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1300 Morris Park Avenue Bronx, NY 10461 Overview Zebrafish is a powerful system for studies of embryogenesis and to investigate mechanisms underlying human diseases. The zebrafish is particularly well suited to study complex and acquired diseases and to identify new disease genes owing to its genetic tractability, transparency of the organism, and the ease of conducting chemical screens to identify diagnostic and potential therapeutic targets. Moreover, the high degree of genetic conservation renders translation between fish and mammals a possibility. For example, this model system can be used to validate and characterize genome-wide association study (GWAS) candidates through gain of function and loss of function approaches. For loss of function analysis the candidate, the gene of interest can be transiently knocked down or stable mutant alleles can be generated through reverse genetic mutagenesis approaches. The phenotypes produced by the normal and mutant versions can provide an indication of the gene’s function in development and disease. The Einstein Zebrafish Core was established to facilitate this type of analysis.
Chanin 523 Overview Zebrafish is a powerful system for studies of embryogenesis and to investigate mechanisms underlying human diseases. The zebrafish is particularly well suited to study complex and acquired diseases and to identify new disease genes owing to its genetic tractability, transparency of the organism, and the ease of conducting chemical screens to identify diagnostic and potential therapeutic targets. Moreover, the high degree of genetic conservation renders translation between fish and mammals a possibility. For example, this model system can be used to validate and characterize genome-wide association study (GWAS) candidates through gain of function and loss of function approaches. For loss of function analysis the candidate, the gene of interest can be transiently knocked down or stable mutant alleles can be generated through reverse genetic mutagenesis approaches. The phenotypes produced by the normal and mutant versions can provide an indication of the gene’s function in development and disease. The Einstein Zebrafish Core was established to facilitate this type of analysis.
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The Contract Research Map is owned and maintained by Scientist.com. It was created to help researchers in the life sciences identify and connect with contract research organizations (CROs) based on geography. Updated nightly, this map features all of the available CROs within our network, so you can order services with a few clicks. Click on a specific country, scroll on the map itself or type into the search bar at the top—there are many ways to find the location and suppliers that you’re looking for. From Argentina to New Zealand, use this map to connect with a CRO near you.
We believe that every researcher across the world should be able to connect with the thousands of global CROs that exist and have the opportunity to work together. Like many industries,the life science supply chain has been disrupted over the last year. But there are many other circumstances such as international customs regulations or sensitive shipping times that create limitations around which countries are feasible to partner with. Sometimes, finding a CRO based in a country that best suits your research needs is imperative. We hope this contract research map allows you to find the right partner in the right place at the right time.
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