focuses on research.

1-10-5, Nihonbashihon-cho, Chuo-ku, Tokyo 103-0023Nissan Chemical offers custom synthesis and manufacturing services.

Nippon Seika Building 4-9 Bingomachi 2-chome, Chuo-ku, Osaka 541-0051 JapanNippon Fine Chemical offers manufacturing of fine chemicals, cosmetic products and industrial chemical products.

1-1-17 Shinmachi, Nishi-ku, Osaka City, Osaka 550-8668, JapanNagase provides resins, enzymes, antibodies, screening, gene expression, and silicone materials.

5-1, Nihonbashi-Kobunacho, Chuo-ku, Tokyo 103-8355, JapanNagase provides resins, enzymes, antibodies, screening, gene expression, and silicone materials.

Bunshokudan Bldg. 7F Kudanminami 1-4-5 Chiyoda-ku Tokyo 102-0074Novasep provides chiral separations, custom synthesis, manufacturing, generics development, and purification scale-up.

26-1, Muraoka-Higashi 2-chome Fujisawa, Kanagawa, 2510012 JapanAxcelead Drug Discovery Partners is the premium CRO in Japan, a spin-out company from Takeda Pharmaceuticals, and provides pharma-standard drug discovery services as your drug discovery engine. Scope of Business: ・Drug discovery services Capability: ・Screening : Assay development, HTS, Hit finding, Compound management, Phenotypic screening, AS-MS ・Chemistry: Medicinal Chemistry, Peptide chemistry, Synthetic chemistry, High-throughput synthesis, Analytical chemistry, Computational chemistry, RNA-Targeting Small Molecules, Targeted Protein Degradation ・Biology: oncology, immunology, neuroscience, cardiovascular and metabolism, gastrointestinal motility, cell therapy using large animals, Omics, Bioinformatics, Genetically modified animals, Histopathology, Spatial Transcriptomics, Single cell RNA-seq, Single nucleus RNA-seq ・DMPK: ADME screening, Discovery DMPK studies, Physicochemistry and preformulation, studies ・Safety: In vitro and in vivo exploratory safety studies ・IND/NDA enabling studies ・Target validation/Efficacy studies ・Lead generation/optimization

Fujisawa, Kanagawa Prefecture, 251-0012 JapanAxcelead Drug Discovery Partners is the premium CRO in Japan, a spin-out company from Takeda Pharmaceuticals, and provides pharma-standard drug discovery services as your drug discovery engine. Scope of Business: ・Drug discovery services Capability: ・Screening : Assay development, HTS, Hit finding, Compound management, Phenotypic screening, AS-MS ・Chemistry: Medicinal Chemistry, Peptide chemistry, Synthetic chemistry, High-throughput synthesis, Analytical chemistry, Computational chemistry, RNA-Targeting Small Molecules, Targeted Protein Degradation ・Biology: oncology, immunology, neuroscience, cardiovascular and metabolism, gastrointestinal motility, cell therapy using large animals, Omics, Bioinformatics, Genetically modified animals, Histopathology, Spatial Transcriptomics, Single cell RNA-seq, Single nucleus RNA-seq ・DMPK: ADME screening, Discovery DMPK studies, Physicochemistry and preformulation, studies ・Safety: In vitro and in vivo exploratory safety studies ・IND/NDA enabling studies ・Target validation/Efficacy studies ・Lead generation/optimization

Yamadaoka 2-2, Suita, Osaka, JapanOsaka University Department of Ophthalmology focuses on research in the field of ocular disease.

Osaka, Osaka Prefecture JapanOsaka University Department of Ophthalmology focuses on research in the field of ocular disease.

KBIC#217, 7-7 Shinkawasaki, Saiwai-ku Kawasaki-shi, Kanagawa, 212-0032 JapanOur mission at ORGANOGENIX, Inc., as a leading company of three-dimensional (3D) cell culture technology, is to provide products and technical support to scientists worldwide to bring innovation to life science research, which leads to breakthroughs in drug discovery and achievement of a longevity society. Our 3D Vison Dedication We are dedicated to the further exploration of the 3D cell culture method and through our expertise and products, bring a new perspective to promote innovation in the field of life science. Discovery Our vision, by advancing bioscience research with our 3D model, is to contribute to the creation of novel drugs and medicines, diagnostic technologies and other medical innovations and discoveries. Dream We dream to achieve a healthy society, that our 3D technology contributes to medical research breakthroughs leading to overcome intractable diseases, increase the human health span, and enhance disease preventions.

No. 4, No. 2, 3-chome, Higashi-Osaka Takaidahondori, JapanOsaka Seiyaku manufactures and sells pharmaceuticals, quasi drugs, hygiene products and cosmetics.

Higashiosaka, Osaka Prefecture, 577-0066 JapanOsaka Seiyaku manufactures and sells pharmaceuticals, quasi drugs, hygiene products and cosmetics.

2nd Fl. IFReC Research Building, Osaka University 3-1 Yamadaoka, Suita Osaka, 565-0871 JapanOsaka University Immunology Frontier Research Center (IFReC), directed by Prof. Shizuo Akira, was selected by the Japanese Ministry of Education, Culture, Sports, Science, and Technology as one of the nation's five exclusive World Premier International (WPI) Research Centers. Since the WPI program was established in 2007, IFReC has engaged in high-level research that is expected to make it an internationally renowned research center in the field of immunology. Immunology explores the mechanisms that protect the body against various pathogens such as bacteria and viruses. Because the immune system is essential for eliminating infectious pathogens from the body, its malfunction gives rise to various immune disorders including allergies, cancers, autoimmune diseases, and allograft rejection during transplantation. The scientific aim of IFReC is to contribute to a more comprehensive understanding of the dynamics of the immune system by employing not only traditional immunology experiments, but also a variety of imaging and bioinformatics technologies. In order to accomplish this goal, IFReC has recruited a diverse team of imaging and informatics scientists. These efforts will enable immunologists to directly track the dynamic behavior of immune cells and their cell-to-cell networks in order to clarify how immune cells respond to pathogens and cancers in vivo.

Ina-shi, Nagano, JapanEstablished in 1929 as Japan’s first yeast manufacturer for bread, Oriental Yeast Co., Ltd. has expanded from being a supplier of various food products including yeast—for which it has the top share—to animal feed and biotechnology. The company sees its future in researching and developing the infinite possibilities of yeast by way of technology sets.

1-Chome, Nishi-KU Kōbe-shi, Hyōgo-ken, 651-2241 JapanSysmex Inostics, a subsidiary of Sysmex Corporation, is a global leader in liquid biopsy clinical testing committed to improving the lives of patients with cancer. Our pioneering technologies, such as the gold-standard OncoBEAM (BEAMing) digital PCR and NGS-based SafeSEQ, deliver unparalleled high sensitivity for detection of tumor molecular alterations in blood and other sample types. We are a trusted partner to leading pharmaceutical companies, advancing their efforts to bring the most effective personalized cancer therapies and solutions to global markets. Sysmex Inostics´ three main areas of focus are: • BioPharma liquid biopsy testing & services • CDx/IVD development • Patient testing services (US only) Our Capabilities: • Custom Biomarker Assay Development • Global footprint of GCP/CLIA certified laboratories • Analytical and Clinical Validation • Global Regulatory Registration/Approval • cGMP Manufacturing • Full Service Clinical Trial Project Management • Companion Diagnostic (CDx) Kit Development and Commercialization

4-7-6, Komaba Meguro-ku Tokyo, 153-0041 JapanPerseus Proteomics supplies antibodies against proteins and transcription factors involved in vascular inflammation and offers ELISA kits.

Tokyo JapanPerseus Proteomics supplies antibodies against proteins and transcription factors involved in vascular inflammation and offers ELISA kits.

3-25-23, Tonomachi, Kawasaki-ku Kawasaki-shi, Kanagawa, 210-0821 JapanBusiness Offices, KOL Building, room 405 Research Labs, KOL Building, 4th floor Komaba Research Campus (Komaba Ⅱ) The University of Tokyo 4-6-1 Komaba, Meguro-ku, Tokyo JAPAN 153–8904

Central Chemicals Co, Inc. Ishida Bldg, 4 Chome 2-17, Nihonbashi-hongokucho, Chuo-ku, Tokyo 103-0021, JapanApollo Scientific is a prominent research chemical company known for its expertise in supplying high-quality chemicals and advanced materials to the scientific and research community. Founded in 1993, Apollo Scientific has established a reputation for excellence in providing a diverse range of chemicals, reagents, and laboratory supplies to support research endeavors in various fields, including pharmaceuticals, chemistry, and biotechnology. With a commitment to quality and safety, Apollo Scientific adheres to stringent quality control standards, ensuring that its products meet the rigorous demands of scientific research. Our extensive catalog includes rare and hard-to-find chemicals, custom synthesis services, and a strong emphasis on environmental responsibility and sustainability in all processes. Researchers and laboratories worldwide rely on Apollo Scientific for their chemical needs, making us a trusted partner in advancing scientific discovery and innovation across numerous disciplines. Our dedication to customer satisfaction and scientific progress drive our success in the research chemical industry.

Guranderu Mizonokuchi 706 1-chome-19-11 Mizonokuchi Kawasaki City, Kanagawa, 2130001 JapanSino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.

Daiichi Enoki Bldg. 4F 5-3-1, Toranomon, Minato-ku, Tokyo 105-0001 JapanProPharma Partners provides a broad range of advisory and consulting services to biotechnology and pharmaceutical industries.

Kita Ward, Hokkaido Prefecture JapanPrimary Cell Co. offers primary cell culture kits, media, and cell based assay reagents.

63 Konaka, Toyama City, Toyama 939-8183 JapanPharmapack manufactures aseptic pharmaceuticals and food products using the BFS (Blow-Fill-Seal) system.

Nagasaki University School of MedicinePharmaCo-Cell offers in vitro Blood-brain barrier (BBB) model for the drug permeability assay.

Tokyo JapanPharmaCo-Cell offers in vitro Blood-brain barrier (BBB) model for the drug permeability assay.

6-19 Chitose Chitose, Hokkaido JapanPharmaCo-Cell offers in vitro Blood-brain barrier (BBB) model for the drug permeability assay.

Hebinami 28 - 3,Johbanshimofunao-Machi, Iwaki-City,Fukushima JapanSogo Pharmaceutical offers pharmaceuticals, cosmetics, chemicals and custom synthesis.

Aza Sonegasaki 408 - 1, Kamisokoino,Nakama-City,Fukuoka JapanSogo Pharmaceutical offers pharmaceuticals, cosmetics, chemicals and custom synthesis.

Fuchinobehoncho 5 - 14 - 12, Sagamihara-City,Kanagawa JapanSogo Pharmaceutical offers pharmaceuticals, cosmetics, chemicals and custom synthesis.

Nippon Bldg., 2 - 6 - 2 Ohtemachi, Chiyoda-Ku,Tokyo JapanSogo Pharmaceutical offers pharmaceuticals, cosmetics, chemicals and custom synthesis.

Tokyo, Tokyo JapanSogo Pharmaceutical offers pharmaceuticals, cosmetics, chemicals and custom synthesis.

Matsumoto Building, 1FPromega Tailored R&D solutions offers comprehensive solution to client drug discovery needs. https://www.promega.com/custom-solutions/tailored-solutions/ Currently we are offering our data only, compound profiling services through the platform. Our kinase selectivity profiling services use NanoBRET™ Target Engagement Intracellular Kinase Assays to test your supplied compounds. It includes a diverse panel of 192 or 240 full-length kinases. https://www.promega.com/custom-solutions/tailored-solutions/kinase-profiling-services/ Our Targeted Protein Degradation Services include; compound degradation profiling, permeability and affinity services, ternary complex formation assays, and Neosubstrate degradation panel. https://www.promega.com/applications/small-molecule-drug-discovery/protein-degradation-drug-discovery/targeted-protein-degradation-services/

1-1-1 Sakuragaoka,Psomagen, Inc. is a trusted contract research organization offering multiomics approaches to research and clinical customers. Our CLIA-certified, CAP-accredited US labs offer highly specialized multi-omics services anchored by our next generation sequencing (NGS) and 3rd Generation (nanopore, HiFi SMRT) portfolio. This includes options in genomics, transcriptomics, epigenomics, metagenomics, bioinformatics, and proteomics. We stay on the cutting edge of biotechnology by partnering with major players in the omics space, including 10x Genomics, Olink Proteomics, Illumina, and Pacific Biosciences. We frequently re-evaluate our customers' needs by adding new platforms and capabilities to our offerings.

TokyoQuanticate offers clinical research services including data management, statistical consultancy/programming/analysis, medical writing, and pharmacovigilance.

Cell Engineering Division / RIKEN BioResource Center 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, JapanThe RIKEN BioResource Center (BRC) is a non-profit institution funded by the Japanese Government. We have been engaging in collection, preservation and distribution of bioresources, with the aim to support research and development in the field of life sciences. We provide bioresources to scientists not only in Japan but also throughout the world with minimum fees that is solely reimburse for preparation and handling costs of the requested bioresources. To continue the smooth distribution of bioresources for overseas organizations, it has become necessary to send bioresources prepaid. We sincerely hope that this change will not cause any inconvenience our users. We very much appreciate your understanding and cooperation, and are looking forward to receiving your requests for our bioresources.

, Tsukuba Tsukuba-shi, Ibaraki-ken 305-0074, JPOur division was established in 1987 as the RIKEN Gene Bank. When the RIKEN BioResource Center was established in 2001, the bank was recognized as Gene Engineering Division. Since 2002, the Division has been selected as a core facility of DNA resources by National BioResource Project funded by the Ministry of Education, Culture, Sports, Science and Technology, Japan for collection, quality control, preservation and distribution of genetic materials of human, animal and microbe origin.

3-1-1 Koyadai Tsukuba Ibaraki, 305-0074 JapanOur division was established in 1987 as the RIKEN Gene Bank. When the RIKEN BioResource Center was established in 2001, the bank was recognized as Gene Engineering Division. Since 2002, the Division has been selected as a core facility of DNA resources by National BioResource Project funded by the Ministry of Education, Culture, Sports, Science and Technology, Japan for collection, quality control, preservation and distribution of genetic materials of human, animal and microbe origin.

5-1-17 Sakurajosui Setagaya-ku, Tokyo 156-0045 JapanROW2 Technologies specializes in synthetic organic chemistry, cheminformatics, and chemical knowledge bases.

Tokyo, Tokyo JapanReqMed provides drug development and pharmaceutical consulting.

Mitsui-Life Bldg. 1-7-23 Morino, Machida-City, Tokyo 194-0022, JapanReqMed provides drug development and pharmaceutical consulting.

KDX Shin-yokohama 381 Bldg. 9F 3-8-11 Shin-yokohama, Kohoku-ku Yokohama, Kanagawa, 222-0033 JapanREPROCELL IMPROVING HUMAN HEALTH THROUGH BIOMEDICAL INNOVATION AND DISCOVERY. REPROCELL is dedicated to providing researchers with single-source solutions for the advancement of stem cell and human tissue research in drug discovery and regenerative medicine. With facilities in the USA, Europe, and Japan, our services are available to our clients worldwide. REPROCELL brands include: BIOPTA • Predictive safety, efficacy and ADME assays in human (and animal) fresh functional tissues for drug development BIOSERVE • Extensive biorepository of human tissue samples from a wide range of patients including COVID-19 • Large network of clinical sites for prospective sample collection • Molecular genomic services STEMGENT • iPSC reprogramming services with RNA reprogramming systems • Differentiation services into neurons and other cell types • CRISPR-SNIPER gene editing services

MetLife Shin-yokohama Bldg. 9F, 3-8-11, Shin-yokohama, Kohoku-ku, Yokohama,, Kanagawa, 2220033 JapanREPROCELL IMPROVING HUMAN HEALTH THROUGH BIOMEDICAL INNOVATION AND DISCOVERY. REPROCELL is dedicated to providing researchers with single source solutions for the advancement of stem cell and human tissue research in drug discovery and regenerative medicine. With facilities in the USA, Europe, and Japan, our services are available to our clients worldwide.

Seavans North Bldg., 1-2-1, Shibaura, Minato-Ku, Tokyo 105-8449 JapanUbe Industries offers chemicals, plastics, pharmaceuticals, APIs, construction products and machinery.

Kanagawa Science Park East 502 3-2-1 Sakado, Takatsu-ku, Kawasaki-shi Kanagawa 213-0012, JapanSCIVAX specializes in 3D cell culture, cancer drug screening, and nanoimprint prototyping.

Kanagawa Science Park East Kawasaki, Kanagawa JapanSCIVAX specializes in 3D cell culture, cancer drug screening, and nanoimprint prototyping.

Kannonji Kashihara City, Nara Prefecture 〒 634-8567 JapanSATO YAKUHIN KOGYO offers contract pharmaceutical proessing, over-the-counter medication, bulk pharmaceuticals, medicinal products and ethical drugs.

Tokyo Sumitomo Twin Building (East), 27-1, Shinkawa 2-chome, Chuo-ku, Tokyo 104-8260, JapanSumitomo Chemical's Corporate Philosophy is based on Sumitomo's Business Principles and is composed of the Business Philosophy, which integrates the company's business principles, mission and values; the Corporate Slogan and Statement, which outlines the commitment and pride to be shared in common by employees; and the Sumitomo Chemical Charter for Business Conduct, which lays out the code of behavior serving as the basis for the Company's compliance system.

104-8260 JapanSumitomo Chemical's Corporate Philosophy is based on Sumitomo's Business Principles and is composed of the Business Philosophy, which integrates the company's business principles, mission and values; the Corporate Slogan and Statement, which outlines the commitment and pride to be shared in common by employees; and the Sumitomo Chemical Charter for Business Conduct, which lays out the code of behavior serving as the basis for the Company's compliance system.

6, Kitahara, Tsukuba, Ibaraki, 300-3266, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

1-135, Kasugade-Naka 3-chome, Konohana-ku, Osaka 554-0022, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

Nakasuji Ekimae Building, 28-13, Nakasuji 3-chome, Asaminami-ku, Hiroshima, 731-0122, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

2200, Tsurusaki, Oita, 870-0106, JapaSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

7-5, Kikumoto-cho 1-chome, Nihama, Ehime, 792-0801, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

NHK Nagoya Broadcasting center Building, 13-3, Higashisakura 1-chome, Higashi-ku, NagoyaSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

Sumitomo Fudosan Hongo Building, 3-22-5, Hongo, Bunkyo-ku, Tokyo, 113-0033, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

Sumika Fudosan Yokobori Building, 6-17, Koraibashi 4-chome, Chuo-ku, Osaka, 541-0043, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

Hulic Kudan Building 1-13-5 Kudan Kita, Chiyoda-ku, Tokyo 102-0073, JapanSumitomo Seika offers absorbent polymers, functional chemicals, fine chemicals, gases and engineering.

The Sumitomo Building 4-5-33 Kitahama, Chuo-ku, Osaka 541-0041, JapanSumitomo Seika offers absorbent polymers, functional chemicals, fine chemicals, gases and engineering.

Osaka, Osaka Prefecture JapanSumitomo Seika offers absorbent polymers, functional chemicals, fine chemicals, gases and engineering.

1253, Tateno 3-chome, Higashiyamato-shi Tokyo 207-0021, JapanSeikagaku offers pharmaceuticals and medical devices specifically related to glycoconjugates.

258-5, Aza-Matsukubo, Oaza-Akahama Takahagi-shi, Ibaraki 318-0001, JapanSeikagaku offers pharmaceuticals and medical devices specifically related to glycoconjugates.

3-1, Kurihama 7-chome, Yokosuka-shi Kanagawa 239-0831, JapanSeikagaku offers pharmaceuticals and medical devices specifically related to glycoconjugates.

6-1, Marunouchi 1-chome, Chiyoda-ku Tokyo 100-0005, JapanSeikagaku offers pharmaceuticals and medical devices specifically related to glycoconjugates.

3. Kanda-Nishikicho 1-chome, Chiyoda-ku, Tokyo 101-8448, JapanShimadzu offers analytical technology, laboratory instruments, testing machines, and scales.

1-22 Suketobashi Tokushima-shi, 770-0815 JapanASPION Corporation offers drug formulation, drug development, clinical trials, analytical services, and pharmaceutical products.

4-20-1, Koishikawa, Bunkyo-ku, Tokyo, 112-0002, JapanSO-TI provides an online search service of patent databases in the USA and Japan.

Kyoto, JapanSanyo Chemical Industries, Ltd. manufactures and sells chemical products in Japan and internationally. The company offers superabsorbent polymers, surfactants for hair care products and detergents, base materials for cosmetics and pharmaceuticals, antibacterial agents, EIA diagnostic reagents, potting resins for artificial kidneys, pressure-sensitive adhesives, and hot melt adhesives; and raw materials for polyurethane foam, polyurethane beads for powder slush molding, lubricating oil and fuel oil additives, base materials for synthetic lubricants, water-soluble cutting fluids, halogen-free cleaning agents, and paste resin for design models. It also provides agents for synthetic fiber production and fiberglass, chemicals for carbon fibers, polyurethane for artificial/synthetic leather production and precision grinding, and modifiers for synthetic fibers; and intermediates for polymerization toners/toner resins, electrolytes for aluminum electrolytic and electric double-layer capacitors, cleaning agents for hard disks manufacturing process, processing agents for semiconductors, and photo-acid generators. In addition, the company offers polymer flocculants for industrial wastewater treatment, polyurethane for heat insulating materials, slurry agents, coat-type permeable waterproof material, and reactive hot-melt adhesives; and permanent antistatic agents, pigment dispersants, resin and rheology modifiers, UV/EB curing resins, base materials for polyurethane elastomer, paint resins, defoaming agents, chemical boards for models, emulsifiers for emulsion polymerization, epoxy resin curing agents and accelerators, and polyurethane catalysts. Further, it is involved in general trucking, insurance and travel agency, and real estate businesses; and sells living ware products. The company was formerly known as Sanyo Chemical Industry Co. and changed its name to Sanyo Chemical Industries, Ltd. in 1966. The company was founded in 1949 and is headquartered in Kyoto, Japan.

9-1 Shirokane-5, Minato-kuKitasato University provides protein modeling services.

2-21 東ビル7F 揚場町 新宿区, 東京都, 162-00824 JapanActive Motif, Inc. is a biotechnology company, founded in 1999. The Company develops cell and molecular biology-based research tools that assist with determining the functions, interactions, and regulation of proteins. Active Motif serves the medical research industry worldwide. Active Motif, is the leader in epigenetic services, including a diverse range of assays such as ATAC-seq, ChIP-Seq FactorPath, ChIP-Seq HistonePath, ChIP-Seq TranscriptionPath, ChIP-Seq Tissue, MeDIP-Seq, hMeDIP-Seq, RNA-seq, RRBS, CUT&Tag (cells & Tissue), Hi-C and ChIP antibody validation. Active Motif also offers the latest epigenetic mass spectrometry services for co-factor identification (RIME) and histone modifications (Mod Spec). Active Motif also has expertise in developing custom B-cell antibodies for epigenetic marks and factors. In addition, Active Motif provides the latest single cell assay services in conjunction with 10x Genomics technologies, such as 3' scRNASeq, scATACSeq, 10X Multiome and TotalSeq. Active Motif is able to provide all services at scale to address the needs of the pharmaceutical research markets.

Minato, Tokyo JapanKitasato University provides protein modeling services.

, Chūō-ku, Ōsaka-fu 541-0045, JPUnder our Company Policy to "supply the best possible medicine to protect the health and wellbeing of the patients we serve," it is our mission as the Shionogi Group to deliver medical products creating a higher level of satisfaction to patients and their families for improved quality of life (QOL). To achieve this goal, we are constantly engaged in the research, development, manufacturing, and marketing activities of medical products, with a focus on prescription drugs. In fulfill our goal, we have set out the following Shionogi efforts: Venture into the field of cutting-edge medical technologies and be active as a research-driven pharmaceutical company. Establish production systems that ensure a stable supply of high-quality products that can be used with confidence. Provide in a timely and accurate manner, through healthcare providers, the information necessary to use our products appropriately. To further serve patients worldwide, we carry out these activities domestically and globally and are committed to making our business efforts to expand our business more actively. Meanwhile, Shionogi is also aware of how essential compliance in business activities is in the light of ensuring the sustainability and advancement of the company itself. We are thoroughly devoted to the ethical conduct required for an enterprise and a member of society, not to mention complying with laws and regulations. In addition, to ensure fair and efficient management, Shionogi has structured a highly operational framework and systems that allow for a swift response to changes in the management environment. As members of the Shionogi Group spread across the globe, we are committed to maintaining high ethical standards and transparency as we face all challenges head on. Through these efforts, we aim to be a company that is trusted by all stakeholders, including shareholders, business partners, and society, as well as patients, their families, and healthcare providers. We also pursue to stay a company where all employees can take on challenges with pride and a strong sense of purpose. We would like to thank you for your interest in our company and our products and your continued support will be greatly appreciated.

1-8, Doshomachi 3-chome Chuo-ku, Osaka, 541-0045 JapanUnder our Company Policy to "supply the best possible medicine to protect the health and wellbeing of the patients we serve," it is our mission as the Shionogi Group to deliver medical products creating a higher level of satisfaction to patients and their families for improved quality of life (QOL). To achieve this goal, we are constantly engaged in the research, development, manufacturing, and marketing activities of medical products, with a focus on prescription drugs. In fulfill our goal, we have set out the following Shionogi efforts: Venture into the field of cutting-edge medical technologies and be active as a research-driven pharmaceutical company. Establish production systems that ensure a stable supply of high-quality products that can be used with confidence. Provide in a timely and accurate manner, through healthcare providers, the information necessary to use our products appropriately. To further serve patients worldwide, we carry out these activities domestically and globally and are committed to making our business efforts to expand our business more actively. Meanwhile, Shionogi is also aware of how essential compliance in business activities is in the light of ensuring the sustainability and advancement of the company itself. We are thoroughly devoted to the ethical conduct required for an enterprise and a member of society, not to mention complying with laws and regulations. In addition, to ensure fair and efficient management, Shionogi has structured a highly operational framework and systems that allow for a swift response to changes in the management environment. As members of the Shionogi Group spread across the globe, we are committed to maintaining high ethical standards and transparency as we face all challenges head on. Through these efforts, we aim to be a company that is trusted by all stakeholders, including shareholders, business partners, and society, as well as patients, their families, and healthcare providers. We also pursue to stay a company where all employees can take on challenges with pride and a strong sense of purpose. We would like to thank you for your interest in our company and our products and your continued support will be greatly appreciated.

Sun Terrace Mikawa Anjo F6, 1-15-8, Mikawa Anjo Minami Machi, Anjo, Aichi, 4460058 JapanSapala specializes in taking up Complex Research assignments in the field of Medicinal and Nucleic acid chemistry. Sapala focuses on early R&D to drug discovery programme to cost effective process development for manufacturing of chemical entities as Full Time Equivalent (FTE) & Fee for Service (FFS) models in the field of Medicinal and Nucleic acid Chemistry. Sapala has been contributing in the niche area of Nucleic acid chemistry by taking up challenging research work for synthesis of high value, low volume compounds. Sapala Organics in collaboration with Japanese company have developed the robust, qualitative and cost effective technology for the global an unmet need of unnatural nucleosides and cap reagents used in the global mRNA vaccine development

124-1 Miyukiyama Tenpaku Nagoya Aichi 468-0075, JapanSapala specializes in taking up Complex Research assignments in the field of Medicinal and Nucleic acid chemistry. Sapala focuses on early R&D to drug discovery programme to cost effective process development for manufacturing of chemical entities as Full Time Equivalent (FTE) & Fee for Service (FFS) models in the field of Medicinal and Nucleic acid Chemistry. Sapala has been contributing in the niche area of Nucleic acid chemistry by taking up challenging research work for synthesis of high value, low volume compounds. Sapala Organics in collaboration with Japanese company have developed the robust, qualitative and cost effective technology for the global an unmet need of unnatural nucleosides and cap reagents used in the global mRNA vaccine development

Fujisawa, Kanagawa Prefecture, 251-0012 JapanWe provide two services for successful discovery of small molecule drugs using our Binder Selection Technology. 1. Compound screening We select the compound that binds to the target from the compound library* using our technology. All proteins are targeted. Membrane proteins are used without solubilization. * We use the compound library owned by Takeda Pharmaceutical Company Limited. 2. Target identification We select the protein that binds to the compound from the protein library with one protein per well using the binder selection technology. Membrane proteins can also be examined. Chemical modification of compounds and proteins is unnecessary. This service makes protein identification easier.

26-1, Muraoka-Higashi 2-Chome Fujisawa, Kanagawa, 251-0012 JapanWe provide two services for successful discovery of small molecule drugs using our Binder Selection Technology. 1. Compound screening We select the compound that binds to the target from the compound library* using our technology. All proteins are targeted. Membrane proteins are used without solubilization. * We use the compound library owned by Takeda Pharmaceutical Company Limited. 2. Target identification We select the protein that binds to the compound from the protein library with one protein per well using the binder selection technology. Membrane proteins can also be examined. Chemical modification of compounds and proteins is unnecessary. This service makes protein identification easier.

19-48, Yoshino, Matsumoto City, Nagano Prefecture 399-8710, JapanHealth and happiness are common desires of people around the world. We at Kissei have met the challenge of developing innovative new drugs that can contribute to the health of people around the world under the management philosophy of "making a social contribution through high-quality, innovative pharmaceutical products" and "serving society through the members who constitute the company." "Pharmaceutical companies are worthless without R&D." These words have been passed on at Kissei ever since it was founded. In addition to demonstrating that R&D is the vital core of the company, they convey the ardor and passion of each and every employee towards the creation of new drugs in the hope that new drugs will allow as many people as possible to recover from illness as soon as possible, to lead lives filled with laughter and joy. The brilliant progress of the life sciences has contributed immeasurably to the health and happiness of mankind. Yet there remain many illnesses for which treatments have yet to be established and illnesses for which no satisfactory treatments exist, and highly useful, new drugs are sought. We at Kissei will continue to constantly incorporate the progress made in the field of the life sciences, strengthening our R&D activities to meet the challenges of developing new drugs, and providing superior drugs to people throughout the world as the fruits of our innovations.

2438 Miyanoura-cho Kagoshima-shi, Kagoshima, 891-1394 JapanSNBL (Shin Nippon Biomedical Laboratories) offers drug safety research and clinical pharmacology research services through its subsidiaries.

RBM Kyobashi Bldg. 3-4-8 Hatchobori Chuo-ku, Tokyo, 104-0032 JapanSRD Co., Ltd. was established in 1989 as a company that specializes in supporting clinical research and development including data management, site selection, study monitoring, statistical analysis, regulatory consulting, and medical writing. Since then, we have provided support services for many clinical trials and have broadly consulted on development and regulatory applications for pharmaceuticals as well as medical devices, quasi-drugs and specified health foods. In response to changes in pharmaceutical development trend, we have built our track record as support specialist for research and development of unmet medical needs and new, highly challenging drugs. Although we are an independent and middle sized CRO, by making full use of our mobility and a wide network of information which can be compared to other competitors in the industry, we are confident that we have a system for providing services with reliable quality in any area and for responding to the diverse needs and requirements of our clients. The basic principles in providing our services are as follows: ・We execute our duties faithfully as a partner who shares the client’s perspective. ・We seek mutual growth and development with our clients by assisting with the achievement of their aspirations and fulfillment of their potential through support of their development initiatives. SRD Group is providing not only full CRO service, but also providng full SMO ervice in Japan and Vietnam so that we have capabilities to manage, operate, and complete your product development in Japan 2015, SRD established Asia Clinical Trial Support Alliance consisted with CROs and SMOs called CSIA (Clinical Service in Asia) in Asian region including Japan, China, Korea, Taiwan, and Vietnam for worldwide pharmaceutical companies and other regional CROs. CSIA is consisted with top ranked 8 companies form above countries and region, and looking for local independent CROs and SMOs to have a partnership in Asian region for our customers to support entire clinical trial in Asia. CSIA web site is now updating especially for Korea part, but please refer to the details of CSIA through web site (http://www.cro-srd.co.jp/csia/en/). We look forward to your continued support and partnership.

Chiyoda-ku, Tokyo, JapanBioView offers MRI imaging, research support, and nondestructive testing of materials.

2-16-1 Minami-Kamata Ota Tokyo, 1440035 JapanSMC Laboratories has been supporting nonclinical pharmacology research for almost 10 years, with over 700 clients globally. It is our proprietary STAM™ mice that has made us a leading CRO in the NASH-HCC research field. In addition to our strong expertise in liver research, SMC Laboratories has accumulated know-how in various experimental conditions associated with NASH, such as metabolic disorders, diabetes, inflammation, fibrosis and cancer, and expanded our service to various other organs and diseases, including pulmonary fibrosis, systemic sclerosis, and chronic kidney disease.

Bunkyō-ku, Tōkyō-to, 113-0034 Japan

Ibaraki-shi, Ōsaka-fu, 567-0054 JapanTaisei Kako Co., Ltd manufactures the products made by some materials such as plastic, aluminum, glass for Pharmaceutical product, Medical products and Cosmetic products.

4321, Uchimoriya-machi Joso-shi, Ibaraki, 303-0043 JapanThe Institute of Environmental Toxicology (IET) in Ibaraki, Japan is a reputable research organization specializing in conducting comprehensive toxicology studies that has supported the registration of agrochemicals for over 50 years. IET collaborates with clients to evaluate the safety of their products. Extensive testing is available, including toxicity studies (e.g. acute oral toxicity, 28-day oral toxicity, bacterial reverse mutation, in vitro chromosome aberration, micronucleus and dermal sensitization, and 4-week immunotoxicity studies), eco-tox, metabolism studies (in soil, water, crops) and residue studies (in soil, water, crops). IET is AAALAC accredited and conducts research to Good Laboratory Practice (GLP) standards, showcasing our commitment to thorough research and ensuring consumer safety.

Uchimoriya machi 4321 Mitsukaido shi, 303 Ibaraki JapanThe Institute of Environmental Toxicology (IET) in Ibaraki, Japan is a reputable research organization specializing in conducting comprehensive toxicology studies that has supported the registration of agrochemicals for over 50 years. IET collaborates with clients to evaluate the safety of their products. Extensive testing is available, including toxicity studies (e.g. acute oral toxicity, 28-day oral toxicity, bacterial reverse mutation, in vitro chromosome aberration, micronucleus and dermal sensitization, and 4-week immunotoxicity studies), eco-tox, metabolism studies (in soil, water, crops) and residue studies (in soil, water, crops). IET is AAALAC accredited and conducts research to Good Laboratory Practice (GLP) standards, showcasing our commitment to thorough research and ensuring consumer safety.

3-14-3 Minamikumamoto, Kumamoto-shi Kumamoto,Trans Genic offers antibodies, transgenic models, phenotyping, and gene targeting products and services.

Tokyo, Tokyo JapanTheravalues Corporation provides nuclear receptor analysis and proteomics analysis services.

JapanTeika Pharmaceutical is an integrated drug manufacturer that offers liquid-to-oral agents, ophthalmic ointment and adhesive patches.

180 Umekoji, Inokuma, Shimogyo-ku,Kyoto, 600-8686, JapanTakii was established in 1835, starting as a seed store, dealing seeds of local Kyoto vegetable. Mr. Jisaburo Takii who was known as a hardworking and reliable farmer, started to produce and to distribute quality seed, which was the very beginning of Takii. Kyoto was an old capital and various kinds of vegetables from other areas were gathered and presented to the Imperial family and for many head’s of temples. Thus Kyoto has become one of the cradles of seed industry in Japan. In 1920, Takii started to export seed overseas, and after 1926 established its International Division. After WWII, Takii has been developing quality seed, creating new distribution networks and new ways of promotion, causing it to be recognized as one of the leading companies in the seed industry.

600-8686 JapanTakii was established in 1835, starting as a seed store, dealing seeds of local Kyoto vegetable. Mr. Jisaburo Takii who was known as a hardworking and reliable farmer, started to produce and to distribute quality seed, which was the very beginning of Takii. Kyoto was an old capital and various kinds of vegetables from other areas were gathered and presented to the Imperial family and for many head’s of temples. Thus Kyoto has become one of the cradles of seed industry in Japan. In 1920, Takii started to export seed overseas, and after 1926 established its International Division. After WWII, Takii has been developing quality seed, creating new distribution networks and new ways of promotion, causing it to be recognized as one of the leading companies in the seed industry.

1-10-11, Hamamatsucho, Minato-ku, Tokyo 105-0013, JAPANTMRC specializes in the development of anti-cancer products.

Tokyo JapanTMRC specializes in the development of anti-cancer products.

4-10-9, Takaido-higashiTN Technos offers fluorescent and phosphorescent pigments.

2-5 Nihonbashi-honcho 2-Chome, Chuo-ku, Tokyo, 103-0023 JapanTeikoku Seiyaku offers development, manufacturing and sales of medicated and medically related supplies.

4-1 Fushimimachi 4-chome, Chuo-ku, Osaka 541-0044, JapanTeikoku Seiyaku offers development, manufacturing and sales of medicated and medically related supplies.

80-11 Kitahara, Donari, Donari-cho, Awa, Tokushima 771-1506, JapanTeikoku Seiyaku offers development, manufacturing and sales of medicated and medically related supplies.

4560, Kaisei-cho, Shunanshi, Yamaguchi 746-8501, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

Sendai Green Place 2F, 1-11-1, Aoba-ku, Honmachi, Sendai, Miyagi 980-0014, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

4-4-9, Kouraibashi, Chuo-ku, Osaka 541-0043, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

Meiko Building, 1-17-13, Nishiki, Naka-ku, Nagoya 460-0003, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

Kogin Building, 1-13-2, Tenjin, Chuo-ku, Fukuoka 810-0001, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

2, Iwase Koshi-machi, Toyama 931-8510, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

1-8, Kasumi, Yokkaichi, Mie 510-8540, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

Tokyo Research Laboratory 2743-1, Hayakawa, Ayase, Kanagawa 252-1123, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

3-8-2 Shiba, Minato-KuTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

2-1-11, Sasazuka, Shibuya, Tokyo 151-0073, JapanToa Pharmaceutical specialize in supplying bacterial probiotics.

Tokyo, Tokyo JapanToa Pharmaceutical specialize in supplying bacterial probiotics.

Higashi Ikebukuro Tokyo 170-0013 JapanFounded in 1989, Thorlabs has its headquarters in Newton, NJ. This location is also home to our mechanics, optics, fiber, advanced systems technology, and advanced applications teams as well as one of our three distribution warehouses. On-site manufacturing allows us to customize our products quickly and efficiently to meet specialized customer requests. Our technical support team, call center, marketing, and web development teams make their homes in Newton as well, and are dedicated to providing comprehensive customer support and services.

Dogenzaka Square Suite 503, Floor 5, 5-18 Shibuya-Ku, Tokyo, JapanTheorem Clinical Research offers full service clinical research solutions including DM, biostatistics, programming including CDISC, PM, clinical operations, and regulatory affairs.

University of Tokyo Entrepreneur Plaza 7-3-1 Hongo Tokyo, Bunkyo-ku, 113-0033 JapanThinkCyte, founded in 2016 and headquartered in Tokyo, Japan, is a biotechnology company developing innovative products for life science research, diagnostics, and therapeutic discovery & development using integrated multidisciplinary technologies (microfluidics, advanced optics, and machine learning). The company has pioneered Ghost Cytometry, a proprietary image-based high-throughput label-free cell sorting technology initially published in Science in 2018. In June 2019, the company was selected for J-Startup by the Ministry of Economy, Trade and Industry of Japan. ThinkCyte is developing commercially available instruments for the life science R&D market and also engages in collaborative research with leading biopharmaceutical companies, clinical research centers, and academic institutes. For more information, please visit our website (https://thinkcyte.com).

2008-2 Wada Tama-city Tama-city, Tokyo, 206-0001 Japan

Fuju Bldg. 5-30-9 Shiba, Minatku Tokyo, Japan, 108-0014 Japan

Lab 1 Science Road Osaka, Oasaka, 12345 JapanTriage Pharmaceuticals is the industry leading global biotechnology organization across the Best Service Ever categories, operating in over 50 facilitates operating in over 15 countries. Our expert team is passionate about our role in building comprehensive _world-class_ solutions that best enables Triage to improve and expedite your pipeline - with laser focus on customer service and delivering results. Our service portfolio includes the earliest stages of drug discovery through clinical trials, and our philosophy is to be a trusted partner with you and your organization to determine the optimal solutions based on your objectives and KPIs. We are the world's leading premier CRO, and fully accredited in a variety of scientific disciplines. Our expertise include: * Next Generation Sequencing * Human Biological Sample Provisioning and Analysis

Japan Tokyo, Tokyo JapanTriage Pharmaceuticals is the industry leading global biotechnology organization across the Best Service Ever categories, operating in over 50 facilitates operating in over 15 countries. Our expert team is passionate about our role in building comprehensive _world-class_ solutions that best enables Triage to improve and expedite your pipeline - with laser focus on customer service and delivering results. Our service portfolio includes the earliest stages of drug discovery through clinical trials, and our philosophy is to be a trusted partner with you and your organization to determine the optimal solutions based on your objectives and KPIs. We are the world's leading premier CRO, and fully accredited in a variety of scientific disciplines. Our expertise include: * Next Generation Sequencing * Human Biological Sample Provisioning and Analysis

2-1 Nihonbashi-Odenmacho Chuo-ku, Tokyo, 1030011 Japan■About Trans Chromosomics Our company was founded in 2014 to put the research outcomes of basic chromosome researches over 40 years into practical use. The beginning of the application of the chromosomal engineering research to medicine was the development of human mono chromosome library and the chromosome transfer technology. In the 1990's, we succeeded in developing the first fully human antibody-producing mouse in the world through collaboration research with Kirin Brewery Co., Ltd. (present Kyowa Hakko Kirin Co., Ltd.). This result has opened up a new era of antibody drugs. In the next 20 years, the foundation of artificial chromosome engineering technology has been completed, and many state-of-the-art platforms are being constructed for drug discovery to combat intractable diseases. Through extensive use of these technologies, we will strive to reach out, even a day earlier, to patients who suffer from intractable diseases. ■Our Mission We contribute to people's living and health by applying innovative chromosome engineering technology developed by Tottori University (Japan) to medical treatment and drug discovering widely. ■Our Business: Research and development and commissioned research of pharmaceuticals by utilizing chromosome engineering technology - Development of humanized model mice & rats - Fully human antibody producing mice (TC-mAb mouse) - Humanized ADME model mice & rats (Tc-huADME Model) - Humanized genetic rare disease model mice & rats - Down Syndrome mouse/rat model (A model animal with human chromosome 21 introduced) - Contract studies - Discovery of fully human antibodies - Pharmacokinetic study using humanized ADME model mice & rats 　- Animal production of above trans-chromosomic mice & rats ____________________________________________________________________________ ■Our Key Technology: Artificial Chromosome Vector The artificial chromosome is a vector having a minimal function and structure as a chromosome by removing the gene region from a natural human or mouse chromosome. It is possible to introduce Mb size giant genes and multiple genes. The artificial chromosome is maintained stably in the cell and is transmitted from the parent to children in mouse and rat. The artificial chromosome vector is not inserted into the chromosome of the host but exists independently within the cell nucleus. Since it can carry various genes, it functions as a high-performance remote controller that issues commands to cells. Examples of practical applications include fully human antibody-producing animals, rare disease animal models, and cells / animals for functional evaluation. ■Fully Human Antibodies Producing Mouse: TC-mAb mouse We established a new generation of human Ab producing Tc mice (TC-mAb mice), which stably maintain a mouse-derived engineered chromosome containing the entire human Ig heavy and kappa chain loci in a mouse Ig knockout background. Comprehensive, high-throughput DNA sequencing revealed that the human Ig repertoire, including variable gene use, was well recapitulated in TC-mAb mice. Despite slightly altered B cell development and a delayed immune response, immunized TC-mAb mice exhibited more subsets of antigen-specific plasmablast and plasma cells compared with wild-type mice, leading to high efficiency hybridoma production. Thus, TC-mAb mice offer a valuable platform to obtain fully human therapeutic Abs and to elucidate the regulation of human Ig repertoire formation. [Contract studies] - Animal production of above trans-chromosomic mice & rats - Custom fully human antibody development using TC-mAb mouse. - We can refer you to our company’s partner. ■Humanized ADME Model Mouse & Rats: Tc-huADME Model In order to solve the problem of animal species differences found in research and development, human pharmacokinetic-related gene was introduced into experimental animals with artificial chromosome vector. Since it is introduced with gene regulatory region induced, it reproduces timing specific and tissue specific expressions in mouse / rat. These animals are useful for predicting human-specific pharmacokinetics, enzyme induction / inhibition tests, and analysis of drug-drug interactions. In addition to supplying animals as collaborative research, we also conduct contract tests from drug administration to sampling. - A model animal in which a pharmacokinetic-related gene cluster is humanized. - Physiological gene expression confirmed in all tissues. - Breeding by mating is possible. [TC-huADME model lines] - hCYP3A-Tc, mCyp3a KO(CYP3A5*3) mouse - hCYP3A-Tc, mCyp3a KO(CYP3A5*1) mouse - hCYP3A-Tc, rCyp3a KO rat - hCYP3A-Tc, mCyp3a KO, hPXR KI mouse - hUGT2-Tc, mUgt2 KO mouse / rat - hMDR1-Tc, mMdr1a/1b KO mouse [Contract pharmacokinetic (PK/TK) studies] In pharmacokinetic (PK/TK) study at our company's partner, temporal blood collection will be conducted after test substance is administered to the animal.Generally, plasma or serum will be separated and delivered in a frozen state. We can also collect urine and feces and dissect for tissue sampling. - Non-GLP study : Conducted by our company. - GLP study : We request our partner company (SHIN NIPPON BIOMEDICAL LABORATORIES, LTD. (SNBL)). ■HepG2 Cell for stable expression of 4CYPs+POR HepG2 cell: TC-HepG2 HepG2 cells, a cell line derived from human liver cancer, have been used as an alternative model of the liver for many years. However, since expression of drug metabolism-related genes (mainly CYP) is remarkably low, and it is considered difficult to use them as a substitute for human primary hepatocytes. We have overcome this problem with artificial chromosome vector connected to four CYPs (CYP2C9, CYP2C19, CYP2D6, CYP3A4) and POR and provide cells showing high CYP activity. [Applications of TC-HepG2 cell] - Inhibition test / drug interaction test - Research of hepatotoxicity - High content screening ■Down Syndrome mouse/rat model: Evaluation of anxiety-like behavior　 A model animal with human chromosome 21 introduced. The animal is useful for; - Phenotypic analysis of higher brain dysfunction etc. - Evaluation of drugs for ameliorating symptoms. - Drug discovery by identifying causative genes. - Drug repositioning search Please refer to the attached PDF for details.

86 Nishi-cho Yonago, Tottori, 6838503 Japan■About Trans Chromosomics Our company was founded in 2014 to put the research outcomes of basic chromosome researches over 40 years into practical use. The beginning of the application of the chromosomal engineering research to medicine was the development of human mono chromosome library and the chromosome transfer technology. In the 1990's, we succeeded in developing the first fully human antibody-producing mouse in the world through collaboration research with Kirin Brewery Co., Ltd. (present Kyowa Hakko Kirin Co., Ltd.). This result has opened up a new era of antibody drugs. In the next 20 years, the foundation of artificial chromosome engineering technology has been completed, and many state-of-the-art platforms are being constructed for drug discovery to combat intractable diseases. Through extensive use of these technologies, we will strive to reach out, even a day earlier, to patients who suffer from intractable diseases. ■Our Mission We contribute to people's living and health by applying innovative chromosome engineering technology developed by Tottori University (Japan) to medical treatment and drug discovering widely. ■Our Business: Research and development and commissioned research of pharmaceuticals by utilizing chromosome engineering technology - Development of humanized model mice & rats - Fully human antibody producing mice (TC-mAb mouse) - Humanized ADME model mice & rats (Tc-huADME Model) - Humanized genetic rare disease model mice & rats - Down Syndrome mouse/rat model (A model animal with human chromosome 21 introduced) - Contract studies - Discovery of fully human antibodies - Pharmacokinetic study using humanized ADME model mice & rats 　- Animal production of above trans-chromosomic mice & rats ____________________________________________________________________________ ■Our Key Technology: Artificial Chromosome Vector The artificial chromosome is a vector having a minimal function and structure as a chromosome by removing the gene region from a natural human or mouse chromosome. It is possible to introduce Mb size giant genes and multiple genes. The artificial chromosome is maintained stably in the cell and is transmitted from the parent to children in mouse and rat. The artificial chromosome vector is not inserted into the chromosome of the host but exists independently within the cell nucleus. Since it can carry various genes, it functions as a high-performance remote controller that issues commands to cells. Examples of practical applications include fully human antibody-producing animals, rare disease animal models, and cells / animals for functional evaluation. ■Fully Human Antibodies Producing Mouse: TC-mAb mouse We established a new generation of human Ab producing Tc mice (TC-mAb mice), which stably maintain a mouse-derived engineered chromosome containing the entire human Ig heavy and kappa chain loci in a mouse Ig knockout background. Comprehensive, high-throughput DNA sequencing revealed that the human Ig repertoire, including variable gene use, was well recapitulated in TC-mAb mice. Despite slightly altered B cell development and a delayed immune response, immunized TC-mAb mice exhibited more subsets of antigen-specific plasmablast and plasma cells compared with wild-type mice, leading to high efficiency hybridoma production. Thus, TC-mAb mice offer a valuable platform to obtain fully human therapeutic Abs and to elucidate the regulation of human Ig repertoire formation. [Contract studies] - Animal production of above trans-chromosomic mice & rats - Custom fully human antibody development using TC-mAb mouse. - We can refer you to our company’s partner. ■Humanized ADME Model Mouse & Rats: Tc-huADME Model In order to solve the problem of animal species differences found in research and development, human pharmacokinetic-related gene was introduced into experimental animals with artificial chromosome vector. Since it is introduced with gene regulatory region induced, it reproduces timing specific and tissue specific expressions in mouse / rat. These animals are useful for predicting human-specific pharmacokinetics, enzyme induction / inhibition tests, and analysis of drug-drug interactions. In addition to supplying animals as collaborative research, we also conduct contract tests from drug administration to sampling. - A model animal in which a pharmacokinetic-related gene cluster is humanized. - Physiological gene expression confirmed in all tissues. - Breeding by mating is possible. [TC-huADME model lines] - hCYP3A-Tc, mCyp3a KO(CYP3A5*3) mouse - hCYP3A-Tc, mCyp3a KO(CYP3A5*1) mouse - hCYP3A-Tc, rCyp3a KO rat - hCYP3A-Tc, mCyp3a KO, hPXR KI mouse - hUGT2-Tc, mUgt2 KO mouse / rat - hMDR1-Tc, mMdr1a/1b KO mouse [Contract pharmacokinetic (PK/TK) studies] In pharmacokinetic (PK/TK) study at our company's partner, temporal blood collection will be conducted after test substance is administered to the animal.Generally, plasma or serum will be separated and delivered in a frozen state. We can also collect urine and feces and dissect for tissue sampling. - Non-GLP study : Conducted by our company. - GLP study : We request our partner company (SHIN NIPPON BIOMEDICAL LABORATORIES, LTD. (SNBL)). ■HepG2 Cell for stable expression of 4CYPs+POR HepG2 cell: TC-HepG2 HepG2 cells, a cell line derived from human liver cancer, have been used as an alternative model of the liver for many years. However, since expression of drug metabolism-related genes (mainly CYP) is remarkably low, and it is considered difficult to use them as a substitute for human primary hepatocytes. We have overcome this problem with artificial chromosome vector connected to four CYPs (CYP2C9, CYP2C19, CYP2D6, CYP3A4) and POR and provide cells showing high CYP activity. [Applications of TC-HepG2 cell] - Inhibition test / drug interaction test - Research of hepatotoxicity - High content screening ■Down Syndrome mouse/rat model: Evaluation of anxiety-like behavior　 A model animal with human chromosome 21 introduced. The animal is useful for; - Phenotypic analysis of higher brain dysfunction etc. - Evaluation of drugs for ameliorating symptoms. - Drug discovery by identifying causative genes. - Drug repositioning search Please refer to the attached PDF for details.

Tenjin Daisan Building 4F, 3-5, Tenjin 3-chome, Chuo-ku, Fukuoka 810-0001 JapanFounded in 1980 by Irish biochemist and entrepreneur Dr. Pearse Lyons, Alltech is a leading global biotechnology company whose mission is to improve the health and performance of people, animals and plants through natural nutrition and scientific innovation. We pursue this mission guided by what we call the ACE principle, our promise that in doing business we have a positive impact on the Animal, the Consumer and the Environment. Animal Health Our core business improves animal health and performance by adding nutritional value to feed, naturally, through Alltech’s innovative use of yeast fermentation, enzyme technology, algae and nutrigenomics, which studies the impact of nutrition at the genetic level. Our technologies and support programs enable farmers to realize greater efficiency, profitability and sustainability on their farms. Alltech Crop Science Our Alltech Crop Science division complements our animal nutrition business by focusing on improving the health of crops. Our technologies enable us to improve the productivity of the field, in terms of yield quality and quantity, and to enhance nutrition beginning with the soil and the seed. Human Health We believe scientific innovation in animal and crop sciences is part of a much more important story, that of human health. Healthier animals and crops, nurtured naturally through Alltech’s nutritional solutions, affect human well-being. For example, fruits, vegetables and animal proteins have become less nutrient-rich in the past half-century. From fish to oranges, you need to eat more today to get the same nutritional value. Our work within animal and crop sciences is restoring value and also exploring ways to naturally enrich foods through improving the animal diet or crop produced. For example, laying hens fed a diet rich in Alltech’s algae produce eggs enriched with DHA omega-3, an essential nutrient for human cognitive development and health at all ages.

Tsukuba-shi, Ibaraki-ken, 305-0006 Japan

67-2 Kashiwa, Kashiwa, Chiba 277-0005 JapanUnitech provides animal experiments, transgenic mice creation, recombination services, and genetic services.

1-2-7 Higashiyama, Meguro-ku, TokyoIn-Vivo Science offers in vivo disease model services.

1-1 Kanosakuradacho, Gifu City, Gifu Prefecture 500-8558, JapanAPI Co. LTD offers manufacturing of dietary supplements, pharmaceuticals and ingredients for drinks and bee products.

Shinkawa KS Building 3F, 2-22-6 ShinkawaCuo-ku, 104-0033 Tokyo, JapanBiologics Consulting Group, Inc. (BCG) provides regulatory and product development advice on production of biological, drug and device products.

Nippon Building 6F, 2-6-2 Otemachi, Chiyoda-ku, Tokyo 100-0004 JapanWe offer contract research services ranging from data management and documentation support to statistical analysis and related application software development. We also dispatch researchers and developers to various institutions on a contract basis.

79 Toyozawa-cho Himeji-shi Hyogo, 670-0964 JapanWe offer contract research services ranging from data management and documentation support to statistical analysis and related application software development. We also dispatch researchers and developers to various institutions on a contract basis.

2-9 Kanda Nishikicho Chiyoda-ku, Tokyo 101-0054 JapanWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

Nomura-fudosan Yotsubashi Bldg. 8F 1-4-4 Awaza Nishi-ku, Osaka-shi Osaka-fu 550-0011 JapanWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

3-11-12, Hatchobori Daiki Bldg. 7F Chuo-Ku, Tokyo 104-0032 JapanWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

105 Higashifukai, Nagareyama City, Chiba 270-0101 JapanBio Matrix Research provides custom base sequencing, DNA microarray analysis, and systematic generation of monoclonal antibodies.

5-1-3 Miyahara, Yodogawa-ku, Osaka 532-0003, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

36-7 Oyama-cho, Shibuya-ku, Tokyo 151-0065, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

Tokyo, JAPAN 1410021Wholesale Group International (WGI) specializes in the supply of food technology and packaging product solutions. Through an associated business, (Total Scientific Solutions), WGI delivers nutritional, food technology and packaging consultancy to small, medium and multinational food manufacturers, and food distributors in Australia and also Japan. We specialize in the implementation of oxygen absorbers and an assortment of other absorbers (eg. CO2 releasing/ absorbing) in food products to extend shelf-life; Superior quality to traditional oxygen-absorbing satchel, reducing preservative use in food products. Our customers have specific quality assurance requirements (eg., WQA, BRC, ISO22000: HACCP, SQF2000) We can also assist in the selection of scientific testing and laboratory equipment for your food company in-house testing lab.

, Wakayama-shi, Wakayama-ken 641-0011, JPThe Laboratory Animal Center was established as the “Joint Use Facility and Animal Room as a part of the Applied Medicial Research Laboratory in 1974. It was re-established as the “Laboratory Animal Center” during the move to the Kimiidera Campus in 1999. The Center supports animal experiments carried out in the University. In addition to rearing laboratory animals, it has in place the environment required for more advanced animal experiments and supplies data and information relevant to animal experiments. The Center has a total area of about 1980 m2. The rearing room is set at a temperature of 23±1°C, 50-60% humidity, with illumination from 8:00 to 20:00 (12L12D). Animals reared include mice (maximum storage capacity of 21,935 animals), rats (maximum storage capacity of 730 animals), hamsters, gerbils, guinea pigs, rabbits (maximum storage capacity of 114 animals), dogs, monkeys (maximum storage capacity of eight animals), and chickens. The Center is equipped with a rearing room with an air conditioning system that uses a one-way airstream method to prevent generation of smells and allergens from the animals and create a pleasant environment for researchers, a microbarrier system for rearing many genetically recombinant animals in a clean environment, an environmentally controlled rearing room with optionally programed temperature, humid, and lighting, and an experimental rearing room for experiments such as stress tests that require irritation of the animals to be prevented as far as possible. In addition, the Center is also involved in the creation of new genetically recombinant animals using gene editing technology and stock preservation of mutant strains. At present, the Center is involved in a wide variety of basic research and applied research, including analysis of stress response in various organs, research into wound healing, research into pain mechanisms, analysis of obesity-related hormone induced genes, basic research into cancer immunotherapy, analysis of genes involved in organogenesis, and analysis of the roles of chemokines and cytokines in various diseases.

, Wakayama-shi, Wakayama-ken 641-0012, JPThe Laboratory Animal Center was established as the “Joint Use Facility and Animal Room as a part of the Applied Medicial Research Laboratory in 1974. It was re-established as the “Laboratory Animal Center” during the move to the Kimiidera Campus in 1999. The Center supports animal experiments carried out in the University. In addition to rearing laboratory animals, it has in place the environment required for more advanced animal experiments and supplies data and information relevant to animal experiments. The Center has a total area of about 1980 m2. The rearing room is set at a temperature of 23±1°C, 50-60% humidity, with illumination from 8:00 to 20:00 (12L12D). Animals reared include mice (maximum storage capacity of 21,935 animals), rats (maximum storage capacity of 730 animals), hamsters, gerbils, guinea pigs, rabbits (maximum storage capacity of 114 animals), dogs, monkeys (maximum storage capacity of eight animals), and chickens. The Center is equipped with a rearing room with an air conditioning system that uses a one-way airstream method to prevent generation of smells and allergens from the animals and create a pleasant environment for researchers, a microbarrier system for rearing many genetically recombinant animals in a clean environment, an environmentally controlled rearing room with optionally programed temperature, humid, and lighting, and an experimental rearing room for experiments such as stress tests that require irritation of the animals to be prevented as far as possible. In addition, the Center is also involved in the creation of new genetically recombinant animals using gene editing technology and stock preservation of mutant strains. At present, the Center is involved in a wide variety of basic research and applied research, including analysis of stress response in various organs, research into wound healing, research into pain mechanisms, analysis of obesity-related hormone induced genes, basic research into cancer immunotherapy, analysis of genes involved in organogenesis, and analysis of the roles of chemokines and cytokines in various diseases.

811-1 Kimiidera Wakayama, Wakayama Prefecture, 641-8509 JapanThe Laboratory Animal Center was established as the “Joint Use Facility and Animal Room as a part of the Applied Medicial Research Laboratory in 1974. It was re-established as the “Laboratory Animal Center” during the move to the Kimiidera Campus in 1999. The Center supports animal experiments carried out in the University. In addition to rearing laboratory animals, it has in place the environment required for more advanced animal experiments and supplies data and information relevant to animal experiments. The Center has a total area of about 1980 m2. The rearing room is set at a temperature of 23±1°C, 50-60% humidity, with illumination from 8:00 to 20:00 (12L12D). Animals reared include mice (maximum storage capacity of 21,935 animals), rats (maximum storage capacity of 730 animals), hamsters, gerbils, guinea pigs, rabbits (maximum storage capacity of 114 animals), dogs, monkeys (maximum storage capacity of eight animals), and chickens. The Center is equipped with a rearing room with an air conditioning system that uses a one-way airstream method to prevent generation of smells and allergens from the animals and create a pleasant environment for researchers, a microbarrier system for rearing many genetically recombinant animals in a clean environment, an environmentally controlled rearing room with optionally programed temperature, humid, and lighting, and an experimental rearing room for experiments such as stress tests that require irritation of the animals to be prevented as far as possible. In addition, the Center is also involved in the creation of new genetically recombinant animals using gene editing technology and stock preservation of mutant strains. At present, the Center is involved in a wide variety of basic research and applied research, including analysis of stress response in various organs, research into wound healing, research into pain mechanisms, analysis of obesity-related hormone induced genes, basic research into cancer immunotherapy, analysis of genes involved in organogenesis, and analysis of the roles of chemokines and cytokines in various diseases.

383-2 Nakahara-machi, Nishi-ku Kumamoto-shi,, Kumamoto-ken JapanARK Resource offers polyclonal and monoclonal antibody production, ascitic fluid production, antibody purification, and geneticall modified mouse/rat services.

Kumamoto, Kumamoto Prefecture JapanARK Resource offers polyclonal and monoclonal antibody production, ascitic fluid production, antibody purification, and geneticall modified mouse/rat services.

1-2-7, Nishiki, Naka-ku, Nagoya 460-8630 JapanAmano Enzyme offers medical, food and industrial enzymes.

Ehime University Academic Support Center Applied Protein Research Lab 4F 3 Bunkyo-cho Matsuyama, Ehime, 790-8577 JapanIt is our goal to make proteins work! CellFree Sciences is using its own wheat germ cell-free protein expression system to serve protein needs in life sciences and for industrial use. Performing protein synthesis outside of the cell in an in vitro system allows us to separate protein production from other processes required to maintain a cell. Thus, working cell-free opens new opportunities to better adopt protein synthesis to protein needs offering dedicated reagents to make for example membrane proteins in a lipid environment, labeled proteins for use in MS or NMR, or well-folded antigens for antibody production. Our scalable and flexible expression system can serve protein needs from the small amounts used for production of our protein bead arrays presenting up to 23,000 human full-length proteins to individual proteins made on large-scale for use in structural biology, medical research, on-demand product production, and diagnostic tests. Our eukaryotic expression system has a strong record on supporting a wide range of projects working on all kinds of proteins from the kingdoms of life.

Ehime University Venture Bus Lab 4F, 3 Bunkyo-cho, Matsuyama, Ehime, 790-8577 JAPANIt is our goal to make proteins work! CellFree Sciences is using its own wheat germ cell-free protein expression system to serve protein needs in life sciences and for industrial use. Performing protein synthesis outside of the cell in an in vitro system allows us to separate protein production from other processes required to maintain a cell. Thus, working cell-free opens new opportunities to better adopt protein synthesis to protein needs offering dedicated reagents to make for example membrane proteins in a lipid environment, labeled proteins for use in MS or NMR, or well-folded antigens for antibody production. Our scalable and flexible expression system can serve protein needs from the small amounts used for production of our protein bead arrays presenting up to 23,000 human full-length proteins to individual proteins made on large-scale for use in structural biology, medical research, on-demand product production, and diagnostic tests. Our eukaryotic expression system has a strong record on supporting a wide range of projects working on all kinds of proteins from the kingdoms of life.

Matsuyama, Ehime Prefecture JapanIt is our goal to make proteins work! CellFree Sciences is using its own wheat germ cell-free protein expression system to serve protein needs in life sciences and for industrial use. Performing protein synthesis outside of the cell in an in vitro system allows us to separate protein production from other processes required to maintain a cell. Thus, working cell-free opens new opportunities to better adopt protein synthesis to protein needs offering dedicated reagents to make for example membrane proteins in a lipid environment, labeled proteins for use in MS or NMR, or well-folded antigens for antibody production. Our scalable and flexible expression system can serve protein needs from the small amounts used for production of our protein bead arrays presenting up to 23,000 human full-length proteins to individual proteins made on large-scale for use in structural biology, medical research, on-demand product production, and diagnostic tests. Our eukaryotic expression system has a strong record on supporting a wide range of projects working on all kinds of proteins from the kingdoms of life.

Tokyo, JapanGene Logic (a division of Ocimum Biosolutions) provides RNA and DNA isolation, qRT-PCR, genotyping, copy number analysis, microdissection and expression analysis services using ABI TaqMan or Agilent, Affymetrix, Ilumina and BioTrove platforms.

Kannami-cho, Tagata-gun, Shizuoka, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

B-Bridge Co., Ltd. Shoji Building 7F 3-4-10 Misakicho Chiyoda-ku, Tokyo 101-0061 JapanB-Bridge International offers kits, reagents, and products related to: adipocytes, antibodies, cell strain, cloning, culture medium, ELISA, hydrogels, stem cells, and nucleic acid purification.

#415 Research Innovation Center, Bldg. 121, Waseda University, 513 Wasedatsurumakicho Shinjuku-ku, Tokyo, Not Applicable, 162-0041 JapanbitBiome is a biotech company with microbial single-cell genome analysis technology and microbial genome database.

8F, SB bldg., 1-4-6, Nezu, Bunkyo-ku, Tokyo 113-0031, JapanBioLegend strives to provide quality research reagents and expert technical support to the scientific community worldwide. We look forward to serving your research needs and becoming your long term research partner.

6F MF Nishi-Umeda Building 5-1-26 Fukushima, Fukushima-ku Osaka, 553-0003 JapanBBK Worldwide provides investigator and ptient recruitment services.

Kamikiyoto Kiyose-shi, Tōkyō-to, 204-0013 Japan

1-10-1 Kamikiyoto Kiyoseshi, Tokyo, 2040013 Japan

Sapporo, Hokkaido Prefecture JapanGP Biosciences offers microarray, glycan profiling, genotyping, and gene expression services.

Kumamoto Techno Research Park Tabaru 2025-5, Mashikimachi, kamimashiki gun Kumamoto 861-2202, JAPANDojindo Molecular Technologies offers assay kits and reagents for cell analysis, Mitochondrial research, Autophagy, protein analysis, oxidative stress detection, and surface modification studies.

Fujii Bldg. 3F, 1-4-4 Ueno Taito-ku, Tokyo, 110-0005 JapanKAC is committed to make contributions to the advancement of sciences and the promotion of human welfare. KAC provide Laboratory Reagents and Materials for Bioresearch. https://www.saibou.jp/en/reagents/ Block Ace powder: Block Ace powder is prepared from milk protein and is a novel blocking agent for immunology experiments. Since milk protein contains many hydrophobic groups, it shows high affinity to plastic and membrane filters. Therefore, compared with conventional blocking agents such as bovine serum albumin (BSA), it is suitable for blocking nonspecific binding of antigens or antibodies when conducting Enzyme-Linked Immunosorbent Assay (ELISA) and Radioimmunoassay (RIA) and an immunoblotting method. https://www.saibou.jp/en/reagents/related/block_ace/ Mycoplasma removal agent (MC-210): Mycoplasma removal agent (MC-210) is a mycoplasma removal agent for cell culture and protects precious cultured cells for research from mycoplasma contamination. This agent demonstrates high removal effects against a common contaminant, i.e., mycoplasma orale. https://www.saibou.jp/en/reagents/related/mc210/ TC Protector: TC protector is a cell cryoprotective agent that does not contain any animal-derived components nor proteins and is chemically defined. It can be used in cells requiring serum addition, those without serum, and cells without proteins.It is suitable for cell line cells and normal cells as well as ES cells, adult stem cells, and human iPS cells. It is not viscous and does not form bubbles. Thus, it is excellent in usability. https://www.saibou.jp/en/reagents/related/tcp/

2-1-20, kukuchi Nishimach Amagasaki-shi, Hyogo, 661-0978 JapanKAC is committed to make contributions to the advancement of sciences and the promotion of human welfare. KAC provide Laboratory Reagents and Materials for Bioresearch. https://www.saibou.jp/en/reagents/ Block Ace powder: Block Ace powder is prepared from milk protein and is a novel blocking agent for immunology experiments. Since milk protein contains many hydrophobic groups, it shows high affinity to plastic and membrane filters. Therefore, compared with conventional blocking agents such as bovine serum albumin (BSA), it is suitable for blocking nonspecific binding of antigens or antibodies when conducting Enzyme-Linked Immunosorbent Assay (ELISA) and Radioimmunoassay (RIA) and an immunoblotting method. https://www.saibou.jp/en/reagents/related/block_ace/ Mycoplasma removal agent (MC-210): Mycoplasma removal agent (MC-210) is a mycoplasma removal agent for cell culture and protects precious cultured cells for research from mycoplasma contamination. This agent demonstrates high removal effects against a common contaminant, i.e., mycoplasma orale. https://www.saibou.jp/en/reagents/related/mc210/ TC Protector: TC protector is a cell cryoprotective agent that does not contain any animal-derived components nor proteins and is chemically defined. It can be used in cells requiring serum addition, those without serum, and cells without proteins.It is suitable for cell line cells and normal cells as well as ES cells, adult stem cells, and human iPS cells. It is not viscous and does not form bubbles. Thus, it is excellent in usability. https://www.saibou.jp/en/reagents/related/tcp/

Nishinokyo Nishigekkocho 40 Nakagyo-ku Kyoto-shi, Kyoto, 604-8423 JapanKAC is committed to make contributions to the advancement of sciences and the promotion of human welfare. KAC provide Laboratory Reagents and Materials for Bioresearch. https://www.saibou.jp/en/reagents/ Block Ace powder: Block Ace powder is prepared from milk protein and is a novel blocking agent for immunology experiments. Since milk protein contains many hydrophobic groups, it shows high affinity to plastic and membrane filters. Therefore, compared with conventional blocking agents such as bovine serum albumin (BSA), it is suitable for blocking nonspecific binding of antigens or antibodies when conducting Enzyme-Linked Immunosorbent Assay (ELISA) and Radioimmunoassay (RIA) and an immunoblotting method. https://www.saibou.jp/en/reagents/related/block_ace/ Mycoplasma removal agent (MC-210): Mycoplasma removal agent (MC-210) is a mycoplasma removal agent for cell culture and protects precious cultured cells for research from mycoplasma contamination. This agent demonstrates high removal effects against a common contaminant, i.e., mycoplasma orale. https://www.saibou.jp/en/reagents/related/mc210/ TC Protector: TC protector is a cell cryoprotective agent that does not contain any animal-derived components nor proteins and is chemically defined. It can be used in cells requiring serum addition, those without serum, and cells without proteins.It is suitable for cell line cells and normal cells as well as ES cells, adult stem cells, and human iPS cells. It is not viscous and does not form bubbles. Thus, it is excellent in usability. https://www.saibou.jp/en/reagents/related/tcp/

1 Sakura-machi Hino-shi, Tokyo, 191-8511 JapanKonica Minolta Business Solutions U.S.A., Inc.: is reshaping and revolutionizing the Workplace of the Future.™ The company guides and supports its customers’ digital transformation through its expansive office technology portfolio, including IT Services, ECM, Managed Print Services and comprehensive industrial and commercial printing and packaging solutions that deliver the latest innovations in printing, applications and expertise. Its All Covered IT Services division offers a range of IT strategy, support, and network security solutions across all industries.

Kuboi bldg 6F, Nihonbashi Horidome-cho 1-1-9 Chuo-ku Tokyo, 103-0012 JapanMediridge Co.,Ltd, we carry out various bio-related testing and bio production contract for pharmaceutical, diagnostics companies and academic researchers in Japan.

7, Yotsuya 1-chome, Shinjuku-ku, Tokyo 160-8515, JapanMochida Pharmaceutical specializes in production and development of cardiovascular, obstetrics, gynecology, dermatology, emergency, and psychiatry medicine.

KBIC#217, 7-7, Shinkawasaki, Saiwai-ku, Kawasaki-shi, Kanagawa 212-0032, JapanOur mission at ORGANOGENIX, Inc., as a leading company of three-dimensional (3D) cell culture technology, is to provide products and technical support to scientists worldwide to bring innovation to life science research, which leads to breakthroughs in drug discovery and achievement of a longevity society. Our 3D Vison Dedication We are dedicated to the further exploration of the 3D cell culture method and through our expertise and products, bring a new perspective to promote innovation in the field of life science. Discovery Our vision, by advancing bioscience research with our 3D model, is to contribute to the creation of novel drugs and medicines, diagnostic technologies and other medical innovations and discoveries. Dream We dream to achieve a healthy society, that our 3D technology contributes to medical research breakthroughs leading to overcome intractable diseases, increase the human health span, and enhance disease preventions.

Shonan Health Innovation Park, 2-26-1, Muraoka-Higashi Fujisawa, Kanagawa, 251-8555 JapanElixirgen Scientific, established in 2016, is a Maryland-based biotechnology firm specializing in iPSC-related technology. Our mission is to dedicate ourselves to quality, innovation, and collaboration, which drives the development of cutting-edge discoveries and therapies through the power of iPSC technology. We are focused on: ● New Cell Type Development Partnership: Engage in a strategic partnership focused on creating clinically relevant and functional cells. These cells find applications in neurodegenerative drug screening and cell therapy, contributing to the evolution of medical solutions. ●Cell Supply Agreement for Drug Screening: Ensure the efficiency of your drug discovery pipeline with our reliable and consistent supply of cells for screening purposes. We prioritize the seamless progression of your research and development initiatives. ●Translational Research Partnership with Patient-Derived Disease Model: Collaborate with us in translational research, benefitting from disease panel assays tailored to your specific needs. Our expertise extends to diseases such as Alzheimer's, Parkinson's, rare diseases and regenerative medicine.

Ina-Shi, Nagano JapanEstablished in 1929 as Japan’s first yeast manufacturer for bread, Oriental Yeast Co., Ltd. has expanded from being a supplier of various food products including yeast—for which it has the top share—to animal feed and biotechnology. The company sees its future in researching and developing the infinite possibilities of yeast by way of technology sets.

7F Wakamatsu Building, 3-3-6 Nihonbashi Hon-cho, Chuo-ku, Tokyo 103-0023 JapanPatheon is the leading publicly listed provider of drug development and manufacturing services to global pharmaceutical, biotechnology and specialty pharmaceutical companies.

3-4-1, Kagamiyama, Higashi-Hiroshima City,PhoenixBio offers high quality pre-clinical CRO services with the PXB-mouse® model (PhoenixBio proprietary human liver chimeric mice)

Higashihiroshima, Hiroshima Prefecture JapanPhoenixBio offers high quality pre-clinical CRO services with the PXB-mouse® model (PhoenixBio proprietary human liver chimeric mice)

3-4-1, KAGAMIYAMA Higashi Hiroshima, Hiroshima, 7390046 JapanPhoenixBio offers high quality pre-clinical CRO services with the PXB-mouse® model (PhoenixBio proprietary human liver chimeric mice)

3-4-1 Kagamiyama Higashi-Hiroshima, Hiroshima, 739-0046 JapanPhoenixBio offers high quality pre-clinical CRO services with the PXB-mouse® model (PhoenixBio proprietary human liver chimeric mice)

3-5-1 Aoihigashi Naka-ku, Hamamatsu 433-8114 JapanPDS Life Sciences provides the all-encompassing services to get your preclinical data SEND-ready. PDS aggregates and translates data to produce SEND export files, including the Study Data Reviewer's Guide as recommended by the FDA.

Kyoto, Kyoto, 602-8482 JapanReal World Data co., Ltd. deals with RWD database. RWD database has over 19 million patients from 170 medical faculties in Japan. RWD database is the only database in Japan that contains electronic medical record(EMR) data source. We supply the data and its analytics that represents Japanese medical situation.

DF Kasumigaseki Place,3-6-7 Kasumigaseki Chiyoda-ku, Tokyo 100-0013 JAPANSCETI Bioscience offers immunoassays, proteins, DNA, antibodies, cell culture products and services.

4th Floor, Dai2 Nagai Building 4-4-13 Nihonbashihoncho Chuo-ku, Tokyo 103-0023 Japan

Nishi Shinbashi 1Chome Kawate Bill 8F 801 1-5-8, Nishi Shinbashi, Minato-Ku, Tokyo 105-0003 JapanSongwon is the second largest manufacturer of polymer stabilizers in the world. Our vision is to be Salient in Additives and become the supplier of choice for polymer additives through our continued commitment to providing better quality, better service and better value to our customers. We are firmly focused on delivering growth by anticipating the needs and desires of our customers and by aspiring to be a leading example in additives technology development.

, Chūō-ku, Ōsaka-fu 541-0046, JPThe characters that comprise Senju's company name in the Japanese language are "千(Sen)" and "寿(Ju)" which literally mean "thousand" and "bringing happiness", respectively. Senju, bringing much (a thousand) happiness, has an objective that we bring a "happiness" to the people associated with Senju through the development of original pharmaceutical products for the care of the five senses (eye, ear, nose, throat and skin), that improve the joy of living. This is our management principle, "Good Company". Furthermore, we strongly believe that Senju should be a trustworthy and essential company by putting ourselves into the other person's shoes and acting under the company concept of "If I were you".

2-5-8,Hirano-machi Chuo-ku, Osaka JapanThe characters that comprise Senju's company name in the Japanese language are "千(Sen)" and "寿(Ju)" which literally mean "thousand" and "bringing happiness", respectively. Senju, bringing much (a thousand) happiness, has an objective that we bring a "happiness" to the people associated with Senju through the development of original pharmaceutical products for the care of the five senses (eye, ear, nose, throat and skin), that improve the joy of living. This is our management principle, "Good Company". Furthermore, we strongly believe that Senju should be a trustworthy and essential company by putting ourselves into the other person's shoes and acting under the company concept of "If I were you".

AMETEK Co., Ltd. CAMECA B.U. Tokyo office: 3F, Shiba NBF Tower 1-1-30, Shiba Daimon, Minato-ku, Tokyo 105-0012, Japan

13F Ochanomizu Solacity 4-6 Kanda-Surugadai Chiyoda-ku, Tokyo, N/A = Not Applicable, 101-0062 JapanINTAGE Healthcare is a leading healthcare marketing intelligence and evidence provider headquartered in Japan. We provide comprehensive pre-launch and post-launch support to meet the full range of healthcare information needs through real-world data analytics, post-marketing surveillance, and marketing research. We combine our deep knowledge of clinical practice with the INTAGE Group’s abundant resources and strength in consumer insights to provide healthcare consumers, providers, manufacturers, and service companies with the information they need to make healthier decisions.

3-1-3 Higashi-Ikebukuro Toshima City, Tokyo, 170-0013 JapanINTAGE Healthcare is a leading healthcare marketing intelligence and evidence provider headquartered in Japan. We provide comprehensive pre-launch and post-launch support to meet the full range of healthcare information needs through real-world data analytics, post-marketing surveillance, and marketing research. We combine our deep knowledge of clinical practice with the INTAGE Group’s abundant resources and strength in consumer insights to provide healthcare consumers, providers, manufacturers, and service companies with the information they need to make healthier decisions.

3-5-7 Kawara-machi Osaka, Osaka, 542-0076 JapanINTAGE Healthcare is a leading healthcare marketing intelligence and evidence provider headquartered in Japan. We provide comprehensive pre-launch and post-launch support to meet the full range of healthcare information needs through real-world data analytics, post-marketing surveillance, and marketing research. We combine our deep knowledge of clinical practice with the INTAGE Group’s abundant resources and strength in consumer insights to provide healthcare consumers, providers, manufacturers, and service companies with the information they need to make healthier decisions.

4-6 Kanda-Surugadai Chiyoda City, Tokyo, 101-0062 JapanINTAGE Healthcare is a leading healthcare marketing intelligence and evidence provider headquartered in Japan. We provide comprehensive pre-launch and post-launch support to meet the full range of healthcare information needs through real-world data analytics, post-marketing surveillance, and marketing research. We combine our deep knowledge of clinical practice with the INTAGE Group’s abundant resources and strength in consumer insights to provide healthcare consumers, providers, manufacturers, and service companies with the information they need to make healthier decisions.

2-15-1 Konan, Minato-ku 港区, Tokyo, 108-6028 JapanInstem provides advanced and best-in-class IT solutions and services to the global health and life sciences community, which help to bring life-changing products to market faster. For the more than 500 clients around the world, we are supplying breakthrough technology and services that help them efficiently access, capture, manage and enrich a wide array of data while generating new insight to advance their mission. Instem clients experience measurable benefits such as: Greater confidence in the safety and efficacy of their product portfolio Shorter R&D cycles with reduced costs Better management controls Increased regulatory compliance More effective resource utilization with greater staff satisfaction Happier and healthier clinical subjects Enhanced care and reduction of animal usage As a result, we enjoy a greater than 98% client retention rate – a statistic that we believe is the true measure of our success. More than just another IT vendor, as a solutions provider we act as a client’s strategic partner helping to optimize their processes, increase the satisfaction of their sponsors and partners while helping them become more competitive in their local, regional and global marketplaces.

5-16-26 Minami-Suita, Suita, Osaka 564-0043, JapanJCL Bioassay USA is a highly dedicated and responsive bioanalytical Contract Research Organization (CRO) for small and large molecule bioanalysis. We partner with our clients throughout the discovery and development process to identify and develop life-changing therapies. With JCL, you can trust that you will receive reliable and timely assay results so you can make informed drug development decisions.

17-18 Nakahata-cho, Nishiwaki, Hyogo 677-0032, JapanJCL Bioassay USA is a highly dedicated and responsive bioanalytical Contract Research Organization (CRO) for small and large molecule bioanalysis. We partner with our clients throughout the discovery and development process to identify and develop life-changing therapies. With JCL, you can trust that you will receive reliable and timely assay results so you can make informed drug development decisions.

Tokyo, JapanWe provide software and services for management and analysis of next generation sequencing (NGS) data.

549,Nakahigano,Inasato-Cho, Nagano 381-2215 JapanJupiter Bioscience provides amino acids, peptide synthesis, process development, and scale up.